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[Evolutionary Biology] How Important Is Variation in Extrinsic Reproductive Isolation to the Process of Speciation?

The strength of reproductive isolation (RI) between two or more lineages during the process of speciation can vary by the ecological conditions. However, most speciation research has been limited to studying how ecologically dependent RI varies among a handful of broadly categorized environments. Very few studies consider the variability of RI and its effects on speciation at finer scales—that is, within each environment due to spatial or temporal environmental heterogeneity. Such variation in RI across time and/or space may inhibit speciation through leaky reproductive barriers or promote speciation by facilitating reinforcement. To investigate this overlooked aspect of speciation research, we conducted a literature review of existing studies of variation in RI in the field and then conducted individual-based simulations to examine how variation in hybrid fitness across time and space affects the degree of gene flow. Our simulations indicate that the presence of variation in hybrid fitness across space and time often leads to an increase in gene flow compared to scenarios where hybrid fitness remains static. This observation can be attributed to the convex relationship between the degree of gene flow and the strength of selection on hybrids. Our simulations also show that the effect of variation in RI on facilitating gene flow is most pronounced when RI, on average, is relatively low. This finding suggests that it could serve as an important mechanism to explain why the completion of speciation is often challenging. While direct empirical evidence documenting variation in extrinsic RI is limited, we contend that it is a prevalent yet underexplored phenomenon. We support this argument by proposing common scenarios in which RI is likely to exhibit variability and thus influence the process of speciation.




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[PERSPECTIVES] The Complex Roles of Redox and Antioxidant Biology in Cancer

Redox reactions control fundamental biochemical processes, including energy production, metabolism, respiration, detoxification, and signal transduction. Cancer cells, due to their generally active metabolism for sustained proliferation, produce high levels of reactive oxygen species (ROS) compared to normal cells and are equipped with antioxidant defense systems to counteract the detrimental effects of ROS to maintain redox homeostasis. The KEAP1-NRF2 system plays a major role in sensing and regulating endogenous antioxidant defenses in both normal and cancer cells, creating a bivalent contribution of NRF2 to cancer prevention and therapy. Cancer cells hijack the NRF2-dependent antioxidant program and exploit a very unique metabolism as a trade-off for enhanced antioxidant capacity. This work provides an overview of redox metabolism in cancer cells, highlighting the role of the KEAP1-NRF2 system, selenoproteins, sulfur metabolism, heme/iron metabolism, and antioxidants. Finally, we describe therapeutic approaches that can be leveraged to target redox metabolism in cancer.




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Avis de deces pour octobre 2024 [Avis de décès]




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Pulmonary complications of bone marrow transplantation

Bone marrow transplantation, now often known as haematopoietic stem cell transplantation (HSCT), is a complex choreographed procedure used to treat both acquired and inherited disorders of the bone marrow. It has proven invaluable as therapy for haematological and immunological disorders, and more recently in the treatment of metabolic and enzyme disorders. As the number of performed transplants grows annually, and with patients enjoying improved survival, a knowledge of both early and late complications of HSCT is essential for respiratory trainees and physicians in practice. This article highlights the spectrum of respiratory complications, both infectious and non-infectious, the timeline of their likely occurrence, and the approaches used for diagnosis and treatment, keeping in mind that more than one entity may occur simultaneously. As respiratory issues are often a leading cause of short- and long-term morbidity, consideration of a combined haematology/respiratory clinic may prove useful in this patient population.




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Palliative care in lung cancer: tumour- and treatment-related complications in lung cancer and their management

Palliative care pertains to the holistic multidimensional concept of "patient-centred" care. It is an interprofessional specialty, primarily aiming to improve quality of care for cancer patients and their families, from the time of diagnosis of malignant disease, over the continuum of cancer care, and extending after the patient's death to the period of bereavement to support the patient's family. There are various complex and frequently unmet needs of lung cancer patients and their families/caregivers, not only physical but also psychological, social, spiritual and cultural. Systematic monitoring of patients’ symptoms using validated questionnaires and patient-reported outcomes (PROs), on a regular basis, is highly encouraged and recommended in recent guidelines on the role of PRO measures in the continuum of cancer clinical care. It improves patient–physician communication, physician awareness of symptoms, symptom control, patient satisfaction, health-related quality of life and cost-effectiveness. This implies that all treating physicians should improve their skills in communication with lung cancer patients/relatives and become more familiar with this multidimensional assessment, repeatedly screening patients for palliative care needs. Therefore, they should receive education and training to develop palliative care knowledge, skills and attitudes. This review is dedicated to lung cancer palliative care essentials that should be within the competences of treating physicians, i.e. pneumologists/thoracic oncologists.




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What We Do in the Shadows Champions Found Families, No Matter How Dysfunctional



Season six's latest episode introduced Laszlo's father—and chaos inevitably followed.




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Even Exxon’s CEO Doesn’t Want Trump to Pull Out of the Paris Climate Agreement



The head of one of the world's largest oil companies has had it with government flip-flopping.




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Can You Really Save a Life? Study Reveals the Impact of Bystander CPR



New research shows that bystander CPR can substantially improve a person's odds of surviving a cardiac arrest while avoiding major brain damage, especially if given immediately.







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WATCH: Trump and Greek prime minister hold joint news conference


Watch President Donald Trump and the Greek prime minister’s joint news conference in the player above.

WASHINGTON — President Donald Trump says the U.S. stands with Greece as they recover from their economic crisis. He is speaking with Prime Minister Alexis Tsipras at the White House in a joint news conference.

The U.S. president says the two leaders have discussed defense, energy, commerce and trade.

Trump is praising Greece for its defense spending under NATO and is noting a potential sale to Greece to upgrade its F-16 aircraft, which he says would be worth up to $2.4 billion and generate thousands of U.S. jobs.

Tsipras says his country has made economic strides and is “leaving behind the economic model that led to the crisis.” He says Greece’s relationship with the U.S. is “more important than ever.”

The post WATCH: Trump and Greek prime minister hold joint news conference appeared first on PBS NewsHour.




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PM preps for campaign launch

ROLLING UPDATES:Malcolm Turnbull heads into tomorrow’s Liberal Party campaign launch with the economy and stability firmly front and centre.




