pro Differentiating carrier protein interactions in biosynthetic pathways using dapoxyl solvatochromism By pubs.rsc.org Published On :: Chem. Sci., 2024, Advance ArticleDOI: 10.1039/D4SC05499G, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Matthew G. Miyada, Yuran Choi, Kyle Rich, James J. La Clair, Michael D. BurkartA highly sensitive solvatochromic system was developed to monitor the loading and interactivity of carrier proteins associated with fatty acid, polyketide and non-ribosomal peptide biosynthesis.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pro Mechanism of action and evaluation of ratiometric probes for uric acid using lanthanide complexes with tetraazatriphenylene sensitisers By pubs.rsc.org Published On :: Chem. Sci., 2024, Advance ArticleDOI: 10.1039/D4SC05743K, Edge Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xinyi Wen, Huishan Li, Zhijie Ju, Renren Deng, David ParkerSix Eu(III) and Tb(III) complexes are evaluated for the rapid ratiometric analysis of urate in diluted serum, together with mechanistic studies probing the intermediate exciplex and the excited state dynamics by transient absorption spectroscopy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pro Direct Ladderization of Cyclooctatetraene-containing, Processable Conjugated Ladder Polymers from Annulated bis-Zirconacyclopentadienes By pubs.rsc.org Published On :: Chem. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4SC06902A, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.August J. Rothenberger, Harrison M. Bergman, He Li, Miao Qi, Yunfei Wang, Yi Liu, T. Don TilleyConjugated ladder polymers (CLPs) are difficult yet captivating synthetic targets due to their fully unsaturated fused backbones. Inherent challenges associated with their synthesis often lead to low yields, structural defects,...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pro Rapid, Potent, and Persistent Covalent Chemical Probes to Deconvolute PI3Kα Signaling By pubs.rsc.org Published On :: Chem. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4SC05459H, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Lukas Bissegger, Theodora Alexandra Alexandra Constantin, Erhan Keles, Luka Raguž, Isobel Barlow-Busch, Clara Orbegozo, Thorsten Schaefer, Valentina Borlandelli, Thomas Bohnacker, Rohitha SriRamaratnam, Alexander Schäfer, Matthias Gstaiger, John E. Burke, Chiara Borsari, Matthias WymannChemical probes have gained importance in the elucidation of signal transduction in biology. Insufficient selectivity and potency, lack of cellular activity and inappropriate use of chemical probes has major consequences...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pro Pronounced Electronic Modulation of Geometrically-Regulated Metalloenediyne Cyclization By pubs.rsc.org Published On :: Chem. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4SC05396F, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Sarah E. Lindahl, Erin M. Metzger, Chun-Hsing Chen, Maren Pink, Jeff ZaleskiUsing a diverse array of thermally robust phosphine enediyne ligands (dxpeb, X = Ph, Ph-pOCH3, Ph-pCF3, Ph-m2CH3, Ph-m2CF3, iPr, Cy, and tBu) a novel suite of cisplatin-like Pt(II) metalloenediynes (3,...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pro Discovery of penicillic acid as a chemical probe against tau aggregation in Alzheimer’s Disease By pubs.rsc.org Published On :: Chem. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4SC05469E, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jennifer Shyong, Jinliang Wang, Tran Quoc Dung Huynh, Marina Fayzullina, Bo Yuan, Ching-Kuo Lee, Thomas Minehan, Paul M. Seidler, Clay WangAlzheimer’s Disease (AD) is a neurodegenerative disorder proven to be caused by the aggregation of protein tau into fibrils, resulting in neuronal death. The irreparable neuronal damage leads to irreversible...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pro Sequence-dependent Conformational Transitions of Disordered Proteins During Condensation By pubs.rsc.org Published On :: Chem. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4SC05004E, Edge Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jiahui Wang, Dinesh Devarajan, Keerthivasan Muthukumar, Youngchan Kim, Arash Nikoubashman, Jeetain MittalIntrinsically disordered proteins (IDPs) can form biomolecular condensates through phase separation. It is recognized that the conformation of IDPs in the dense and dilute phases, as well as at the...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pro Progressive forces to unite at Goa meet By www.thehindu.com Published On :: Wed, 09 Nov 2016 00:00:00 +0530 Full Article Mumbai
