Everything is at stake. Everything is at stake with nuclear weapons. While working as a nuclear war planner for the Kennedy administration, Daniel Ellsberg was shown a document calculating that a U.S. nuclear attack on communist countries would result in 600 million dead. As he put it later: “A hundred Holocausts.” That was in 1961. […]

The United Nations continues to be virtually paralyzed – and remains politically impotent amidst two raging conflicts—as Russia and Israel keep defying the world body. The killings of civilians and the destruction of cities, particularly by Israel, are devastating and continue despite repeated warnings from the UN, its humanitarian agencies, the International Criminal Court (ICC), […]

MANILA, Philippines — The Office of the Civil Defense (OCD) on Wednesday said the government is ready to respond to the effects of typhoons in the coming days and weeks of the year. OCD head Ariel Nepomuceno, however, admitted that the consecutive storms/typhoons in the past few weeks are unprecedented, even in the current system the government has for disaster response. “Nakalatag naman ‘yung sistema natin, although admittedly itong sistema natin hindi na-assume ‘yung ganitong scenario, bago rin sa’tin ito,” said Nepomuceno during a Kapihan sa Manila Hotel briefing. (Our system is in place, although admittedly our system did not […]...

Keep on reading: Gov't ready for calamity response; staff fatigue a big concern - OCD

LUCENA CITY — Classes were suspended on Wednesday afternoon, Nov. 13, in Calaca City, Batangas province, due to the harmful presence of volcanic smog or “vog” from Taal Volcano. The Calaca public information office announced the suspension around 11:30 a.m. in a post on its Facebook page. “In accordance with the directive of the DepEd Calaca City Sub-Office and Calaca City DRRMO, the suspension of classes this afternoon is recommended for all public and private schools at all levels in Calaca City due to volcanic smog or “vog” from Taal Volcano,” the post said in Filipino. Local authorities advised the […]...

Keep on reading: Calaca City suspends classes due to 'vog' from Taal Volcano

[Shabelle] Kismayo, Somalia -- The regional state of Jubaland has announced the suspension of all cooperation with the Federal Government of Somalia, escalating tensions over political and governance issues. The decision, made public early Sunday, marks a significant rift in the country's federal structure.

Kremlin denies Putin spoke with Trump over de-escalation in Ukraine

Slackliners set world record, balancing at 2,500 metres high between hot air balloons

Wonka is based on Roald Dahl’s book 'Charlie and the Chocolate Factory'Timothée Chalamet starrer, Wonka, which turned out to be a commercial success in 2023, will now be getting a sequel.Director Paul King confirmed the new entry of the family-musical in an interview, where he also...

Timothée Chalamet was told to gain weight to get more roles.Timothée Chalamet doesn’t struggle to land big roles for movies anymore.However, there was a time when the Wonka star was rejected from two movie roles at the initial stages of his career.On Monday, November 11th,...

Queen Camilla issues statement after cancelling another event amid recoveryQueen Camilla returned to her public duties on Tuesday after doctor’s instructed her to cancel scheduled events due to her health condition.A week after Palace issued a statement about her “seasonal chest...

This is the third presidential election in a row that the state's voters have rejected Trump -- after going in 2016 for Hillary Clinton, and in 2020 for President Joe Biden.

Georgiev looks like a different goaltender in early November than he did last month.

As climate change threatens the cryosphere — the frozen parts of the Earth — at an alarming rate putting almost a quarter of humanity at risk, Pakistan has advocated for coordinated regional efforts and international support to save the eco-system and build climate resilience, particularly across the Hindu Kush and Himalaya region.

The study ‘The State of the Cryosphere 2024’, released on Tuesday on the sidelines of COP29 in Baku, urged urgent action to control emissions to save glaciers, which are melting at a rapid pace due to global warming.

“Under a high emissions scenario…Hindu Kush Himalaya (HKH), may experience up to 80% of ice loss. With very low emissions however, up to 40% of glacier ice in the HKH region could be preserved,” it said, adding that projections in a few glacier regions even show slow re-growth beginning between 2100 and 2300, but only with very low emissions and essentially carbon neutrality by 2050.