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Housebuilder completes 'one of the largest' new Highland homes projects since 1970s

A rural housing project branded as ‘truly transformative’ has been completed




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Campaigners 'fear' for Argyll and Bute tourism as they warn against visitor levy

Campaigners in Argyll and Bute are demanding a proposed tourist tax is rejected when it goes to a council vote next month.




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RPG Cast – Episode 563: “Isn’t Compile Heart Jail Against the Geneva Convention?”

We can't believe we have to say this, but this week Chris tries to understand water vapor. Anna Marie takes a week off to go date some demons. Josh frequents a sex shop to pick up some weapons. Pascal starts vaping in his Xbox. And Robert and Kelley are testing the jiggle physics of sacks in World of Warcraft.

The post RPG Cast – Episode 563: “Isn’t Compile Heart Jail Against the Geneva Convention?” appeared first on RPGamer.



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RPG Cast – Episode 691: “Hello, What Did Scamper Do Today?”

Chris dresses Pikachu up like a schoolboy with a camera. Josh wants his flight stick, he needs a HOTAS. Kelley wants Final Fantasy VII Rebirth to end like an episode of JoJo. Follow Solstice Warriors on their Myspace music page.

The post RPG Cast – Episode 691: “Hello, What Did Scamper Do Today?” appeared first on RPGamer.





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A Late Look: Red Dead Redemption II

Welcome to A Late Look, a series of articles where I take a belated look at games from yesteryear that I missed out on the first time around. Not quite review and not quite rant, it’s more a casual assessment of what I – the gamer of the future – consider to be each game’s strengths and weaknesses in retrospect.

This time we’re saddling up for a look at Red Dead Redemption II, one of the biggest critical and commercial successes of the last ten years. It conveniently went completely under my radar, allowing me to look at it now. I was ten years late to the first game, this time it’s only six, so at this rate I’ll definitely be playing Red Dead Redemption IV on launch day. I'm looking forward to that, but for now let’s see how the second game fares in 2024.

    

Strength: The Van der Linde Gang

Travel back to a time before former-outlaw John Marston got pulled from his farmer life in the first title, to when he was… well, an outlaw. While you might play as Arthur Morgan, in this game you become part of John’s old gang – the Van der Linde gang – together with Marston himself and other familiar and unfamiliar characters. While RDR2 also boasts a few other strong characters, this gang is at the heart of the game and, luckily, is also its strongest element, with plenty of faces and personalities that (almost) all get their time to shine. What adds all the more to the connection and believability of these characters is the living nature of the camp itself; it's your home base outside of missions, where the gang will go about their daily tasks and have conversations & arguments that you can occasionally join in on – there are even celebrations and songs around the campfire. Even if it’s mostly just flavor, the strength of this particular feature and what it adds in terms of immersion shouldn’t be understated.

   

Weakness: Red Dead Redemption II: Usability Nightmare

Full Article



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Nintendo and The Pokemon Company Seeking Injunction and Damages from Pocketpair

Nintendo and The Pokémon Company in September filed a patent infringement lawsuit against Palworld developer Pocketpair. 

At the time Nintendo did not share which patents Palworld infringed on, however, Pocketpair has now revealed what patents Nintendo are claiming were infringed on.

"As announced on September 19, 2024, The Pokémon Company and Nintendo Co Ltd (hereinafter referred to as the Plaintiffs) have filed a patent infringement lawsuit against us," said Pocketpair. "We have received inquiries from various media outlets regarding the status of the lawsuit, and we would like to report the details and current status of this case as follows.

"The Plaintiffs claim that Palworld, released by us on January 19, 2024, infringes upon the following three patents held by the Plaintiffs, and are seeking an injunction against the game and compensation for a portion of the damages incurred between the date of registration of the patents and the date of filing of this lawsuit."

Nintendo and The Pokémon Company are each seeking an injunction and damages of five million yen plus late payment damages.

Pocketpair added, "We will continue to assert our position in this case through future legal proceedings. Please note that we will refrain from responding individually to inquiries regarding this case. If any matters arise that require public notice, we will announce them on our website, etc."

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463022/nintendo-and-the-pokemon-company-seeking-injunction-and-damages-from-pocketpair/




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Sega Sells Humankind Developer Amplitude Studios

Sega has sold Humankind and Endless developer Amplitude Studios to members of its internal team, announced the developer in a community post. This means the studio is now independent.

"Our studio is backed by strong and meaningful franchises and our team is committed to creating the best games possible," said Amplitude Studios founder Romain de Waubert de Genlis.

"With our extensive experiences in strategy game development and two exciting titles currently in progress, we are confident in our ability to deliver outstanding experience to players. This decision allows us to be more agile in our approach while continuing to shape the vision that has been ours from the very beginning, empowering us to push boundaries and be closer as ever of our community."

Sega in its own statement said: "Sega Europe has today announced the sale of Amplitude Studios following a management buyout from senior leaders and employees at the Parisian studio. The move will see Amplitude go back to its roots as an independent organisation and concludes the structural reforms that have been taking place in Sega’s European business.  

"The decision to part ways follows a period of close consultation between Sega Europe and Amplitude. As an independent studio once more, Amplitude will focus on its in-development projects and growing its own franchises, while Sega will continue to advance its strong and diverse stable of Japanese and Western IP. 

“Sega Europe acquired Amplitude in 2016, and together have released epic strategy titles like Endless Space 2 and Humankind, along with Endless Dungeon, the successor to 2014’s indie hit, Dungeon of the Endless.

"While Amplitude is no longer a part of the Sega family of studios, the two entities will continue to work together on the smooth transition of services and operations, ensuring minimum disruption for Amplitude employees and continuity of service for players of Amplitude games."

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463024/sega-sells-humankind-developer-amplitude-studios/




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PS5 vs Xbox Series X|S vs Switch 2024 Japan Sales Comparison Charts Through October

Here we see data representing the sales through to consumers and change in sales performance of the three current platforms (PlayStation 5, Xbox Series X|S, and Nintendo Switch) and two legacy platforms (PlayStation 4 and Xbox One) over comparable periods for 2021, 2022, 2023, and 2024. Also shown is the market share for each of the consoles over the same periods.

