ev Shatianyu (Citrus grandis L. Osbeck) whole fruit alleviated loperamide-induced constipation via enhancing gut microbiota-mediated intestinal serotonin secretion and mucosal barrier homeostasis By pubs.rsc.org Published On :: Food Funct., 2024, 15,10614-10627DOI: 10.1039/D4FO02765E, PaperMei Deng, Jiamin Ye, Ruifen Zhang, Shuai Zhang, Lihong Dong, Dongxiao Su, Mingwei Zhang, Fei HuangThe effects of Citrus grandis Shatianyu whole fruit powder enriched in flavonoids and dietary fiber on loperamide-induced constipation after a 4-week administration in the diet, together with possible microbiota-mediated mechanisms were explored.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Multi-omics analysis reveals that agaro-oligosaccharides with different degrees of polymerization alleviate colitis in mice by regulating intestinal flora and arginine synthesis By pubs.rsc.org Published On :: Food Funct., 2024, 15,10628-10643DOI: 10.1039/D4FO03650F, PaperLong Yuan, Chunhui Liu, Bolun Li, Sai Wang, Jianan Sun, Xiangzhao MaoInflammatory bowel disease (IBD) is a common chronic disease with a complex etiology, characterized by body weight loss, intestinal barrier damage, and an imbalance of intestinal flora, posing a significant threat to people's health.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Impact of complementary feeding on infant gut microbiome, metabolites and early development By pubs.rsc.org Published On :: Food Funct., 2024, 15,10663-10678DOI: 10.1039/D4FO03948C, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yudong Shi, Ran Yin, Jinzhu Pang, Yun Chen, Zhouyong Li, Shengpeng Su, Yongping WenIntroducing complementary foods is critical for promoting infant health and development.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Novel selenium-enriched Pichia kudriavzevii as a dietary supplement to alleviate dextran sulfate sodium-induced colitis in mice by modulating the gut microbiota and host metabolism By pubs.rsc.org Published On :: Food Funct., 2024, 15,10698-10716DOI: 10.1039/D4FO02598A, PaperHuijuan Wang, Yue Chen, Zhouli Wang, Yahong Yuan, Tianli YueInflammatory bowel disease (IBD) poses persistent challenges due to its chronic and recurrent nature, exacerbated by the unsatisfactory outcomes of the traditional treatment approaches.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Lacticaseibacillus paracasei 207-27 alters the microbiota–gut–brain axis to improve wearable device-measured sleep duration in healthy adults: a randomized, double-blind, placebo-controlled trial By pubs.rsc.org Published On :: Food Funct., 2024, 15,10732-10745DOI: 10.1039/D4FO01684J, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jinxing Li, Jincheng Zhao, Xiaolei Ze, Liang Li, Yapeng Li, Zhimo Zhou, Simou Wu, Wen Jia, Meixun Liu, Yun Li, Xi Shen, Fang He, Ruyue ChengProbiotics have been reported to exert beneficial effects on sleep through the gut–brain axis.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Integrated transcriptomics and untargeted metabolomics reveal bone development and metabolism of newly weaned mice in response to dietary calcium and boron levels By pubs.rsc.org Published On :: Food Funct., 2024, 15,10853-10869DOI: 10.1039/D4FO03657C, PaperShuo Li, Xuehai Cao, Tiande Zou, Zirui Wang, Xingping Chen, Jun Chen, Jinming YouBoron supplementation in diets with varying calcium levels modulates bone development and bone parameters in mice by regulating calcium signaling, lipid metabolism, and neural signaling and inflammatory signaling.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Dietary supplementation with novel selenium-enriched Pichia kudriavzevii regulates gut microbiota and host metabolism in mice By pubs.rsc.org Published On :: Food Funct., 2024, 15,10896-10912DOI: 10.1039/D4FO03633F, PaperHuijuan Wang, Dan Shi, Yue Chen, Zhouli Wang, Yahong Yuan, Tianli YueInsufficient selenium intake can lead to serious health problems.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Gastroprotective effects of Pediococcus acidilactici GKA4 and Lactobacillus brevis GKL93 against ethanol-induced gastric ulcers via regulation of the immune response and gut microbiota in mice By pubs.rsc.org Published On :: Food Funct., 2024, Advance ArticleDOI: 10.1039/D4FO04106B, PaperYun-En Huang, Sheng-Yi Chen, Tsung-Ju Li, You-Shan Tsai, Chin-Chu Chen, Gow-Chin YenPediococcus acidilactici GKA4 and Lactobacillus brevis GKL93 exert gastroprotective effects against ethanol-induced gastric ulcers through multiple mechanisms.