Small-scale fishers play a fundamental role in feeding people—they use sustainable methods of catching and processing fish products and are a significant force in the employment and livelihoods of millions of people internationally—yet, until now, they have been excluded from climate and biodiversity conferences. For the first time at COP 16, which closed in Cali, […]

The Arab region is among the most water-scarce areas globally, as nearly 392 million people live in countries facing water scarcity or absolute water scarcity. So dire is the situation that, of the 22 Arab countries, 19 fall below the annual threshold for water scarcity in renewable resources, defined as 1,000 cubic meters per person. […]

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This report considers how finance and planning ministries can respond strategically to climate risk, highlighting best practices from Southeast Asia and identifying crosscutting priorities.

X-ray videos of Japanese eels swallowed whole by dark sleeper fish have revealed how the eels can make a daring escape from being digested

A species of leaf chameleon newly named Brookesia nofy was discovered in a patch of coastal rainforest, a highly threatened habitat in Madagascar

During a fight between two male mice, one will often run to a female mouse to distract their aggressor, a bait-and-switch strategy that could help abate social conflicts

Never underestimate what a single gopher can achieve in a day: one of the burrowing mammals helped boost soil fungi in an area blanketed by ash from the explosive eruption of Mount St Helens in Washington state

Some people find the scale of the universe existentially frightening, but here's why you should take it as a source of comfort

From the vastness of the universe to the infinitesimal particles that comprise it, extremes of scale defy comprehension – and present a problem for physicists seeking a unified theory of everything

A weird quantum phenomenon called delocalisation has been measured for a 100-nanometre glass bead, helping reveal where the boundary lies between quantum and classical physics

Global warming means many of the world’s ancient rivers of ice will be gone within decades, threatening ecosystems that rely on their meltwater, a looming crisis that photographer Edward Burtynsky highlights in his work

Never underestimate what a single gopher can achieve in a day: one of the burrowing mammals helped boost soil fungi in an area blanketed by ash from the explosive eruption of Mount St Helens in Washington state

A southern mammoth skeleton found in Spain bears cut marks from stone tools and bite marks from carnivore teeth, suggesting that both hominins and felids feasted on its meat

Title: Brain Scans Show Risk Factor for Alzheimer's
Category: Health News
Created: 8/25/2011 11:01:00 AM
Last Editorial Review: 8/25/2011 12:00:00 AM

Title: Frequent MRI Scanner Exposure Might Affect Memory: Study
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Title: Simple Steps Make Shots Less Scary for Kids, Nurse Says
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Title: Electrical Pulses to Scalp May Boost Memory: Study
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Title: CT Scan Use in Kids Fell Over Past Decade
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Title: Scans Show Range of Zika-Linked Infant Brain Defects
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Title: Brain Scans Offer Clues to Why Some Teens Pile on Pounds
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Title: Security Scanners Safe for Patients With Heart Devices: Study
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Title: Get Cooking With Elegant, Flavorful Scallops
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The transcription factor (TF) cone-rod homeobox (CRX) is essential for the differentiation and maintenance of photoreceptor cell identity. Several human CRX variants cause degenerative retinopathies, but most are variants of uncertain significance. We performed a deep mutational scan (DMS) of nearly all possible single amino acid substitutions in CRX using a cell-based transcriptional reporter assay, curating a high-confidence list of nearly 2000 variants with altered transcriptional activity. In the structured homeodomain, activity scores closely aligned to a predicted structure and demonstrated position-specific constraints on amino acid substitution. In contrast, the intrinsically disordered transcriptional effector domain displayed a qualitatively different pattern of substitution effects, following compositional constraints without specific residue position requirements in the peptide chain. These compositional constraints were consistent with the acidic exposure model of transcriptional activation. We evaluated the performance of the DMS assay as a clinical variant classification tool using gold-standard classified human variants from ClinVar, identifying pathogenic variants with high specificity and moderate sensitivity. That this performance could be achieved using a synthetic reporter assay in a foreign cell type, even for a highly cell type-specific TF like CRX, suggests that this approach shows promise for DMS of other TFs that function in cell types that are not easily accessible. Together, the results of the CRX DMS identify molecular features of the CRX effector domain and demonstrate utility for integration into the clinical variant classification pipeline.

