ABSTRACTPolitics is one of the critical factors that influence health policy agendas. However, scholarly efforts, especially in low- and middle-income countries, rarely focus on how politics influence health policy agenda-setting. We conducted a qualitative document review to examine the factors that led to developing the free primary health care policy for maternal health in Papua New Guinea. We also discuss mechanisms through which national politics, as an overriding factor, influenced the development of the policy. The review draws on Kingdon’s multiple-stream model for agenda-setting and incorporates theoretical insights from Fox and Reich’s framework for analyzing the politics of health reform for universal health coverage in low- and middle-income countries.

The National Center for Complementary and Integrative Health (NCCIH), which is part of the US National Institutes of Health (NIH), has a broad interest in studying the biologic activities of natural products, especially those for which compelling evidence from preclinical research suggests biologic activities that may be beneficial to health or have a potential role in disease treatment, as well as products used extensively by the American public. As of 2023, use of cannabis for medical purposes is legal in 38 states and Washington, D.C. Such use continues to climb generally without sufficient knowledge regarding risks and benefits. In keeping with NCCIH’s natural product research priorities and recognizing this gap in knowledge, NCCIH formally launched a research program in 2019 to expand research on the possible benefits for pain management of certain substances found in cannabis: minor cannabinoids and terpenes. This Viewpoint provides additional details and the rationale for this research priority at NCCIH. In addition, NCCIH’s efforts and initiatives to facilitate and coordinate an NIH research agenda focused on cannabis and cannabinoid research are described.

The class F of G protein-coupled receptors (GPCRs) consists of 10 Frizzleds (FZD_1–10) and Smoothened (SMO). FZDs bind and are activated by secreted lipoglycoproteins of the Wingless/Int-1 (WNT) family, and SMO is indirectly activated by the Hedgehog (Hh) family of morphogens acting on the transmembrane protein Patched. The advance of our understanding of FZDs and SMO as dynamic transmembrane receptors and molecular machines, which emerged during the past 14 years since the first-class F GPCR IUPHAR nomenclature report, justifies an update. This article focuses on the advances in molecular pharmacology and structural biology providing new mechanistic insight into ligand recognition, receptor activation mechanisms, signal initiation, and signal specification. Furthermore, class F GPCRs continue to develop as drug targets, and novel technologies and tools such as genetically encoded biosensors and CRISP/Cas9 edited cell systems have contributed to refined functional analysis of these receptors. Also, advances in crystal structure analysis and cryogenic electron microscopy contribute to the rapid development of our knowledge about structure-function relationships, providing a great starting point for drug development. Despite the progress, questions and challenges remain to fully understand the complexity of the WNT/FZD and Hh/SMO signaling systems.

BackgroundAttention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, for which there are effective pharmacological treatments that improve symptoms and reduce complications. Guidelines published by the National Institute for Health and Care Excellence recommend that primary care practitioners prescribe medication for adult ADHD under shared-care agreements with Adult Mental Health Services (AMHS). However, provision remains uneven, with some practitioners reporting a lack of support.AimThis study aimed to describe elements of support, and their availability/use, in primary care prescribing for adult ADHD medication in England to improve access for this underserved population and inform service improvement.Design and settingCross-sectional surveys were used to elicit data from commissioners, health professionals (HPs), and people with lived experience of ADHD (LE) across England about elements supporting pharmacological treatment of ADHD in primary care.MethodThree interlinked cross-sectional surveys were used to ask every integrated care board in England (commissioners), along with convenience samples of HPs and LEs, about prescribing rates, AMHS availability, wait times, and shared-care agreement protocols/policies for the pharmacological treatment of ADHD in primary care. Descriptive analyses, percentages, and confidence intervals were used to summarise responses by stakeholder group. Variations in reported provision and practice were explored and displayed visually using mapping software.ResultsData from 782 responders (42 commissioners, 331 HPs, 409 LEs) revealed differences in reported provision by stakeholder group, including for prescribing (95% of HPs versus 64% of LEs). In all, >40% of responders reported extended AMHS wait times of ≥2 years. There was some variability by NHS region – for example, London had the lowest reported extended wait time (25%), while East of England had the highest (55%).ConclusionElements supporting appropriate shared-care prescribing of ADHD medication via primary care are not universally available in England. Coordinated approaches are needed to address these gaps.