pro Placental microphysiological systems: new advances on promising platforms that mimic the microenvironment of the human placenta By pubs.rsc.org Published On :: Lab Chip, 2025, Advance ArticleDOI: 10.1039/D4LC00500G, Critical ReviewInês M. Gonçalves, Muhammad Afzal, Nithil Kennedy, Ana Moita, Rui Lima, Serge Ostrovidov, Takeshi Hori, Yuji Nashimoto, Hirokazu KajiThis review presents new advancements in placental MPS models for toxicological screening, preeclampsia assessment, and embryo uterine implantation and an overview of bioprinting technology and current advances in endometrial MPSs.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pro Rapid miRNA detection in skin interstitial fluid using a hydrogel microneedle patch integrated with DNA probes and graphene oxide By pubs.rsc.org Published On :: Lab Chip, 2024, 24,4989-4997DOI: 10.1039/D4LC00715H, PaperHanjia Zheng, Fatemeh Keyvani, Sadegh Sadeghzadeh, Dragos F. Mantaila, Fasih A. Rahman, Joe Quadrilatero, Mahla PoudinehA simple and rapid fluorescence-based sensor sensors using DNA functionalized graphene oxide for miRNA detection from skin interstitial fluid.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pro Compact lens-free imager using a thin-film transistor for long-term quantitative monitoring of stem cell culture and cardiomyocyte production By pubs.rsc.org Published On :: Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00528G, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Taishi Kakizuka, Tohru Natsume, Takeharu NagaiA novel compact lens-free imager achieved high-throughput long-term monitoring within an incubator, demonstrating the quantification of the confluency of human iPS cells, epithelial-to-mesenchymal transition, and cardiomyocyte beating dynamics.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pro A microfluidic hanging droplet as a programmable platform for mammalian egg vitrification By pubs.rsc.org Published On :: Lab Chip, 2024, Advance ArticleDOI: 10.1039/D4LC00428K, Paper Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Haidong Feng, Georgios Katsikis, India D. Napier, Gong Du, Josh Lim, Joseph O. Doyle, Scott R. Manalis, Linda G. GriffithProgrammable microfluidic hanging drop system for motorized, contactless cryoprotectant loading and egg vitrification.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pro Effect of base methylation on binding and mobility of bacterial protein Hfq on double-stranded DNA By pubs.rsc.org Published On :: Lab Chip, 2024, 24,5137-5144DOI: 10.1039/D4LC00628C, PaperJijo Easo George, Rajib Basak, Indresh Yadav, Chuan Jie Tan, Jeroen A. van Kan, Frank Wien, Véronique Arluison, Johan R. C. van der MaarelUsing nanofluidics to probe protein mobility on DNA reveals how DNA base methylation impacts protein–DNA interactions.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pro RTO to probe operator’s failure to provide accommodation to students By www.thehindu.com Published On :: Wed, 06 Nov 2024 01:48:10 +0530 Full Article Kerala
pro Syro-Malabar Church affirms solidarity with Munambam protesters By www.thehindu.com Published On :: Thu, 07 Nov 2024 21:33:51 +0530 State government must urgently intervene in the issue, since hundreds of families are facing threat of displacement from the land they had purchased and had been staying in for decades, says Church spokesperson Full Article Kerala
pro Hurdles abound for SilverLine as Railways seek revised DPR for project By www.thehindu.com Published On :: Thu, 07 Nov 2024 21:35:16 +0530 Full Article Kerala
pro Not afraid of any probe, says Mamkootathil By www.thehindu.com Published On :: Fri, 08 Nov 2024 20:58:33 +0530 Full Article Kerala
pro CM owes Oommen Chandy an apology for sabotaging seaplane project: Sudhakaran By www.thehindu.com Published On :: Sat, 09 Nov 2024 21:49:31 +0530 Full Article Kerala
pro Centre, State must intervene in Munambam Waqf property issue, says Thattil By www.thehindu.com Published On :: Sun, 10 Nov 2024 01:31:14 +0530 Full Article Kerala
pro Catholic Church to intensify Munambam protests By www.thehindu.com Published On :: Sun, 10 Nov 2024 19:54:43 +0530 Protest gatherings were held in over 1,500 parishes of the Syro-Malabar Church across the State Full Article Kerala