ABSTRACTDespite global consensus on the importance of male involvement in family planning, disparities persist in low- and middle-income countries, where women continue to bear the responsibility for these initiatives. The Philippines, with a high fertility rate and unmet family planning needs, exemplifies this challenge. We present the experiences and lessons learned from implementing the no-scalpel vasectomy (NSV) program in Davao City, showcasing its potential for increasing male engagement in family planning decisions. Launched in 2008, the program aimed to address gender disparity by promoting NSV as a safe and effective contraceptive alternative to female-centric methods. Through the use of culturally sensitive information campaigns and couple-focused counseling, the program challenged traditional notions of masculinity and encouraged shared decision-making. Strong local government commitment and public-private partnerships played key roles in driving the program’s success. Results showed an average annual increase of 80% in NSV clients over the past 3 years compared to before the COVID-19 pandemic, underscoring its effectiveness. The program presents a compelling intervention model for similar initiatives, highlighting how overcoming cultural barriers, infrastructure limitations, and budgetary constraints through policy advocacy, strategic partnerships, and tailored approaches can significantly boost male involvement in family planning and improve reproductive health outcomes within communities.

The role of somatostatin receptor (SSTR) PET/CT, using ⁶⁸Ga-based tracers or [⁶⁴Cu]Cu-DOTATATE (⁶⁴Cu-DOTATATE), in the management of patients with neuroendocrine neoplasm (NEN) is guided by appropriate use criteria (AUC). In this study, we performed systematic analyses of referral patterns and image findings of routine ⁶⁴Cu-DOTATATE PET/CT scans to support AUC development. Methods: We included all clinical routine ⁶⁴Cu-DOTATATE PET/CT scans performed between April 10, 2018 (start of clinical use), and May 2, 2022, at Copenhagen University Hospital–Rigshospitalet. We reviewed the referral text and image report of each scan and classified the indication according to clinical scenarios as listed in the AUC. Results: In total, 1,290 patients underwent 2,249 ⁶⁴Cu-DOTATATE PET/CT scans. Monitoring of patients with NEN seen both on conventional imaging and on SSTR PET without clinical evidence of progression was the most common indication (defined as "may be appropriate" in the AUC) and accounted for 703 (31.3%) scans. Initial staging after NEN diagnosis ("appropriate" in the AUC) and restaging after curative-intent surgery ("may be appropriate" in the AUC) accounted for 221 (9.8%) and 241 (10.7%) scans, respectively. Selection of patients eligible for peptide receptor radionuclide therapy ("appropriate" in the AUC) and restaging after peptide receptor radionuclide therapy completion ("appropriate" in the AUC) accounted for 95 (4.2%) and 115 (5.1%) scans, respectively. The number of scans performed for indications not defined in the AUC was 371 (16.5%). Image result analysis revealed no disease in 669 scans (29.7%), stable disease in 582 (25.9%), and progression in 461 (20.5%). In 99 of the 461 (21.5%) scans, progression was detected on PET but not on CT. Conclusion: Our study provided real-life data that may contribute to support development of ⁶⁴Cu-DOTATATE/SSTR PET/CT guidelines including AUC. Some scenarios listed as "may be appropriate" in the current AUC were frequent in our data. Monitoring of patients with NEN without clinical evidence of progression was the most frequent indication for ⁶⁴Cu-DOTATATE PET/CT, in which disease progression was detected in more than one third, and a large proportion was visible by PET only. We therefore conclude that this scenario could potentially be classified as appropriate.

BACKGROUND AND PURPOSE:

Intracranial vessel wall imaging is technically challenging to implement, given the simultaneous requirements of high spatial resolution, excellent blood and CSF signal suppression, and clinically acceptable gradient times. Herein, we present our preliminary findings on the evaluation of a deep learning–optimized sequence using T1-weighted imaging.

