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You Could Live 9 Years Longer in Hawaii Than in Mississippi, New Data Shows

Title: You Could Live 9 Years Longer in Hawaii Than in Mississippi, New Data Shows
Category: Health News
Created: 8/23/2022 12:00:00 AM
Last Editorial Review: 8/23/2022 12:00:00 AM




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Enzyme Replacement Therapy for CLN2 Disease: MRI Volumetry Shows Significantly Slower Volume Loss Compared with a Natural History Cohort [CLINICAL PRACTICE]

BACKGROUND AND PURPOSE:

Neuronal ceroid lipofuscinoses are a group of neurodegenerative disorders. Recently, enzyme replacement therapy (ERT) was approved for neuronal ceroid lipofuscinosis type 2 (CLN2), a subtype of neuronal ceroid lipofuscinoses. The aim of this study was to quantify brain volume loss in CLN2 disease in patients on ERT in comparison with a natural history cohort using MRI.

MATERIALS AND METHODS:

Nineteen (14 female, 5 male) patients with CLN2 disease at 1 UK center were studied using serial 3D T1-weighted MRI (follow-up time, 1–9 years). Brain segmentation was performed using FreeSurfer. Volume measurements for supratentorial gray and white matter, deep gray matter (basal ganglia/thalami), the lateral ventricles, and cerebellar gray and white matter were recorded. The volume change with time was analyzed using a linear mixed-effects model excluding scans before treatment onset. Comparison was made with a published natural history cohort of 12 patients (8 female, 4 male), which was re-analyzed using the same method.

RESULTS:

Brain volume loss of all segmented brain regions was much slower in treated patients compared with the natural history cohort. For example, supratentorial gray matter volume in treated patients decreased by a mean of 3% (SD, 0.74%) (P < .001) annually compared with an annual volume loss of a mean of 16.8% (SD, 1.5%) (P < .001) in the natural history cohort.

CONCLUSIONS:

Our treatment cohort showed a significantly slower rate of brain parenchymal volume loss compared with a natural history cohort in several anatomic regions. Our results complement prior clinical data that found a positive response to ERT. We demonstrate that automated MRI volumetry is a sensitive tool to monitor treatment response in children with CLN2 disease.




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Secret Level‘s Creator Hopes Concord Episode Showcases Its Lost Potential



Tim Miller hopes Amazon's anthology series will help viewers appreciate the "blood, sweat, and tears" Firewalk Studios put into the scrapped game.




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Andy Murray announces Glasgow and Edinburgh stage shows as part of UK tour

Sir Andy Murray will swap Centre Court for the stage next summer as he embarks on a tour discussing his illustrious tennis career.




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RPG Cast – Episode 666: “A Beast of a Show”

Chris hugs a bear. Kelley's kitten almost Leeroy Jenkins into a toilet. Matt knocks everyone out in Octopath. And Jason goes round right round with his turntable.

The post RPG Cast – Episode 666: “A Beast of a Show” appeared first on RPGamer.



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Showa American Story is Yakuza: Dead Souls meets Tokyo Gore Police, and it looks incredible

Some days, I wonder if every word written before a trailer is actually superfluous. It’s a visual medium, after all. What can a description achieve save to clumsily gesture at the true shape of something; a dog-eared tour brochure for a thrilling weekend spelunking in Plato’s cave? I can usually shake this feeling, but gory zombie action game Showa American Story is my breaking point. There is nothing I can impart about this thing that will not be conveyed better by allowing its new trailer to wash over you like a tide of sheer videogame. Here’s it:

Read more




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Get ready to watch the dazzling Perseid meteor shower in August

It is nearly time for one of astronomy's top annual sights – the Perseid meteor shower. This year is a bit special, says Abigail Beall




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Starlink tests show how to save radio astronomy from satellites

Radio astronomers teamed up with SpaceX to find a promising solution for helping expensive telescopes avoid interference from thousands of Starlink satellites




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The Starliner stranding shows why NASA was wise to have a backup plan

Space missions are extremely hard. Things going wrong should be expected, so having a sensible plan B is crucial




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Astronomy Photographer of the Year showcases world's best space images

See the world's best space images from the Astronomy Photographer of the Year 2024 award




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10 stunning James Webb Space Telescope images show the beauty of space

Maggie Aderin-Pocock, who has worked on the JWST, catalogues the science behind its most stunning images in her new book, Webb's Universe. Here's her pick of the telescope’s best shots




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Do the 2024 Nobel prizes show that AI is the future of science?