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Interaction of oat bran and exercise training improved exercise adaptability via alleviating oxidative stress and promoting energy homeostasis By pubs.rsc.org Published On :: Food Funct., 2024, Advance ArticleDOI: 10.1039/D4FO03374D, PaperRui Dong, Hamad Rafique, Qianwen Niu, Xin Zeng, Maria Cristina Messia, Li Yuan, Lin Shi, Liang Zou, Lu Li, Xinzhong HuInteraction of oat bran (OB) diet and moderate intensity exercise training (MlET) reinforced the positive effect on skeletal muscle function.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Review on mechanisms of hypoglycemic effects of compounds from highland barley and potential applications By pubs.rsc.org Published On :: Food Funct., 2024, Advance ArticleDOI: 10.1039/D4FO00940A, Review ArticleYanan Liu, Yuanqiang Jia, Yingying Wu, Huijuan Zhang, Feiyue Ren, Sumei ZhouThe value and mechanism of highland barley in the prevention of diabetes and its application in food products.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Brassica rapa L. crude polysaccharide meditated synbiotic fermented whey beverage ameliorates hypobaric and hypoxia induced intestinal damage By pubs.rsc.org Published On :: Food Funct., 2024, Accepted ManuscriptDOI: 10.1039/D4FO04667F, PaperYuanlin Niu, Tingting Zhao, Zhenjiang Liu, Diantong Li, Dongxu Wen, Bin Li, Xiaodan HuangHypobaric hypoxia causes oxidative stress and inflammatory responses and disrupts the gut microbiome and metabolome. In this study, we developed a synbiotic fermented whey beverage, combining kefir and Brassica rapa...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Bioactive compounds regulate appetite through the melanocortin system: a review By pubs.rsc.org Published On :: Food Funct., 2024, Advance ArticleDOI: 10.1039/D4FO04024D, Review ArticleYujia Niu, Wancong Yu, Xiaohong Kou, Shuqi Wu, Mengyi Liu, Chenlong Chen, Jiaxin Ji, Ying Shao, Zhaohui XueThe melanocortin system is regulated by long-term and short-term regulatory hormones and nutrients. Bioactive compounds influence appetite through multiple pathways: central nervous system, peripheral hormones, and intestinal microbiota.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev A probiotic multi-strain mixture combined with hydroxyectoine improves intestinal barrier function by alleviating inflammation in lipopolysaccharide stimulated differentiated Caco-2 cells By pubs.rsc.org Published On :: Food Funct., 2024, Advance ArticleDOI: 10.1039/D4FO03130J, PaperAzza Dabous, Antonietta Stellavato, Donatella Cimini, Valentina Vassallo, Maria D'Agostino, Chiara SchiraldiFreeze-dried formula containing three probiotic strains and hydroxyectoine reduces LPS-induced inflammation in Caco-2 cells, assessed via RT-PCR, western blot, ELISA, and immunofluorescence for tight junction integrity.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Selenium-mediated alleviation of skeletal muscle atrophy through enterotype modulation in mice By pubs.rsc.org Published On :: Food Funct., 2024, Advance ArticleDOI: 10.1039/D4FO03889D, PaperYixin Cheng, Xiaofan Liu, Yingao Hao, Shixu Wang, FangFang Wu, Lingzhuo Zhao, Du Peng, Du Yawen, Sun Sheng, Li Jianguo, Guangxu RenSelenium element improves dexamethasone-induced skeletal muscle atrophy by affecting enterotype.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Lactobacillus plantarum 69-2 combined with α-lactalbumin hydrolysate alleviates DSS-induced ulcerative colitis through the TLR4/NF-κB inflammatory pathway and the gut microbiota in mice By pubs.rsc.org Published On :: Food Funct., 2024, 15,10987-11004DOI: 10.1039/D4FO02975E, PaperYue Ma, Chuanbing Hu, Jing Zhang, Cong Xu, Lizhi Ma, Yunhe Chang, Muhammad Altaf Hussain, Jiage Ma, Juncai Hou, Zhanmei JiangUlcerative colitis (UC), an inflammatory bowel disease, seriously affects people's quality of life.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Lacticaseibacillus plantarum postbiotics prepared by the combined technique of pasteurization and ultrasound: effective measures to alleviate obesity based on the SCFAs-GPR41/GPR43 signaling pathway By pubs.rsc.org Published On :: Food Funct., 2024, 15,11005-11019DOI: 10.1039/D4FO03591G, PaperChao Miao, Linge Wang, Huabing Wang, Yu Shen, Chaoxin Man, Wei Zhang, Yu Zhang, Qianyu Zhao, Yujun JiangPostbiotics prepared by ultrasound and pasteurization are used for the alleviation of obesity.