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Differentiating carrier protein interactions in biosynthetic pathways using dapoxyl solvatochromism

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC05499G, Edge Article
Open Access
Matthew G. Miyada, Yuran Choi, Kyle Rich, James J. La Clair, Michael D. Burkart
A highly sensitive solvatochromic system was developed to monitor the loading and interactivity of carrier proteins associated with fatty acid, polyketide and non-ribosomal peptide biosynthesis.
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Mechanism of action and evaluation of ratiometric probes for uric acid using lanthanide complexes with tetraazatriphenylene sensitisers

Chem. Sci., 2024, Advance Article
DOI: 10.1039/D4SC05743K, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Xinyi Wen, Huishan Li, Zhijie Ju, Renren Deng, David Parker
Six Eu(III) and Tb(III) complexes are evaluated for the rapid ratiometric analysis of urate in diluted serum, together with mechanistic studies probing the intermediate exciplex and the excited state dynamics by transient absorption spectroscopy.
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Direct Ladderization of Cyclooctatetraene-containing, Processable Conjugated Ladder Polymers from Annulated bis-Zirconacyclopentadienes

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC06902A, Edge Article
Open Access
August J. Rothenberger, Harrison M. Bergman, He Li, Miao Qi, Yunfei Wang, Yi Liu, T. Don Tilley
Conjugated ladder polymers (CLPs) are difficult yet captivating synthetic targets due to their fully unsaturated fused backbones. Inherent challenges associated with their synthesis often lead to low yields, structural defects,...
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Rapid, Potent, and Persistent Covalent Chemical Probes to Deconvolute PI3Kα Signaling

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05459H, Edge Article
Open Access
Lukas Bissegger, Theodora Alexandra Alexandra Constantin, Erhan Keles, Luka Raguž, Isobel Barlow-Busch, Clara Orbegozo, Thorsten Schaefer, Valentina Borlandelli, Thomas Bohnacker, Rohitha SriRamaratnam, Alexander Schäfer, Matthias Gstaiger, John E. Burke, Chiara Borsari, Matthias Wymann
Chemical probes have gained importance in the elucidation of signal transduction in biology. Insufficient selectivity and potency, lack of cellular activity and inappropriate use of chemical probes has major consequences...
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Pronounced Electronic Modulation of Geometrically-Regulated Metalloenediyne Cyclization

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05396F, Edge Article
Open Access
Sarah E. Lindahl, Erin M. Metzger, Chun-Hsing Chen, Maren Pink, Jeff Zaleski
Using a diverse array of thermally robust phosphine enediyne ligands (dxpeb, X = Ph, Ph-pOCH3, Ph-pCF3, Ph-m2CH3, Ph-m2CF3, iPr, Cy, and tBu) a novel suite of cisplatin-like Pt(II) metalloenediynes (3,...
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Discovery of penicillic acid as a chemical probe against tau aggregation in Alzheimer’s Disease

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05469E, Edge Article
Open Access
Jennifer Shyong, Jinliang Wang, Tran Quoc Dung Huynh, Marina Fayzullina, Bo Yuan, Ching-Kuo Lee, Thomas Minehan, Paul M. Seidler, Clay Wang
Alzheimer’s Disease (AD) is a neurodegenerative disorder proven to be caused by the aggregation of protein tau into fibrils, resulting in neuronal death. The irreparable neuronal damage leads to irreversible...
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Sequence-dependent Conformational Transitions of Disordered Proteins During Condensation

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05004E, Edge Article
Open Access
Jiahui Wang, Dinesh Devarajan, Keerthivasan Muthukumar, Youngchan Kim, Arash Nikoubashman, Jeetain Mittal
Intrinsically disordered proteins (IDPs) can form biomolecular condensates through phase separation. It is recognized that the conformation of IDPs in the dense and dilute phases, as well as at the...
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Progressive forces to unite at Goa meet




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Placental microphysiological systems: new advances on promising platforms that mimic the microenvironment of the human placenta