Year to Date Sales Comparison (Same Periods Covered)

Market Share (Same Periods Covered)

2021 – (January 2021 to October 2021)

2022 – (January 2022 to October 2022)

2023 – (January 2023 to October 2023)

2024 – (January 2024 to October 2024)

"Year to date" sales for 2021, 2022, 2023, and 2024 sales are shown in series at the top of the table and then just below a comparison of 2024 versus 2023 and 2024 versus 2022 is displayed.  This provides an easy-to-view summary of all the data.

Total Sales and Market Share for Each Year

Microsoft

  • Xbox Series X|S
    • 0.09 million units sold year-to-date
    • Down year-on-year 0.03 million units (-23.2%)

Nintendo

  • Nintendo Switch
    • 2.47 million units sold year-to-date
    • Down year-on-year 0.75 million units (-23.4%)

Sony

  • PlayStation 5
    • 1.16 million units sold year-to-date
    • Down year-on-year 0.94 million units (-44.9%)
  • PlayStation 4
    • 0.01 million units sold year-to-date
    • Down year-on-year 0.05 million (-77.2%)

Note: VGChartz 2024 estimates through October includes 44 weeks, while 2023, 2022, and 2021 estimates includes 43 weeks.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463009/ps5-vs-xbox-series-xs-vs-switch-2024-japan-sales-comparison-charts-through-october/




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PS5 vs PS4 Sales Comparison in Japan - October 2024

The VGChartz sales comparison series of articles are updated monthly and each one focuses on a different sales comparison using our estimated video game hardware figures. The charts include comparisons between the PlayStation 5, Xbox Series X|S, and Nintendo Switch, as well as with older platforms. There are articles based on our worldwide estimates, as well as the US, Europe, and Japan.

This monthly series compares the aligned Japanese sales of the PlayStation 5 and PlayStation 4.

The PlayStation 5 launched in November 2020 in Japan, while the PlayStation 4 launched in February 2014. This does mean the holiday periods for the two consoles do not lineup.

PS5 Vs. PS4 Japan:

Gap change in latest month: 277,262 - PS4

Gap change over last 12 months: 300,542 - PS4

Total Lead: 234,400 - PS4

PlayStation 5 Total Sales: 6,121,649

PlayStation 4 Total Sales: 6,356,049

October 2024 is the 48th month the PlayStation 5 has been available for. In the latest month, the gap grew in favor of the PlayStation 4 when compared to the aligned launch of the PlayStation 5 by 0.28 million units.

In the last 12 months, the PS4 has outsold the PS5 by 0.30 million units. The PS5 is currently behind the PS4 by 0.23 million units.

The 48th month for the PS5 in Japan is October 2024, while for the PS4 it is January 2018. The PS5 has sold 6.36 million units, while the PS4 sold 6.12 million units during the same timeframe.

The PS4 crossed 7 million in month 53, 8 million in month 61, and 9 million in month 72. The PS4 has sold 9.68 million units to date. The PS5 is currently 3.56 million units behind the lifetime sales of the PS4 in Japan.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463011/ps5-vs-ps4-sales-comparison-in-japan-october-2024/




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Defiant JD Vance Says ‘No,’ Trump Did Not Lose 2020 Election

C-SPAN

Republican vice presidential candidate JD Vance boldly said “no,” Donald Trump did not lose the 2020 election, when pressed on the issue at a campaign event Wednesday in Williamsport, Pennsylvania.

The Ohio senator has avoided directly denying the results over the past few weeks.

When quizzed by The New York Times about the results over the weekend, for example, he refused multiple times to answer the question, on one occasion claiming he was “focused on the future”—echoing an answer he gave to Democratic opponent Tim Walz at the vice presidential debate.

Read more at The Daily Beast.




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Fox News’ Bret Baier Whines About Harris After Bad-Tempered Interview

Roy Rochlin/Getty Images

Fox News host Bret Baier recapped his Wednesday night interview with Vice President Kamala Harris, telling his colleagues that he got a sense early on that Harris “was going to be tough to redirect without me trying to interrupt.”

The interview, Harris’ first on the right-wing network since becoming the Democratic nominee, was broadcast on Special Report after being filmed in the previous hour. According to Baier, the interview had been scheduled for 5 p.m., but Harris showed up 15 minutes late. This, he complained, was like “icing the kicker” in football.

“We were supposed to start at 5 p.m. This was the time they gave us. Originally, we were going to do 25 or 30 minutes. They came in and said, ‘Well, maybe 20.’ So, it’s already getting whittled down. And then the vice president showed up at about 5:15 p.m. We were pushing the envelope to be able to turn it around for the top of the 6 p.m.. So that’s how it started,” Baier said.

Read more at The Daily Beast.




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‘Real Housewives of Salt Lake City’: Is Heather Gay a Hypocrite for Taking Ozempic?

Photo Illustration by Thomas Levinson/The Daily Beast/Bravo

The Real Housewives of Salt Lake City is TV’s best soap opera, week after week offering twists more shocking than secret twins and characters returning from the dead. That’s because it’s all real, happening in the most haunted suburb in the continental United States.

Where else do two women connect over knowing the long-lost birth father of one’s child? Is there another city where women squabble over body positivity in a parking lot off the side of a snowy mountain? Surely, there’s no other place on Earth where Lisa Barlow could come across anywhere near a voice of reason.

But that all happens here in Salt Lake City. Five episodes in, Season 5 has continued to evolve into the most captivating season in modern Real Housewives history, carried by the ever-changing bonds between our OGs and a team of wonderfully bizarre newbies.

Read more at The Daily Beast.




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Anderson Cooper Literally Calls Bulls*** on Surrogate’s Trump Defense

CNN

CNN anchor Anderson Cooper was flabbergasted Wednesday by a surrogate’s defense of Donald Trump, calling his explanation for the former president’s bombastic statements literal “bulls---.”

On AC360, former California Lieutenant Gov. Abel Maldonado, a Republican, said that Trump’s recent comments calling for the military to “handle” Democrats were simply his way of expressing his inner New Yorker. “He’s a fighter,” Maldonado added.