Against this backdrop, the environment ministers from the HKH met on Tuesday at the Baku Olympics Stadium to come together to save the “third pole” and to keep global temperatures below 1.5 Celsius.

This gathering aimed to discuss the rapidly increasing climate risks and vulnerabilities in the region and beyond, while identifying areas for urgent collective actions, inevitable to addressing the pressing challenges and fulfilling the hopes of the quarter of humanity impacted by these changes, said a statement.

It stated that over the past decade, the rate of glacier melting in the HKH has accelerated by 65 per cent compared to the previous decade (2000-2010) and the trend is projected to continue.

“Over the last decade, the rate of glacier melting in the HKH has accelerated by 65% compared to the previous decade (2000- 2010), and the trend is projected to continue.”

Speaking at the event, Bhutan Prime Minister Tshering Tobgay said this was an opportune time for the region to unite to push for a new collective quantified role that would directly address the need of the countries which were most vulnerable to climate change.

Pakistan Prime Minister Adviser on Climate Change Romina Khurshid Alam said no country across the HKH region could tackle the climate crisis in isolation and besides regional unity, international response was essential.

She said Pakistan stood for regional partnership aiming to save the ecosystem and species, and build climate resilience. She argued for easy access to climate finance to ensure these countries could erect safeguards to protect themselves from climate change.

She said Pakistan was experiencing first-hand the impacts of climate change, increasing the risk of natural disasters in the form of GLOFs and threatening water security and agriculture as well as biodiversity.

Other speakers included delegates from China, Bangladesh, India, and Nepal. The event was organised by the Kingdom of Bhutan and the International Centre for Integrated Mountain Development.

Bleak state of Cryosphere

According to the State of Cryosphere 2024 report, if the current Nationally Determined Contributions (NDCs) are met, global temperatures will likely reach 2.3°C by 2100, leading to irreversible ice loss, significant sea-level rise, and severe impacts on coastal regions, mountain communities, and polar ecosystems.

In case of a high emissions scenario, the temperature may rise to 3-3.5°C, which will cause extreme damage, including rapid ice sheet loss, the disappearance of glaciers, and widespread permafrost thaw.

However, the 1.5°C temperature in line with the Paris Agreement can help stabilise the cryosphere and preserve part of glaciers but that cannot happen unless there is a drastic cut in emissions.

“This requires urgent action, however, with emergency-scale tightening of mitigation commitments and fossil fuel emissions declining 40% by 2030,” the report added.

In case there is no action to stop the melting of glaciers, “severe and potentially permanent changes to the water cycle, due to loss of snowpack and ice run-off during the warm summer growing season, will impact food, energy and water security.”

Produced as part of the 2024 Climate Change Media Partnership, a journalism fellowship organised by Internews’ Earth Journalism Network and the Stanley Centre for Peace and Security.

Header image: View of the landscape from Langtang, Nepal can be seen in this undated handout image. — Tika Gurung via Reuters

Published in Dawn, November 13th, 2024

• Omar Ayub, Shibli Faraz, Asad Qaiser among those detained, then released
• Party slams govt over detention of senior leaders who sought to meet Imran in prison
• Police cite Section 144 violations as basis for action

ISLAMABAD: Several PTI leaders were briefly detained on Tuesday outside Adiala Jail while attempting to meet the party’s incarcerated chairman, Imran Khan, sparking condemnation from the party.

Opposition leaders in the National Assembly and Senate, Omar Ayub Khan and Shibli Faraz, former National Asse­mbly speaker Asad Qaiser, Opposition Leader in the Pun­jab Assembly Malik Ahmad Khan Bhachar, and Sunni Itte­had Council (SIC) Chairman Sahibzada Hamid Raza were among those arrested.

The police claimed that the party leaders were arrested under Section 144 of the Code of Criminal Procedure (CrPC) but were later released with a warning.

