actor Barry Turner posing with his new tractor and grader By www.abc.net.au Published On :: Thu, 07 Mar 2019 15:03:00 +1100 Full Article ABC Broken Hill brokenhill Disasters and Accidents:Drought:All Rural:Rural Media:All Rural:Sustainable and Alternative Farming:All Science and Technology:Earth Sciences:All Australia:NSW:Broken Hill 2880
actor Ivanhoe truck and tractor show brings joy in hard times with visitors rolling into struggling outback town By www.abc.net.au Published On :: Thu, 10 Oct 2019 07:03:00 +1100 Locals are worried for the future of the small NSW town of Ivanhoe, but a colourful truck and tractor show brought in crowds about three times the size of its population. Full Article ABC Broken Hill brokenhill Community and Society:Community and Multicultural Festivals:All Rural:Agricultural Machinery:All Rural:Community Development:All Rural:Rural Tourism:All Australia:NSW:Broken Hill 2880
actor The comedian of COVID-19: Actor Sam Neill's 'cheering up' business By www.abc.net.au Published On :: Mon, 27 Apr 2020 04:46:01 +1000 Sam Neill says he's in the "cheering-up" business. Acting is his profession, winemaking is his passion and now in times of COVID-19, the 72-year-old is delighting the masses on social media. Full Article Film (Movies) Human Interest
actor 'Disobedient' contractor to blame for fatal hospital gas mix-up as company cleared By www.abc.net.au Published On :: Thu, 30 Apr 2020 15:56:44 +1000 A judge finds BOC Limited is not responsible for the actions of a "disobedient" contractor involved in a gas mix-up at Bankstown-Lidcombe Hospital that left a newborn baby dead. Full Article Infant Health Healthcare Facilities Courts and Trials Law Crime and Justice Community and Society Death Health Administration Health Healthcare Facilities Babies - Newborns
actor What happened behind the scenes of Australian Story's program on actor Sam Neill By www.abc.net.au Published On :: Fri, 01 May 2020 07:15:08 +1000 There's no fuss, no entourage and no star ego, writes producer Vanessa Gorman, on filming with Sam Neill. Full Article Arts and Entertainment Film (Movies) Journalism Information and Communication Television Broadcasting ABC Agriculture
actor Australian millet broom factory tries to resist sweeping changes in consumer culture By www.abc.net.au Published On :: Mon, 15 Jul 2019 16:18:00 +1000 Sixty years ago it would have been difficult to find a home in Australia without a millet broom. Now, as an industry dies around them, two men are refusing to be brushed aside by the passage of time. Full Article ABC Riverina riverina Arts and Entertainment:Design:Craft Community and Society:All:All Community and Society:History:All Human Interest:All:All Human Interest:People:All Rural:Agricultural Crops:All Australia:All:All Australia:NSW:Tumut 2720
actor Anne Phelan, acclaimed actor on Australian stages and screens, dies aged 71 By www.abc.net.au Published On :: Mon, 28 Oct 2019 20:09:00 +1100 Much-loved actor Anne Phelan, who featured in Australian TV programs including Bellbird and Prisoner, dies at the age of 71. The acclaimed actor was described as "simply one of the best humans". Full Article ABC Radio Melbourne melbourne Arts and Entertainment:All:All Arts and Entertainment:Film (Movies):Actor Arts and Entertainment:Film (Movies):All Community and Society:All:All Community and Society:Death:All Australia:All:All Australia:VIC:All Australia:VIC:Melbourne 3000
actor Young actors keeping it real in shock value road safety campaign By www.abc.net.au Published On :: Thu, 20 Aug 2015 17:29:00 +1000 Young actors made up to look like accident victims experience the life-changing process of getting into character as they aim to reduce the youth road toll. Warning: This story contains graphic imagery and content that may upset some people. Full Article ABC Local centralwest Community and Society:Death:All Community and Society:Grief:All Community and Society:Youth:All Disasters and Accidents:Accidents:Road Education:Community Education:All Education:Subjects:Safety Human Interest:All:All Rural:Community Development:All Rural:Rural Youth:All Community and Society:Relationships:All Community and Society:Regional:All Community and Society:Volunteers:All Health:safety:All Community and Society:Emotions:All Australia:NSW:Condobolin 2877 Australia:NSW:Forbes 2871 Australia:NSW:Lake Cargelligo 2672 Australia:NSW:Parkes 2870