The conversation began when Cooper brought up Trump’s former chairman of the Joint Chiefs of Staff, Mark Milley, who, alongside other military leaders, have begun to warn of the dangers of re-electing the former president. Milley has called Trump a “fascist to his core.”

Read more at The Daily Beast.




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Trump Gushes Over ‘Fair’ Bret Baier After Fox News Kamala Harris Interview

Fox News/Marco Bello via Reuters

Donald Trump praised Fox News chief political anchor Bret Baier for a “great job” in his interview with Democratic 2024 presidential hopeful Kamala Harris on Wednesday night, claiming Baier had “showed how totally incompetent Kamala is” while himself demanding she undergo a cognitive ability test.

Trump joined his campaign in calling the interview a total disaster for Harris. During the interview, Harris and Baier engaged in multiple back-and-forths; at one point, on the topic of immigration, Harris clapped back at Baier as he interrupted her: “May I finish responding to you?”

Immediately after the interview aired, the campaign—notably advisers Stephen Miller and Steven Cheung—took to X to decry Harris’ responses.

Read more at The Daily Beast.




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Trump Calls Jan. 6, the Day His Supporters Led a Failed Insurrection, ‘A Day of Love’

Marco Bello/Reuters

Former President Donald Trump said Wednesday that Jan. 6, 2021— the day his supporters occupied Congress in a failed insurrection to try to stop lawmakers from certifying Joe Biden’s election victory—was a “day of love.”

Trump made the baffling claim during a televised election town hall hosted by Univision.

Ramiro González, a construction worker from Tampa, told the meeting he deregistered as a Republican because he found Trump’s “inaction” during both Jan. 6 and the COVID-19 pandemic “disturbing.” He asked Trump to square his controversial behavior during the attack on the U.S. Capitol—and the fact that many of his own former administration officials don’t support him any longer—with why he should be re-elected.

Read more at The Daily Beast.




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Stormy Daniels Says Trump Is Trying to Silence Her Again

Phillip Faraone/Getty Images

It appears Donald Trump is once again attempting to silence Stormy Daniels, despite his recent convictions in that category.

MSNBC’s Rachel Maddow reports that Trump’s lawyers tried to “get another hush money deal” with the adult film star, to keep her from making any “public or private statements related to any alleged past interactions” with the former president. In exchange for her written agreement, Trump’s team reportedly offered to adjust the debt she owes Trump for the unsuccessful defamation case her lawyer brought against him in 2018.

Daniels still needs to pay “hundreds of thousands of dollars” in legal fees, Maddow explained, and in hammering out the exact amount, Trump’s lawyers allegedly offered to “pretend” she owed their client “less than they actually believed” she did. Whereas they first estimated Daniels’ debt at $650,000, Maddow reported, they said they would settle her tab for $620,000, if she promised not to make any “defamatory or disparaging statements about him, his business, and/or any affiliates, or his suitability as a candidate for president.” They then adjusted the fee, asking $635,000 if she refused to sign a non-disclosure agreement. Daniels reportedly turned them down, paying $627,500 and declining to sign the NDA.

Read more at The Daily Beast.




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Mitch McConnell Called Donald Trump a ‘Stupid’ and ‘Despicable Human Being’

Saul Loeb, Mandel Ngan/AFP/Getty

Senate Minority Leader Mitch McConnell called his party’s presidential nominee, Donald Trump, a “stupid,” “ill-tempered,” and “despicable human being,” according to his own records.

McConnell made the withering assessments in a series of private “personal oral histories” that he gave to Michael Tackett, the deputy Washington bureau chief of the Associated Press, who has a forthcoming biography about the Kentucky senator called The Price of Power. The AP conveniently reported the book’s juicy details.

McConnell’s remarks were made after the 2020 election that Trump lost, and the senator was apparently elated to see the backside of the former president, musing, “it’s not just the Democrats who are counting the days” until he leaves office.

Read more at The Daily Beast.




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Donald Trump Cancels Second Mainstream Interview in Days

Marco Bello/Reuters

Donald Trump pulled out of another mainstream interview Thursday–this time nixing a sit-down with NBC News.

The interview, CNN reported, would be in Philadelphia with NBC News' senior business correspondent, Christine Romans. CNN’s Brian Stelter said one source suggested that it had only been “postponed.”

It was the second time in a week that he had canceled a scheduled appearance outside the conservative news sphere, CNN’s Reliable Sources reported Thursday. He had canceled an in-studio appearance on the CNBC flagship show, Squawk Box, which was due on Friday.

Read more at The Daily Beast.




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Hello Rockstar, please make an open world based on my unplayable Xbox edition of Red Dead Redemption

I never completed the original Red Dead Redemption, but not for the usual reasons of being terrible at the game, or thinking that open worlds are too big and boring these days and I just want to lie down forever and watch anime. I never finished it because my Xbox 360 version was not, in practice, an open world game, but a lonely farm at the bottom of a vortex of butchered spacetime. In the prologue, reformed outlaw John Marston confronts an old bandit acquaintance and gets himself roundly shot to bits. He’s rescued by local rancher Bonnie MacFarlane, who nurses him back to health and gives him a few odd jobs to warm him up for the next plot point.

Read more




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Microsoft closing Arkane Austin was “stupid”, says founder: recreating “a very special group” like that would be “impossible”

Today in "person you already like says something you already agree with, but it’s still good to hear them say it" news, Arkane founder and im-simmy RPG studio WolfEye head Raphael Colantonio has spoken on Microsoft’s decision to shutter Prey (2017) studio Arkane Austin - alongside a handful of others - back in May.

Colantonio, who founded Arkane in 1999 and departed in 2017 to form Weird West studio WolfEye, recently chatted to Jeremy Peel for PC Gamer about Arkane’s closure, saying:

I think if you look a little bit, it's obvious that Arkane Austin was a very special group of people that have made some cool things and that could pull it off again. I think it was a decision that just came down to, 'We need to cut something.' Was it to please the investors, the stock market? They're playing a different game.