Pilocytic astrocytomas are the most common pediatric brain tumors, typically presenting as low-grade neoplasms. We report two cases of pilocytic astrocytoma with atypical tumor progression. Case 1 involves a 12-yr-old boy with an unresectable suprasellar tumor, negative for BRAF rearrangement but harboring a BRAF p.V600E mutation. He experienced tumor size reduction and stable disease following dabrafenib treatment. Case 2 describes a 6-yr-old boy with a thalamic tumor that underwent multiple resections, with no actionable driver detected using targeted next-generation sequencing. Whole-genome and RNA-seq analysis identified an internal tandem duplication in FGFR1 and RAS pathway activation. Future management options include FGFR1 inhibitors. These cases demonstrate the importance of escalating molecular diagnostics for pediatric brain cancer, advocating for early reflexing to integrative whole-genome sequencing and transcriptomic profiling when targeted panels are uninformative. Identifying molecular drivers can significantly impact treatment decisions and improve patient outcomes.

Sleep is a fundamental feature of life for virtually all multicellular animals, but many questions remain about how sleep is regulated and what biological functions it plays. Substantial headway has been made in the study of both circadian rhythms and sleep in the fruit fly Drosophila melanogaster, much of it through studies of individual fly activity using beam break counts from Drosophila activity monitors (DAMs). The number of laboratories worldwide studying sleep in Drosophila has grown from only a few 20 years ago to hundreds today. The utility of these studies is limited by the quality of the metrics that can be extracted from the data. Many software options exist to help analyze DAM data; however, these are often expensive or have significant limitations. Therefore, we describe here a method for analyzing DAM-based data using the sleep and circadian analysis MATLAB program (SCAMP). This user-friendly software has an advantage of combining several analyses of both sleep and circadian rhythms in one package and produces graphical outputs as well as spreadsheets of the outputs for further statistical analysis. The version of SCAMP described here is also the first published software package that can analyze data from multibeam DAM5Ms, enabling determination of positional preference over time.

The respiratory literature, both written and in online formats, is growing exponentially. Capturing quality content, to meet the learning needs of those working in all fields of respiratory medicine and delivering it in a palatable, accessible format is challenging but paramount. In this article we discuss ways to determine the information content and review different methods of delivering this content to those who need it.

Chris dresses Pikachu up like a schoolboy with a camera. Josh wants his flight stick, he needs a HOTAS. Kelley wants Final Fantasy VII Rebirth to end like an episode of JoJo. Follow Solstice Warriors on their Myspace music page.

The post RPG Cast – Episode 691: “Hello, What Did Scamper Do Today?” appeared first on RPGamer.

Movies can’t, by definition, be all things to all people, and yet Anora—winner of the Cannes Film Festival’s highest honor, the Palme d’Or—manages to vacillate between assorted registers with stunning, and ultimately affecting, aplomb.

Another of The Florida Project and Red Rocket writer/director Sean Baker’s tales of marginalized individuals struggling to survive and find themselves in an often-unforgiving world, the film is a character study, romance, crime saga, screwball comedy, and vérité drama all wrapped into one unique and dexterous package. More impressive than its nimbleness, however, is its poise and empathy, the latter of which is chiefly bestowed upon its protagonist, whose life is thrown for a rollercoaster-grade loop-di-loop thanks to a chance introduction.

Ani (Mikey Madison, in a star-making turn) is a Brighton Beach 23-year-old who lives with her sister and earns a living stripping at a local club. Anora, which hits theaters Oct. 18, introduces her at the end of a long pan along a bench where men are receiving lap dances from erotic professionals. Fixating on Ani’s face as she flashes the fake smile that her customers crave and her superiors demand, Baker’s camera creates immediate, intimate engagement with the young woman, and that continues as it presents snapshots of her daily (or, rather, nightly) routine at her place of employment.

Read more at The Daily Beast.