pro Detailed probe launched into fire at commercial unit near Aluva By www.thehindu.com Published On :: Tue, 12 Nov 2024 01:42:35 +0530 Full Article Kerala
pro Kerala HC quashes criminal case against former postal officials for taking possession of Waqf property By www.thehindu.com Published On :: Tue, 12 Nov 2024 18:29:32 +0530 The post office was functioning from 1999, even before the insertion of section 52A in Waqf Act, which makes purchase or possession of Waqf property without Waqf Board nod punishable Full Article Kochi
pro Migrant's progress By www.thehindubusinessline.com Published On :: Wed, 08 May 2013 14:09:44 +0530 Full Article R K Nair
pro Rains curtails Thursday’s race programme By www.thehindu.com Published On :: Thu, 17 Oct 2024 19:24:16 +0530 Full Article Races
pro Rise And Reign, Densetsu, Promiseofthefuture, Elfin Knight, Irish Rockstar and Storm Shadow catch the eye By www.thehindu.com Published On :: Tue, 05 Nov 2024 17:34:44 +0530 Full Article Races
pro Day 1 of Modi 3.0: PM signed file to release Kisan Nidhi, Cabinet approves 3 cr homes By www.thehindubusinessline.com Published On :: Mon, 10 Jun 2024 11:55:40 +0530 PM Kisan Nidhi provides income support to 14.5 crore small and marginal farmers Full Article News
pro Govt approves viability gap funding for offshore wind energy projects By www.thehindubusinessline.com Published On :: Wed, 19 Jun 2024 21:07:58 +0530 The outlay also includes ₹6,853 crore for installation and commissioning of 1 GW of offshore wind energy projects and a grant of ₹600 crore for upgradation of two ports to meet logistics requirements for offshore wind energy projects Full Article Economy
pro Consumer Affairs Ministry releases draft guidelines to curb pesky promotional calls, messages By www.thehindubusinessline.com Published On :: Thu, 20 Jun 2024 19:55:32 +0530 Draft guidelines released by DoCA protect consumers from unsolicited and unwarranted communications business communication Full Article Info-tech
pro Govt to provide financial assistance to North Eastern States for hydro power development By www.thehindubusinessline.com Published On :: Wed, 28 Aug 2024 16:56:18 +0530 This scheme has an outlay of ₹4,136 crore to be implemented from FY25 to FY32 Full Article Economy
pro Cabinet approves e-auction to roll out FM Radio stations in 234 new cities By www.thehindubusinessline.com Published On :: Wed, 28 Aug 2024 18:57:17 +0530 The Cabinet also clears the proposal to change annual licensing fee conditions Full Article Economy
pro Paytm gets Finmin approval for downstream investment into its payment services arm By www.thehindubusinessline.com Published On :: Wed, 28 Aug 2024 18:57:52 +0530 PPSL will now resubmit application with RBI for Payment Aggregator licence Full Article Money & Banking
pro Cabinet approves ₹6,456 crore worth of new rail projects across West Bengal, Jharkhand, Odisha and Chhattisgarh By www.thehindubusinessline.com Published On :: Wed, 28 Aug 2024 19:10:22 +0530 Three projects include setting up of two new lines and one multi-tracking project across Indian Railways Full Article Logistics
pro A dozen industrial smart cities worth ₹28,602 cr get CCEA approval By www.thehindubusinessline.com Published On :: Wed, 28 Aug 2024 20:51:53 +0530 Projects to be completed by 2027, attract investment of ₹1.5 lakh crore, general 10 lakh direct jobs, says Piyush Goyal Full Article Policy
pro Govt proposes new window in NRS auctions for buying coal without end use requirement By www.thehindubusinessline.com Published On :: Thu, 29 Aug 2024 19:02:13 +0530 Coal Ministry proposes new window in NRS Linkage Auction Policy for long-term coal linkages without end use restrictions Full Article Commodities
pro Government may approve fresh applications for chip facilities in India By www.thehindubusinessline.com Published On :: Thu, 29 Aug 2024 20:34:16 +0530 New projects could be announced in the upcoming Semicon India between September 11 and 13 Full Article Info-tech
pro India enforces mandatory CCI approval for M&As over ₹2,000 crore under new regulations By www.thehindubusinessline.com Published On :: Tue, 10 Sep 2024 13:07:50 +0530 The updated regulations define ‘India nexus’ criteria, including user metrics and turnover, and introduce a ₹500 crore monetary threshold. Full Article Economy
