ev Exploring 7β-amino-6-nitrocholestens as COVID-19 antivirals: in silico, synthesis, evaluation, and integration of artificial intelligence (AI) in drug design: assessing the cytotoxicity and antioxidant activity of 3β-acetoxynitrocholestane By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00257A, Research Article Shahabuddin, Uzma, Mohammad Azam, Mehtab Parveen, Nurul Huda Abd Kadir, Kim Min, Mahboob AlamIn light of the ongoing pandemic caused by SARS-CoV-2, effective and clinically translatable treatments are desperately needed for COVID-19 and its emerging variants.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Design, synthesis, and evaluation of benzhydrylpiperazine-based novel dual COX-2/5-LOX inhibitors with anti-inflammatory and anti-cancer activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00471J, Research ArticlePoorvi Saraf, Bhagwati Bhardwaj, Akash Verma, Mohammad Aquib Siddiqui, Himanshu Verma, Pradeep Kumar, Samridhi Srivastava, Sairam Krishnamurthy, Saripella Srikrishna, Sushant Kumar ShrivastavaScreening piperazine derivatives via ChEMBL database led to the design and synthesis of novel dual COX-2/5-LOX inhibitors with strong anti-inflammatory, analgesic, and anti-cancer activity.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Synthesis and biological evaluation of novel D-ring fused steroidal N(2)-substituted-1,2,3-triazoles By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00297K, Research ArticleBranislava Tenjović, Sofija Bekić, Andjelka Ćelić, Edward Petri, Julia Scholda, Florian Kopp, Marija Sakač, Andrea NikolićIn this study, a series of 13 new D-ring fused steroidal N(2)-substituted-1,2,3-triazoles were synthesized, characterized and evaluated for their biological activities.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Synthesis and evaluation of tetrahydropyrrolo[1,2-a]quinolin-1(2H)-ones as new tubulin polymerization inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00541D, Research ArticleMikhail N. Anisimov, Maksim A. Boichenko, Vitaly V. Shorokhov, Julia N. Borzunova, Marina Janibekova, Vadim V. Mustyatsa, Ilya A. Lifshits, Andrey Yu. Plodukhin, Ivan A. Andreev, Nina K. Ratmanova, Sergey S. Zhokhov, Elena A. Tarasenko, Daria A. Ipatova, Alexander R. Pisarev, Ivan A. Vorobjev, Igor V. Trushkov, Olga A. Ivanova, Nikita B. GudimchukNew 1,5-disubstituted pyrrolidin-2-ones 1, 2 and 5-aryl-3,3a,4,5-tetrahydropyrrolo[1,2-a]quinoline-1(2H)-ones 3 were explored as inhibitors of tubulin polymerization.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00594E, Research ArticleNagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza ElrayessOne benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Ligand-centred phenotype-driven development of potent kinase inhibitors against oesophageal cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00579A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Cecilia C. Ayala-Aguilera, Yang Ge, Álvaro Lorente-Macías, Benjamin N. Jones, Catherine Adam, Neil O. Carragher, Asier Unciti-BrocetaA ligand-centred strategy combined with phenotypic screening was used to develop novel antiproliferative inhibitors against oesophageal cancer and identified a lead compound that induces potent anticancer activity and inhibits Aurora kinase A.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Design, synthesis, and biological evaluation of pyrazole–ciprofloxacin hybrids as antibacterial and antibiofilm agents against Staphylococcus aureus By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00623B, Research ArticleOjaswitha Ommi, Priyanka Sudhir Dhopat, Shashikanta Sau, Madhu Rekha Estharla, Srinivas Nanduri, Nitin Pal Kalia, Venkata Madhavi YaddanapudiA series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, aiming to combat antibiotic resistance.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Novel quinoxaline-derived derivatives: design, synthesis, bioactive evaluation, SARs and preliminary antibacterial mechanism By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00670D, Research ArticleYuting Liu, Pengju Yang, Yunyun Zhou, Zhiwen ZhouIn the current study, we have designed and prepared a series of quinoxaline-based compounds, which were derived from o-phenylenediamine. Among which, compounds 5m-p displayed good to moderate antibacterial activity with...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00626G, Research ArticleAleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan VeerappanLipidation modulates the Gram-selective antibacterial activity of QPyNATh.