BACKGROUND Neurofibroma/schwannoma hybrid nerve sheath tumors (N/S HNSTs) are neoplasms associated with larger nerves that occur sporadically and in the context of schwannomatosis or neurofibromatosis type 2 or 1. Clinical management of N/S HNSTs is challenging, especially for large tumors, and established systemic treatments are lacking.METHODS We used next-generation sequencing and array-based DNA methylation profiling to determine the clinically actionable genomic and epigenomic landscapes of N/S HNSTs.RESULTS Whole-exome sequencing within a precision oncology program identified an activating mutation (p.Asp769Tyr) in the catalytic domain of the ERBB2 receptor tyrosine kinase in a patient with schwannomatosis-associated N/S HNST, and targeted treatment with the small-molecule ERBB inhibitor lapatinib led to prolonged clinical benefit and a lasting radiographic and metabolic response. Analysis of a multicenter validation cohort revealed recurrent ERBB2 mutations (p.Leu755Ser, p.Asp769Tyr, p.Val777Leu) in N/S HNSTs occurring in patients who met diagnostic criteria for sporadic schwannomatosis (3 of 7 patients), but not in N/S HNSTs arising in the context of neurofibromatosis (6 patients) or outside a tumor syndrome (1 patient), and showed that ERBB2-mutant N/S HNSTs cluster in a distinct subgroup of peripheral nerve sheath tumors based on genome-wide DNA methylation patterns.CONCLUSION These findings uncover a key biological feature of N/S HNSTs that may have important diagnostic and therapeutic implications.FUNDING This work was supported by grant H021 from DKFZ-HIPO, the University Cancer Center Frankfurt, and the Frankfurt Research Funding Clinician Scientist Program.

Claudia Stauber provides a perfect metaphor of how she felt listening to Bernie Sanders today in Vermont, telling us how much he still fights for us against the 1% and the oligarchs. Continue reading →

The indie cinema chain is going digital.

The post Studio Coffee Run 5/8/20: Alamo On Demand brings new and old films to your home theater appeared first on The Beat.

The publisher is adding videos of their creators entertaining themselves while sheltering in place.

The post SHUT IN THEATER: What are Dynamite creators in quarantine up to? appeared first on The Beat.

What's the Beat staff reading this weekend? Let's find out!

The post SHUT IN THEATER: Weekend Reading 7 appeared first on The Beat.

Head Auror Harry Potter hated the Department of Mysteries. He hated dealing with Unspeakables and disliked their holier than thou attitude. When Harry is called upon to identify a man who has been dead for years that the Unspeakables found, he suspects that there’s something more sinister going on.

Emmy Nominee Leslye Headland to write, produce, and serve as showrunner for new untitled Star Wars series for Disney+.

A new play by Nick Dear, based on the novel by Mary Shelley. Watch Danny Boyle’s monster hit Frankenstein with Benedict Cumberbatch as the creature and Jonny Lee Miller as Victor Frankenstein. Frankenstein with Benedict Cumberbatch as the creature is streaming for free from 7pm UK time on Thursday 30 April. Available on demand until […]

It doesn’t matter what website you’re looking at, every site online has something that naturally catches your attention. It could be a picture, a graphic, a video, there will be something that naturally stands out and gets your attention. If you’re looking at turning your website into a source of revenue you want your ads or products displayed in such a way that they grab your visitor’s attention. There are two ways you can go about doing this, the wrong way which is to force your ads on people which will drive them away from your site. Or using heat maps to attract your visitors to them without forcing them..........

It’s not unusual for the mother of Canadian Prime Minister Justin Trudeau to be in the news. Margaret Sinclair Trudeau is a celebrity in her own right – author, speaker, and mental-health advocate.   But Ms. Trudeau, 71, made headlines

NOTE: You may pre-download this game, but it will not be playable until the release date/time: 07/10/2019 (check the product page for release date/time in your region). Get three days early access when you purchase the Gold Edition. Product Info: Developer: Motorsport Games Publisher: 704 Games Company Website: NASCAR Heat 5 Twitter: @704Games / @MSportgames / @NASCARHeat

When Ed and Leigh approached Colorado-based architecture firm F9 Productions to design their custom Rocky Mountain home, the couple wanted a residence that could last well into the future. This meant that the forever home not only had to be engineered with ADA-compliant features, but it also needed to be robust enough to weather the region’s extreme winter conditions for years to come. As a result, the architects crafted the Eastwatch House, a highly durable home that also takes advantage of passive solar conditions to reduce energy demands.[...]