Background

In an evolving landscape of practices and policies, reviewing and incorporating the latest scientific evidence is necessary to ensure optimal clinical management for people with opioid use disorder. We provide a synopsis of the 2024 update of the 2018 National Guideline for the Clinical Management of Opioid Use Disorder, from the Canadian Research Initiative in Substance Matters.

NFL Commissioner Roger Goodell held a news conference today after the second day of the annual owners meeting. Watch his remarks in the player above.

NFL players will be encouraged to stand for the national anthem at the start of the football games, the league’s chief told reporters today.

After two days of meeting with owners of each NFL team, representatives for the players’ union and players themselves, the NFL has reiterated its decision to keep its existing policy of not requiring players to stand during the anthem. Goodell said yesterday that the league wouldnot instate a rule that would penalize players who refuse to stand for the anthem.

“We believe everyone should stand for the national anthem,” he told reporters at a news conference today. “That’s an important part of our policy. It’s also an important part of our game that we all take great pride in. And it’s also important for us to honor our flag and our country and I think our fans expect us to do that.”

Goodell’s remarks came after President Donald Trump continued his criticism of the NFL this morning. On Twitter, Trump said: “The NFL has decided that it will not force players to stand for the playing of our National Anthem. Total disrespect for our great country!”

After former San Francisco 49ers quarterback Colin Kaepernick kneeled during the anthem last year to protest police killings of unarmed black men, dozens of other players joined him to draw greater attention to social and racial injustice. Last month, Trump said the NFL ought to fire players who didn’t stand for the anthem.

The players “are not doing this in any way to be disrespectful to the flag,” Goodell said today. “But they also understand how it’s being interpreted.”

Goodell also said the league wanted to stay out of the political arena over the issue.

“We’re not looking to get into politics,” he told reporters. “What we’re looking to do is to continue to get people focused on football.”

The post WATCH: NFL commissioner says players ‘should stand for the national anthem’ appeared first on PBS NewsHour.

As the International Space Station comes to the end of its life, we should recognise its biggest achievement – showing that a better world is possible

From artificial retinas to ageing mice, here are five of the most promising results from research performed on the ISS – and what they might mean for humans on Earth and in space

AlphaProof, an AI from Google DeepMind, came close to matching the top participants in a prestigious competition for young mathematicians

Two large grizzly bears followed 13 hikers down a trail in Banff National Park for 20 minutes — with one even making a few quick runs at the group.

President-elect Donald Trump announced Tuesday that John Ratcliffe, a former Texas congressman and director of national intelligence, will serve as the director of the Central Intelligence Agency in his administration.

Kraft Heinz has announced it is removing its Lunchables meal kits from the National School Lunch Program. With eight $1 billion+ brands, Kraft Heinz is North America’s third-largest food and beverage company and the fifth-largest in the world. The National School Lunch Program (NSLP) is America’s second-largest food and nutrition... Continue Reading

The three 1980s staples are new National Toy Hall of Fame inductees. Hess Toy Trucks, the Pokémon Trading Card Game, the trampoline, and balloons were among the finalists.

The national chief of the Assembly of First Nations says the International Criminal Court should investigate the disappearance of Indigenous children from Canadian residential schools.

The Indian Council of Medical Research─National Institute of Cancer Prevention and Research (ICMR─NICPR) is set to launch its first─ever DHR─funded National NICPR─ECHO online certificate course on cervical

Pesky leaks on the International Space Station aren’t the most serious issue facing U.S. human spaceflight

The U.S. Food and Drug Administration posted a photo:

Catherine Dasenbrock, director of the U.S. Food and Drug Administration’s National Forensic Chemistry Center, speaks to guests prior to officially reopening the center during a ribbon-cutting ceremony, Sept. 24, 2024, celebrating the completion of the 64,000-square-foot expansion and renovation of the facility in Cincinnati, Ohio. The NFCC is a specialty laboratory that serves as the FDA’s national forensic laboratory providing specialized laboratory services in analytical chemistry and molecular/microbiology related to adulteration/contamination, counterfeiting, and product tampering of FDA regulated commodities including drugs, dietary supplements, foods, cosmetics, veterinary feeds, and medical devices.

