Paytm plans to double down on existing categories like payments, content and gaming and push usage in Tier 3 and 4 geographies.

The post Financial services, gaming strategies to keep Paytm relevant in current times, says CEO appeared first on DealStreetAsia.

At 24 per cent of Indonesia’s GDP, the country’s logistics costs are among the highest in Southeast Asia.

The post Current challenges in Indonesian logistics sector throw up opportunities appeared first on DealStreetAsia.

Person registered under GST proprietorship firm but Rent from house property to an individual it is taxable under Gst?

You may have form the idea that celebrities are the trendiest person ever, no matter their dressing-up or making-up. Thus keep an eye on what they look is a wise means to keep pace with trend. How to make themselves different from other...

Robert Jenrick says trial in Isle of Wight will inform decision making on technology

The pair have helped redefine the role over the past two seasons as Liverpool won the Champions League, Club World Cup and lead the Premier League this season.

Wood Ants Store Short- And Long-Term Memories on Different Sides of Their Brains  ScienceAlert

Brent Everett, he’s still at it and he just gets better and better looking yeah? He’s always been eye candy of the sweetest variety. With his piercing glance, his chiseled body and killer dick he’s a perfect spunky package. See more at Lucas Entertainment.

The post Lucas Entertainment: Brent Everett appeared first on QueerClick.

Dean of the Faculty Deborah Prentice will take office as Princeton University's provost on July 1, succeeding Provost David Lee. Lee has decided to return to full-time teaching and research after serving since 2013 as the University's second-ranking officer.

Since the Middle Ages, alchemists have sought to transmute elements, the most famous example being the long quest to turn lead into gold. Now, Princeton University theorists have proposed a different approach to this ancient ambition — just make one material behave like another. The researchers demonstrate that any two systems can be made to look alike, even if just for the smallest fraction of a second.

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

This report focuses on the development of children of Black immigrants in the United States, comparing against the outcomes for their peers in native-born and other immigrant families. It also compares these U.S. children to those in the United Kingdom, where there is a large Black immigrant population but a notably different policy context of reception.

Car-rental companies in Jamaica are facing a serious crush, with at least one medium player looking to shut down operations, and others, big and small, saying that they are barely holding on. The collapse in the vacation market and travel...

In this webinar, experts discuss barriers immigrant and LEP individuals face in accessing the WIA system, how a revitalized WIA could address these barriers, and the extent to which the current Senate Health, Education, Labor, and Pensions (HELP) Committee's WIA reauthorization proposal addresses these barriers.

Six young people joined STEP OUT 2014 and an outreach in the Philippines to challenge their comfort zones, and they were not disappointed.

Since 2005, Rachel Chua (22) has been involved in TeenStreet Malaysia and she attended OCZ for the 2nd time this year. Her passion is contagious.

By Deborah Anderson

The power of unity and the diversity of the body of Christ was enjoyed during an outreach in El Salvador.

Mi 10 5G by Xiaomi has finally made its debut in India. The Xiaomi Mi 10 5G comes in two storage models and is offered in two colour options. Additionally, the phone packs the Qualcomm Snapdragon 865...

Idealist notions of the State overtaking the Market as the one in charge are unfounded.

By Abhinav Mukerji Recently, there have been a spate of news reports on measures issued through executive orders directing waiver of rents, reduction or freezing of school fees, continuation of employment, restriction on termination of employees, and restriction on reduction in salary in the wake of the Covid-19 pandemic. The government has also issued executive […]

With more than 49,000 positive Coronavirus cases in India, rolling out a vaccine has become a key focus for Indian scientists and researchers.

Amid massive exercises to contain the COVID-19 pandemic in Kerala, the state police on Saturday operated its rented helicopter to transport the heart of a brain dead patient from Thiruvananthapuram to...

Mainland professionals and middle class residents have found that a decision that was intended to make their life easier may well have backfired on them. Historically, many mainland couples have taken a trip to Hong Kong to have their children, due to…

From Shoppers Stop to Fujifilm and Nivea, brands take to social media to celebrate Mother’s Day

The possibility of producing shale gas in some European countries has triggered a very heated debate about the environmental and social impacts of the technique used to extract gas from shale rocks (today only in the US and Canada); this technique is widely known as hydraulic fracturing or fracking.

"The Chinese use two brush strokes to write the word 'crisis'. One brush stroke stands for danger; the other for opportunity. In a crisis, be aware of the danger, but recognise the opportunity," said former U.S. president John F. Kennedy.

On 1 December 2014 we are expecting legislation to come into force that will give effect to the new shared parental leave regime. The new regime will apply to employees in England, Scotland and Wales whose babies are due, or who will adopt a child, ...

In an important decision for landlords, Scottish & Newcastle plc v Raguz, the House of Lords has restored common sense and commercial reality to the procedures that a landlord has to follow before it can recover arrears of rent from a former t...

In our previous e-briefing, we discussed the advent, from 1 December 2008, of rules on abnormal rent increases. HM Revenue & Customs (HMRC) has acknowledged that the current rules do not work fairly and, in some cases, do not work at all. It is...

Eversheds Sutherland property column: March 2019 Over the last half decade, institutions and investors have become increasingly attracted by the dependable longterm income offered by large-scale professional residential letting. The way investors ac...

Lucas Leiva can recall a 16-year-old Trent Alexander-Arnold on a 'different level' and his belief early on that the full-back would become one of the best in the world. Lucas was an important member of the Reds squad around the time Alexander-Arnold started to gain a taste of life in first-team football in the 2015-16 and...

At a meeting this week the European Council agreed to extend the existing right for parents to take leave from work from three to four months per parent, per child. The European Council's decision comes as no surprise as t...

Today, a consultation has been launched on government plans to: Full Article