Emily Mann speaks on “She Roars” about 30 years at McCarter Theatre, being named to the American Theater Hall of Fame, and the latest staging of her play “Gloria: A Life.”

But airports and airlines call on Govt for more support

April 15th and just like clock work it looks like it is going to rain and not a minute to soon thought I was living in a giant sauna for the past month here in Cambodia. The Khmer new Year is going on and it signifies the beginning of the rainy season so

The Clippers shook off a slow start to beat the Miami Heat 128-111.

Angels pitcher Andrew Heaney struggled against the Houston Astros in 2018, and he's irate not only at the sign stealing but because players haven't apologized.

French satire Deerskin was scheduled to screen in movie theaters this week. Instead, it is now opening online and will help theaters with the money earned on streaming views.

Some states are allowing movie theaters to reopen, but will they? Big theater chains say no, so it's up to independent theater owners who are "proceeding with an abundance of caution."

Long and intense heat waves are nothing new in Southern California and the Southwest, but amid COVID-19, public health experts are warning they could become deadlier for people self-isolating in homes they can't keep cool.

New analyses show that cheating didn't help the Astros, and may have hurt their record

The Dodgers are tired of talking about what the Houston Astros did in 2017. They're excited about what lies ahead for the team this season.

The Houston Astros cheated and Mike Fiers shined the brightest light on their scheme, LZ Granderson writes.

Trips to the movies and baseball stadiums are out of the question at the moment, but taunting the Astros over their 2017 World Series title remains in season.

Don't let the coronavirus outbreak obscure the lessons of theater, the connection to great thinkers, the inspiration that comes from the art of creation.

A remembrance of theater actor-writer-director Diane Rodriguez from a fellow El Teatro Campesino family member, 'Zoot Suit' playwright Luis Valdez.

Diane Rodriguez, ex-associate artistic director of Center Theatre Group, is remembered for her work with Luis Valdez and Culture Clash, among others.

Move productions outdoors? Present different work? Faced with so many unknowns, one artistic director vows: "We all will sit in a theater again."

Richard Nelson's new Apple Family play opens on YouTube to confront the pandemic. What can storytelling offer us right now?

Kerry English was a beloved "professional audience member," a fan who saw up to five shows a week and provided the support theaters so critically need.

A after visiting every U.S. county in the lower 48, William Least Heat-Moon is the master of the topographical journey. Now 80, he takes another trip through his new novel — into the imperfect history of American democracy.

The coronavirus pandemic has shut down theaters, which may result in big changes for the Oscars.

Boss of Britain's busiest air hub calls for 'a common international standard for healthcare screening in airports'

'Do I think that the UK would benefit from private investors putting £14 billion of their own money into the UK in the next few years? Absolutely,' says John Holland-Kaye

The Man Who Pays His Way: will happen to the Sussex airport?

Screening technology will be trialled in Terminal 2, without passengers being aware they are being checked

Airport chief told MPs earlier this week that expansion might not be back on the agenda for a decade

Heatstroke danger: Never leave an unattended child or pet in a car, even if the windows are down.

Coronavirus may have shut down movie theaters, but even if they stayed closed, we'd have a strong slate of Oscar contenders beyond Elisabeth Moss in "Invisible Man."

Warner Bros.'s animated Scooby Doo movie is going straight to home viewing platforms amid the COVID-19 pandemic.

Movie theaters might start opening up as soon as mid-June. That's going to be more complicated than it sounds.

Photos capture Hollywood's movie houses in this pandemic moment.

Marcia Cross, Laura Leighton, Heather Locklear and more members of the original "Melrose Place" cast got together via video chat for coronavirus relief.

BBC WEATHER has forecast temperatures of up to 25C as Brits celebrate VE day but by Sunday, conditions will drastically change as stormy downpours washout the UK.

BRITONS saw temperatures climb yesterday into the 20's as many welcomed the early Bank Holiday sunshine, however this weekend a dramatic change will take place as cold Arctic air will sweep snow in.

A HOT and sunny Saturday is set across the UK before a cooler Sunday.