Two of the three science Nobel prizes in 2024 have been won by people working in AI, but does this mean that AI models are now vital for science?





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Mike Tyson eyes Tyson Fury showdown and 'full comeback' after Jake Paul fight



Mike Tyson has not fought professionally since suffering a stoppage defeat to Kevin McBride in 2005.








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How to get the best view of the Perseids meteor shower

The annual Perseids meteor shower is expected to continue through September. Astronomers say it's one of the brightest and most visible meteor showers of the year.



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Perseid meteor shower peaks Sunday night, potentially giving stargazers big show

The annual Perseid meteor shower is set to peak on Sunday night into early Monday morning, giving stargazers the chance to see hundreds of meteors.



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Orionid meteor shower to light up night sky through most of November

The Orionids meteor shower peaks on Monday, but will continue to light up the sky through Nov. 22, as debris from Halley's Comet enters Earth's atmosphere.



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CBD shows promise as pesticide for mosquitoes

Mosquito larvae die after consuming hemp leaves because they react strongly to the cannabidiol in the foliage. The discovery might lead to the development of a new pesticide to control mosquito numbers




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Boston Dynamics’ Latest Vids Show Atlas Going Hands On



Boston Dynamics is the master of dropping amazing robot videos with no warning, and last week, we got a surprise look at the new electric Atlas going “hands on” with a practical factory task.

This video is notable because it’s the first real look we’ve had at the new Atlas doing something useful—or doing anything at all, really, as the introductory video from back in April (the first time we saw the robot) was less than a minute long. And the amount of progress that Boston Dynamics has made is immediately obvious, with the video showing a blend of autonomous perception, full body motion, and manipulation in a practical task.

We sent over some quick questions as soon as we saw the video, and we’ve got some extra detail from Scott Kuindersma, senior director of Robotics Research at Boston Dynamics.


If you haven’t seen this video yet, what kind of robotics person are you, and also here you go:

Atlas is autonomously moving engine covers between supplier containers and a mobile sequencing dolly. The robot receives as input a list of bin locations to move parts between.

Atlas uses a machine learning (ML) vision model to detect and localize the environment fixtures and individual bins [0:36]. The robot uses a specialized grasping policy and continuously estimates the state of manipulated objects to achieve the task.

There are no prescribed or teleoperated movements; all motions are generated autonomously online. The robot is able to detect and react to changes in the environment (e.g., moving fixtures) and action failures (e.g., failure to insert the cover, tripping, environment collisions [1:24]) using a combination of vision, force, and proprioceptive sensors.

Eagle-eyed viewers will have noticed that this task is very similar to what we saw hydraulic Atlas (Atlas classic?) working on just before it retired. We probably don’t need to read too much into the differences between how each robot performs that task, but it’s an interesting comparison to make.

For more details, here’s our Q&A with Kuindersma:

How many takes did this take?

Kuindersma: We ran this sequence a couple times that day, but typically we’re always filming as we continue developing and testing Atlas. Today we’re able to run that engine cover demo with high reliability, and we’re working to expand the scope and duration of tasks like these.

Is this a task that humans currently do?

Kuindersma: Yes.

What kind of world knowledge does Atlas have while doing this task?

Kuindersma: The robot has access to a CAD model of the engine cover that is used for object pose prediction from RGB images. Fixtures are represented more abstractly using a learned keypoint prediction model. The robot builds a map of the workcell at startup which is updated on the fly when changes are detected (e.g., moving fixture).