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Synthesis, in silico and bio-evaluation studies of new isothiocyanate derivatives with respect to COX inhibition and H2S release profiles By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00495G, Research ArticleYakup Berkay Yilmaz, Tuğba Güngör, Serhat Dönmez, Hazal Nazlıcan Atalay, Pınar Siyah, Serdar Durdağı, Mehmet Ay, Tugba Boyunegmez TumerNew isothiocyanate derivatives (I1–3 and I1a–e) were synthesized and screened for their anti-inflammatory activities and H2S-releasing capacities. Compounds I1 and I1c demonstrated the most potent and selective COX-2 inhibition.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Generation and capture of naphthoquinonynes: a new frontier in the development of trypanocidal quinones via aryne chemistry By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00558A, Research ArticleLaura P. R. Figueroa, Renato L. de Carvalho, Renata G. Almeida, Esther R. S. Paz, Emilay B. T. Diogo, Maria H. Araujo, Warley S. Borges, Victor F. S. Ramos, Rubem F. S. Menna-Barreto, James M. Wood, John F. Bower, Eufrânio N. da Silva JúniorThis article presents A-ring functionalized quinones via a modern and efficient new strategy involving the generation and capture of benzyne quinones and their evaluation against Trypanosoma cruzi.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Technical, preclinical, and clinical developments of Fc-glycan-specific antibody–drug conjugates By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00637B, Review Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Qiang Yang, Yunpeng LiuFc-glycan-specific ADC is a significant advance in site-specific ADCs for cancer therapy. Notably, JSKN003 and IBI343 have demonstrated promising results in phase 1 clinical trials and are advancing into phase 3 studies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev A practical guide for the assay-dependent characterisation of irreversible inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00707G, Review ArticleLavleen K. Mader, Jessica E. Borean, Jeffrey W. KeillorKinetic evaluations for assay dependent characterization of irreversible inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Synthesis and antifungal evaluation of new azole derivatives containing 1,2,3-triazole By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00724G, Research ArticleZhengxiao Huang, Hongjie Chen, Xiao Zhang, Ruirui Wang, Chunyan Hu, Zewei MaoA series of novel azole derivatives containing 1,2,3-triazole have been synthesized with good antifungal effects on sensitive and drug-resistant C. albicans.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Water level in Mettur Dam stands at 107.04 feet By www.thehindu.com Published On :: Tue, 05 Nov 2024 16:35:38 +0530 Full Article Tiruchirapalli
ev Heavy weed growth at Kasi Viswanathar Temple tank prevents replenishing of underground water table, say Tiruchi residents By www.thehindu.com Published On :: Tue, 05 Nov 2024 21:04:51 +0530 Full Article Tiruchirapalli
ev Water level in Mettur dam stands at 106.89 feet By www.thehindu.com Published On :: Wed, 06 Nov 2024 18:06:24 +0530 Full Article Tiruchirapalli
ev Ensure time-bound implementation of development schemes, says Thirumavalavan By www.thehindu.com Published On :: Wed, 06 Nov 2024 18:29:00 +0530 Full Article Tiruchirapalli
ev Pumping stations to be set up in eight low-lying areas in Tiruchi to prevent inundation By www.thehindu.com Published On :: Wed, 06 Nov 2024 19:30:58 +0530 Full Article Tiruchirapalli
ev Udhayanidhi lays foundation stone for infrastructure development projects in Thanjavur district By www.thehindu.com Published On :: Thu, 07 Nov 2024 18:48:04 +0530 Buildings at the Government Arts and Science College, Thirukkattupalli, construction of compound wall and an indoor stadium at the Government Rajah Serfoji College, Thanjavur, are among the projects Full Article Tiruchirapalli
ev High-level committee formed to facilitate clearances for companies that signed MoU, says Minister By www.thehindu.com Published On :: Fri, 08 Nov 2024 18:56:40 +0530 Constant monitoring was being done now from the time of signing of MoUs to providing employment in new industrial units, says Industries Minister T.R.B. Rajaa Full Article Tiruchirapalli
ev Water level in Mettur Dam stands at 106.58 feet By www.thehindu.com Published On :: Sat, 09 Nov 2024 18:10:37 +0530 Full Article Tiruchirapalli