Mr Qaiser told Dawn that PTI had approached the Islamabad High Court (IHC) after being denied access to meet Imran Khan. “The court summoned the jail superintendent, who assured us that we could meet Khan Sahib. On Tuesday, we arrived around 2pm with the court order in hand, but the jail authorities still barred our entry,” he said.

“It feels like there’s a law of the jungle in Pakistan. We were taken to a nearby police post and, after contacting others through our mobile phones, the media arrived, and we were eventually allowed to leave,” he said.

“We have decided to lodge an FIR, submit a privilege motion and raise the matter in sta­nding committees,” he added, denou­ncing the act as a violation of basic human rights and contempt of the IHC’s directive.

The PTI leaders also accused Prime Minister Shehbaz Sha­rif, Punjab Chief Minister Mar­yam Nawaz and Inspector Gen­e­ral of Police in Punjab Dr Usman Anwar for issuing ord­ers of their illegal detention.

A police official told Dawn that the PTI leaders were taken to a police post after they ignored warnings about the prohibition of gatherings due to Section 144. However, they were soon freed after being issued a warning. “If they had refused to leave, the police would have taken legal action against them,” a senior police official said.

‘Absolutely shameful’

The PTI also condemned the incident on social media.

“Absolutely shameful! Omar Ayub Khan, Shibli Faraz, Asad Qaiser, Ahmed Bhachar and Sahibzada Hamid Raza have been arrested outside Adiala Jail for simply exercising their right to meet with Imran Khan, as permitted by law. This should alarm anyone who values the rule of law, as it shows how basic freedoms are being trampled upon,” the party said on the social media platform X (formerly Twitter).

A video posted online by the party showed Omar Ayub in a vehicle with police officers nearby, and Hamid Raza being pulled aside by uniformed personnel. A police van was also visible in the video.

Later, at a press conference, Mr Faraz decried the police action, calling it a breach of constitutional rights. He said the party leaders who went to meet Imran Khan were arrested even though they did not hold any rallies or public meetings or show any aggression.

In a statement, PTI’s Central Information Secretary Sheikh Waqas Akram denounced the government’s actions as a violation of democratic freedoms and called for legal consequences for those responsible.

He denounced the government’s “disregard for the judiciary” and for allegedly committing contempt of court, urging the court to take stern measures against those responsible for violating the law.

Mr Akram said that the senior PTI leaders waited until 3pm outside Adiala Jail but were not allowed to meet Imran Khan. However, when they attempted to leave, they were taken into custody.

He said the government was “crossing all limits of barbarism and brutalities” as the PTI leaders, workers and supporters were being detained and harassed in total disregard for the law.

Maryam’s trip

Separately, the PTI lashed out at the Sharif family over Maryam Nawaz’s visit to Geneva for what the party called a “minor medical procedure”.

The party’s spokesperson accused Ms Nawaz of abandoning the residents of Punjab, who are facing severe smog, inflation and rising crime, while she seeks treatment abroad at public expense.

Mohammad Asghar in Rawalpindi also contributed to this report

Published in Dawn, November 13th, 2024

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During a fight between two male mice, one will often run to a female mouse to distract their aggressor, a bait-and-switch strategy that could help abate social conflicts

Diets that claim to control excess oestrogen or stress hormones are all the rage on Instagram and TikTok. They could be good for us, just not for the reasons claimed

Cosmological puzzles are tempting astronomers to rethink our simple picture of the universe – and ask whether dark matter is even stranger than we thought

Photographer Matjaz Krivic has been charting the effects of lithium mining on locals in the world's largest salt flat in Bolivia since 2016

Taylor Roades's images of a river in north-west Alaska that has turned orange because of global warming have won the New Scientist Editors Award at the Earth Photo competition

Diets that claim to control excess oestrogen or stress hormones are all the rage on Instagram and TikTok. They could be good for us, just not for the reasons claimed