Does Atlas’s torso have a front or back in a meaningful way when it comes to how it operates?

Kuindersma: Its head/torso/pelvis/legs do have “forward” and “backward” directions, but the robot is able to rotate all of these relative to one another. The robot always knows which way is which, but sometimes the humans watching lose track.

Are the head and torso capable of unlimited rotation?

Kuindersma: Yes, many of Atlas’s joints are continuous.

How long did it take you folks to get used to the way Atlas moves?

Kuindersma: Atlas’s motions still surprise and delight the team.

OSHA recommends against squatting because it can lead to workplace injuries. How does Atlas feel about that?

Kuindersma: As might be evident by some of Atlas’s other motions, the kinds of behaviors that might be injurious for humans might be perfectly fine for robots.

Can you describe exactly what process Atlas goes through at 1:22?

Kuindersma: The engine cover gets caught on the fabric bins and triggers a learned failure detector on the robot. Right now this transitions into a general-purpose recovery controller, which results in a somewhat jarring motion (we will improve this). After recovery, the robot retries the insertion using visual feedback to estimate the state of both the part and fixture.

Were there other costume options you considered before going with the hot dog?

Kuindersma: Yes, but marketing wants to save them for next year.

How many important sensors does the hot dog costume occlude?

Kuindersma: None. The robot is using cameras in the head, proprioceptive sensors, IMU, and force sensors in the wrists and feet. We did have to cut the costume at the top so the head could still spin around.

Why are pickles always causing problems?

Kuindersma: Because pickles are pesky, polarizing pests.




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'America's Got Talent': How the Show Addressed Simon Cowell's Absence Following His Bike Accident

Kelly Clarkson filled in for Cowell as he recuperates from back surgery.

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‘Fashion shows have a purpose,’ says British Vogue editor Chioma Nnadi

The huge four-storey walls of the Lightroom in London are showing ‘Vogue: Inventing the Runway'.







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Dem Rep. Torres: Biden Showed 'Incompetence' on Immigration Because He Catered to 'Far-Left Elites'


On Tuesday’s broadcast of MSNBC’s “Morning Joe,” Rep. Ritchie Torres (D-NY) stated that “the Biden administration demonstrated incompetence in managing the migrant crisis,” President Joe Biden “had the unilateral ability to issue an executive order restricting migration at the border, and he waited two-and-a-half years,” because the order “was unpopular among far-left elites who have outsized power over the policymaking and messaging of the Democratic Party.” Torres said, “[O]n the subject of immigration, there was genuine political malpractice. Since 2022, there has been an unprecedented wave of migration, whose impact was felt, not only at the border, but in cities like New York, where the shelter system and our municipal finances were completely overwhelmed. … Despite clear signs of popular discontent, it took the Biden administration two-and-a-half years to issue an executive order restricting migration at the border, and by then it was too late. The Republicans had won the issue, had weaponized it against us. And when the President issued the executive order, polling revealed that it was popular among the American people, among people from every racial category, blacks and whites, Latinos and Asians. So, if it was effective at reducing migration at the border and if it was

The post Dem Rep. Torres: Biden Showed ‘Incompetence’ on Immigration Because He Catered to ‘Far-Left Elites’ appeared first on Breitbart.





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First Day First Show | Reviews of ‘Here’ and ‘Vijay 69’

The Hindu’s First Day First Show newsletter brings you news and reviews from the world of cinema and streaming




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‘Citadel: Honey Bunny’ series review: Varun Dhawan, Samantha’s spy show sparks intermittent joy

Directors Raj & DK bring texture and technique to this Indian spin-off of ‘Citadel’, with uneven results




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BookMyShow announces new Hyderabad edition, Competition Segment for the Red Lorry Film Festival 2025

The inaugural Red Lorry Film Festival in 2024 saw over 100 international films across various categories and languages





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‘Dragon Ball Project:Multi’ Gets New Character Trailers Showcasing Super Saiyan Goku, Krillin, and Piccolo