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Dietary supplementation of pterostilbene, a major component in small berries, prevents alcohol-induced liver injury associated with lipid accumulation and inflammation By pubs.rsc.org Published On :: Food Funct., 2024, 15,11206-11219DOI: 10.1039/D4FO03898C, PaperJia-Yi Dou, Sai-Hu Liu, Jia Guo, Chen-Yu Wang, Xu Dai, Li-Hua Lian, Zhen-Yu Cui, Ji-Xing Nan, Yan-Ling WuPterostilbene (PTE), a natural stilbene found in small berries, exhibits multiple pharmacological activities, particularly antioxidant and anti-inflammatory activities.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Regulation of redox enzymes by nutraceuticals: a review of the roles of antioxidant polyphenols and peptides By pubs.rsc.org Published On :: Food Funct., 2024, 15,10956-10980DOI: 10.1039/D4FO03549F, Review ArticleJoy I. Obeme-Nmom, Raliat O. Abioye, Samanta S. Reyes Flores, Chibuike C. UdenigweSeveral nutraceutical compounds, such as polyphenols and peptides, modulate the enzymatic antioxidant defence system, providing an avenue for the development of multifunctional functional foods.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Allergenicity evaluation of an extensively hydrolyzed infant formula based on cow milk protein By pubs.rsc.org Published On :: Food Funct., 2024, 15,11036-11046DOI: 10.1039/D4FO03582H, PaperHongbo Li, Lin Yang, Jiayi Li, Quan Gao, Tiantian Liu, Yang Zou, Xiaohong Chen, Hongjuan Li, Jinghua YuWe developed an extensively hydrolyzed infant formula (EHF) with a protein composition similar to breast milk (whey protein-to-casein ratio of 6 : 4) and evaluated its sensitization in vitro and in vivo.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Effects of vegetarian diets on blood lipids, blood glucose, and blood pressure: a systematic review and meta-analysis By pubs.rsc.org Published On :: Food Funct., 2024, Advance ArticleDOI: 10.1039/D4FO03449J, Review ArticleXin Xia, Jinkai Zhang, Xinfang Wang, Ke Xiong, Zhaobao Pan, Jinyu WangOur systematic review and meta-analyses showed that vegetarian diets significantly reduced blood lipids and blood glucose and had null effects on blood pressure.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Development of Pickering water-in-oil emulsions using a dual stabilization of candelilla wax and acylated EGCG derivatives to enhance the survival of probiotics (Lactobacillus plantarum) powder By pubs.rsc.org Published On :: Food Funct., 2024, 15,11141-11157DOI: 10.1039/D4FO01342E, PaperZhaojuan Shi, Jun Wu, Xingting Wang, Tongqiao Nie, Qingmei Zeng, Chuanxun Yuan, Risheng JinCandelilla wax reinforced the stability of Pickering W/O emulsions with a three-dimensional crystal network. The oil phase volume fraction of the emulsions showed dramatic differences in protecting probiotic viability from environmental stresses.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Alleviating effect of whey protein supplementation on oxidative stress in hypothyroidism By pubs.rsc.org Published On :: Food Funct., 2024, 15,11158-11168DOI: 10.1039/D4FO03186E, PaperAnn Liya Sajan, Jenat Pazheparambil Jerom, Bhagyasree Rajasekharan Nair, Devanandana Dileep Kumar Sajitha, Reshma Soman, Ajmal Jalal, Raveendran Harikumaran NairSupplementation with whey protein is effective for treating hypothyroidism-associated oxidative stress by enhancing the antioxidant system, reducing lipid peroxidation and maintaining cellular ionic balance.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Mechanistic insights into EGCG's preventive effects on obesity-induced precocious puberty through multi-omics analyses By pubs.rsc.org Published On :: Food Funct., 2024, 15,11169-11185DOI: 10.1039/D4FO03844D, PaperQiuyun Gu, Qiujv Du, Lina Xia, Xiaoting Lu, Xiaoqing Wan, Ying Shao, Jieyi He, Peiying WuEpigallocatechin gallate (EGCG) has demonstrated potential effects on obesity-induced precocious puberty, but the underlying mechanisms remain unclear.