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Title: Study Casts Doubt on 'Chemical Imbalance' Theory of Depression
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In this study, the nonclinical pharmacokinetics of OLX702A-075-16, an RNA interference therapeutic currently in development, were investigated. OLX702A-075-16 is a novel N-acetylgalactosamine conjugated asymmetric small-interfering RNA (GalNAc-asiRNA) used for the treatment of an undisclosed liver disease. Its unique 16/21-mer asymmetric structure reduces nonspecific off-target effects without compromising efficacy. We investigated the plasma concentration, tissue distribution, metabolism, and renal excretion of OLX702A-075-16 following a subcutaneous administration in mice and rats. For bioanalysis, high-performance liquid chromatography with fluorescence detection was used. The results showed rapid clearance from plasma (0.5 to 1.5 hours of half-life) and predominant distribution to the liver and/or kidney. Less than 1% of the liver concentration of OLX702A-075-16 was detected in the other tissues. Metabolite profiling using liquid chromatography coupled with high-resolution mass spectrometry revealed that the intact duplex OLX702A-075-16 was the major compound in plasma. The GalNAc moiety was predominantly metabolized from the sense strand in the liver, with the unconjugated sense strand of OLX702A-075-16 accounting for more than 95% of the total exposure in the rat liver. Meanwhile, the antisense strand was metabolized by the sequential loss of nucleotides from the 3'-terminus by exonuclease, with the rat liver samples yielding the most diverse truncated forms of metabolites. Urinary excretion over 96 hours was less than 1% of the administered dose in rats. High plasma protein binding of OLX702A-075-16 likely inhibited its clearance through renal filtration.

ABSTRACTIntroduction:Emergency contraceptive pills (ECPs) are effective and can be used safely at any age repeatedly within the same cycle. They are often favored by youth yet are underutilized. Private facilities can increase ECP access but present barriers including cost. Identifying effective public-sector ECP distribution models can help ensure equitable access. The Malawi Ministry of Health developed a strategy to improve ECP access in 2020. We documented ECP provision through select public, youth-serving channels recommended by the strategy: general and youth-specific outreach, paid and unpaid community health workers (CHWs), and youth clubs.Methods:We conducted this mixed methods study from November 2022–March 2023 in 2 rural districts (Mchinji and Phalombe) implementing the strategy. We conducted qualitative interviews with 10 national stakeholders, 46 providers, and 24 clients aged 15–24 years about ECP service delivery. Additionally, 25 providers collected quantitative tally data about clients seeking ECPs. We analyzed qualitative data using grounded theory and quantitative data descriptively.Results:Stakeholders and providers reported ECP uptake increased in geographies where the strategy was implemented, especially among youth. Providers documented 3,988 client visits for ECPs over 3 months. Of these visits, 26% were from male clients, 36% were from clients aged younger than 20 years, and 64% received ECPs for the first time. Across channels, youth club leaders and unpaid CHWs reported the most client visits per provider and served the youngest clients. However, no ECPs were dispensed during 29% of visits due to stock-outs. While many providers were supportive of youth accessing ECPs, most held unfavorable attitudes toward repeat use.Conclusion:ECP access should be expanded through provision in the studied channels, especially youth clubs and CHWs. However, to meet demand, the supply chain must be strengthened. We recommend addressing providers’ attitudes about repeat use to ensure informed method choice.

ABSTRACTMore than half of births among Indigenous women in Guatemala are still being attended at home by providers with no formal training. We describe the incorporation of comadronas (traditional midwives) into casas maternas (birthing centers) in the rural highlands of western Guatemala. Although there was initial resistance to the casa, comadronas and clients have become increasingly enthusiastic about them. The casas provide the opportunity for comadronas to continue the cultural traditions of prayers, massages, and other practices that honor the vital spiritual dimension of childbirth close to home in a home-like environment with extended family support while at the same time providing a safer childbirth experience in which complications can be detected by trained personnel at the casa, managed locally, or promptly referred to a higher-level facility. Given the growing acceptance of this innovation in an environment in which geographical, financial, and cultural barriers to deliveries at higher-level facilities lead most women to deliver at home, casas maternas represent a feasible option for reducing the high level of maternal mortality in Guatemala.This article provides an update on the growing utilization of casas and provides new insights into the role of comadronas as birthing team members and enthusiastic promotors of casas maternas as a preferable alternative to home births. Through the end of 2023, these casas maternas had cared for 4,322 women giving birth. No maternal deaths occurred at a casa, but 4 died after referral.The Ministry of Health of Guatemala has recently adopted this approach and has begun to implement it in other rural areas where home births still predominate. This approach deserves consideration as a viable and feasible option for reducing maternal mortality throughout the world where home births are still common, while at the same time providing women with respectful and culturally appropriate care.

