ba Sidechain structure–activity relationships of cyclobutane-based small molecule αvβ3 antagonists By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3616-3624DOI: 10.1039/D4MD00306C, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Adam Throup, Manar Saleh Zraikat, Andrew Gordon, Shohreh Jafarinejad Soumehsaraei, Kathrin D. Haase, Laurence H. Patterson, Patricia A. Cooper, Katherine Hanlon, Paul M. Loadman, Mark Sutherland, Steven D. Shnyder, Helen M. SheldrakeCyclobutanes provide a versatile scaffold for the synthesis of small molecule integrin antagonists with good metabolic stability and in vivo tolerability.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ba Design, synthesis, and evaluation of benzhydrylpiperazine-based novel dual COX-2/5-LOX inhibitors with anti-inflammatory and anti-cancer activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00471J, Research ArticlePoorvi Saraf, Bhagwati Bhardwaj, Akash Verma, Mohammad Aquib Siddiqui, Himanshu Verma, Pradeep Kumar, Samridhi Srivastava, Sairam Krishnamurthy, Saripella Srikrishna, Sushant Kumar ShrivastavaScreening piperazine derivatives via ChEMBL database led to the design and synthesis of novel dual COX-2/5-LOX inhibitors with strong anti-inflammatory, analgesic, and anti-cancer activity.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ba Design and Synthesis of coumarin-based amphoteric antimicrobials with the biofilm interference and immunoregulation effects By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00721B, Research ArticleQun Tang, Haiyang Zhang, Kasemsiri Chandarajoti, Zirui Jiao, Lianhua Nie, Sai Lv, Jiakun Zuo, Wen Zhou, Xiangan HanBacterial infections pose a threat to the health of animals and human being, and the biofilm formation exacerbates the microbial threat. New antimicrobial agents to address this challenge are much...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ba Modulating polybasic character of galactose-based glycosylated antitumor ether lipids for enhanced cytotoxic response By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00662C, Research ArticleRajat Arora, Ayan Mukherjee, Gilbert Arthur, Mark W. Nachtigal, Frank SchweizerWe describe the multi-step synthesis of different dibasic and tribasic galactosamine-based glycosylated antitumor ether lipids (GAELs) and their cytotoxic response in comparison to doxorubicin and cisplatin.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ba Human microbiome derived synthetic antimicrobial peptides with activity against Gram-negative, Gram-positive, and antibiotic resistant bacteria By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00383G, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Walaa K. Mousa, Ashif Y. Shaikh, Rose Ghemrawi, Mohammed Aldulaimi, Aya Al Ali, Nour Sammani, Mostafa Khair, Mohamed I. Helal, Farah Al-Marzooq, Emilia OueisAn AMP-derived short 15-mer peptide and its cyclic derivatives have low micromolar broad spectrum antibacterial activity, with rapid onset of bactericidal effect and a membrane-targeting mode of action.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ba Azo derivatives of monoterpenes as anti-Helicobacter pylori agents: from synthesis to structure-based target investigation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00511B, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Francesco Melfi, Marialuigia Fantacuzzi, Simone Carradori, Ilaria D'Agostino, Alessandra Ammazzalorso, Noemi Mencarelli, Marialucia Gallorini, Mattia Spano, Paolo Guglielmi, Mariangela Agamennone, Sazan Haji Ali, Ali Al-Samydai, Francesca SistoMonoterpene-derived azo benzenes showed selective antibacterial activity against Helicobacter pylori with a safe profile. An in silico investigation highlighted the inosine 5'-monophosphate dehydrogenase enzyme as the putative target.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ba Medicinal chemistry-based perspective on thiophene and its derivatives: Exploring the structural insights to discover plausible druggable leads By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00450G, Review ArticleShikha Thakur, Devendra Kumar, shivani jaiswal, Kapil Kumar Goel, Pramod Rawat, Vivek Srivastava, Sonia Dhiman, Hemant R Jadhav, Ashish Ranjan DwivediThiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes. The thiophene moiety has been ranked 4th in US FDA drug approval of small drug molecules,...