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Functional yogurt: a comprehensive review of its nutritional composition and health benefits By pubs.rsc.org Published On :: Food Funct., 2024, 15,10927-10955DOI: 10.1039/D4FO03671A, Review ArticleSangkaran Pannerchelvan, Leonardo Rios-Solis, Helmi Wasoh, Mohamad Zulfazli Mohd Sobri, Fadzlie Wong Faizal Wong, Mohd Shamzi Mohamed, Rosfarizan Mohamad, Murni HalimFunctional yogurt contains a variety of nutritional components that offer numerous health benefits, with limitations that can potentially be overcome.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Association between olive oil consumption and all-cause, cardiovascular and cancer mortality in adult subjects: a systematic review and meta-analysis By pubs.rsc.org Published On :: Food Funct., 2024, Advance ArticleDOI: 10.1039/D4FO04161E, PaperAndrea del Saz-Lara, Alicia Saz-Lara, Iván Cavero-Redondo, Carlos Pascual-Morena, Carmen Mazarío-Gárgoles, Francesco Visioli, María-Carmen López de las Hazas, Alberto DávalosFourteen studies were systematically reviewed and seven were included in the meta-analysis. Consumption of OO is associated with a reduction of cardiovascular mortality (16%), all-cause mortality (15%) and cancer mortality (11%) in adult population.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Lacticaseibacillus paracasei JM053 alleviates osteoporosis in rats by increasing the content of soy isoflavone aglycones in fermented soymilk By pubs.rsc.org Published On :: Food Funct., 2024, Accepted ManuscriptDOI: 10.1039/D4FO04381B, PaperYaping Zheng, Shasha Cheng, Hongxuan Li, Yilin Sun, Ling Guo, Chaoxin Man, Yu Zhang, Wei Zhang, Yujun JiangLacticaseibacillus paracasei JM053 has a high ability to convert soy isoflavones and can be used as a fermentation strain to ferment soymilk, thereby increasing the content of free aglycones in...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Correction: Using integrated transcriptomics and metabolomics to explore the effects of infant formula on the growth and development of small intestinal organoids By pubs.rsc.org Published On :: Food Funct., 2024, Advance ArticleDOI: 10.1039/D4FO90094D, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xianli Wang, Yuxin Jing, Chengdong Zheng, Chenxuan Huang, Haiyang Yao, Zimo Guo, Yilun Wu, Zening Wang, Zhengyang Wu, Ruihong Ge, Wei Cheng, Yuanyuan Yan, Shilong Jiang, Jianguo Sun, Jingquan Li, Qinggang Xie, Xiaoguang Li, Hui WangTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ev Editorial. German Chancellor’s visit can boost multi-level engagement By www.thehindubusinessline.com Published On :: Wed, 30 Oct 2024 21:24:35 +0530 Germany’s overtures to India are significant on various counts — geo-politics, technology sharing, immigration and trade talks Full Article Editorial
ev Tepid FDI flows call for a policy review By www.thehindubusinessline.com Published On :: Sun, 03 Nov 2024 21:07:50 +0530 The government must look beyond rules and procedures and rationalise taxation, particularly in sectors like electronics Full Article Opinion
ev Trump’s message on immigration prevails By www.thehindubusinessline.com Published On :: Wed, 06 Nov 2024 20:33:23 +0530 Despite the crude and vicious rhetoric, Trump’s agenda on economics and migration resonated with voters Full Article Opinion
ev India on road to achieving 500 GW of RE By www.thehindubusinessline.com Published On :: Sun, 10 Nov 2024 20:33:44 +0530 Renewable energy is a sector where there is strong alignment and co-operation between the Centre and the States. Public sector units and the private sector must now deliver Full Article Opinion
ev Sam Bahadur Review By www.rediff.com Published On :: Fri, 01 Dec 2023 09:34:02 +0530 Sam Bahadur is a mechanical summary of his life, ticking off one chapter after another without bothering to pause or ponder over their significance and influences, observes Sukanya Verma. Full Article
ev Dhootha Review By www.rediff.com Published On :: Fri, 01 Dec 2023 10:11:51 +0530 At the end of eight episodes, the climax is bound to leave you with questions but it would be fair to say that the two-episode backstory and the characters seemed far more interesting than the six-episode drama and tension that led to it, observes Divya Nair. Full Article
ev Animal Review By www.rediff.com Published On :: Fri, 01 Dec 2023 12:56:28 +0530 Animal's violence isn't for the fainted-hearted unless you have an appetite for Korean style mayhem, like Sukanya Verma. Full Article