actor German style house tells of migrant history of Orange's Electrolux factory By www.abc.net.au Published On :: Tue, 01 Sep 2015 11:56:00 +1000 A quirky, German-styled house at Orange in central west New South Wales tells of the city's heritage of migrants and their close ties with the Electrolux refrigeration factory. Full Article ABC Local centralwest Arts and Entertainment:Design:Architecture Community and Society:History:All Community and Society:Immigration:All Human Interest:Offbeat:All Lifestyle and Leisure:Gardening:Architectural Lifestyle and Leisure:Lifestyle:House and Home Australia:NSW:Orange 2800
actor Factory By www.abc.net.au Published On :: Fri, 10 May 2019 18:54:00 +1000 Full Article ABC Ballarat ballarat milduraswanhill southwestvic melbourne Community and Society:All:All Community and Society:Family and Children:All Community and Society:Indigenous (Other Peoples):All Education:Bullying:All Health:All:All Health:Men's Health:All Health:Mental Health:All Human Interest:All:All Human Interest:People:All Lifestyle and Leisure:All:All Sport:All:All Australia:VIC:Ballarat 3350 Australia:VIC:Robinvale 3549 Australia:VIC:Terang 3264 Australia:VIC:Torquay 3228 Australia:VIC:Warrnambool 3280
actor Vintage tractor collection goes to auction in the Victorian Otways as owner retires By www.abc.net.au Published On :: Thu, 07 Nov 2019 10:23:00 +1100 'You don't have to be a scientist to work on them': Vintage tractors, some more than 80-years-old go under the hammer, attracting buyers from around Australia. Full Article ABC Ballarat ballarat melbourne westernvic Business Economics and Finance:Industry:Automotive Rural:Agricultural Machinery:All Rural:All:All Rural:Crop Harvesting:All Australia:VIC:Colac 3250 Australia:VIC:Geelong 3220 Australia:VIC:Gellibrand 3239
actor 'I cannot think of a more tragic case': Contractor fined over fatal hospital gas bungle By www.abc.net.au Published On :: Fri, 08 May 2020 15:17:38 +1000 Christopher Turner, the contractor responsible for a gas mix-up that poisoned two newborns with nitrous oxide at a Sydney hospital, is convicted and fined $100,000. Full Article Law Crime and Justice Courts and Trials Health Infant Health Health Policy Healthcare Facilities Children
actor Chiropractor who indecently filmed hundreds of clients at Adelaide clinic faces victim in court By www.abc.net.au Published On :: Fri, 27 Sep 2019 20:01:00 +1000 One of hundreds of victims of an Adelaide chiropractor who indecently filmed clients, including children, says the man took away her "dignity" and "confidence", but has vowed to move on with her life. Full Article ABC Radio Adelaide adelaide Law Crime and Justice:All:All Law Crime and Justice:Courts and Trials:All Law Crime and Justice:Crime:All Law Crime and Justice:Sexual Offences:All Australia:All:All Australia:SA:Adelaide 5000 Australia:SA:All Australia:SA:Rostrevor 5073
actor A factory has been engulfed in flames in Kewdale By www.abc.net.au Published On :: Thu, 06 Jun 2019 16:04:00 +1000 Full Article ABC Local perth Disasters and Accidents:Fires:Industrial Australia:WA:Kewdale 6105
actor Australian actor Paul Cronin dies aged 81 By www.abc.net.au Published On :: Sat, 14 Sep 2019 14:21:00 +1000 Full Article 639 ABC North and West northandwest Arts and Entertainment:Film (Movies):Actor Australia:SA:Jamestown 5491
actor Paul Cronin, celebrated Australian actor who helped set up Brisbane Bears, dies aged 81 By www.abc.net.au Published On :: Sat, 14 Sep 2019 16:23:00 +1000 The actor, who became an Australian household name through shows such as The Sullivans and Matlock Police, won five silver Logies and also helped set up Brisbane's first AFL team. Full Article 639 ABC North and West brisbane northandwest melbourne Arts and Entertainment:All:All Arts and Entertainment:Television:All Community and Society:All:All Community and Society:Death:All Australia:QLD:All Australia:QLD:Brisbane 4000 Australia:SA:All Australia:SA:Jamestown 5491 Australia:VIC:All Australia:VIC:Melbourne 3000
actor Nuclear reactor and steelworks plan once considered for pristine beaches of Jervis Bay By www.abc.net.au Published On :: Mon, 12 Aug 2019 14:13:00 +1000 Jervis Bay one of Australia's world-renowned coastal tourist hotspots, celebrated for its idyllic white beaches, nearly became home to Australia's first nuclear power plant. Full Article 1233 ABC Newcastle canberra illawarra newcastle Community and Society:History:All Environment:Alternative Energy:Nuclear Energy Environment:Environmental Policy:All Environment:Nuclear Issues:All Government and Politics:Federal - State Issues:All Australia:ACT:Canberra 2600 Australia:ACT:Jervis Bay 2540 Australia:NSW:Newcastle 2300 Australia:NSW:Nowra 2541 Australia:NSW:University of Newcastle 2308 Australia:NSW:Wollongong 2500
