Tattoo pistols are definitely the devices that are used to create and use tattoos. These pistols are also known as tattoo models. They have been utilized for several years to create stylish and delightful bits of system craft. Right now,… Continue Reading →

Think about all of the products you use every day, both at home and at work. Every single thing you use started out as an idea or concept from someone who thought, “If I had something like this, it would make life so much easier.” We all have those ideas. But how does a product go from concept to solid object sitting on a shelf waiting for you to buy it? The process is long and complex and inv; (read more)

Source: Suzy - Discipline: BioTech

OK, let’s pick up our discussion where we left off last week, at feasibility.  You did it. You successfully convinced a room full of vice presidents and directors, or maybe even the CEO that they should take your fabulous product idea to the next level.  You’ve got marketing on board, excited to promote it and now it’s time for the work to begin.You are the lead scientist s; (read more)

Source: Suzy - Discipline: BioTech

Picking up our discussion on the new product development life cycle, we last talked about R&D and before that feasibility. The next department to work on the new product is marketing. The person who will announce to the world the arrival of this new kit is the Product Manager or Marketing Manager.(If you do not recognize some terms used here, please ask or check the Marketing Dictionary.)Today; (read more)

Source: Suzy - Discipline: BioTech

I walked past the mini-conference room area that AACR set up in the middle of the exhibit hall and my eyes immediately zeroed in on the name of one of my science idols: Elizabeth Blackburn.  She was going to be speaking about careers to young scientists and allow them to ask her questions. I noted the day and time. It wouldn’t matter to me what she was talking about. I would be there. ; (read more)

Source: Suzy - Discipline: Careers

Anyone with strong bioinformatics skills looking for a job with a fantastic energetic new PI at the University of Arizona? Today I spent time with a friend and new PI at the University of Arizona talking about her metagenomics projects. She's been advertising for an opening for a computational biologist for quite a while.  She tells me that she can't find anyone to fill this position beca; (read more)

Source: Suzy - Discipline: Careers

“Even after weeks of staying home, my kids are just not interested in all the stuff we have. Let’s be honest. If a toy isn’t getting any action amid this distraction-free, stuck-at-home living, chances are it’s never getting touched again.” Liz Russell figures out what really engages and changes kids during the quarantine, and will […]

Daron Acemoglu of MIT and Pascual Restrepo of Boston University find that robots really do decrease human employment. As robots and other computer-assisted technologies take over tasks previously performed by labor, there is increasing concern about the future of jobs and wages. We analyze the effect of the increase in industrial robot usage between 1990 and 2007 on US local labor markets. Using a model in which robots compete against human labor in the production of different tasks, we show that robots may reduce employment and wages, and that the local labor market effects of robots can be estimated by regressing the change in employment and wages on the exposure to robots in each local labor market—defined from the national...

Date: May 8, 2020

Location: South Korea

Tags: Parents' Day, carnations, flowers, stop-motion, Animation

The post The Angler’s Code: What are the Best Practices for a Better Fishing Future? appeared first on Ocean Blue Fishing Adventures.

The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Although gene-environment interactions have been implicated in the etiology of several disorders, the impact of paternal and/or maternal metabolic syndrome on the clinical phenotypes of offspring and the underlying genetic and epigenetic contributors of NAFLD have not been fully explored. To this end, we used the liver-specific insulin receptor knockout (LIRKO) mouse, a unique nondietary model manifesting 3 hallmarks that confer high risk for the development of NAFLD: hyperglycemia, insulin resistance, and dyslipidemia. We report that parental metabolic syndrome epigenetically reprograms members of the TGF-β family, including neuronal regeneration–related protein (NREP) and growth differentiation factor 15 (GDF15). NREP and GDF15 modulate the expression of several genes involved in the regulation of hepatic lipid metabolism. In particular, NREP downregulation increases the protein abundance of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and ATP-citrate lyase (ACLY) in a TGF-β receptor/PI3K/protein kinase B–dependent manner, to regulate hepatic acetyl-CoA and cholesterol synthesis. Reduced hepatic expression of NREP in patients with NAFLD and substantial correlations between low serum NREP levels and the presence of steatosis and nonalcoholic steatohepatitis highlight the clinical translational relevance of our findings in the context of recent preclinical trials implicating ACLY in NAFLD progression.

This week saw a couple of big announcements, led by the launch of an update for the 13-inch MacBook Pro line. Most notably, the update brought the improved Magic Keyboard previously introduced on its 16-inch sibling and the MacBook Air, with high-end models also receiving updated processors.