When nightmarish sci-fi extraction shooter The Forever Winter launched into early access in September it was somewhat messy. Bugs and maddening enemy spawns diminished the tension of being a fleshy human scavenger in a mech battlefield. But one feature annoyed some players much more - fresh water. See, you need to keep your headquarters stocked with water, as it gets steadily used by your settlement's inhabitants. The catch being that this water diminishes even while you're not playing the game. If it runs out completely, then everything you've collected gets wiped. The developers have listened to complaints about this most Farmville of mechanics, and they've answered in an interesting way. Water thieves! Now, on top of the usual downward trickle, burglars will come to steal your H2O as well.

It's not as bad as it sounds.

Read more

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HARI SREENIVASAN: Let’s turn to the continuing fallout and reaction to the Harvey Weinstein story.

Yesterday, Weinstein resigned from the board of his production company following numerous revelations of sexual harassment and several allegations of assault.

More than three dozen women have said Weinstein harassed them. While Weinstein has admitted to behaving inappropriately, he has said he didn’t physically assault anyone.

One of those women is Katherine Kendall. She was a 23-year-old actress who met Weinstein in 1993. She alleges that he invited her to his apartment in New York, where, she says, he took off his clothes and asked for a massage.

As other actresses began coming forward about their painful experiences, she also went public with her own story.

She joins me now from Los Angeles.

First, thanks for joining us.

And I don’t want to relive something that’s painful for you, but you are taking a public stance on it.

For people who don’t know your story, what happened?

KATHERINE KENDALL, Actress/ Photographer: Well, I was you know, a young actress, and I had had a formal meeting at the Miramax office earlier that day.

And then, at the end of the meeting, which I thought went really well, he invited me to come to screenings. He said: “Welcome to the Miramax family. You know, come to premieres, screenings, et cetera. In fact, there’s one this afternoon. Would you like to come?”

And I said, “Sure.”

And I ended up going to see a movie with him. It ended up just being a movie, not a screening, but the film “Red Rock West.” And, you know, that’s right when I had this sort of sinking feeling that something wasn’t going right.

And then, after the movie, we walked for a few blocks. And he said he needed to go up to his apartment to get something, and would I just come with him real quick? And I sort of said no, and we went back and forth on that for a minute. It was sort of a negotiation with him always, trying to sort of stand my ground, but then be convinced it was OK.

I did go into his apartment. Once there, we talked for a long time about art and movies. And I felt like he was treating me like an intellect.

And I felt like the meeting was going really well, and sort of continued. I didn’t feel unsafe once I was in there. And, at one point, then, he got up to go to the bathroom. And he came back in a robe and asked me to give him a massage.

And I was extremely uncomfortable. And I was like, oh, God, no, I’m not comfortable with that. And we went back and forth on that.

And then he went back to the bathroom again, and came back this time completely naked. And, you know, that changed it entirely for me, too. It just took it to the next place. It was completely disorienting. And I was scared, you know? I was really scared.

And then it became sort of a cat-and-mouse game of, like, how am I going to get out of there?

And I’m — it’s hard to make sense of what someone is trying to do to you when they’re fully naked, and they’re…

HARI SREENIVASAN: Yes.

KATHERINE KENDALL: You know, I’m 105 pounds. He’s a large man standing between me and the door.

And, I mean, I felt very resolute, like, I will definitely get out of here somehow. But I’m not — I’m not sure — I’m not sure what’s going to happen here. You know, a lot was going through my head.

And he said, well, if you won’t give me a massage, will you at least show me your breasts? And it was just — you know, it was, all in all, an extremely humiliating experience for me.

And even though I got away, I felt like something had still — like something horrible had just happened to me.

HARI SREENIVASAN: You know, in the immediate aftermath, did you tell someone about it? Because you have said before that you felt ashamed…

KATHERINE KENDALL: I did.

HARI SREENIVASAN: … even though you were the victim.

KATHERINE KENDALL: I did.

It’s really interesting how that happens. And I think — you know, I’m older now, and I have done some work on myself. And I have learned that a lot of people feel that way.

It’s — it’s not — it wasn’t just me. But the just me feeling that this is my fault, this must have only happened to me, there’s something wrong with me, is so common when someone perpetrates against you.

HARI SREENIVASAN: What were the…

KATHERINE KENDALL: And I did. I told my mom.