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ba A decade of pyridine-containing heterocycles in US FDA approved drugs: a medicinal chemistry-based analysis By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00632A, Review ArticleAshish Ranjan Dwivedi, Shivani Jaiswal, Deepak Kukkar, Roshan Kumar, Thakur Gurjeet Singh, Mahendra Pratap Singh, Abhay M. Gaidhane, Sorabh Lakhanpal, K. Nagendra Prasad, Bhupinder KumarThe present review is a concerted effort to cover drugs bearing pyridine rings approved in the last decade, and it provides thorough discussion and commentary on their pharmacokinetics and pharmacodynamics together with in-depth structural analysis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ba Synthesis and anti-tumor activity of new benzofuran-based chalcone derivatives as potent VEGFR-2 inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00621F, Research ArticleChunfei Zhang, Yixin Liu, Xiao Zhang, Chunping Wan, Zewei MaoA series of novel benzofuran-based chalcone derivatives could be considered as potent VEGFR-2 inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ba Advances in antibacterial agents for Mycobacterium fortuitum By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00508B, Review ArticleCarlos Roberto Tavolari Jortieke, Angélica Rocha Joaquim, Fernando FumagalliThis review presents the recent findings on antibacterial agents against Mycobacterium fortuitum and reveals the most promising and effective chemical frameworks to inspire the development of new drugs.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ba Design, synthesis, and biological evaluation of pyrazole–ciprofloxacin hybrids as antibacterial and antibiofilm agents against Staphylococcus aureus By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00623B, Research ArticleOjaswitha Ommi, Priyanka Sudhir Dhopat, Shashikanta Sau, Madhu Rekha Estharla, Srinivas Nanduri, Nitin Pal Kalia, Venkata Madhavi YaddanapudiA series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, aiming to combat antibiotic resistance.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ba Novel quinoxaline-derived derivatives: design, synthesis, bioactive evaluation, SARs and preliminary antibacterial mechanism By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00670D, Research ArticleYuting Liu, Pengju Yang, Yunyun Zhou, Zhiwen ZhouIn the current study, we have designed and prepared a series of quinoxaline-based compounds, which were derived from o-phenylenediamine. Among which, compounds 5m-p displayed good to moderate antibacterial activity with...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ba Enhancing the antimycobacterial efficacy of pyridine-4-carbohydrazide: linkage to additional antimicrobial agents via oxocarboxylic acids By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00663A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Václav Pflégr, Klára Konečná, Jiřina Stolaříková, Jan Ősterreicher, Ondřej Janďourek, Martin KrátkýLinking pyridine-4-carbohydrazide to other antimicrobial agents via oxocarboxylic acids significantly enhances efficacy against mycobacteria with promising selectivity and safety profiles.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ba Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00626G, Research ArticleAleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan VeerappanLipidation modulates the Gram-selective antibacterial activity of QPyNATh.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ba Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00600C, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Gennaro Sanità, Maria Laura Alfieri, Barbara Carrese, Serena Damian, Vincenza Mele, Gaetano Calì, Brigida Silvestri, Sebastiano Marra, Susan Mohammadi, Giuseppina Luciani, Paola Manini, Annalisa LambertiBiological assays carried out on melanoma and breast cancer cells highlighted the role of light in boosting the cytotoxic effect of a ruthenium complex featuring a dihydroisoquinoline ligand suggesting applications in photodynamic therapy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ba Property-based optimisation of PROTACs By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00769G, OpinionJames Scott, Iacovos Michaelides, Markus SchadePROTACs are an emerging therapeutic approach towards targeted protein degradation. This article examines the leading examples of this modality that are in clinical development through the prism of their physicochemical...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ba Duo arrested for possession of banned tobacco products worth ₹3 lakh in Tiruchi By www.thehindu.com Published On :: Wed, 06 Nov 2024 18:23:30 +0530 Full Article Tiruchirapalli
ba TNSTC Kumbakonam Division mops up ₹17.13 crore in four days By www.thehindu.com Published On :: Wed, 06 Nov 2024 18:59:26 +0530 Full Article Tiruchirapalli
ba Urban Primary Health Centre stuck in cramped, temporary facility By www.thehindu.com Published On :: Wed, 06 Nov 2024 20:31:50 +0530 Full Article Tiruchirapalli
