THE FREEZING plunge in temperatures over the next 24 hours even sparked disbelief from the meteorologist on BBC Breakfast, who warned that Britain could go from its warmest day of the year on Saturday to being hit by snow on Sunday.

BRITON'S are due to see temperatures soar to 26C on Saturday in a heatwave hotter than Lanzarote.

THEATRES all over the country and working to make sure fans do not miss shows - so how can you watch West End shows online?

THEATRES are some of the most important aspects of our culture, with theatre fans desperate to see them open once more. When will theatres reopen?

THE National Theatre has been streaming its shows online in a fantastic new service - but which new shows are being made available online?

Mother's Day will bring Arctic blasts, wintry conditions and records low temperatures for two-thirds of the US. Meanwhile, a heat wave will hit Alaska

The play is the theater program's way of countering anti-drug programs that haven't worked — the kind where adults shake fingers at students.

Indiana Repertory Theatre's new plays include Mary Lincoln's reclusiveness, 'Fahrenheit 451' and a celebration of Indianapolis' bicentennial.

Don't forget to put the speaker back.

Empty seats. Silent screens. How Franklin's Artcraft Theater is weathering the pandemic.

New guidelines announced by Gov. Eric Holcomb include timeline for resuming social gatherings and entertainment events, including bars and nightclubs.

The last business standing on a flood-prone piece of land is expected to vacate this year, making way for a 15-acre park with an amphitheater.

A 15-acre park with amphitheater, playground and farmer's market plaza is planned for the southwest side of Franklin.

The Historic Artcraft Theater in Franklin has to survive the pandemic shutdown. The downtown economy depends on it.

Jam-band roots, revamped lineup and a new album translate into a fresh performance by the Dave Matthews Band at the venue once known as Deer Creek.

Modern rock giants Weezer and Pixies deliver power-meets-melody masterpieces in Indiana.

Sidewalk splash pools have long been a summertime staple, particularly for families with young kids. But the virus pandemic has boosted their appeal.

A trough off the West Coast is expected to bring a robust cooling trend to California next week.

The Queen has officially opened the National Theatre on the South Bank in London after years of delays.

Areas such as India, Australia and Africa are predicted to be among the worst affected.

A discussion about the impeachment hearings turned into a showdown between the co-hosts.

The health expert who helped shaped Britain’s lockdown policies in response to the coronavirus has resigned after admitting he broke his own rules by having his married lover visit him at his home. Professor Neil Ferguson, 51, of Imperial College in London was a prominent member of the Scientific Advisory Group for Emergencies. The Telegraph…

The post Scientist Behind Social Distancing Breaks Own Rules To Cheat with Married Woman, Resigns appeared first on The Western Journal.

Heat shock factor 1 (HSF1) regulates cellular adaptation to challenges such as heat shock and oxidative and proteotoxic stresses. We have recently reported a previously unappreciated role for HSF1 in the regulation of energy metabolism in fat tissues; however, whether HSF1 is differentially expressed in adipose depots and how its levels are regulated in fat tissues remain unclear. Here, we show that HSF1 levels are higher in brown and subcutaneous fat tissues than in those in the visceral depot and that HSF1 is more abundant in differentiated, thermogenic adipocytes. Gene expression experiments indicated that HSF1 is transcriptionally regulated in fat by agents that modulate cAMP levels, by cold exposure, and by pharmacological stimulation of β-adrenergic signaling. An in silico promoter analysis helped identify a putative response element for activating transcription factor 3 (ATF3) at −258 to −250 base pairs from the HSF1 transcriptional start site, and electrophoretic mobility shift and ChIP assays confirmed ATF3 binding to this sequence. Furthermore, functional assays disclosed that ATF3 is necessary and sufficient for HSF1 regulation. Detailed gene expression analysis revealed that ATF3 is one of the most highly induced ATFs in thermogenic tissues of mice exposed to cold temperatures or treated with the β-adrenergic receptor agonist CL316,243 and that its expression is induced by modulators of cAMP levels in isolated adipocytes. To the best of our knowledge, our results show for the first time that HSF1 is transcriptionally controlled by ATF3 in response to classic stimuli that promote heat generation in thermogenic tissues.

G. Kresin and V. Maz'ya
St. Petersburg Math. J. 31 (2020), 495-507.
Abstract, references and article information

Mohamed Jleli, Bessem Samet and Philippe Souplet
Proc. Amer. Math. Soc. 148 (2020), 2579-2593.
Abstract, references and article information

Heat shock factor 1 (HSF1) regulates cellular adaptation to challenges such as heat shock and oxidative and proteotoxic stresses. We have recently reported a previously unappreciated role for HSF1 in the regulation of energy metabolism in fat tissues; however, whether HSF1 is differentially expressed in adipose depots and how its levels are regulated in fat tissues remain unclear. Here, we show that HSF1 levels are higher in brown and subcutaneous fat tissues than in those in the visceral depot and that HSF1 is more abundant in differentiated, thermogenic adipocytes. Gene expression experiments indicated that HSF1 is transcriptionally regulated in fat by agents that modulate cAMP levels, by cold exposure, and by pharmacological stimulation of β-adrenergic signaling. An in silico promoter analysis helped identify a putative response element for activating transcription factor 3 (ATF3) at −258 to −250 base pairs from the HSF1 transcriptional start site, and electrophoretic mobility shift and ChIP assays confirmed ATF3 binding to this sequence. Furthermore, functional assays disclosed that ATF3 is necessary and sufficient for HSF1 regulation. Detailed gene expression analysis revealed that ATF3 is one of the most highly induced ATFs in thermogenic tissues of mice exposed to cold temperatures or treated with the β-adrenergic receptor agonist CL316,243 and that its expression is induced by modulators of cAMP levels in isolated adipocytes. To the best of our knowledge, our results show for the first time that HSF1 is transcriptionally controlled by ATF3 in response to classic stimuli that promote heat generation in thermogenic tissues.