Subscribe to the MacRumors YouTube channel for more videos.
The second significant announcement this week was that Apple's first all-digital Worldwide Developers Conference will kick off on June 22. Other news this week included a firmware update for the AirPods Pro, an update on Apple's Mini-LED efforts, and more.

Read on below and check out our video above for recaps of all of this week's most important stories!

New 13-Inch MacBook Pro Announced With Magic Keyboard, 10th-Gen Processors, Up to 32GB RAM and 4TB SSD, and More

Apple this week refreshed its 13-inch MacBook Pro lineup, with key features including the same Magic Keyboard as the 16-inch MacBook Pro, up to 80 percent faster Intel graphics than the previous generation, up to 32GB of RAM, up to 4TB of SSD storage, and 6K display support.


First introduced on the 16-inch MacBook Pro last year, the Magic Keyboard features a far more reliable scissor mechanism with 1mm of key travel. After five years, Apple has finally transitioned its entire notebook lineup away from its issue-prone butterfly keyboard.

10th-generation Intel processor options are only available on higher-end models, with the $1,799 configuration proving to be up to 16.5% faster than the $1,299 base model with an older 8th-generation processor.

Apple's Virtual WWDC Event to Kick Off on June 22

Apple has announced that its first-ever online-only WWDC will begin Monday, June 22 via the Apple Developer app and website. The weeklong event will include a virtual keynote, sessions, and labs, with more details to be shared in June. And it's free!


Apple is expected to introduce iOS 14, iPadOS 14, macOS 10.16, tvOS 14, and watchOS 7 at WWDC 2020, with beta testing to take place over the summer.

Student developers from all over the world can enter Apple's Swift Student Challenge by creating an interactive scene in Swift Playgrounds that can be experienced in three minutes. Winners will receive an exclusive WWDC20 jacket and pin set. Submissions are open through May 17.

Apple Updates AirPods Pro Firmware to Version 2D15

Apple this week released a new firmware version 2D15 for the AirPods Pro, replacing version 2C54.


In recent months, some AirPods Pro owners have been complaining about reduced noise cancellation and crackling or static sounds, so users have listened for any improvements following the update.

Perhaps proving how subjective sound quality can be, feedback has been decidedly mixed, with some users noticing an improvement, some noticing no change, and some noticing further degradation to noise cancellation.

Apple has offered some help in the form of two new support documents for users to troubleshoot noise cancellation or crackling sound issues.

10 Tips and Tricks for the iPad Pro Magic Keyboard

Have you recently picked up a new Magic Keyboard for the iPad Pro? Here's a list of our favorite tips and tricks that you need to know.


The tips and tricks relate to adjusting the backlight brightness, customizing the cursor's behavior, enabling tap-to-click on the trackpad, other trackpad gestures, accessing the Emoji keyboard, and more.

Apple's Mini-LED Product Roadmap May Have Been Pushed Back to 2021

Disappointed that the new 13-inch MacBook Pro was not the rumored 14-inch model? That may be due to a slight delay in Apple's plans to release a range of new products with Mini-LED backlit displays.

Kuo believes Apple's first Mini-LED products might not launch until 2021. The analyst has previously said these products would include a new 14.1-inch MacBook Pro, 16-inch MacBook Pro, 12.9-inch iPad Pro, and more.


Kuo has previously said that Mini-LED displays will allow for thinner and lighter product designs, while offering many of the same benefits of OLED displays used on the latest iPhones, including good wide color gamut performance, high contrast and dynamic range, and local dimming for truer blacks.

NFC-Based Digital Key Specification Released Ahead of Apple's Rumored CarKey Feature on iPhone

Amid rumors that Apple is working on a digital "CarKey" feature for iPhone, the Car Connectivity Consortium has announced that its NFC-based Digital Key Release 2.0 specification has been finalized and made available to its members, which includes Apple.


"CarKey" will allow an iPhone or Apple Watch to unlock, lock, and start an NFC-compatible vehicle. Just like credit cards and boarding passes, users will be able to add a digital car key to the Wallet app, eliminating the need to use a physical car key or key fob.

MacRumors Newsletter

Each week, we publish an email newsletter like this highlighting the top Apple stories, making it a great way to get a bite-sized recap of the week hitting all of the major topics we've covered and tying together related stories for a big-picture view.