Here, we highlight the case of a 31-yr-old man who had clinical features of primary hypertrophic osteoarthropathy (PHOAR) and harbored a homozygous variant (c.38C > A, p.Ala13Glu) in the HPGD gene, as indicated by whole-exome sequencing (WES). This variant has been previously classified by our laboratory as a variant of uncertain significance (VUS). However, another patient with the same phenotype and the same homozygous variant in HPGD was subsequently reported. In reassessing the variant, the absence of this variant in the gnomAD population database, supporting computational predictions, observation in homozygosity in two probands, and specificity of the phenotype for HPGD, all provide sufficient evidence to reclassify the HPGD c.38C > A, p.Ala13Glu variant as likely pathogenic.

Pilocytic astrocytomas are the most common pediatric brain tumors, typically presenting as low-grade neoplasms. We report two cases of pilocytic astrocytoma with atypical tumor progression. Case 1 involves a 12-yr-old boy with an unresectable suprasellar tumor, negative for BRAF rearrangement but harboring a BRAF p.V600E mutation. He experienced tumor size reduction and stable disease following dabrafenib treatment. Case 2 describes a 6-yr-old boy with a thalamic tumor that underwent multiple resections, with no actionable driver detected using targeted next-generation sequencing. Whole-genome and RNA-seq analysis identified an internal tandem duplication in FGFR1 and RAS pathway activation. Future management options include FGFR1 inhibitors. These cases demonstrate the importance of escalating molecular diagnostics for pediatric brain cancer, advocating for early reflexing to integrative whole-genome sequencing and transcriptomic profiling when targeted panels are uninformative. Identifying molecular drivers can significantly impact treatment decisions and improve patient outcomes.

The aim of this work is to test whether the use of a transparent capsule affects the residual capsule weight after inhalation as a surrogate of the inhaled delivered dose for patients with non-reversible chronic airway disease. Researchers conducted an observational cross-sectional study with patients using a single-dose dry powder inhaler. The weight of the capsule was measured with a precision microbalance before and after inhalation. Ninety-one patients were included, of whom 63 (69.2%) used a transparent capsule. Inhalation with a transparent capsule achieved a weight decrease of 30.1% vs 8.6% for devices with an opaque capsule (P <0.001). These data reinforce the need to provide patients with mechanisms that verify the correct inhalation technique.

On heritage, identity, and what it means and looks like to be a practicing artist today.

The post Interview: Tschabalala Self appeared first on Fact Magazine.

Call of Duty: Black Ops 6 has remained in first place on the New Zealand charts, according to IGEA for the week ending November 3, 2024.

There were two new releases in the top 10 this week with Dragon Age: The Veilguard debuting in second place and Horizon Zero Dawn Remastered in fourth place.

Hogwarts Legacy is down one spot to third place, Grand Theft Auto V is up three spots to fifth place, and NBA 2K25 climbed from ninth to sixth place.

Red Dead Redemption is in seventh place, Borderlands 3 is in eight place, Battlefield 2042 is in ninth place, and EA Sports FC 25 rounds out the top 10.

Here are the top 10 best-selling titles in New Zealand for the week:

1. Call of Duty: Black Ops 6
2. Dragon Age: The Veilguard - NEW
3. Hogwarts Legacy
4. Horizon Zero Dawn Remastered - NEW
5. Grand Theft Auto V
6. NBA 2K25
7. Red Dead Redemption
8. Borderlands 3
9. Battlefield 2042
10. EA Sports FC 25 

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463029/dragon-age-the-veilguard-debuts-in-2nd-on-the-new-zealand-charts/

WASHINGTON CROSSING, Pennsylvania—At a campaign rally in the most important swing state in the country, anti-Trump activist George Conway told the Daily Beast why he thinks Kamala Harris can win over Republicans.