ba Property owners block the entrance to Balasubramanya temple in Karur By www.thehindu.com Published On :: Thu, 07 Nov 2024 17:35:45 +0530 Full Article Tiruchirapalli
ba Tiruchi Corporation embarks on special drive at night to capture and sterilise street dogs By www.thehindu.com Published On :: Thu, 07 Nov 2024 19:10:58 +0530 About 125 stray dogs have been caught and sterilised at Tiruchi animal birth control centres in the last 10 days after the Corporation launched the special drive Full Article Tiruchirapalli
ba Tiruchi district SHGs compete to prepare healthy millet-based recipes at food festival By www.thehindu.com Published On :: Fri, 08 Nov 2024 07:51:25 +0530 Women entrepreneurs urged to take advantage of social media platforms to advertise and market their products to a wider customer base Full Article Tiruchirapalli
ba Guidelines issued for fertilizer distribution in Karaikal for samba, thaladi paddy cultivation By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:25:49 +0530 Full Article Tiruchirapalli
ba EPS’s dream of AIADMK staging a comeback in 2026 election will not materialise: Law Minister Regupathy By www.thehindu.com Published On :: Fri, 08 Nov 2024 20:25:59 +0530 Full Article Tiruchirapalli
ba Advanced baggage handling system introduced in Tiruchi airport By www.thehindu.com Published On :: Sat, 09 Nov 2024 18:01:36 +0530 Full Article Tiruchirapalli
ba 544: Feedback, RSS Talk, Arc Brower, and Product Talk By shoptalkshow.com Published On :: Mon, 05 Dec 2022 08:15:42 +0000 Getting feedback for what you're building or writing, RSS feed reminiscing, Arc browser thoughts, products that didn't make that should have. Full Article All Episodes browsers Feedback rss
ba 547: WordPress and GraphQL with Jason Bahl By shoptalkshow.com Published On :: Mon, 09 Jan 2023 09:31:13 +0000 Jason Bahl joins the show to talk about the GraphQL and WordPress connection, his work on WP GraphQL plugin, Faust and Atlas from WP Engine, Jamstack and Wordpress, and more. Full Article All Episodes graphql Wordpress
ba 601: Brad Frost on A Global Design System + Frostapalooza By shoptalkshow.com Published On :: Mon, 05 Feb 2024 11:00:03 +0000 Brad Frost has got design systems on his mind—at a global scale. What is a global design system? Are two design systems ever the same? How would this slot inside atomic design? What has been the response from the web community to global design system as an idea? And what's Frostapalooza? Full Article All Episodes atomic design design systems web componnets
ba 606: Web Sustainability with Michelle Barker By shoptalkshow.com Published On :: Mon, 11 Mar 2024 08:35:40 +0000 Show DescriptionWe're talking with Michelle Barker about the idea of paying to support bloggers (and podcasters!) via services like Patreon, drumming as a fun side gig from CSS, how big of an issue digital sustainability is, trying to understand the environmental impact of our websites and digital life, wondering why YouTube embeds are still so […] Full Article All Episodes energy environment sustainability
ba 607: Astro Launches an Integrated Database By shoptalkshow.com Published On :: Mon, 18 Mar 2024 08:39:41 +0000 Fred K. Schott stops by to talk about Astro announcement of Astro DB, the pluses and minuses of it, whether you have to always use the database with Astro DB, how to migrate data, seeding your database, upgrading the database, and what about Astro DB pricing? Full Article All Episodes Astro astro db database
ba 618: Matt Visiwig on SVGBackgrounds By shoptalkshow.com Published On :: Mon, 03 Jun 2024 08:08:44 +0000 Matt Visiwig stops by to chat with us about his site, SVGBackgrounds.com, a membership site for copy-and-paste website graphics built around SVG. We talk about why he built the site, how he decided to monetize it, competing with AI garbage on the web, pricing membership options, and how he's running the site. Full Article All Episodes ecommerce Making Money SEO SVG
ba 624: Blogging, In App Browsers are Bad, and Teaching CSS from Scratch By shoptalkshow.com Published On :: Mon, 15 Jul 2024 08:37:37 +0000 On this epsiode we're talking about the current state of blogging and social media, the polyfill hack, whether in app browsers should be banned, web components and the difficulty of front end web dev, and how we would go about teaching CSS from scratch in 2024. Full Article All Episodes Blogging CSS Education polyfill
ba 629: The Great Divide, Global Design + Web Components, and Job Titles By shoptalkshow.com Published On :: Mon, 19 Aug 2024 08:01:48 +0000 A bit of follow-up on vibe driven development and JavaScript not causing The Great Divide, writing testing automation, global design systems and web components, could PHP be used for web components, what if view transitions are going to be everywhere, and frontend engineer vs design systems engineer job titles and descriptions. Full Article All Episodes design systems engineer PHP view transitions