Read more




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The Monster Hunter Wilds beta is live with an early glimpse of the new camping, wound and weather systems

Stroll on down to Uncle Capcom's garage, girls and boys, because it's time to meddle with a cat's voicebox, ride a combat peacock and meticulously injure a vast, blubbery teddybear. By which I mean, the Monster Hunter Wilds beta is now live on Steam through to 4th November at 2.59am GMT. That's 2.59am sharp. If you're hurrying along at 3am on Monday absolutely desperate to polish the aesthetics of a small enslaved catperson, you can sod off and play Dragon Age: The Veilguard instead.

Read more




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Thysiastery is an anime Legend Of Grimrock, and you can attack the dinosaur merchants if you’re a complete monster

One of my lesser quality tests for an RPG is whether the shopkeepers complain at you for not buying anything. Grumpy shopkeepers, good RPG. This most specific of litmus tests has served me well, although I must admit that I’d happily upgrade it to ‘shopkeepers you can attack’, would that not disqualify 99% of games. But not turn based dungeon crawler Thysiastery, it turns out. This “dungeon crawler RPG featuring traditional roguelike and turn-based gameplay” apparently trusts you enough to let you recklessly batter its friendly wandering lizard merchants. You’d be a monster for it, of course, but it’s nice to have options.

Read more




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The Forever Winter devs answer complaints about water scarcity... by adding thieves who invade your HQ and steal your water

When nightmarish sci-fi extraction shooter The Forever Winter launched into early access in September it was somewhat messy. Bugs and maddening enemy spawns diminished the tension of being a fleshy human scavenger in a mech battlefield. But one feature annoyed some players much more - fresh water. See, you need to keep your headquarters stocked with water, as it gets steadily used by your settlement's inhabitants. The catch being that this water diminishes even while you're not playing the game. If it runs out completely, then everything you've collected gets wiped. The developers have listened to complaints about this most Farmville of mechanics, and they've answered in an interesting way. Water thieves! Now, on top of the usual downward trickle, burglars will come to steal your H2O as well.

It's not as bad as it sounds.

Read more



  • Shooter: Third Person
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  • Fun Dog Studios

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Here’s a new launch trailer for Attenborough-em-up RTS Empire Of The Ants, out this week

Much the same as anyone with a soul, I find ants deeply fascinating and, much the same as anyone who occasionally drops small pieces of sandwich on the floor, I will continue to uphold my respect for them as long as they come nowhere near my feet. Yes. I admit it: I am a bug hypocrite, loudly extolling their virtue and beauty at a distance then getting irritated if they decide to come sit on me.

Fortunately, real time strategy Empire Of The Ants understands that the best place for insects to be is inside a screen, where they can be appreciated but cannot under any circumstances touch you. It’s out this week, as it happens, and here’s a new launch trailer to celebrate. Follow your pheromone trail to the video below.

Read more




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Call Of Duty: Black Ops 6 campaign review: a military shooter that comes disguised as other, better games

As a yearly blockbuster, Call of Duty, through sheer expense and effort, would like you to think it is the Die Hard of video games. Or, depending on the setting, the Saving Private Ryan of video games. But it is barely Black Hawk Down. This latest campaign in Call Of Duty: Black Ops 6 reminds me more of the forgettable Netflix shootfests that thumbnail their way across your TV screen as you try to find some gritty nothing to aid you in zoning out of life. Still, there is an anecdotal contingent of casual sofa sitters for whom Call Of Duty is the game. A balls-to-the-wall shooter to return to every winter and rinse through in a weekend. Ed has already gestured at its multiplayer, announcing: "yup, it's COD", like a deeply tired Captain Birdseye inspecting the day's catch, wondering when his life will change. But never mind that. How does the single player story mode hold up? Some are calling it the best campaign in years. And I guess that's true, in the sense that it is the least worst.

Read more




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Some guy complained this fishing game only caters to queer players, so the dev added a "straight" title - it costs $9999

When multiplayer fishing game Webfishing came out last month, it offered a relaxing hangout zone for cats and dogs. Everything revolves around catching, selling, and collecting the fish that gather in the rivers of a small island. It also lets you customise your character with clothing. Mostly simple hats and shorts, but some options let players celebrate their sexuality, such as a rainbow-adorned t-shirts, or titles that hang above your character which simply say "Trans" or "Bi". All this led one player to complain there was no "Straight" title. So, the developer added one. It costs 10 grand.

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VED: Purification is a free prologue to the full hand-drawn RPG, complete with Stetson hats and Evil Dead trees

Got an email about this. Looks cool. Is free. “I’ll write about that,” I thought. “I’ll write about that for Rock Paper Shotgun, a place that semi-regularly posts articles about cool and free games.” So here we are. If you’re waiting for the other shoe to drop, assuming the only reason I’d open an article in a superfluous and straightforward manner is because I’m about to deliver some sort of third sentence twist, you’re completely wrong! There’s no twist at all. I’m simply going to deliver some information about the game in a neutral tone. You can find VED: Purification, a free prologue demo to RPG VED, here.

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The co-creator of magic puzzler Hidden Folks is making a sumptuous, spaced-out tower defender

Could tower defence be the ultimate "it's Friday and I am here in body only" genre? I haven't really thought about it before, but Rift Riff's effusively laidback crowd control has me pondering those optimal moments in any tower defender when the incoming horde hits the flamer-MG triangle just right, and you can settle back comfortably into the role of clockwatcher.

Rift Riff encourages this behaviour by being nice to look at. Created by a trio of developers including Hidden Folks designer Adriaan de Jongh, it's a world of spacey, sun-carved mountains, forests and monoliths. The towers resemble the sacred architecture of Monument Valley, and the colour scheme and general ambience remind me of Cocoon. There's a demo, if you fancy it.

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Here are the patents Nintendo and the Pokémon Company are suing Palworld about, according to Pocketpair

Palworld developers Pocketpair have finally revealed which patents Nintendo and the Pokémon Company are suing them about. It looks like they're focusing on the act of throwing capsular items to catch or release monsters, together with the usage of monsters as mounts.

If you've somehow yet to encounter Palworld, it's a bestselling survival game that takes hefty - some would say, scandalous - inspiration from Pokémon, with players poaching Pokésque critters using magic spheres, and deploying them as soldiers and minions.