actor Australian actor Ningali Lawford-Wolf dies on tour aged 52 By www.abc.net.au Published On :: Wed, 14 Aug 2019 23:53:00 +1000 Australian Indigenous actor Ningali Lawford-Wolf dies at the age of 52 in Edinburgh, Scotland, while touring with the stage production of The Secret River. Full Article ABC Kimberley sydney adelaide kimberley Arts and Entertainment:Theatre:All Business Economics and Finance:Industry:Film Community and Society:Death:All Community and Society:Indigenous (Aboriginal and Torres Strait Islander):Aboriginal Community and Society:Indigenous (Aboriginal and Torres Strait Islander):Indigenous Culture Australia:NSW:Sydney 2000 Australia:SA:Edinburgh 5111 Australia:WA:Broome 6725 Australia:WA:Fitzroy Crossing 6765 Australia:WA:Kununurra 6743
actor Latrobe Valley workers' co-op opens own factory in a bid to create new jobs By www.abc.net.au Published On :: Mon, 10 Jun 2019 06:41:00 +1000 Since the privatisation of Victoria's coal-fired power stations in the 1990s, the Latrobe Valley has struggled with high unemployment. But a workers' group has decided not to wait around for new jobs to appear. Full Article ABC Gippsland gippsland Business Economics and Finance:Industry:All Business Economics and Finance:Industry:Coal Business Economics and Finance:Industry:Electricity Energy and Utilities Environment:All:All Environment:Alternative Energy:All Environment:Alternative Energy:Solar Energy Australia:VIC:Moe 3825 Australia:VIC:Morwell 3840 Australia:VIC:Newborough 3825 Australia:VIC:Yallourn North 3825
actor Adani engineering contractor GHD pushed into 'crisis mode', say some staff, after protests over Carmichael coal mine involvement By www.abc.net.au Published On :: Thu, 24 Oct 2019 10:59:00 +1100 Leaks from one of Adani's most significant contractors for its Carmichael coal mine, engineering firm GHD, show it has been rocked by internal dissent and management has been bombarded with complaints and questions about its work on the mine. Full Article ABC North Queensland northqld Business Economics and Finance:All:All Business Economics and Finance:Industry:Coal Environment:All:All Environment:Environmental Impact:All Australia:QLD:All Australia:QLD:Bowen 4805
actor Bilba Group pipe factory By www.abc.net.au Published On :: Tue, 08 Oct 2019 15:23:00 +1100 Full Article ABC Radio Darwin darwin Rural:Agribusiness:All Rural:All:All Australia:NT:Darwin 0800
actor NT writer, director and actor Trisha Morton-Thomas on travelling to Cannes Film Festival By www.abc.net.au Published On :: Mon, 04 Nov 2019 18:57:00 +1100 From Crocodile Dundee to Baz Luhrmann's Australia, Northern Territory landscapes have featured on the international stage, but it has been mainly 'outsiders' who have had the resources to produce films in the Territory. Full Article ABC Radio Darwin alicesprings darwin Arts and Entertainment:All:All Arts and Entertainment:Film (Movies):All Arts and Entertainment:Film (Movies):Director Australia:All:All Australia:NT:Alice Springs 0870 Australia:NT:All Australia:NT:Darwin 0800
actor Lawn mowing contractor dies after car explosion in Cairns By www.abc.net.au Published On :: Wed, 21 Aug 2019 17:46:00 +1000 Witnesses say neighbours tried in vain to rescue a man from a burning vehicle after the ute exploded on a Cairns street, describing the scene as "horrific". Full Article ABC Far North farnorth Disasters and Accidents:Accidents:All Disasters and Accidents:Accidents:Workplace Australia:QLD:All Australia:QLD:Cairns 4870 Australia:QLD:Edmonton 4869
actor Maurice on Tractor By www.abc.net.au Published On :: Fri, 26 Jul 2019 19:02:00 +1000 Full Article ABC Central West NSW centralwest Australia:NSW:Bribbaree 2594
actor Contractors' State Licensing Board v. Superior Court (Black Diamond Electric, Inc.) By feeds.findlaw.com Published On :: 2018-10-29T08:00:00+00:00 (California Court of Appeal) - Held that an electrical contractor could not proceed with its lawsuit challenging a state licensing board's disciplinary decision, because the contractor was required to exhaust its administrative remedies before filing suit. Granted the licensing board's petition for a writ of mandate. Full Article Government Law Construction
actor ACCO Engineered Systems, Inc. v. Contractors' State License Board By feeds.findlaw.com Published On :: 2018-12-15T08:00:00+00:00 (California Court of Appeal) - Upheld a decision of the Contractors' State License Board finding that a large contracting company violated California law by failing to obtain a building permit before replacing a boiler. Affirmed the denial of the company's writ petition. Full Article Construction