Lab Chip, 2025, Advance Article
DOI: 10.1039/D4LC00500G, Critical Review
Inês M. Gonçalves, Muhammad Afzal, Nithil Kennedy, Ana Moita, Rui Lima, Serge Ostrovidov, Takeshi Hori, Yuji Nashimoto, Hirokazu Kaji
This review presents new advancements in placental MPS models for toxicological screening, preeclampsia assessment, and embryo uterine implantation and an overview of bioprinting technology and current advances in endometrial MPSs.
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Rapid miRNA detection in skin interstitial fluid using a hydrogel microneedle patch integrated with DNA probes and graphene oxide

Lab Chip, 2024, 24,4989-4997
DOI: 10.1039/D4LC00715H, Paper
Hanjia Zheng, Fatemeh Keyvani, Sadegh Sadeghzadeh, Dragos F. Mantaila, Fasih A. Rahman, Joe Quadrilatero, Mahla Poudineh
A simple and rapid fluorescence-based sensor sensors using DNA functionalized graphene oxide for miRNA detection from skin interstitial fluid.
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Compact lens-free imager using a thin-film transistor for long-term quantitative monitoring of stem cell culture and cardiomyocyte production

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00528G, Paper
Open Access
Taishi Kakizuka, Tohru Natsume, Takeharu Nagai
A novel compact lens-free imager achieved high-throughput long-term monitoring within an incubator, demonstrating the quantification of the confluency of human iPS cells, epithelial-to-mesenchymal transition, and cardiomyocyte beating dynamics.
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A microfluidic hanging droplet as a programmable platform for mammalian egg vitrification

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00428K, Paper
Open Access
Haidong Feng, Georgios Katsikis, India D. Napier, Gong Du, Josh Lim, Joseph O. Doyle, Scott R. Manalis, Linda G. Griffith
Programmable microfluidic hanging drop system for motorized, contactless cryoprotectant loading and egg vitrification.
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Effect of base methylation on binding and mobility of bacterial protein Hfq on double-stranded DNA

Lab Chip, 2024, 24,5137-5144
DOI: 10.1039/D4LC00628C, Paper
Jijo Easo George, Rajib Basak, Indresh Yadav, Chuan Jie Tan, Jeroen A. van Kan, Frank Wien, Véronique Arluison, Johan R. C. van der Maarel
Using nanofluidics to probe protein mobility on DNA reveals how DNA base methylation impacts protein–DNA interactions.
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RTO to probe operator’s failure to provide accommodation to students




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Syro-Malabar Church affirms solidarity with Munambam protesters

State government must urgently intervene in the issue, since hundreds of families are facing threat of displacement from the land they had purchased and had been staying in for decades, says Church spokesperson




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Hurdles abound for SilverLine as Railways seek revised DPR for project




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Not afraid of any probe, says Mamkootathil




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CM owes Oommen Chandy an apology for sabotaging seaplane project: Sudhakaran 




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Centre, State must intervene in Munambam Waqf property issue, says Thattil




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Catholic Church to intensify Munambam protests

Protest gatherings were held in over 1,500 parishes of the Syro-Malabar Church across the State




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Detailed probe launched into fire at commercial unit near Aluva




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Kerala HC quashes criminal case against former postal officials for taking possession of Waqf property

The post office was functioning from 1999, even before the insertion of section 52A in Waqf Act, which makes purchase or possession of Waqf property without Waqf Board nod punishable




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Migrant's progress



  • R K Nair

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Rains curtails Thursday’s race programme




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Rise And Reign, Densetsu, Promiseofthefuture, Elfin Knight, Irish Rockstar and Storm Shadow catch the eye




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Day 1 of Modi 3.0: PM signed file to release Kisan Nidhi, Cabinet approves 3 cr homes

PM Kisan Nidhi provides income support to 14.5 crore small and marginal farmers




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Govt approves viability gap funding for offshore wind energy projects

The outlay also includes ₹6,853 crore for installation and commissioning of 1 GW of offshore wind energy projects and a grant of ₹600 crore for upgradation of two ports to meet logistics requirements for offshore wind energy projects




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Consumer Affairs Ministry releases draft guidelines to curb pesky promotional calls, messages

Draft guidelines released by DoCA protect consumers from unsolicited and unwarranted communications business communication




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Govt to provide financial assistance to North Eastern States for hydro power development