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Ubisoft is being sued over The Crew in a lawsuit that compares the server shutdown to a bumperless pinball machine

"Imagine you buy a pinball machine, and years later, you enter your den to go play it, only to discover that all the paddles are missing, the pinball and bumpers are gone, and the monitor that proudly displayed your unassailable high score is removed". As reported by Polygon, that's an argument put forth by a new lawsuit against Ubisoft, filed by two Californian players of The Crew. They're suing the company in a proposed class action lawsuit over shutting down the racing game's servers, rendering it unplayable.

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Trump’s claim about predecessors, fallen troops disputed

File photo of President Donald Trump by Joshua Roberts/Reuters

WASHINGTON — For U.S. presidents, meeting the families of military personnel killed in war is about as wrenching as the presidency gets. President Donald Trump’s suggestion Monday that his predecessors fell short in that duty brought a visceral reaction from those who witnessed those grieving encounters.

“He’s a deranged animal,” Alyssa Mastromonaco, a former deputy chief of staff to President Barack Obama, tweeted about Trump. With an expletive, she called Trump’s statement in the Rose Garden a lie.

Trump said in a news conference he had written letters to the families of four soldiers killed in an Oct. 4 ambush in Niger and planned to call them, crediting himself with taking extra steps in honoring the dead properly. “Most of them didn’t make calls,” he said of his predecessors. He said it’s possible that Obama “did sometimes” but “other presidents did not call.”

The record is plain that presidents reached out to families of the dead and to the wounded, often with their presence as well as by letter and phone. The path to Walter Reed and other military hospitals, as well as to the Dover, Delaware, Air Force Base where the remains of fallen soldiers are often brought, is a familiar one to Obama, George W. Bush and others.

Bush, even at the height of two wars, “wrote all the families of the fallen,” said Freddy Ford, spokesman for the ex-president. Ford said Bush also called or met “hundreds, if not thousands” of family members of the war dead.

READ MORE: What Trump said about his drug czar pick, health care fixes

Obama’s official photographer, Pete Souza, tweeted that he photographed Obama “meeting with hundreds of wounded soldiers, and family members of those killed in action.” Others recalled his frequent visits with Gold Star families, and travels to Walter Reed, Dover and other venues with families of the dead and with the wounded.

Retired Gen. Martin E. Dempsey, the former chairman of the Joint Chiefs of Staff, confirmed these contacts, tweeting: “POTUS 43 & 44 and first ladies cared deeply, worked tirelessly for the serving, the fallen, and their families. Not politics. Sacred Trust.”

Trump addressed the matter when asked why he had not spoken about the four soldiers killed in Niger. They died when militants thought to be affiliated with the Islamic State group ambushed them while they were patrolling in unarmored trucks with Nigerien troops.

“I actually wrote letters individually to the soldiers we’re talking about, and they’re going to be going out either today or tomorrow,” he said, meaning he wrote to the families of the fallen soldiers. He did not explain why letters had not been sent yet, more than a week after the attack.

“If you look at President Obama and other presidents, most of them didn’t make calls,” Trump said.

Pressed on that statement later, he said of Obama: “I was told that he didn’t often, and a lot of presidents don’t. They write letters.” He went on: “President Obama, I think, probably did sometimes, and maybe sometimes he didn’t. I don’t know. That’s what I was told. … Some presidents didn’t do anything.”

Press Secretary Sarah Huckabee Sanders said later that Trump “wasn’t criticizing predecessors, but stating a fact.” She argued that presidents didn’t always call families of those killed in battle: “Sometimes they call, sometimes they send a letter, other times they have the opportunity to meet family members in person.”

She said anyone claiming a former president had called every family was “mistaken.”

Bush’s commitment to writing to all military families of the dead and to reaching out by phone or meeting with many others came despite the enormity of the task. In the Iraq war alone, U.S. combat deaths were highest during his presidency, exceeding 800 each year from 2004 through 2007. The number fell to 313 in Bush’s last year in office as the insurgency faded. Bush once said he felt the appropriate way to show his respect was to meet family members in private.

READ MORE: What the Bannon vs. McConnell fight means for Trump and the GOP

Obama declared an end to combat operations in Iraq in August 2010 and the last U.S. troops were withdrawn in December 2011. As Obama wound down that war, he sent tens of thousands more troops into Afghanistan in 2009 and 2010, and the death count mounted. From a total of 155 Americans killed in Afghanistan in 2008, which was Bush’s last full year in office, the number jumped to 311 in 2009 and peaked the next year at 498. In all, more than 1,700 died in Afghanistan on Obama’s watch.

Among other rituals honoring military families, the Obamas had a “Gold Star” Christmas tree in the White House decorated with hundreds of photos and notes from people who had lost loved ones in war. Gold Star families visited during the holidays, bringing ornaments.

Trump visited Dover early in his presidency, going in February with his daughter Ivanka for the return of the remains of a U.S. Navy SEAL killed during a raid in Yemen, William “Ryan” Owens.

Trump’s relations with Gold Star families have not always been smooth, dating from his belittlement of the parents of slain U.S. soldier Humayun Khan, who was Muslim. Trump was angered when the soldier’s father, Khizr Khan, was given a platform to criticize him at the Democratic National Convention.

Owens’ grieving father said he didn’t want to talk with Trump at Dover. But the sailor’s widow, Carryn, attended Trump’s address to Congress and wept as he thanked her.

___

Associated Press writers Robert Burns and Jesse J. Holland contributed to this report.

The post Trump’s claim about predecessors, fallen troops disputed appeared first on PBS NewsHour.




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Trump ignites furor with claim past presidents didn’t console military families by phone

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JUDY WOODRUFF: Now: new questions surrounding the deaths of four Green Berets in the Western African nation of Niger and the role of the president as consoler in chief.

John Yang has the story.

JOHN YANG: Sending young Americans into harm’s way can be the most serious decision a president makes. Consoling the families of the fallen has become the latest controversy to engulf President Trump.

To bolster his claim that he does more than his predecessors, Mr. Trump today invoked the dead son of his chief of staff, retired Marine general John Kelly.