pro Chennai Metro Phase 2 now a ‘Central Sector’ project, Centre to fund 65% of costs By www.thehindubusinessline.com Published On :: Sat, 05 Oct 2024 18:38:10 +0530 The decision shifts financial responsibility largely to the central government, freeing up state resources and triggering loan renegotiations with international agencies. Full Article Logistics
pro Need clear laws, standard operating procedures to protect workers, manufacturers' interests: GTRI By www.thehindubusinessline.com Published On :: Sun, 06 Oct 2024 15:37:13 +0530 Amid the ongoing Samsung workers’ strike in Tamil Nadu, economic think tank GTRI suggests seven-step strategy to foster a more stable industrial environment in the country Full Article Policy
pro Govt proposes 15-year PPA for FDRE projects with battery storage By www.thehindubusinessline.com Published On :: Tue, 29 Oct 2024 18:47:57 +0530 The Power Ministry seeks stakeholder feedback on amendments Full Article Policy
pro India’s new biodiversity strategy aims to protect 30% of ecosystems, restore degraded habitats by 2030 By www.thehindubusinessline.com Published On :: Fri, 01 Nov 2024 09:26:35 +0530 This plan aligns with the global targets set by the Kunming-Montreal Global Biodiversity Framework. Full Article Policy
pro Aviation Minister proposes over 50 helicopter emergency medical units along highways By www.thehindubusinessline.com Published On :: Tue, 05 Nov 2024 20:48:52 +0530 This initiative aims to enhance rapid medical assistance, particularly in remote areas, and align with global healthcare standards Full Article Logistics
pro GoI invites proposals for establishing Centres of Excellence under Green Hydrogen Mission By www.thehindubusinessline.com Published On :: Thu, 07 Nov 2024 19:18:28 +0530 This initiative, launched by the Ministry of New and Renewable Energy, aims to position India as a global leader in Green Hydrogen technologies by enhancing research in production, storage, and utilization Full Article Policy
pro XUV400: Pro and Cons By www.thehindubusinessline.com Published On :: Fri, 26 Jan 2024 15:19:46 +0530 The updated Mahindra XUV400 is ready to take on the refreshed Nexon.ev Full Article Auto focus
pro 'Nation is proud of you': West Bengal Guv to GRSE on laying keels of two NGOPVS By www.newkerala.com Published On :: Tue, 05 Nov 2024 22:32:02 +0530 Full Article
pro Delhi pollution: Tips to protect your lungs as AQI levels rise By www.dnaindia.com Published On :: Sat, 19 Oct 2024 11:20:00 GMT Here are some essential tips to help protect your lungs during this pollution surge. Full Article Health
pro Combination targeted treatment produces lasting remissions in people with resistant aggressive B-cell lymphoma By www.cancer.gov Published On :: Wed, 19 Jun 2024 12:00:00 +0000 More than half of clinical trial participants treated with venetoclax, ibrutinib, prednisone, obinutuzumab, and lenalidomide (ViPOR) had substantial tumor shrinkage. Of those, 38% had tumors that disappeared completely. Full Article
pro Immunotherapy approach shows potential in some people with metastatic solid tumors By www.cancer.gov Published On :: Thu, 11 Jul 2024 12:00:00 +0000 A new cellular immunotherapy approach shrank tumors in 3 of 7 patients with metastatic colon cancer, in a small NCI clinical trial. Normal white blood cells from each patient were genetically engineered to produce receptors that recognize and attack their specific cancer cells. Full Article
pro NIH study links neighborhood environment to prostate cancer risk in men with West African genetic ancestry By www.cancer.gov Published On :: Mon, 16 Sep 2024 12:00:00 +0000 A new study suggests, for men with West African genetic ancestry, living in a disadvantaged neighborhood was associated with a higher risk of prostate cancer. The researchers posit that chronic stress—such as from racial profiling, housing discrimination, and exposure to violence—may be a possible driver. Full Article
pro Researchers uncover new role of mutant RAS proteins in some of the deadliest cancers By www.cancer.gov Published On :: Mon, 11 Nov 2024 12:00:00 +0000 A new study led by NCI researchers shows that mutant RAS proteins help release a nuclear protein from a complex transported from the nucleus to the cytoplasm, kicking off a series of events that lead to the breakdown of a tumor suppressor protein. Full Article
pro Data | World’s largest producer of milk hits a dry patch By www.thehindu.com Published On :: Sun, 30 Apr 2023 18:02:34 +0530 Milk prices are ruling high as supply is constrained by lumpy skin disease and high fodder costs Full Article Data