ev 543: Zach Leatherman on Eleventy, Mastodon, Twitter, and is-land By shoptalkshow.com Published On :: Tue, 29 Nov 2022 16:30:32 +0000 Zach Leatherman talks with us about what's new with Eleventy, setting up on Mastodon, what's happened with Twitter, and is-land. Full Article All Episodes eleventy mastodon Twitter Web Components
ev 565: The Hurdy-Gurdy, OKLCH, Edge Dev Tools, and Ad Blocking By shoptalkshow.com Published On :: Mon, 15 May 2023 08:20:15 +0000 Dave doesn't hate the hurdy-gurdy, but it's creation is an interesting parallel to software development. OKLCH follow up, @media, Edge drops new dev tools, CSS and Astro theming, JavaScript devs discover PHP, how many people block ads, and accessibility and grids. Full Article All Episodes Accessibility edge oklch
ev 567: Full Stack Dev, Load Bearing Developer, and Being Zod Curious By shoptalkshow.com Published On :: Mon, 29 May 2023 09:00:16 +0000 What do you do if your computer dies? Chris applies to work at Luro, Dave applies at CodePen, Dave's Zod curious, TypeScript, sorting out a 10MB blog post, and how much do you miss jQuery? Full Article All Episodes full stack Jquery Zod
ev 572: Text Sqwunch Property, Figma Developer Mode, Stripe Elements By shoptalkshow.com Published On :: Mon, 03 Jul 2023 08:24:15 +0000 Show DescriptionDave reports back from the Figma Conference, how to build a better developer to designer bridge, do clients really want to update their website, using Stripe in 2023, permissions and sharing, and are you feeling overwhelmed by CSS in 2023? Listen on Website →Links Config 2023 | Figma’s Annual Conference Figma Visual Studio Code […] Full Article All Episodes CSS figma stripe
ev 575: CSS Errors, Proxy and Reverse Proxy, and What’s The Edge? By shoptalkshow.com Published On :: Mon, 24 Jul 2023 09:00:16 +0000 Bluesky adds first class support for urls as a username, text-wrap pretty update, sqwunching text update, should CSS spit out errors, anchor functionality, what does the edge mean, eSports and bowling, how to test websites on slower CPUs, and what does proxy or reverse proxy mean? Full Article All Episodes edge proxy text-wrap
ev 581: DevRel, Musical Mics, Social Sharing, and 100 Years of WordPress By shoptalkshow.com Published On :: Mon, 04 Sep 2023 08:25:38 +0000 Dave calls a quick Luro branding meeting, some thoughts on DevRel, Chris tries to figure out musical instrument mics, follow up on WordPress from a previous episode, Chris' journey through the social graph options, 100 year hosting with WordPress, and the introduction of a new segment: Happy Project Share Time. Full Article All Episodes guitar happy project share time Luro social graph Wordpress
ev 608: Can WordPress Kill Your Resume, Fav Parts of Web Dev, Exploring HTMX, and more! By shoptalkshow.com Published On :: Mon, 25 Mar 2024 07:55:38 +0000 We're opening up the ShopTalk mailbag and answering your questions, including does WordPress on your resume kill your job chances, what are our fav and least fav parts of web dev, our thoughts on HTMX, and what is it like to use pnpm instead of npm. Full Article All Episodes HTMX npm pnpm Wordpress
ev 614: CSS Grid Level 3 aka Masonry with Adam Argyle By shoptalkshow.com Published On :: Mon, 06 May 2024 08:00:02 +0000 Adam Argyle stops by to chat about the conversation that's happening around CSS Grid / Masonry. What do we want? What might Apple's response to Google be? And nitpicking the spec just for fun. Full Article All Episodes CSS css grid masonry
ev 627: Getting Comfortable with the Struggle and Vibe Driven Development By shoptalkshow.com Published On :: Mon, 05 Aug 2024 08:52:17 +0000 Chris brings some blog posts to talk about including being comfortable with the struggle of developer life, Cloudflare Workers + monorepos, vibe driven development, and questions about database migrations, and whether we think AI free blogs are going to be a rarity in the future? Full Article All Episodes cloudflare workers database struggle
ev 632: Adam Coster on Game Development and Crashlands 2 By shoptalkshow.com Published On :: Mon, 09 Sep 2024 08:00:41 +0000 Adam Coster talks with us about working with his family in game development, how they get started making games, what all is involved with publishing games, deciding to go Steam and Netflix only for Crashlands 2, how web tech is involved in game development, and the fun of testing and doing Q&A for games. Full Article All Episodes Apple Arcade Development netflix Publishing steam video games