PRESIDENT DONALD TRUMP: To the best of my knowledge, I think I have called every family of somebody that’s died. Now, as far as other representatives, I don’t know. I mean, you could ask General Kelly, did he get a call from Obama?

JOHN YANG: Kelly’s 29-year-old son, Robert, a Marine lieutenant, was killed in 2010 when he stepped on a land mine in Afghanistan, an episode Kelly rarely talks about publicly. Kelly and his wife did attend a 2011 Memorial Day breakfast President Obama hosted for Gold Star families.

President Trump ignited the furor when he was asked about his public silence on four Green Berets killed two weeks ago in Niger.

PRESIDENT DONALD TRUMP: If you look at President Obama and other presidents, most of them didn’t make calls. A lot of them didn’t make calls. I like to call when it’s appropriate, when I think I’m able to do it.

JOHN YANG: Reporters pressed him to back up the claim.

PRESIDENT DONALD TRUMP: I don’t know. That’s what I was told. All I can do — all I can do is ask my generals.

JOHN YANG: The response from former Obama officials was swift and forceful.

Former Attorney General Eric Holder tweeted this photo and insisted: “Stop the damn lying. I went to Dover Air Force base with 44 and saw him comfort families,” a reference to one of Mr. Obama’s late-night trips to pay his respects to troops killed in Afghanistan.

Mr. Obama and President George W. Bush often visited wounded warriors at Walter Reed and Bethesda hospitals, a practice Mr. Trump has continued. In February, the president and his daughter Ivanka went to Dover for the return of the remains of a Navy SEAL killed in Yemen, the first casualty of his administration.

So far this year, the Pentagon says 16 Americans have been killed in action. Another 17 sailors died in accidents. In the first year of the Obama presidency, 344 were killed in action.

During last year’s campaign, Mr. Trump publicly feuded with the Khans, the parents of a Muslim American soldier killed in Iraq, after they criticized him at the Democratic Convention.

Today, the Khans said: “President Trump’s selfish and divisive actions have undermined the dignity of the high office of the presidency.”

The current controversy comes as questions are being raised about how and why the four soldiers died in Niger.

Senator Jack Reed is the top Democrat on the Armed Services Committee.

SEN. JACK REED, D-R.I.: I think the administration has to be much more clear about our role in Niger and our role in other areas in Africa and other parts of the globe.

JOHN YANG: The Pentagon is investigating the deaths. Reportedly among the questions, did commanders adequately assess the risk, and was there ready access to medical support?

Today, President Trump called the families of the four dead Green Berets.

For the PBS NewsHour, I’m John Yang.

The post Trump ignites furor with claim past presidents didn’t console military families by phone appeared first on PBS NewsHour.




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News Wrap: Trump’s latest travel ban blocked by federal judge

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JUDY WOODRUFF: And in the day’s other news: A federal judge in Hawaii struck down the Trump administration’s latest travel ban.

That temporarily blocks enforcement of the order nationwide, but the Justice Department says it will appeal. The ban extended to six mostly Muslim nations, plus North Korea and Venezuela.

Pennsylvania Congressman Tom Marino withdrew today from consideration to be President Trump’s drug czar. That followed an investigation by The Washington Post and CBS News. They found Marino was key in passing a 2016 law that limits the Drug Enforcement Administration’s ability to rein in opioid distribution.

A new verbal battle has broken out between the president and Republican Senator John McCain. It began last night in Philadelphia, when the Arizona senator and former Vietnam POW appeared to criticize Mr. Trump and his followers. He cited a list of failings.

SEN. JOHN MCCAIN, R-Ariz.: To fear the world we have organized and led for three-quarters-of-a-century, to abandon the ideals we have advanced around the globe for the sake of some half-baked, spurious nationalism cooked up by people who would rather find scapegoats than solve problems.

(CHEERING AND APPLAUSE)

JUDY WOODRUFF: The president answered by saying, “At some point, I fight back, and it won’t be pretty.”

In turn, McCain said, “I have faced tougher adversaries.”

In Afghanistan, Taliban bombings and shootings left at least 74 people dead today. The worst was Paktika province in the east, where two car bombs killed dozens, including the provincial police chief, and wounded more than 100 others. Taliban militants also staged attacks in the south and west of the country.

In Syria, militia forces backed by the U.S. say they have retaken the Islamic State group’s de facto capital. The city of Raqqa had been under ISIS control since 2014. The battle to recapture it began in June. Today, Kurdish-led fighters celebrated as they moved into the city center. The U.S. military said 90 percent of Raqqa has been taken, with pockets of militants remaining.

There’s word that U.S. airstrikes in Yemen killed dozens of Islamic State fighters on Monday. The strikes were apparently carried out by drones. The Pentagon says the targets were training camps for recruits.

In Northern Iraq, Kurdish forces withdrew from more territory today, as Iraqi government troops advanced. It came on the heels of the Kurds’ vote for independence. Federal forces and allied militia had already forced the Kurds to leave the area in and around Kirkuk and its oil fields.

Iraq’s prime minister said that paves the way for talks.

HAIDER AL-ABADI, Prime Minister, Iraq (through interpreter): I call for dialogue on the basis of partnership in one country and under the Constitution. The referendum is finished and has become a thing from the past. We hoped that they would cancel it, but we have finished it on the ground.

JUDY WOODRUFF: Meanwhile, the president of Iraqi Kurdistan, Massoud Barzani, insisted that the referendum will not be in vain.

Another 10,000 to 15,000 Rohingya Muslims fled Buddhist Myanmar for Bangladesh over the weekend. Drone video showed snaking lines of refugees making the trek to already crowded camps. Many told of villages torched by mobs and soldiers. Others said they were starved out of their homes.

Back in this country, a new fire broke out in the San Francisco Bay Area, just as crews had made major progress against other fires in Northern California. Thick smoke billowed from the new site early today, as it burned through forests in the Santa Cruz Mountains. Weary fire crews said they’re calling in more help.

ROB SHERMAN, Division Chief, Cal Fire: So, the idea is to hit it pretty hard with aircraft and then go ahead and hit it with the ground resources at the same time. We have had north winds, a lot of drying, and everything’s really, really dry. So it’s challenging.