actor A.J. Fistes Corp. v. GDL Best Contractors, Inc. By feeds.findlaw.com Published On :: 2019-08-13T08:00:00+00:00 (California Court of Appeal) - Reversed and remanded. The trial court sustained the Defendant’s demurrer without leave to amend to Plaintiff’s third amended complaint. The appellate court held that Plaintiff made a sufficient showing for leave to amend and directed Plaintiff to amend their complaint consistent with this opinion. Full Article Government Law Civil Procedure
actor Payton v. CSI Electrical Contractors, Inc. By feeds.findlaw.com Published On :: 2018-09-28T08:00:00+00:00 (California Court of Appeal) - Affirmed the denial of class certification in an action alleging wage and hour violations, finding substantial evidence that individual questions would predominate and also that the named plaintiff was not an adequate class representative. Full Article Class Actions Labor & Employment Law
actor Brian Dennehy, Tony-winning stage, screen actor, dies at 81 By feeds.denverpost.com Published On :: Thu, 16 Apr 2020 21:01:13 +0000 Brian Dennehy, the burly actor who started in films as a macho heavy and later in his career won plaudits for his stage work in plays by William Shakespeare, Anton Chekhov, Eugene O’Neill and Arthur Miller, has died. He was 81. Full Article Entertainment Latest News Obituaries Television celebrity deaths
actor Brian Dennehy, Tony-winning stage, screen actor, dies at 81 By www.denverpost.com Published On :: Thu, 16 Apr 2020 21:01:13 +0000 Brian Dennehy, the burly actor who started in films as a macho heavy and later in his career won plaudits for his stage work in plays by William Shakespeare, Anton Chekhov, Eugene O’Neill and Arthur Miller, has died. He was 81. Full Article Entertainment Latest News Obituaries Television celebrity deaths
actor Denver Actors Fund readies $35,000 in immediate funding for shut-out theater pros By feeds.denverpost.com Published On :: Wed, 25 Mar 2020 15:09:22 +0000 The Denver Actors Fund on Tuesday announced a $35,000 emergency relief fund for Colorado theater artists who have been hurt by the coronavirus shutdown. Full Article Entertainment Latest News Theater coronavirus economic impact of coronavirus The Know theater
actor “Exorcist” actor Max von Sydow dies at age 90 By www.denverpost.com Published On :: Mon, 09 Mar 2020 15:00:53 +0000 Max von Sydow, the self-described “shy boy”-turned-actor known to art house audiences through his work with Swedish director Ingmar Bergman and later to moviegoers everywhere when he played the priest in the horror classic “The Exorcist,” has died. He was 90. Full Article Entertainment Latest News Movies News Obituaries Television celebrity deaths
actor Vivica Fox On How Hollywood Has Changed For Black Actors By feeds.bet.com Published On :: Tue, 28 Apr 2020 11:09:00 EDT The actress has seen an evolution for the good. Full Article Celebrity News
actor Black Actors to Watch in 2016 By feeds.bet.com Published On :: Fri, 8 Jan 2016 12:17:00 EST #StayWoke! These actors are about to break records. Full Article BET Star Cinema
actor #WillSmithSoGreat: The Actor's Impact on Hollywood By feeds.bet.com Published On :: Fri, 5 Feb 2016 11:49:00 EST "I-Robot" premieres on BET on Saturday, February 6 at 7P/6C. Full Article BET Star Cinema
actor Which Actor Should Play Pres. Obama In a Biopic? By feeds.bet.com Published On :: Fri, 12 Feb 2016 16:00:00 EST Not sure who could pull this one off. Full Article BET Star Cinema
actor 5 Black Actors We Need to Know More About By feeds.bet.com Published On :: Fri, 11 Mar 2016 16:58:00 EST Our interest is peeked! Full Article BET Star Cinema
actor 10 Powerful Quotes From Black Actor-vists By feeds.bet.com Published On :: Fri, 1 Jul 2016 09:45:00 EDT Jesse Williams isn't the only one dropping gems. Full Article BET Star Cinema
actor Top 25 Greatest Black Actors By feeds.bet.com Published On :: Mon, 13 Feb 2017 08:00:00 EST These men are just 'flawless' on the big screen. Full Article BET Star Cinema
actor Bermudian Actor Reflects On Motown Role By bernews.com Published On :: Sun, 22 Jun 2014 10:46:06 +0000 With the tour of hit show “Motown the Musical” recently kicking off in Chicago, Illinois, Bermudian actor Nicholas Christopher, a member of the show’s original cast who is currently playing Smokey Robinson in the production, was interviewed by Broadway World about growing up in Bermuda, the role that Motown-era music played in his upbringing, and […](Click to read the full article) Full Article All Entertainment Music #ActorsTheatre #GoodNews #NicholasChristopher