So if you want to have top stories like the above recap delivered to your email inbox each week, subscribe to our newsletter!
This article, "Top Stories: New 13" MacBook Pro, WWDC Starts June 22, AirPods Pro Firmware Update, and More" first appeared on MacRumors.com

Discuss this article in our forums

Rick May, best known to furries and non-furries alike as the voice of Peppy Hare in the English version of the game Star Fox 64 passed away April 13, 2020 due to COVID-19. May was born September 21, 1940 (with the full name of Richard J. May), meaning he would have turned 80 later this year. May had also recently suffered a stroke in February, making him even more vulnerable to the disease caused by the novel coronavirus.

May will forever be known as the man who originally uttered the memetic line "Do a barrel roll! (Z or R twice.)" in Star Fox 64, explaining to players how to perform what is technically an aileron roll in order to deflect enemy attacks. May also played the villain of Star Fox 64, Andross. Outside of furry video games, May is probably best known for voicing the Soldier of Team Fortress 2; furries might also recognize his voice behind the villainous Dr. M from the third Sly Cooper game. In addition to voice work for video games, May has had a long history of working both on and for the stage as both a director and actor, beginning with USO shows while stationed in Japan. His part in a Renton, Washington production of Cotton Patch Gospel featured a combination of his voice and stage work, as he used different voices to portray 21 characters in what was reportedly his favorite stage role.

read more

Wow, talk about bad at updating, damian! I have continued posting comics and sketches and paintings and…you get the idea!! BUT….I have been posting them primarily on Instagram (I know, terrible) – sorry, things have been busy (as usual), and[…]↓ Read the rest of this entry...

Hang in there, everyone. — seeya soon, boring details about today’s comic: made with: love

— seeya soon, boring details about today’s comic: made with:

Erowid Exp101191

On the Young Turks, Cenk Uygur quotes passages from Bob Woodward's book, "The Price of Politics", quoting statements made by President Obama proving that he intends to cut entitlements like social security, medicare, and medicaid. Continue reading →

Glenn Greenwald predicts over the next four years that "it's all going to get much worse", with President Obama shifting politically more to the right while the Democratic base continues to support him. Continue reading →

Thinking of using TurboTax to file your tax returns? Think again. The Minnesota Department of Revenue advises against using Intuit software to file tax returns! It found unacceptable errors in Intuit tax software, including TurboTax, ProSeries, Lacerte, and Intuit online. Continue reading →

I am still holding on a call to the Internal Revenue Service, even though I called (800) 829-0115 two hours ago. This telephone number is the one often included in notices from the Internal Revenue Service for overdue business taxes. … Continue reading →

Have you ever noticed that the Internal Revenue Service's regulations often are illogical? Does anyone at the IRS think through its regulations? Continue reading →

Are you a taxpreparer who is unsatisfied with the quality of Intuit's ProSeries tax software program? I am not a happy user of ProSeries tax software. Choose your tax software carefully. I will be searching for an alternative tax software vendor for the year 2014. Continue reading →

Does a stooge prepare your income tax returns? Watch the Three Stooges prepare a tax return and learn from them. Don't be a stooge: hire a CPA to prepare your next tax return! Continue reading →

Are accountants destined to be the anthropologists of the cyber era? Gillian Tett appears to suspect such. Continue reading →

Have you ever observed the mating dance of the birds of paradise? The male moves dramatically, and in response, the female inches away, but ultimately the male conquers the female, and achieves the purpose of this ritualistic, instinctive dance. Well, … Continue reading →

"Well, reducing the election to personalities is kind of infantile at this point. The fact is, we live in a system that Sheldon Wolin calls inverted totalitarianism. It’s a system where corporate power has seized all of the levers of control. There is no way to vote against the interests of Goldman Sachs or ExxonMobil or Raytheon." Continue reading →

The middle class needs to vote for Donald Trump in order to oppose the elites, Corporate America, Wall Street, the career politicians, and the media, who have all conspired to destroy the middle class. Donald Trump is the Molotov cocktail, the human hand grenade, that every beaten-down, nameless, forgotten working stiff who used to be part of what was called the middle class can legally throw into the system that stole their lives from them. Continue reading →

Claudia Stauber provides a perfect metaphor of how she felt listening to Bernie Sanders today in Vermont, telling us how much he still fights for us against the 1% and the oligarchs. Continue reading →

Lobbyists are buying our government out from under us Continue reading →

Connecticut General Assembly Majority Leader Joe Aresimowicz speaking at the 2014 CEUI Convention. Joe Aresimowicz, in speaking to a governmental employee union group in 2014, assured governmental union employees that he would be looking out for them: "You guys have one of your own that sits in the caucus room of the General Assembly. You cannot replicate that." "I will never allow an anti-collective bargaining bill to be called to the House floor. I'm the majority leader. I can make that guarantee." "Please, stand together, stand as brothers and sisters, and be a family. And make sure we are looking out for our own." Continue reading →

NCIS and NCIS: New Orleans aired new episodes last night. You can find ratings and links to watch the episodes below, along...

