disease

Heat shock protein 60 in human diseases and disorders / Alexzander A. A. Asea, Punit Kaur, editors

Online Resource




disease

Heat shock protein 90 in human diseases and disorders Alexzander A.A. Asea, Punit Kaur, editors

Online Resource




disease

Models, Molecules and Mechanisms in Biogerontology: Physiological Abnormalities, Diseases and Interventions / Pramod C. Rath, editor

Online Resource




disease

How nutrition and diet can influence autoimmune diseases




disease

Low vitamin D levels in body linked to cancer, heart disease




disease

No celiac disease? You could still be gluten-sensitive




disease

Sugar addiction is key contributor to heart disease, cancer risk




disease

Healthy diet can delay and reverse autoimmune diseases




disease

Celiac disease, a common but elusive diagnosis




disease

Covid-19 hinterland digest: Rajasthan has 31 districts fighting disease

In less than a month, 20 districts reported new cases. Sri Ganganagar and Bondi are virus-free in Rajasthan




disease

I am healthy, not suffering from any disease: Amit Shah issues statement

"I am totally healthy and I am not suffering from any disease," he said in the statement in Hindi which was posted on his Twitter handle




disease

Applications of the microphysiology systems database for experimental ADME-Tox and disease models

Lab Chip, 2020, 20,1472-1492
DOI: 10.1039/C9LC01047E, Paper
Open Access
Mark Schurdak, Lawrence Vernetti, Luke Bergenthal, Quinn K. Wolter, Tong Ying Shun, Sandra Karcher, D. Lansing Taylor, Albert Gough
The Microphysiology Systems Database (MPS) is a critical tool for the design, management, analysis, and sharing of MPS study data.
The content of this RSS Feed (c) The Royal Society of Chemistry




disease

[ASAP] Fast Identification of Possible Drug Treatment of Coronavirus Disease-19 (COVID-19) through Computational Drug Repurposing Study

Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.0c00179




disease

Development of the cerebellum from molecular aspects to diseases / Hassan Marzban, editor

Online Resource




disease

The biopsychosocial model of health and disease: new philosophical and scientific developments / Derek Bolton, Grant Gillett

Online Resource




disease

Neuroglia in neurodegenerative diseases / Alexei Verkhratsky, Margaret S. Ho, Robert Zorec, Vladimir Parpura, editors

Online Resource




disease

Bihar govt denies outbreak of diseases

However, 900 cases of dengue have come to light in Bihar, of which 640 are in Patna alone




disease

Study finds method to diagnose Lyme disease within 15 minutes

Caused by Borrelia burgdorferi and transmitted by the bite of infected Ixodes ticks, Lyme disease if left untreated can cause serious neurologic, cardiac, and/or rheumatologic complications




disease

Antibody-based eye drop may treat dry eye disease: Study

Dry eye disease is caused by abnormalities in the tear fluid and results in dry areas over the cornea, the transparent outer layer of the eye, which can lead to disabling eye pain and sensitivity to light in severe cases




disease

80% of adolescents don't even spend an hour on physical activity, at risk of heart disease: WHO study

An alarming highlight in the study is the fact that India, along with Bangladesh and the United States (US), ranks the lowest in physical activity among boys.




disease

Bis(ethylmaltolato)oxidovanadium(IV) inhibited the pathogenesis of Alzheimer's disease in triple transgenic model mice

Metallomics, 2020, 12,474-490
DOI: 10.1039/C9MT00271E, Paper
Zhijun He, Shuangxue Han, Chong Wu, Lina Liu, Huazhang Zhu, Ang Liu, Qiying Lu, Jingqiang Huang, Xiubo Du, Nan Li, Qinguo Xie, Lu Wan, Jiazuan Ni, Lingling Chen, Xiaogai Yang, Qiong Liu
BEOV activates PPARγ to affect JAK2/STAT3/SOCS1 signaling and eventually prevents Aβ generation. Meanwhile, BEOV inactivates PTP1B to affect PI3K/Akt/GSK3β signaling and finally reduces tau hyperphosphorylation.
The content of this RSS Feed (c) The Royal Society of Chemistry




disease

Correction: Bis(ethylmaltolato)oxidovanadium(IV) inhibited the pathogenesis of Alzheimer's disease in triple transgenic model mice

Metallomics, 2020, 12,631-631
DOI: 10.1039/D0MT90008G, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Zhijun He, Shuangxue Han, Chong Wu, Lina Liu, Huazhang Zhu, Ang Liu, Qiying Lu, Jingqiang Huang, Xiubo Du, Nan Li, Qingguo Xie, Lu Wan, Jiazuan Ni, Lingling Chen, Xiaogai Yang, Qiong Liu
The content of this RSS Feed (c) The Royal Society of Chemistry




disease

Diphenyl Diselenide Protects Caenorhabditis elegans Model for Huntington's Disease by Activation of Antioxidant Pathway and Decrease in Protein Aggregation

Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00074D, Paper
Fabiane Bicca Obetine Baptista, Marina Lopes Machado, Aline da Silva Franzen, Larissa Marafiga Cordeiro, Tassia da Silveira, Leticia Arantes, Félix A. A. Soares
Huntington’s disease (HD) is an autosomal dominant, progressive neurodegenerative disease with a distinct phenotype. It occurs due to a mutation in huntingtin (or IT19) gene with abnormal CAG repeat, leading...
The content of this RSS Feed (c) The Royal Society of Chemistry




disease

A liver-targeting Cu(I) chelator relocates Cu in hepatocytes and promotes Cu excretion in a murine model of Wilson’s disease

Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00069H, Paper
Marie Monestier, AnaÏS M. Pujol, Aline Lamboux, Martine Cuillel, Isabelle Pignot-Paintrand, Doris Cassio, Peggy Charbonnier, Khémary Um, Amélie Harel, Sylvain BOHIC, Christelle GATEAU, Vincent Balter, Virginie Brun, Pascale Delangle, Elisabeth Mintz
Copper chelation is the most commonly used therapeutic strategy nowadays to treat Wilson’s disease, a genetic disorder primarily inducing a pathological accumulation of Cu in the liver. The mechanism of...
The content of this RSS Feed (c) The Royal Society of Chemistry




disease

The study of levels from redox-active elements in cerebrospinal fluid of amyotrophic lateral sclerosis patients carrying disease-related gene mutations shows potential copper dyshomeostasis

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00051E, Paper
Federica Violi, Nikolay Solovyev, Marco Vinceti, Jessica Mandrioli, Marianna Lucio, Bernhard Michalke
Gene-environment interaction is as a possible key factor in the development of ALS. The levels of redox species of Cu, Fe, and Mn were assessed in cerebrospinal fluid, showing a possible positive association between Cu and genetic ALS.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




disease

Evidence that levels of nine essential metals in post-mortem human-Alzheimer's-brain and ex vivo rat-brain tissues are unaffected by differences in post-mortem delay, age, disease staging, and brain bank location

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00048E, Paper
Melissa Scholefield, Stephanie J. Church, Jingshu Xu, Sarah Kassab, Natalie J. Gardiner, Federico Roncaroli, Nigel M. Hooper, Richard D. Unwin, Garth J. S. Cooper
Metal findings in human Alzheimer brains are consistent despite differences in sample post-mortem delay, age, Braak stage and biobank location.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




disease

How the measles virus disables immunity to other diseases and a news roundup

Michael Mina discusses how measles destroys immunity to other infectious diseases and why the measles vaccine has led to disproportionate reductions in childhood mortality since its introduction 50 years ago, and David Grimm discusses daily news stories. Hosted by Susanne Bard. [Img: UNICEF Ethiopia/Creative Commons License BY-NC-ND 2.0, via flickr]




disease

3-parent gene therapy for mitochondrial diseases and a news roundup

Kimberly Dunham-Snary discusses the long-term health considerations of gene therapy for mitochondrial diseases and David Grimm talks about the smell of death, Mercury crashing, and animal IQ. Hosted by Susanne Bard. [Image credit: Ben Gracewood CC BY-NC 2.0, via flickr]




disease

Podcast: Pollution hot spots in coastal waters, extreme bees, and diseased dinos

News stories on bees that live perilously close to the mouth of a volcano, diagnosing arthritis in dinosaur bones, and the evolution of the female orgasm, with David Grimm.  From the magazine Rivers deliver water to the ocean but water is also discharged along the coast in a much more diffuse way. This “submarine groundwater discharge” carries dissolved chemicals out to sea. But the underground nature of these outflows makes them difficult to quantify.  Audrey Sawyer talks with Sarah Crespi about the scale of this discharge and how it affects coastal waters surrounding the United States.  [Image: Hilary Erenler/Music: Jeffrey Cook]




disease

Podcast: An ethics conundrum from the Nazi era, baby dinosaur development, and a new test for mad cow disease

This week, we chat about how long dinosaur eggs take—or took—to hatch, a new survey that confirms the world’s hot spots for lightning, and replenishing endangered species with feral pets with Online News Editor Catherine Matacic. Plus, Science’s Alexa Billow talks to Megan Gannon about the dilemma presented by tissue samples collected during the Nazi era. And Sarah Crespi discusses a new test for mad cow disease with Kelly Servick.   Listen to previous podcasts.   [Image: NASA/flickr; Music: Jeffrey Cook]




disease

How the appendix could hold the keys to Parkinson’s disease, and materials scientists mimic nature