FDA photo by Matthew MacRoberts

The U.S. Food and Drug Administration posted a photo:

U.S. Food and Drug Administration officials and General Services Administration leaders officially reopen the National Forensic Chemistry Center during a ribbon-cutting ceremony, Sept. 24, 2024, highlighting the completion of the 64,000-square-foot expansion and renovation of the center in Cincinnati, Ohio. The NFCC is a specialty laboratory that serves as the FDA’s national forensic laboratory providing specialized laboratory services in analytical chemistry and molecular/microbiology related to adulteration/contamination, counterfeiting, and product tampering of FDA regulated commodities including drugs, dietary supplements, foods, cosmetics, veterinary feeds, and medical devices.

(From left)
Marie Maguire, Assistant Special Agent in Charge, Headquarters Operations, Office of Criminal Investigations, FDA
James Sigg, Deputy Commissioner for Operations and Chief Operating Officer, Office of the Commissioner, FDA
Catherine Dasenbrock, Director, National Forensic Chemistry Center, Office of Inspections and Investigations (OII), FDA
Duane Satzger, Associate Director, Office of Medical Products and Specialty Laboratory Operations, OII, FDA
Katy Kale, Deputy Administrator, GSA
Douglas Stearn, Principal Deputy Associate Commissioner, OII, FDA

FDA photo by Matthew MacRoberts

The U.S. Food and Drug Administration posted a photo:

Scientists explain the work they do to guests attending a ribbon-cutting ceremony celebrating the completion of a 64,000-square-foot expansion and renovation of the U.S. Food and Drug Administration’s National Forensic Chemistry Center in Cincinnati, Ohio, Sept. 24, 2024.

The NFCC is a specialty laboratory that serves as the FDA’s national forensic laboratory providing specialized laboratory services in analytical chemistry and molecular/microbiology related to adulteration/contamination, counterfeiting, and product tampering of FDA regulated commodities including drugs, dietary supplements, foods, cosmetics, veterinary feeds, and medical devices.

FDA photo by Matthew MacRoberts

The U.S. Food and Drug Administration posted a photo:

Scientists explain the work they do to guests attending a ribbon-cutting ceremony celebrating the completion of a 64,000-square-foot expansion and renovation of the U.S. Food and Drug Administration’s National Forensic Chemistry Center in Cincinnati, Ohio, Sept. 24, 2024.

The NFCC is a specialty laboratory that serves as the FDA’s national forensic laboratory providing specialized laboratory services in analytical chemistry and molecular/microbiology related to adulteration/contamination, counterfeiting, and product tampering of FDA regulated commodities including drugs, dietary supplements, foods, cosmetics, veterinary feeds, and medical devices.

FDA photo by Matthew MacRoberts

The U.S. Food and Drug Administration posted a photo:

Scientists explain the work they do to guests attending a ribbon-cutting ceremony celebrating the completion of a 64,000-square-foot expansion and renovation of the U.S. Food and Drug Administration’s National Forensic Chemistry Center in Cincinnati, Ohio, Sept. 24, 2024.

The NFCC is a specialty laboratory that serves as the FDA’s national forensic laboratory providing specialized laboratory services in analytical chemistry and molecular/microbiology related to adulteration/contamination, counterfeiting, and product tampering of FDA regulated commodities including drugs, dietary supplements, foods, cosmetics, veterinary feeds, and medical devices.

FDA photo by Matthew MacRoberts

Aug 8, 2023

When states use moral language in a dispute, they reduce the possibility of compromise. The possibility of military escalation, meanwhile, rises in response to moral language when states’ domestic audiences accuse their governments of hypocrisy for their willingness to compromise. The Falkland Islands/Islas Malvinas case explores the theory.