ev 634: Fabian Kägy on WordPress, Blocks, and Enterprise Dev By shoptalkshow.com Published On :: Mon, 23 Sep 2024 08:36:23 +0000 Fabian Kägy helps us understand the modern WordPress development process, Gutenberg vs Block editor vs full site editing, building with blocks or pages, what's coming in the Twenty Twenty-Five Theme, and whether the theme authoring process has been made too difficult in 2024? Full Article All Episodes Block Gutenberg Themes Wordpress
ev How ‘priority sector’ status can rev up Jan Dhan banking By www.thehindubusinessline.com Published On :: Sun, 29 Sep 2024 21:31:00 +0530 How regulation can nudge private banks to promote financial inclusion Full Article Current Account
ev Flat organisation believers: Can you imagine a world without managers? By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:24:36 +0530 What does a manager do that we keep hiring new ones or keep promoting more of them? Which managerial layer is the most important? Full Article Corporate File
ev How Ratan Tata pushed for evidence-led ayurveda By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 20:38:00 +0530 Ratan Tata sought to promote research that could validate ayurveda through contemporary science Full Article Pulse
ev Bengaluru startup develops new tech for battery recycling, begins production By www.thehindubusinessline.com Published On :: Sun, 27 Oct 2024 18:13:56 +0530 Li-ion battery recycler Metastable Materials launches commercial ops Full Article Clean Tech
ev Planned meals, personal trainer, and a tea for every reason By www.thehindubusinessline.com Published On :: Sun, 03 Nov 2024 19:20:49 +0530 Personal fitness diary Full Article Pulse
ev Nvidia: The lynchpin of the AI revolution By www.thehindubusinessline.com Published On :: Sat, 09 Nov 2024 18:18:47 +0530 The meteoric rise of the Santa Clara-headquartered chipmaker is powered by bold innovation Full Article Corporate File
ev Several Delhi govt. schemes to tackle toxic air yet to take off By www.thehindu.com Published On :: Tue, 05 Nov 2024 03:07:30 +0530 AAP govt. yet to implement at least 5 programmes it announced over the past two years to curb air pollution; these include using drones to map bad air sources and making PUC mandatory to buy fuel; our plans have been stopped by Centre: AAP Full Article Delhi
ev Delhi enveloped in toxic haze, AQI in severe zone in some areas By www.thehindu.com Published On :: Tue, 05 Nov 2024 10:58:46 +0530 Data from the CPCB's Sameer app, which provides hourly AQI updates, showed that out of the 38 monitoring stations, 13 were in the severe category with readings above 400 Full Article Delhi
ev Chhath Puja: Devotees take dip in Yamuna even as toxic foam floats over river By www.thehindu.com Published On :: Wed, 06 Nov 2024 00:35:50 +0530 Full Article Delhi
ev Devotees throng Delhi ghats, mark Chhath Puja festivity with prayers, songs, selfies By www.thehindu.com Published On :: Fri, 08 Nov 2024 01:05:44 +0530 Lakhs of devotees offer ‘Sandhya Arghya’ to the setting sun on the third day of the four-day festival; political leaders make a beeline for ghats with an eye on Purvanchali voters ahead of Assembly poll Full Article Delhi
ev Never asked people to pick up weapons: Tahir Hussain to court By www.thehindu.com Published On :: Sat, 09 Nov 2024 00:43:34 +0530 Full Article Delhi
ev Delhi’s air quality ‘very poor’ to ‘severe’ on November 11 By www.thehindu.com Published On :: Mon, 11 Nov 2024 10:34:47 +0530 Delhi’s air quality persists in the ‘very poor’ category more than a week post-Deepavali Full Article Delhi
ev Economic reforms’ eventful journey By www.thehindubusinessline.com Published On :: Sun, 21 Feb 2021 21:18:47 +0530 Bimal Jalan gives a bird’s eye view of how the Indian economy and polity evolved since 1991 Full Article Books
ev The economics of everyday life By www.thehindubusinessline.com Published On :: Sun, 28 Mar 2021 21:03:31 +0530 An economics book shorn of jargon, equations and graphs Full Article Books
ev The inevitability of uncertainty By www.thehindubusinessline.com Published On :: Sun, 16 May 2021 20:07:22 +0530 The book tells us quite convincingly that the future is unknown. But it does not offer an alternative Full Article Books
ev Leveraging cognitive branding By www.thehindubusinessline.com Published On :: Sun, 01 Aug 2021 20:31:49 +0530 The author has delved deep into behavioural economics to apply it to branding problems Full Article Books
ev Book Review: Demystifying Leadership: Unveiling the Mahabharata Code by Asha Kaul and Vishal Gupta By www.thehindubusinessline.com Published On :: Wed, 02 Feb 2022 17:42:46 +0530 The Mahabharata shows that leaders need to navigate moral codes that are as complex, varied, and subtle as the situations in which they find themselves Full Article Book Reviews