For a long time, Parkinson’s disease was thought to be merely a disorder of the nervous system. But in the past decade researchers have started to look elsewhere in the body for clues to this debilitating disease—particularly in the gut. Host Meagan Cantwell talks with Viviane Labrie of the Van Andel Institute in Grand Rapids, Michigan, about new research suggesting people without their appendixes have a reduced risk of Parkinson’s. Labrie also describes the possible mechanism behind this connection. And host Sarah Crespi talks with Peter Fratzl of the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany, about what materials scientists can learn from nature. The natural world might not produce innovations like carbon nanotubes, but evolution has forged innumerable materials from very limited resources—mostly sugars, proteins, and minerals. Fratzl discusses how plants make time-release seedpods that are triggered by nothing but fire and rain, the amazing suckerin protein that comprises squid teeth, and how cicadas make their transparent, self-cleaning wings from simple building blocks. Fratzl’s review is part of a special section in Science on composite materials. Read the whole package, including a review on using renewables like coconut fiber for building cars and incorporating carbon nanotubes and graphene into composites. This week’s episode was edited by Podigy. Download the transcript (PDF) Listen to previous podcasts. About the Science Podcast [Image: Roger Smith/Flickr; Music: Jeffrey Cook]




disease

Race and disease risk and Berlin’s singing nightingales

Noncancerous tumors of the uterus—also known as fibroids—are extremely common in women. One risk factor, according to the scientific literature, is “black race.” But such simplistic categories may actually obscure the real drivers of the disparities in outcomes for women with fibroids, according to this week’s guest. Host Meagan Cantwell speaks with Jada Benn Torres, an associate professor of anthropology at Vanderbilt University in Nashville, about how using interdisciplinary approaches— incorporating both genetic and cultural perspectives—can paint a more complete picture of how race shapes our understanding of diseases and how they are treated. In our monthly books segment, book review editor Valerie Thompson talks with David Rothenberg, author of the book Nightingales in Berlin: Searching for the Perfect Sound, about spending time with birds, whales, and neuroscientists trying to understand the aesthetics of human and animal music. This week’s episode was edited by Podigy. Download the transcript (PDF) Listen to previous podcasts. About the Science Podcast [Image: Carlos Delgado/Wikipedia; Matthias Ripp/Flickr; Music: Jeffrey Cook]




disease

An app for eye disease, and planting memories in songbirds

Host Sarah Crespi talks with undergraduate student Micheal Munson from Baylor University in Waco, Texas, about a smartphone app that scans photos in the phone’s library for eye disease in kids.  And Sarah talks with Todd Roberts of the University of Texas Southwestern Medical Center in Dallas, Texas, about incepting memories into zebra finches to study how they learn their songs. Using a technique called optogenetics—in which specific neurons can be controlled by pulses of light—the researchers introduced false song memories by turning on neurons in different patterns, with longer or shorter note durations than typical zebra finch songs. This week’s episode was edited by Podigy. Ads on this week’s show: MOVA Globes; KiwiCo.com Download a transcript (PDF) Listen to previous podcasts. About the Science Podcast  




disease

Researchers flouting clinical reporting rules, and linking gut microbes to heart disease and diabetes

Though a law requiring clinical trial results reporting has been on the books for decades, many researchers have been slow to comply. Now, 2 years after the law was sharpened with higher penalties for noncompliance, investigative correspondent Charles Piller took a look at the results. He talks with host Sarah Crespi about the investigation and a surprising lack of compliance and enforcement. Also this week, Sarah talks with Brett Finlay, a microbiologist at the University Of British Columbia, Vancouver, about an Insight in this week’s issue that aims to connect the dots between noncommunicable diseases like heart disease, diabetes, and cancer and the microbes that live in our guts. Could these diseases actually spread through our microbiomes? This week’s episode was edited by Podigy. Listen to previous podcasts. About the Science Podcast Download a transcript (PDF). [Image: stu_spivack/Flickr; Music: Jeffrey Cook]




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Why some diseases come and go with the seasons, and how to develop smarter, safer chemicals

On this week’s show, host Joel Goldberg gets an update on the coronavirus pandemic from Senior Correspondent Jon Cohen. In addition, Cohen gives a rundown of his latest feature, which highlights the relationship between diseases and changing seasons—and how this relationship relates to a potential coronavirus vaccine. Also this week, from a recording made at this year’s AAAS annual meeting in Seattle, host Meagan Cantwell speaks with Alexandra Maertens, director of the Green Toxicology initiative at Johns Hopkins University, Baltimore, about the importance of incorporating nonanimal testing methods to study the adverse effects of chemicals. This week’s episode was produced with help from Podigy. Download a transcript (PDF) Listen to previous podcasts. About the Science Podcast [Image: Let Ideas Compete/Flickr; Music: Jeffrey Cook] 




