Worried that far too many students have weak reading skills, states are passing new laws that require aspiring teachers—and, increasingly, teachers who are already in the classroom—to master reading instruction that’s solidly grounded in research.

The Pittsburgh Penguins returned home after a three-game road trip only to get blown out by the Dallas Stars 7-1 on Monday night.

The Montreal Canadiens snapped a six-game losing streak with a 7-5 come-from-behind victory against the Buffalo Sabres on Remembrance Day.

St. Louis led 2-0 after two periods, was outscored 3-0, allowed game-winner to Pastrnak with 1:47 remaining

The principal of an elementary school in Washington, DC, describes how she and her staff broadened the focus of the school towards broader, more holistic goals for students.

Worried that far too many students have weak reading skills, states are passing new laws that require aspiring teachers—and, increasingly, teachers who are already in the classroom—to master reading instruction that’s solidly grounded in research.

Targeting altered expression and/or activity of GABA (-aminobutyric acid) transporters (GATs) provide therapeutic benefit for age-related impairments, including cognitive dysfunction. However, the mechanisms underlying the transcriptional regulation of GATs are unknown. In the present study, we demonstrated that the stimulator of interferon genes (STING) upregulates GAT1 and GAT3 expression in the brain, which resulted in cognitive dysfunction. Genetic and pharmacological intervention of STING suppressed the expression of both GAT1 and GAT3, increased the ambient GABA concentration, and therefore, enhanced tonic GABA_A inhibition of principal hippocampal neurons, resulting in spatial learning and working memory deficits in mice in a type I interferon-independent manner. Stimulation of the STING->GAT pathway efficiently restored cognitive dysfunction in STING-deficient mice models. Our study uncovered for the first time that the STING signaling pathway regulates GAT expression in a cell autonomous manner and therefore could be a novel target for GABAergic cognitive deficits.

South-South Cooperation is the mutual sharing and exchange of development solutions - knowledge, experiences and good practices, policies, technology and resources - between and among countries in the global [...]

Cellist Yo-Yo Ma talks with the founder of the Girls Computing League about the promise of her generation

In March 1895, Boston and New York City began an epic and highly competitive race to become the first American city with a working subway system.

Over the years, the mail has been delivered by train, donkey, bus, truck and even rocket (Produced by: Boaz Frankel )

Read more at http://www.smithsonianmag.com/arts-culture/Wayne-Thiebaud-is-Not-a-Pop-Artist.html He made a name for himself painting pastries and other everyday objects, but his other work--cartoons and cityscapes--showcase the scope of his talents.

Two Metropolitan Atlanta Rapid Transit Authority railcars were added to an artificial reef off the coast of Georgia to create more wildlife habitat

Kleptoparasitism, in which a bird harasses another to steal its food, might introduce avian flu to the continent, currently the only one without the severe H5N1 strain

The “beloved” rodent named Cinnamon was spotted this week with help from drones. She has been wandering and eating grass after escaping her zoo enclosure last Friday

Orbiting Barnard's star, the nearest solo star to Earth, the world is too hot to be habitable—a scorching 257 degrees Fahrenheit

No one was injured in the blast, and authorities are investigating why the ordnance detonated after so many years underground

At a new park in Bosnia and Herzegovina, two dozen gardeners have spent years replicating the Dutch artist's masterpiece using the land as their canvas

Identified as an Arctic fox, the animal is believed to have been kept in captivity far from its native habitat in the tundra. Now, it's receiving care from wildlife officials

A new exhibition in New York celebrates Berthe Weill, an often overlooked but visionary figure who jumpstarted the careers of many of modern art's giants

The robbers only made away with two of the screen prints, which they swiped from a gallery in the Netherlands. They abandoned the other artworks on the street

The Whitney Museum has been gifted 400 works by the famed pop artist, while the Smithsonian Archives of American Art will receive half a million documents

A candidate for the Nova Scotia NDP has apologized and is no longer running for the party in the provincial election after her comments on Israel and the Holocaust drew concern from the Jewish organizations. 

Building highways isn't the only solution to the growing problem of traffic congestion in and around the Halifax Regional Municipality, says the head of an organization that advocates for rail-based public transit.

On this episode of Generation Anthropocene, we dive into one of the most underappreciated elements on the periodic table

Former Ohio state Senator Nina Turner discusses the 2024 elections.

There is a sign of progress in the effort toward four-laning the final section of Highway 69 that links northern Ontario to the southern part of the province, and improving the safety of the heavily-travelled route.

Medical student Samuel Bonne had read everything he could to prepare for his group's dissection of a cadaver. But after the first cut, he left with lingering questions about what it means to lead a good life and die with dignity.

RCMP say a 23-year-old woman was found dead in a residence in central Manitoba on Tuesday. 

Benjamin Mora, a finalist for Canadian Premier League coach of the year, has left York United FC after five months and 22 matches at the helm.

The National Capital Commission says it opened the Rideau Canal Skateway below its usual stands for ice thickness a few times last season — and plans to do the same this year. 

The office of Kamloops Mayor Reid Hamer-Jackson is being relocated to the basement of city hall.

In his new book, former Maple Leafs captain Mats Sundin dives into the pressures and anxieties of being the first European drafted first overall to the NHL, getting traded by Quebec Nordiques to Toronto for Wendel Clark, and the turbulent end to his time with the team.

Nine games into the Washington Capitals' season, Alex Ovechkin is scoring at a rate that would put him past Wayne Gretzky as soon as this spring.

St. Louis Blues forward Dylan Holloway was back at the team's practice facility Wednesday and appeared to escape serious injury a day after being struck in the neck by a puck and leaving the ice on a stretcher against the Tampa Bay Lightning.

Ontario Provincial Police (OPP) have released dashcam footage of a crash that sent two people to hospital in life-threatening condition, linked to an ongoing investigation into rocks being thrown at moving vehicles in the GTA.

DWGgateway plug-in lets AutoCAD users share designs with virtually anyone

Sliding 'Counter-Balanced Motion' seat's performance in crash tests precisely matched COSMOSWorks analysis

Quiet, cozy dome solves problems identified by working pediatric professionals

More than 100,000 AutoCAD software users download free compatibility solution from SolidWorks Corporation

Using SOLIDWORKS Software, Norwegian Company Seabed Rig Designs Breakthrough System Operating on Ocean Floor

Bitcoin prices have passed a record $84,000 in what could be the start of its post-halving rally after the presidential elections last week.

A Transform 2012 Dancelink team in Mondim, Portugal, clears the way for a Transform Transit team to see the Gospel bear fruit four months later.

A trekking team in Moldova encourages two local believers and discover they found God through a team member’s father ten years before.

A group of people open to the Holy Spirit's leading find an open door for ministry in Nazareth.

By utilising short-term teams and partnering with local churches, OM Israel realigns its field focus.

In an annual OM Guatemala outreach, volunteers are challenged to leave their comfort zone and share God’s love in a different way.

Singapore :: A Frenchman makes friends with a community of foreign workers in Singapore.

International short-term volunteers reach out to an elderly Jewish couple and share comfort from God's Word.