“She’s kind of done it already,” he said. “Look at all those people who voted for [Nikki] Haley when she was already done. I actually think there’s kind of a hidden Harris vote for Republicans who are just exhausted by Donald Trump.”

Turnout is another factor that plays to Democrat’s advantage, Conway predicted. “I also think that even the people who are still for Trump and won’t vote for Harris, I don’t think the turnout’s going to be great for him.”

Read more at The Daily Beast.

Journalists at CNN, including some of the network’s biggest personalities, are living in fear of “inevitable” layoffs and pay cuts as its new CEO looks to shore up finances amid declining ratings.

That’s according to The Ankler, which reported Wednesday that 77-year-old Chris Wallace—whose already been relegated to a weekend program—is among the network’s most well-known names whose future is in limbo.

Wallace’s $8.5 million contract, signed by the ex-CNN boss Jeff Zucker to recruit him away from Fox News three years ago, is reportedly up and he was spotted in CEO Mark Thompson’s office on Tuesday.

Read more at The Daily Beast.

Donald Trump praised Fox News chief political anchor Bret Baier for a “great job” in his interview with Democratic 2024 presidential hopeful Kamala Harris on Wednesday night, claiming Baier had “showed how totally incompetent Kamala is” while himself demanding she undergo a cognitive ability test.

Trump joined his campaign in calling the interview a total disaster for Harris. During the interview, Harris and Baier engaged in multiple back-and-forths; at one point, on the topic of immigration, Harris clapped back at Baier as he interrupted her: “May I finish responding to you?”

Immediately after the interview aired, the campaign—notably advisers Stephen Miller and Steven Cheung—took to X to decry Harris’ responses.

Read more at The Daily Beast.

Remedy's Alan Wake 2 has now "recouped most of its development and marketing expenses", CEO Tero Virtala has announced in a business review for January-September 2024. Speaking as somebody who would quite like there to be more Alan Wake games - or at least, moderately weird and pretty decent blockbuster singleplayer horror games - I am both pleased by this news and a little troubled that Remedy's eldritch forest fable (which came out in October 2023) has yet to break even.

Read more

There must be hundreds of typewriters in the hall, their collective clacks a tidal wave of soulless automation, rising up to greet agent Kiran Estevez as she enters, pistol and flashlight in hands. Exploring rooms to the side, Alan Wake 2: The Lake House’s star finds whiteboards and documents revealing the typewriter’s purpose: to mimic Wake’s writing. Pages are graded along criteria such as ‘style’, ‘tone’, and ‘content’, then “fed into the algorithm” as references until “near-identical stories” to Wake’s can be produced.

“If Jules could simply cut the painter open and pull the painting out of him, he would,” reads one of the real Alan’s typewritten pages. That’s Jules Marmont, the obsessive head of the titular FBC centre. The Marmonts - Jules and his wife Diana - are running experiments to forcibly and synthetically create works of art, aiming to mimic creative passion convincingly enough for the paranatural entity inside Cauldron Lake to respond, as it has in the past.

Read more

Astronomers have been spotting strange banana-shaped galaxies and the evidence seems to indicate that filaments of dark matter make them take this shape

Astronomers have identified patterns within the motion of stars stretching across the Milky Way, hinting at the presence of a vast wave

The Milky Way may be home to strange black holes from the first moments of the universe, and the best candidates are the three closest black holes to Earth

‘Little red dot’ galaxies seen by JWST appear to be much more tightly packed with stars than other galaxies, raising big questions about how they came to be this way

Plans to create an interactive AI model of the legendary code breaker Alan Turing are reckless and problematic, says Matthew Sparkes

Joe Marler discussed his recent comments about the Haka, which sparked backlash.

The Health and Human Services Department employs 294 people whose jobs focus on diversity, and the department maintains seven separate "minority health" offices spread across its various agencies, according to a new report that suggests it will be tough for the incoming Trump administration to unwind it all.