(Clemson University) While the world admires the beauty and fragrance of flowers, most of us are missing out on the extraordinary processes these seemingly delicate life forms are carrying out every moment of the day. Matthew Koski, an assistant professor at Clemson, is not only paying attention, he is advancing his research with a three-year, $455,000 grant from the NSF for a study of flower adaptations titled 'Modifying the floral microenvironment: elevational divergence in floral thermoregulatory mechanisms.'

Heat shock factor 1 (HSF1) regulates cellular adaptation to challenges such as heat shock and oxidative and proteotoxic stresses. We have recently reported a previously unappreciated role for HSF1 in the regulation of energy metabolism in fat tissues; however, whether HSF1 is differentially expressed in adipose depots and how its levels are regulated in fat tissues remain unclear. Here, we show that HSF1 levels are higher in brown and subcutaneous fat tissues than in those in the visceral depot and that HSF1 is more abundant in differentiated, thermogenic adipocytes. Gene expression experiments indicated that HSF1 is transcriptionally regulated in fat by agents that modulate cAMP levels, by cold exposure, and by pharmacological stimulation of β-adrenergic signaling. An in silico promoter analysis helped identify a putative response element for activating transcription factor 3 (ATF3) at −258 to −250 base pairs from the HSF1 transcriptional start site, and electrophoretic mobility shift and ChIP assays confirmed ATF3 binding to this sequence. Furthermore, functional assays disclosed that ATF3 is necessary and sufficient for HSF1 regulation. Detailed gene expression analysis revealed that ATF3 is one of the most highly induced ATFs in thermogenic tissues of mice exposed to cold temperatures or treated with the β-adrenergic receptor agonist CL316,243 and that its expression is induced by modulators of cAMP levels in isolated adipocytes. To the best of our knowledge, our results show for the first time that HSF1 is transcriptionally controlled by ATF3 in response to classic stimuli that promote heat generation in thermogenic tissues.

Marriage vows are one thing, but the public service Code of Conduct, that's serious.

1 February 2008 , Number 3

23 February 2017

Although most renewable energy policy frameworks treat biomass as carbon-neutral at the point of combustion, biomass emits more carbon per unit of energy than most fossil fuels. 

One hundred years ago, Pennsylvanian surgeon Evan Kane penned a brief letter to JAMA in which he declared himself a rigorous proponent of the “benefic [sic] effects of the phonograph within the operating room.” Now David Bosenquet, a surgeon from University Hospital of Wales in Cardiff has written a Christmas editorial about the evidence for the...

Waiting times in theatre can be a source of friction – but is the delay due to mandatory anaesthetic faff around time (MAFAT), or AWOL surgeons? Elizabeth Travis, and orthopaedic house officer in New Zealand and colleagues, have been trying to create and evidence base to argue the toss, and she joins me now to discuss her study, Operating...

This week a very different kind of conversation on the Recommended Dose – one that considers the art of medicine more than the science. Iona Heath is a long-time family doctor who has worked in a London GP clinic for over 30 years, and at one time became President of the Royal College of General Practitioners. With an international profile, gained...

A new podcast from The BMJ, to help GP's feel more connected, heard, and supported. Subscribe on; Apple podcasts - https://bit.ly/applepodsDBI Spotify - https://bit.ly/spotifyDBI Google podcasts - https://bit.ly/googlepodsDBI This week, our topic is fear: we try to get a better understanding of fear, how it affects all of us as clinicians for...

While the Global Compact for Safe, Orderly, and Regular Migration was formally adopted by 164 of the UN's 193 Member States, it's worth asking how it became a point of contention and ultimately was rejected by more than a dozen countries. The answer? A long lag time between negotiation and adoption, during which overheated claims against it went largely unanswered, as this commentary explores.

British scientists said Monday that an amino acid swap can help protect wheat crops from rising heat due to global warming.

Test results suggest N95 masks can be safely disinfected through heating 50 times before their filtration efficiency begins to decline.

Both athletes were stars. Both faltered, then staged dramatic comebacks -- displaying the tenacity that separates heroes from also-rans. Both now face drug charges that could end their careers.

Economists have long known there are two reasons that people cheat on their taxes. One is that they are poor and need the extra cash so badly they are willing to risk getting caught. The other is that they are rich and have lots of "non-matchable" income -- mostly investment income not directly...

As the cold weather sets in, this nourishing winter dish is perfect to warm hands, feet and heart. The addition of buckwheat flour to polenta gives it a delicious smoky earth flavour and adds to the nutrition level of this dish. Rich in fibre and silica, gluten free buckwheat contain rutin, a bioflavonoid that is know to increase blood circulation and reduce high blood pressure. Perfect for winter!

I love a carrot cake . Usually walnuts are used however who doesn't want to take advantage of the local new season pecans at our local markets . Happy baking!

Racism makes our economy worse -- and not just in ways that harm people of color, says public policy expert Heather C. McGhee. From her research and travels across the US, McGhee shares startling insights into how racism fuels bad policymaking and drains our economic potential -- and offers a crucial rethink on what we can do to create a more prosperous nation for all. "Our fates are linked," she says. "It costs us so much to remain divided."

Five El Paso educators have been charged with scheming to defraud the federal accountability system and, in some cases, retaliating against co-workers who cooperated with the FBI's 5½-year investigation of the Texas school district.