NCIS: Los Angeles aired the twelfth episode of season eight last night. “Kulinda” pulled in 10.35 million viewers at 8:00pm, earning a...

The tenth annual Open Hardware Summit will be in New York held online on March 13. I’ll be participating in a panel looking back at the past ten years of open source hardware and looking forward to the next decade as well. The schedule is filled with great speakers and I’m looking forward to seeing … Continue reading Open Hardware Summit 2020 →

Руководитель McLaren Group Зак Браун не исключил участия Дженсона Баттона в отдельных гонках серии Indycar за рулём третьей машины команды...

Руководитель команды McLaren Андреас Зайдль заявил, что в Уокинге не рассматривают сценарий клиентской команды Mercedes – и будут самостоятельно стремиться к успеху…

В этом году у McLaren появилась команда в Indycar, а через несколько лет команда может принять участие в гонках на выносливость...

В следующем году команда McLaren поменяет поставщика силовых установок, перейдя с Renault на Mercedes. Ландо Норрис считает, что это поможет коллективу из Уокинга прибавить.

Британское правительство отказало McLaren Group в получении специального коммерческого кредита в 150 млн. фунтов стерлингов, за которым руководство группы компаний обратилось, чтоы преодолеть последствия пандемии...

В виртуальном Гран При Испании, который пройдёт в воскресенье, McLaren будут представлять Ландо Норрис и Николас Хэмилтон, брат шестикратного чемпиона мира...

An updated Disaster Resilience Scorecard to help cities and local government agencies improve their preparedness and reduce risks from disasters was launched today at the Global Platform for Disaster Risk Reduction. Developed for the UN Office for Disaster Risk Reduction by AECOM, IBM with support from USAID and the European Commission, the Scorecard gives better access to information, knowledge resources, and tools to effectively reduce risks from the impacts of natural hazards and climate change.

The publisher is adding videos of their creators entertaining themselves while sheltering in place.

The post SHUT IN THEATER: What are Dynamite creators in quarantine up to? appeared first on The Beat.

The Weather Company, an IBM Business announced today that it is enhancing its global flight operations solution WSI Fusion, with live flight tracking data from FlightAware. WSI Fusion provides early insight into changing flight, airport and airspace conditions, enabling aviation providers to carefully plan and track flights, optimize operations and reduce the impacts of disruptive events. With the addition of FlightAware’s data, including its private network of over 12,000 Automatic Dependent Surveillance – Broadcast (ADS-B) ground stations in over 160 countries, WSI Fusion customers will have access to enhanced flight following capabilities worldwide.

Each year, weather-related power outages cost the U.S. economy as much as $33 billion a year. Additionally, one severe weather event has the potential to impact the daily lives and routines of millions of people. As 2017 marks the fifth anniversary of Superstorm Sandy, The Weather Company, an IBM Business (NYSE: IBM) and Zpryme are releasing the results of a survey that found that U.S. utility companies still feel underprepared for weather-related outages and that their reactive approach to outage prediction leads to lost time and resources.

The best way I know to cook beans, and the one I always return to. A version of the much-loved Tuscan bean recipe - fagioli al fiasco. Traditionally, beans were baked overnight in a Chianti bottle placed near the embers of that night's fire. While not exactly authentic (no fire here), I do a riff on the general idea, using a low-temperature oven and enamel-lined pot.

Continue reading How to Cook Beans that are Tender, Creamy, and Nearly Perfect on 101 Cookbooks

IBM today announced a significant new release of its PowerAI deep learning software distribution on Power Systems that attacks the major challenges facing data scientists and developers by simplifying the development experience with tools and data preparation while also dramatically reducing the time required for AI system training from weeks to hours.

Sci-Tech Daresbury and IBM today announced the opening of a new building for the collaborative research facility at The Hartree Centre in Daresbury. The building, opened by the Duke of York, is the latest evolution of the long-running collaboration between Sci-Tech Daresbury and IBM.

IBM today announced that CipherHealth, a SaaS healthcare provider, has deployed IBM Power Systems™ infrastructure to run its technology platform that helps healthcare providers reduce re-admissions and improve the patient experience by providing effective patient engagement from pre-hospitalization through to post-discharge. The move to the new infrastructure has halved CipherHealth’s monthly infrastructure costs, and improved its data processing times by nearly 90 percent.