And I told some good friends. But, you know, one of the things that happened was, I didn’t want them to tell anybody. You know, people wanted to help me, but they didn’t know how, and I didn’t want them to try too hard, because I didn’t want it to backlash.

I was scared. And I think that it’s important to remember that we don’t really come from a culture that supports women in talking about sexual harassment, in my — in my experience, that is. And, you know, I just haven’t felt like it was something I was going to get support on…

HARI SREENIVASAN: You know, how long…

KATHERINE KENDALL: … in the bigger picture.

HARI SREENIVASAN: Yes.

How long did this feeling last? Or, I guess, what are the longer-term ripple effects here? Did it shake your confidence in your abilities?

KATHERINE KENDALL: I think it did. I think it did. I think it did.

I think it made me feel like, wow, you know, that was a wash. He wasn’t interested at all in what I had to say, or, you know, he didn’t see any talent there or intellect there. He was assessing the situation the whole time for something else.

And I think that — that did hurt. You know, I wish it didn’t.

HARI SREENIVASAN: Yes.

KATHERINE KENDALL: But he had produced so many movies that I thought were wonderful. And it was — it’s hard when someone has made art that you love, and how do you stay attached to liking their art, but feeling conflicted about them?

And, yes, I think it does have long-term effects. I think you tuck it away. And then, for me, also, I realized that it came back when I would see his name or see him in person. I would start to sort of tremble all over again.

I mean, I wouldn’t think about him on a daily basis or anything for years, and then I would see him, and I would think, oh, I don’t feel well. I got to get out of here.

HARI SREENIVASAN: Right.

KATHERINE KENDALL: You know, it would bring up so much emotion.

And the most recent one was the woman in New York, the Italian model. I felt so, so enraged when I saw what happened there, and that they sort of — the police had him, and that then he got away. And then she was being dragged through the press as somebody who just, you know, wanted a payout, et cetera.

HARI SREENIVASAN: You know, in the wake of that, there was — a friend of yours had tweeted, “At some point, all the women who have been afraid to speak out about Harvey Weinstein are going to have to hold hands and jump.” This was back in 2015.

And from your Twitter account, you said, “Agreed.”

It seemed like you almost had the opportunity to come forward.

What made you want to come forward now? Has this become a turning point in the industry?

KATHERINE KENDALL: This is a turning point. It’s a turning point.

There are so many times when I thought about it, and then felt like — there were times when I thought about it and said, well, I have nothing to lose, I will just do it. And then I thought, I — I just didn’t have the strength or the courage yet.

And I think somebody like Jodi Kantor doing the story for The New York Times, the fact that she thought it was a story at all was startling to me and made me feel like, wow, something is going to be done.

And I knew she had told me — I mean, they were looking for women that this had happened to, because they’d been hearing rumors for so long that it happened to so many people. And she had told me other people were coming out.

And I thought, I can’t — when I watched Rose McGowan or any of the other actresses come forward, I just — or Ashley Judd — I just thought, they look strong to me, and I don’t want to be the one that stays silent.

HARI SREENIVASAN: Well, Katherine Kendall…

KATHERINE KENDALL: I want to stand beside them.

HARI SREENIVASAN: Katherine Kendall, thank you very much for speaking with us.

And, hopefully, there are other people that are empowered by you coming forward.

KATHERINE KENDALL: I hope so. Thank you.

The post Escaping Harvey Weinstein was a ‘cat-and-mouse game,’ says Katherine Kendall appeared first on PBS NewsHour.

Google has built a quantum computer that makes fewer errors as it is scaled up, and this may pave the way for machines that could solve useful real-world problems for the first time

Large language models can be used to scam humans, but AI is also susceptible to being scammed – and some models are more gullible than others

Treat yourself to a Becky Lynch book signing, games with the Dropout stars, Kevin Smith’s Dogma, and so much more!

PlayStation 5 Pro is out, and with plenty of availability, scalpers are shifting the £700 console at a loss and turning their attention to a key accessory instead

In this week's issue of our environment newsletter, we look at the carbon capture potential of the world's oceans and what effect beavers are having in the Arctic (spoiler: it's not good).