JUDY WOODRUFF: In Southern California, yet another fire spread on Mount Wilson, about 25 miles north of downtown Los Angeles. It threatened a historic observatory and communications towers.

President Trump’s overall wealth has taken a hit, as his New York real estate loses some of its luster. Forbes ranks him 248 this year on its list of the 400 wealthiest Americans. That’s down nearly 100 points from last year. His estimated worth is $3.1 billion.

Microsoft co-founder Bill Gates again tops the list. He’s worth nearly $90 billion.

And on Wall Street, the Dow Jones industrial average traded above 23,000 for the first time. In the end, it gained 40 points to close at 22997. The Nasdaq fell a fraction, and the S&P 500 added one point.

The post News Wrap: Trump’s latest travel ban blocked by federal judge appeared first on PBS NewsHour.




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Trump and the new politics of honoring war dead

Coffins of U.S. military personnel are prepared to be offloaded at Dover Air Force Base in Dover, Delaware in this undated photo by a Reuters stringer.

WASHINGTON — After her Army son died in an armored vehicle rollover in Syria in May, Sheila Murphy says, she got no call or letter from President Donald Trump, even as she waited months for his condolences, wrote to him to say “some days I don’t want to live,” and still heard nothing.

In contrast, Trump called to comfort Eddie and Aldene Lee about 10 days after their Army son was killed in an explosion while on patrol in Iraq in April. “Lovely young man,” Trump said, according to Aldene. She thought that was a beautiful word to hear about her boy, “lovely.”

Like presidents before him, Trump has made personal contact with some families of the fallen, not all. What’s different is that Trump, alone among them, has picked a political fight over who’s done better to honor the war dead and their families.

He placed himself at the top of this pantheon, boasting Tuesday that “I think I’ve called every family of someone who’s died” while past presidents didn’t place such calls.

But The Associated Press found relatives of two soldiers who died overseas during Trump’s presidency who said they never received a call or a letter from him, as well as relatives of a third who did not get a call. And proof is plentiful that Barack Obama and George W. Bush — saddled with far more combat casualties than the roughly two dozen so far under Trump, took painstaking steps to write, call or meet bereaved military families.

The subject arose because nearly two weeks passed before Trump called the families of four U.S. soldiers who were killed in Niger nearly two weeks ago. He made the calls Tuesday.

READ MORE: Trump ignites furor with claim past presidents didn’t console military families by phone

Meanwhile, Rep. Frederica Wilson said late Tuesday that Trump told the widow of a slain soldier that he “knew what he signed up for.” Early Wednesday, the president called Wilson’s version of the conversation a fabrication.

The Florida Democrat said she was in the car with Myeshia Johnson on the way to Miami International Airport to meet the body of Johnson’s husband, Sgt. La David Johnson, when Trump called. Wilson says she heard part of the conversation on speakerphone.

When asked by Miami station WPLG if she indeed heard Trump say that she answered: “Yeah, he said that. To me, that is something that you can say in a conversation, but you shouldn’t say that to a grieving widow.” She added: “That’s so insensitive.”

Trump took strong issue with that recounting early Wednesday.

“Democrat Congresswoman totally fabricated what I said to the wife of a soldier who died in action (and I have proof). Sad!” he said on Twitter.

Sgt. Johnson was among four servicemen killed in the Niger ambush.

Wilson said that she didn’t hear the entire conversation and Myeshia Johnson told her she couldn’t remember everything that was said.

The White House didn’t immediately comment.

READ MORE: Trump’s claim about predecessors, fallen troops disputed

Trump’s delay in publicly discussing the men lost at Niger did not appear to be extraordinary, judging from past examples, but his politicization of the matter is. He went so far Tuesday as to cite the death of chief of staff John Kelly’s son in Afghanistan to question whether Obama had properly honored the war dead.

Kelly was a Marine general under Obama when his Marine son Robert died in 2010. “You could ask General Kelly, did he get a call from Obama?” Trump said on Fox News radio.

Democrats and some former government officials were livid, accusing Trump of “inane cruelty” and a “sick game.”

Democratic Sen. Tammy Duckworth of Illinois, an Iraq veteran who lost both legs when her helicopter was attacked, said: “I just wish that this commander in chief would stop using Gold Star families as pawns in whatever sick game he’s trying to play here.”

For their part, Gold Star families, which have lost members in wartime, told AP of acts of intimate kindness from Obama and Bush when those commanders in chief consoled them.

Trump initially claimed that only he among presidents made sure to call families. Obama may have done so on occasion, he said, but “other presidents did not call.”

He equivocated Tuesday as the record made plain that his characterization was false. “I don’t know,” he said of past calls. But he said his own practice was to call all families of the war dead.

But that hasn’t happened:

No White House protocol demands that presidents speak or meet with the families of Americans killed in action — an impossible task in a war’s bloodiest stages. But they often do.

Altogether some 6,900 Americans have been killed in overseas wars since the Sept. 11, 2001, attacks, the overwhelming majority under Bush and Obama.

Despite the much heavier toll on his watch — more than 800 dead each year from 2004 through 2007 — Bush wrote to all bereaved military families and met or spoke with hundreds if not thousands, said his spokesman, Freddy Ford.

Veterans groups said they had no quarrel with how presidents have recognized the fallen or their families.

“I don’t think there is any president I know of who hasn’t called families,” said Rick Weidman, co-founder and executive director of Vietnam Veterans of America. “President Obama called often and President Bush called often. They also made regular visits to Walter Reed and Bethesda Medical Center, going in the evenings and on Saturdays.”

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Bynum reported from Savannah, Georgia. Jonathan Drew in Raleigh, North Carolina, Kristen de Groot in Philadelphia, Jennifer McDermott in Providence, Rhode Island, Michelle Price in Salt Lake City, and Hope Yen and Robert Burns in Washington contributed to this report.

The post Trump and the new politics of honoring war dead appeared first on PBS NewsHour.




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Five of the most important International Space Station experiments

From artificial retinas to ageing mice, here are five of the most promising results from research performed on the ISS – and what they might mean for humans on Earth and in space