ev The Archies Review By www.rediff.com Published On :: Thu, 07 Dec 2023 13:31:43 +0530 The Archies is an evergreen thought passed on from generation to generation. But Sukanya Verma wishes it had some of the comic's tee-hee humour and hyuk hyuk too. Full Article
ev Kadak Singh Review By www.rediff.com Published On :: Fri, 08 Dec 2023 12:08:50 +0530 ITo steer clear of sanctimonious newspaper stories all your life, and then be saddled with movies like Kadak Singh -- now there's a rotten bit of luck worth moaning about, sighs Sreehari Nair. Full Article
ev Chamak Review By www.rediff.com Published On :: Fri, 08 Dec 2023 12:48:13 +0530 It's not uncommon for performers to become bigger than the stories they are placed in and Sreehari Nair would happily pay to watch Isha Talwar and Paramvir Singh Cheema riffing on love, bad life choices, psychology, rhythm, and oven-baked Kulchas in Chamak. Full Article
ev Joram Review By www.rediff.com Published On :: Fri, 08 Dec 2023 12:49:05 +0530 When an actor has worked for as long as Manoj Bajpayee, one tends to lose their sense of originality under the sheen of stardom. But the actor's versatility sparkles in his willingness to start on a fresh note every single time, applauds Sukanya Verma. Full Article
ev Mast Mein Rehne Ka Review By www.rediff.com Published On :: Fri, 08 Dec 2023 14:19:42 +0530 Mast Mein Rehne Ka is a thoroughly human film, which makes you laugh as hard as it will make you feel for the characters, notes Mayur Sanap. Full Article
ev First Act Review By www.rediff.com Published On :: Fri, 15 Dec 2023 11:44:13 +0530 The lives of the kids Deepa Bhatia portrays in the series are bleak, with small periods of sunshine when they get picked for an ad or serial, punctuating the longer periods of struggle, observes Deepa Gahlot. Full Article
ev The Crown Review: Appropriate Finale By www.rediff.com Published On :: Tue, 19 Dec 2023 13:40:16 +0530 After the debacle of the first episodes of Season 6, the latter half give an even-handed treatment to intriguing not-so-well-known events of Queen Elizabeth II's reign, observes Vaihayasi Pande Daniel. Full Article
ev Dunki Review By www.rediff.com Published On :: Thu, 21 Dec 2023 14:51:18 +0530 Rajkumar Hirani has a mastery in bromance. In Dunki, Sukanya Verma doesn't feel that chemistry one bit, it's more like SRK babysitting a bunch of clueless kids running helter-skelter in a garden believing the grass is always greener on the other side. Full Article
ev Dunki Review By www.rediff.com Published On :: Fri, 22 Dec 2023 09:39:03 +0530 Dunki doesn't have any repeat value unlike other Hirani films. And that perhaps is saying a lot, notes Mayur Sanap. Full Article
ev Dry Day Review By www.rediff.com Published On :: Fri, 22 Dec 2023 13:01:34 +0530 There is an authenticity and sense of purpose about Dry Day which is appealing, observes Deepa Gahlot. Full Article
ev Salaar Review By www.rediff.com Published On :: Fri, 22 Dec 2023 16:46:14 +0530 The play-off between Prabhas and Prithviraj is the high-octane fuel that lends Salaar momentum, observes Mayur Sanap. Full Article
ev Kho Gaye Hum Kahan Review By www.rediff.com Published On :: Tue, 26 Dec 2023 18:24:17 +0530 Kho Gaye Hum Kahan is a light glimpse into healthy young lives ready to soar in their own sweet skin, applauds Sukanya Verma. Full Article
ev Wedding.con Review By www.rediff.com Published On :: Fri, 29 Dec 2023 09:55:12 +0530 Wedding.con is a watchable show, if only to caution people about the latest scams, notes Deepa Gahlot. Full Article
ev Safed Review: Misery Porn By www.rediff.com Published On :: Fri, 29 Dec 2023 12:11:32 +0530 Safed is a lame attempt at social commentary, with terribly dull and thoughtless direction, observes Mayur Sanap. Full Article Safed Sandeep Singh Abhay Verma Meera Chopra Safed Review OTT film Rediff Review
ev Killer Soup Review By www.rediff.com Published On :: Thu, 11 Jan 2024 13:29:43 +0530 Killer Soup's plots grow too convoluted and the strain of keeping the momentum going shows when its shrewd and surreal visuals lose steam, observes Sukanya Verma. Full Article
ev Merry Christmas Review By www.rediff.com Published On :: Fri, 12 Jan 2024 10:48:56 +0530 Merry Christmas has a breathtaking climax that will have you sighing like you've never sighed in a Sriram Raghavan movie before, applauds Sukanya Verma. Full Article