ba 630: Frostapalooza Recap, Follow Up, and Messy Codebases By shoptalkshow.com Published On :: Mon, 26 Aug 2024 08:22:05 +0000 Chris has a birthday today 🎉, we recap our Frostapalooza experience celebrating Brad Frost's birthday, do all codebases become a mess, Mermaid, TLDraw, and Figjam thoughts, making tiny games, where's the follow up in web and world news, and what's the current state of CMS' on the web? Full Article All Episodes birthday CMS drawing Wordpress
ba 639: DX, JSON, XML, HTML, and Databases! Oh My! By shoptalkshow.com Published On :: Mon, 28 Oct 2024 08:49:04 +0000 How important is the DX of software vs how important is the person showing off the software, Douglas Crockford and JSON, remembering XML, trying to write better HTML for email, new TC39 proposal, workshopping t-shirts, and what do you do if you want a little bit of database on your website? Full Article All Episodes database dx Javascript
ba Laying a strong base By www.thehindu.com Published On :: Fri, 26 Dec 2014 15:42:56 +0530 The Centre has various plans to meet the housing needs of the country, writes K.A. Martin Full Article Property Plus
ba Guidelines for green urbanisation By www.thehindu.com Published On :: Fri, 02 Oct 2015 21:12:45 +0530 The Ministry of Urban Development has proposed environmental guidelines for construction projects in urban areas. Nidhi Adlakha reports Full Article Property Plus
ba The four Rs of urban living By www.thehindu.com Published On :: Fri, 22 Apr 2016 22:45:33 +0530 Each one of us has a role to play in combating drought and we should adopt the mantra of reject, reduce, reuse and recycle, says S. Vishwanath Full Article Green Living
ba Balrampur Chini hopes success of polylactic acid plant will be sweet By www.thehindubusinessline.com Published On :: Sun, 29 Sep 2024 20:46:00 +0530 In conversation with Avantika Saraogi, ED, and Stefan Barot, President, Chemicals Division, Balrampur Chini Mills Full Article Corporate File
ba How ‘priority sector’ status can rev up Jan Dhan banking By www.thehindubusinessline.com Published On :: Sun, 29 Sep 2024 21:31:00 +0530 How regulation can nudge private banks to promote financial inclusion Full Article Current Account
ba Urban Safari By www.thehindubusinessline.com Published On :: Sat, 05 Oct 2024 06:01:00 +0530 Old or new, whichever iteration of the Tata Safari you look at, there’s a lot of charm, utility, and driving appeal, but which one gets our vote? Full Article Auto focus
ba The delicate balance in doctor-patient interaction By www.thehindubusinessline.com Published On :: Sun, 06 Oct 2024 22:06:15 +0530 How clear communication and accountability in healthcare can significantly improve patient outcomes Full Article Pulse
ba Putting cholera back in focus By www.thehindubusinessline.com Published On :: Sun, 06 Oct 2024 22:22:57 +0530 Surge in cholera cases renews attention on the need to fortify public health Full Article Pulse
ba Why banks are branching furiously By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:13:00 +0530 From financial inclusion to wooing back savings deposits, lenders have reasons to reject digital-only mode Full Article Current Account
ba Galathea Bay: New major port can be game changer By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 19:56:00 +0530 Transshipment port at Galathea Bay is strategically located on the East-West international trade and shipping route Full Article Logistics
ba A ‘shadow ban’ in plain sight By www.thehindubusinessline.com Published On :: Mon, 21 Oct 2024 17:02:24 +0530 The confusion and stigma surrounding the ‘morning after’ pill puts women’s health at risk Full Article Pulse
ba Indo National plans battery of home-care launches By www.thehindubusinessline.com Published On :: Sun, 27 Oct 2024 14:00:42 +0530 The maker of Nippo batteries plans to innovate in its core business and get into LED bulbs Full Article Corporate File
ba Getting the gig economy to care for its backbone By www.thehindubusinessline.com Published On :: Sun, 27 Oct 2024 14:25:45 +0530 Why startups in India cannot afford to take a hands-off approach towards the armies of gig workers they have created Full Article Emerging Entrepreneurs
ba Bengaluru startup develops new tech for battery recycling, begins production By www.thehindubusinessline.com Published On :: Sun, 27 Oct 2024 18:13:56 +0530 Li-ion battery recycler Metastable Materials launches commercial ops Full Article Clean Tech
ba Toxic air chokes urban India By www.thehindubusinessline.com Published On :: Sun, 03 Nov 2024 18:59:29 +0530 Residents grapple with respiratory, cardiac, and other ailments as the air thickens Full Article Pulse