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How COVID-19 disease models shape shutdowns, and detecting emotions in mice

On this week’s show, Contributing Correspondent Kai Kupferschmidt talks with host Sarah Crespi about modeling coronavirus spread and the role of forecasts in national lockdowns and other pandemic policies. They also talk about the launch of a global trial of promising treatments. See all of our News coverage of the pandemic here. See all of our Research and Editorials here. Also this week, Nadine Gogolla, research group leader at the Max Planck Institute of Neurobiology, talks with Sarah about linking the facial expressions of mice to their emotional states using machine learning. This week’s episode was produced with help from Podigy. Listen to previous podcasts. About the Science Podcast Download a transcript (PDF)




disease

A deep learning approach to identify association of disease–gene using information of disease symptoms and protein sequences

Anal. Methods, 2020, 12,2016-2026
DOI: 10.1039/C9AY02333J, Paper
Xingyu Chen, Qixing Huang, Yang Wang, Jinlong Li, Haiyan Liu, Yun Xie, Zong Dai, Xiaoyong Zou, Zhanchao Li
Prediction of disease–gene association based on a deep convolutional neural network.
The content of this RSS Feed (c) The Royal Society of Chemistry




disease

[ASAP] Bifunctional Au@Pt/Au core@shell Nanoparticles As Novel Electrocatalytic Tags in Immunosensing: Application for Alzheimer’s Disease Biomarker Detection

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00760




disease

[ASAP] 27-Plex Tandem Mass Tag Mass Spectrometry for Profiling Brain Proteome in Alzheimer’s Disease

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00655




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Positive Findings from Year 2 of the Centers for Medicare & Medicaid Services’ Million Hearts® Cardiovascular Disease Risk Reduction Model

Mathematica has released positive evaluation findings from Year 2 of the Million Hearts® model, just in time for American Heart Month this February.




disease

Powdery mildew disease of crucifers: biology, ecology and disease management / Govin Singh Saharan, Naresh K. Mehta, Prabhu Dayal Meena

Online Resource




disease

The Stockholm paradigm: climate change and emerging disease / Daniel R. Brooks, Eric P. Hoberg, and Walter A. Boeger

Dewey Library - QH543.B76 2019




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Sustainable management of phytoplasma diseases in crops grown in the tropical belt: biology and detection / Chrystel Y. Olivier, Tim J. Dumonceaux, Edel Pérez-López, editors

Online Resource




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Forest pest and disease management in Latin America: modern perspectives in natural forests and exotic plantations / Sergio A. Estay, editor

Online Resource




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Ocean outbreak: confronting the rising tide of marine disease / Drew Harvell

Hayden Library - QH541.5.S3 H37 2019




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Biosecurity : the socio-politics of invasive species and infectious diseases / edited by Andrew Dobson, Kezia Barker and Sarah L. Taylor




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Disease that kills kids reaches Bengal



  • DO NOT USE West Bengal
  • India

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Predicting Pulmonary to Systemic Flow Ratio Using Chest Radiograph in Congenital Heart Disease

This study develops and validates a quantitative method to predict the pulmonary to systemic flow ratio in patients with congenital heart disease from chest radiographs using deep learning.




disease

Blood Pressure Patterns in Young Adulthood and Cardiovascular Disease and Mortality in Middle Age

This cohort study assesses whether long-term variability and rate of change of blood pressure from young adulthood to midlife are associated with cardiovascular disease and all-cause mortality by middle age.




disease

Opportunities & Challenges for Polygenic Risk Scores in Prognostication & Prevention of Cardiovascular Disease

Lowering low-density lipoprotein cholesterol (LDL-C) levels remains a mainstay of cardiovascular disease prevention, but gaps in treatment remain, even in persons with hypercholesterolemia and greatly elevated LDL-C levels. Although well-described gene variants in the apolipoprotein B (APOB), low-density lipoprotein receptor (LDLR), and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes explain small but important fractions of monogenic hypercholesterolemia, recent attention has turned to prognostication of cardiovascular disease using polygenic risk scores (PRS) that incorporate common genetic variants derived from large-scale genome-wide association studies of lipid subfractions. Earlier PRS considered only variants with genome-wide significance, and newer studies have focused on methods that better capture the variance conferred by millions of variants, suggesting an ability to identify risk equivalent to monogenic mutations. There remains a gap in evidence from prospective observational studies or treatment trials regarding the appropriate placement of PRS in risk assessment and lipid treatment decisions relative to information on rare monogenic gene variants, particularly in multiethnic populations.