The Pakistani Taliban on Monday claimed responsibility for the January 30 mosque attack in Peshawar which left 100 people dead and over 220 injured

Aug 12, 2022

Companies that rely on certain countries in Asia for their supply lines will face continued challenges as geopolitical stresses, let alone global pandemics, cause supply shortages. Beyond causing economic harm, these shortages pose a direct threat to U.S. national security interests.

Jun 18, 2024

The rise of political populism and economic protectionism are serious barriers impeding efforts to combat global climate change. Robert Lawrence, the Albert Williams Professor of International Trade and Investment at Harvard Kennedy School, expressed those concerns in the latest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.”

Apr 9, 2024

On April 2, the study group met for the second time to evaluate the role of international humanitarian groups in shaping political and social outcomes in Africa. The group examined how these organizations deal with emergencies, crises, and conflict situations across the continent, and scrutinized their influence on policy decisions and discuss the potential benefits and drawbacks of their involvement. Discussions covered the expanding influence of organizations like the United Nations High Commissioner for Refugees (UNHCR), Médecins Sans Frontières (Doctors Without Borders), and the International Rescue Committee (ICR). The study group counted with the presence of external expert guest Professor Sabs K. Quereshi, a senior-level leader with 17+ years of experience in global health, gender equality, health policy and equity, national security, humanitarian response, and government and multilateral affairs sectors in the U.S., with the UN, and worldwide.

Jun 14, 2024

Dr. Gloria Ayee led a study group over the course of five sessions during the Spring of 2024, exploring the current pivotal moment on the African continent. Participants of the study group were invited to reflect on the role that international cooperation must play in supporting inclusive, sustainable development in Africa, as well as to move beyond outdated perspectives and learn about Africa’s profound transformation through trade, investments in clean energy and health, and youth empowerment initiatives.

Jun 21, 2024

Dr. Gloria Ayee led a study group over the course of five sessions during the Spring of 2024, exploring the current pivotal moment on the African continent. Reflecting back, Dr. Ayee highlights the key takeaways from the study group.

Mar 13, 2024

David Kearn argues that even in the absence of restrictive resource and budgetary constraints, a focus on identifying and achieving concrete objectives that will position the United States and its allies to effectively deter aggression in critical regional flashpoints should be the priority given the stressed nature of the defense industrial base and the nuclear enterprise.

Redefining the American Auto Industry. - The Growing Impact of International Automakers on the U.S. Economy.

Summary of the 2014 St. Petersburg International Economic Forum

Long Term Care Consumer Resources

CrissCross Representative Payee Services

Associates at VPI share their stories in honor of National Pet Cancer Awareness Month. Find out how you can help #CurePetCancer, visit www.CurePetCancer.com

#ChangeTheNumbers - Entdecken Sie die Ergebnisse der Studie

Lee and Lucille Allen share the story of how their Clayton Home changed their lives.

Gary Sinise and nearly 100 WWII veterans mark the opening to the newest exhibit at the National WWII Museum. Road to Tokyo: Pacific Theater Galleries, retraces the grueling trail that led from Pearl Harbor to Tokyo Bay. Through personal narratives, artifacts and oral histories, the exhibit tells the story of the American spirit that carried the day.

The London Look International Contest With Rita Ora Teaser

3 minute aquatic and coastal film

Featuring one of our new sweet and tangy margaritas, the Grilled Pineapple Margarita is a mix of grilled pineapple, tequila and Falernum syrup. Learn how to make your own!

XCMG Apprentice Program introduces latest technologies and Chinese culture to international apprentices.

From unique cereal recipes by Chef Justin Warner to simply enjoying a favorite bowl, cereal lovers of all ages are encouraged to share how they are enjoying cereal again on #NationalCerealDay.

International Stars at the Closing of the XVIII Habanos Festival

41st Annual National Odor-Eaters Rotten Sneaker Contest

#DearHairStylist TLC Commercial

2017 Kia Cadenza

2017 Hyundai IONIQ Hybrid Dynamic B-roll

Genesis Reveals Hybrid Sports Sedan Concept At New York International Auto Show