This scheme has an outlay of ₹4,136 crore to be implemented from FY25 to FY32




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Cabinet approves e-auction to roll out FM Radio stations in 234 new cities

The Cabinet also clears the proposal to change annual licensing fee conditions




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Paytm gets Finmin approval for downstream investment into its payment services arm 

PPSL will now resubmit application with RBI for Payment Aggregator licence



  • Money & Banking

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Cabinet approves ₹6,456 crore worth of new rail projects across West Bengal, Jharkhand, Odisha and Chhattisgarh

Three projects include setting up of two new lines and one multi-tracking project across Indian Railways




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A dozen industrial smart cities worth ₹28,602 cr get CCEA approval

Projects to be completed by 2027, attract investment of ₹1.5 lakh crore, general 10 lakh direct jobs, says Piyush Goyal




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Govt proposes new window in NRS auctions for buying coal without end use requirement

Coal Ministry proposes new window in NRS Linkage Auction Policy for long-term coal linkages without end use restrictions




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Government may approve fresh applications for chip facilities in India

New projects could be announced in the upcoming Semicon India between September 11 and 13




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India enforces mandatory CCI approval for M&As over ₹2,000 crore under new regulations

The updated regulations define ‘India nexus’ criteria, including user metrics and turnover, and introduce a ₹500 crore monetary threshold.  




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Chennai Metro Phase 2 now a ‘Central Sector’ project, Centre to fund 65% of costs

The decision shifts financial responsibility largely to the central government, freeing up state resources and triggering loan renegotiations with international agencies. 




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Need clear laws, standard operating procedures to protect workers, manufacturers' interests: GTRI

Amid the ongoing Samsung workers’ strike in Tamil Nadu, economic think tank GTRI suggests seven-step strategy to foster a more stable industrial environment in the country




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Govt proposes 15-year PPA for FDRE projects with battery storage

The Power Ministry seeks stakeholder feedback on amendments




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India’s new biodiversity strategy aims to protect 30% of ecosystems, restore degraded habitats by 2030

This plan aligns with the global targets set by the Kunming-Montreal Global Biodiversity Framework.




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Aviation Minister proposes over 50 helicopter emergency medical units along highways

This initiative aims to enhance rapid medical assistance, particularly in remote areas, and align with global healthcare standards




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GoI invites proposals for establishing Centres of Excellence under Green Hydrogen Mission

This initiative, launched by the Ministry of New and Renewable Energy, aims to position India as a global leader in Green Hydrogen technologies by enhancing research in production, storage, and utilization




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XUV400: Pro and Cons

 The updated Mahindra XUV400 is ready to take on the refreshed Nexon.ev 




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'Nation is proud of you': West Bengal Guv to GRSE on laying keels of two NGOPVS




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Delhi pollution: Tips to protect your lungs as AQI levels rise

Here are some essential tips to help protect your lungs during this pollution surge.




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Combination targeted treatment produces lasting remissions in people with resistant aggressive B-cell lymphoma

More than half of clinical trial participants treated with venetoclax, ibrutinib, prednisone, obinutuzumab, and lenalidomide (ViPOR) had substantial tumor shrinkage. Of those, 38% had tumors that disappeared completely.




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Immunotherapy approach shows potential in some people with metastatic solid tumors

A new cellular immunotherapy approach shrank tumors in 3 of 7 patients with metastatic colon cancer, in a small NCI clinical trial. Normal white blood cells from each patient were genetically engineered to produce receptors that recognize and attack their specific cancer cells.




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NIH study links neighborhood environment to prostate cancer risk in men with West African genetic ancestry

A new study suggests, for men with West African genetic ancestry, living in a disadvantaged neighborhood was associated with a higher risk of prostate cancer. The researchers posit that chronic stress—such as from racial profiling, housing discrimination, and exposure to violence—may be a possible driver.




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Researchers uncover new role of mutant RAS proteins in some of the deadliest cancers

A new study led by NCI researchers shows that mutant RAS proteins help release a nuclear protein from a complex transported from the nucleus to the cytoplasm, kicking off a series of events that lead to the breakdown of a tumor suppressor protein.




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Data | World’s largest producer of milk hits a dry patch

Milk prices are ruling high as supply is constrained by lumpy skin disease and high fodder costs