Earlier this month, Bandai Namco Entertainment and developer Ganbarion revealed Dragon Ball Project:Multi, the franchise’s first 4v4 team based battle …




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‘Honkai Star Rail’ Version 2.5 “Flying Aureus Shot to Lupine Rue” Update Releases on September 10th, New Trailer Showcased During Livestream

HoYoverse’s Honkai Star Rail (Free) version 2.5 update titled “Flying Aureus Shot to Lupine Rue" was just showcased during a …











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Strictly pro isn’t happy with BBC show’s treatment of Shayne Ward

‘You deserve something better!’ Ward’s partner Nancy Xu said of result




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SNL cast member reveals Elon Musk made her cry when he hosted the show

‘I’m gonna come out and say it at long last,’ sketch show star said




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I’m a Celeb has made a huge casting mistake. The show won’t be the same

ITV previously seemed very happy to oblige politicians in urgent need of money, rehabilitation or just missing the attention, writes Sean O’Grady. But this year’s roster is different




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Harry Potter TV show’s first choice for Dumbledore ‘revealed’

New show is on the hunt for high-profile stars to play Hogwarts staff




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Nintendo will show off 'Donkey Kong Country' theme park expansion at live event today

Nintendo is set to show off the Donkey Kong Country expansion of its Super Nintendo World theme park today (Monday, November 11) at 5PM ET, the company revealed in a post on X. That means the new Universal Studios Japan area might finally open soon, after being delayed from the previously announced launch window of Spring 2024. 

The new park attraction featuring Mario's barrel-throwing nemesis was first revealed in 2021. The centerpiece is a ride called Mine Cart Madness, named after the best level in the 1994 SNES game Donkey Kong Country. After being blasted out of a barrel cannon, you'll take a mine cart ride through the jungle that includes a "leap across a collapsed track" as Nintendo showed in a render earlier this year.  

The direct livestream appears to be focused on Donkey Kong world alone, and Nintendo specifically pointed out that "no game information will be featured" — so don't expect any news on the next-gen Switch 2 console either. 

Donkey Kong Country will expand the park size by up to 70 percent, Nintendo said when it was announced. Current attractions at the Japan park are the Mario Kart: Kuppa's Challenge rollercoaster and Yoshi Adventure. Nintendo recently announced that it would open a Super Nintendo World attraction at Universal Studios Orlando on May 22nd, 2025 with the same attractions as the park in Osaka. 

This article originally appeared on Engadget at https://www.engadget.com/gaming/nintendo/nintendo-will-show-off-donkey-kong-country-theme-park-expansion-at-live-event-today-130015655.html?src=rss




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A TV show about EA Sports' Madden games hits Prime Video on November 26

Madden NFL has been around for almost 40 years (really) so it’s high time the gaming franchise got the documentary treatment. Prime Video has got you covered. The platform just announced that It’s in the Game: Madden NFL will stream on November 26, which is just ahead of Thanksgiving.

The four-part docuseries will explore “one of the biggest video games of all time” that “became a worldwide phenomenon, spanning generations.” The show will explore Madden’s “archaic 8-bit origins to its success as an annual must have.” Prime Video says EA Sports has given it access to the vaults, so there should be plenty of new footage for diehard fans.

As the story goes, EA founder Trip Hawkins approached commentator John Madden back in 1984 for his endorsement and expertise, but the game took four long years of development before coming out in 1988. This extended development time was allegedly due to Madden himself, who demanded a realistic football experience. I’m sure the documentary will get into all of that.

Formerly known as John Madden Football, the franchise became an annual event in 1990 and changed its name to Madden NFL in 1993. These games have sold over 130 million copies worldwide since 1988. The latest iteration, Madden NFL 25, released back in August to fairly middling reviews.

This article originally appeared on Engadget at https://www.engadget.com/entertainment/tv-movies/a-tv-show-about-ea-sports-madden-games-hits-prime-video-on-november-26-194833398.html?src=rss




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Big picture show catches on

A RUSH is on to convert the nation’s mothballed wheat silos into the world’s biggest art gallery.