actor Actor Herbert Plays Historic Role In Production By bernews.com Published On :: Thu, 19 Feb 2015 12:15:07 +0000 Bermudian actor Daren A. Herbert is getting set to take on the role of Burrs, a vaudeville performer who makes his living in blackface, in a Toronto-based production of the musical ‘The Wild Party’. The Toronto production is casting — for the first time, to anyone’s knowledge — a black actor in the role, according […](Click to read the full article) Full Article All Entertainment News #ActorsTheatre #DarenAHerbert #GoodNews
actor the actor and the bishop By www.oglaf.com Published On :: Sun, 26 Feb 2017 00:00:00 +0000 Full Article
actor Factors affecting female bear harvest rates By feedproxy.google.com Published On :: Wed, 29 Jan 2020 17:00:40 EST Examining the factors that affect the number of females being harvested during the bear hunting season will help Pennsylvania wildlife officials manage population. Full Article
actor Utah Pulls Plug On Surveillance Contractor After CEO's Past As A White Supremacist Surfaces By www.techdirt.com Published On :: Thu, 7 May 2020 13:53:02 PDT A couple of months ago, a records request revealed a private surveillance contractor had access to nearly every piece of surveillance equipment owned and operated by the state of Utah. Banjo was the company with its pens in all of the state's ink. Banjo's algorithm ran on top of Utah's surveillance gear: CCTV systems, 911 services, location data for government vehicles, and thousands of traffic cameras. All of this was run through Banjo's servers, which are conveniently located in Utah government buildings. Banjo's offering is of the predictive policing variety. The CEO claims its software can "find crime" without any collateral damage to privacy. This claim is based on the "anonymization" of harvested data -- a term that is essentially meaningless once enough data is collected. This partnership is now on the rocks, thanks to an investigation by Matt Stroud and OneZero. Banjo's CEO, Damien Patton, apparently spent a lot of his formative years hanging around with white supremacists while committing crimes. In grand jury testimony that ultimately led to the conviction of two of his associates, Patton revealed that, as a 17-year-old, he was involved with the Dixie Knights of the Ku Klux Klan. On the evening of June 9, 1990 — a month before Patton turned 18 — Patton and a Klan leader took a semi-automatic TEC-9 pistol and drove to a synagogue in a Nashville suburb. With Patton at the wheel, the Ku Klux Klan member fired onto the synagogue, destroying a street-facing window and spraying bullets and shattered glass near the building’s administrative offices, which were next to that of the congregation’s rabbi. No one was struck or killed in the shooting. Afterward, Patton hid on the grounds of a white supremacist paramilitary training camp under construction before fleeing the state with the help of a second Klan member. If you're wondering where the state of Utah's due diligence is in all of this, there's a partial explanation for this lapse: the feds, who brought Patton in, screwed up on their paperwork. Because Patton’s name was misspelled in the initial affidavit of probable cause filed in Brown’s case — an FBI agent apparently spelled Damien with an “o” rather than an “e” — any search of a federal criminal court database for “Damien Patton” would not have surfaced the affidavit. Now that his past has been exposed, the state of Utah has announced it won't be working with Banjo. The Utah attorney general’s office will suspend use of a massive surveillance system after a news report showed that the founder of the company behind the effort was once an active participant in a white supremacist group and was involved in the shooting of a synagogue. The AG's office can only shut down so much of Banjo's surveillance software. Other government agencies not directly controlled by the state AG are making their own judgment calls. The University of Utah is suspending its contract with Banjo, but the state's Department of Public Safety has only gone so far as to "launch a review" of its partnership with the company. City agencies and a number of police departments who have contracts with Banjo have yet to state whether they will be terminating theirs. And the AG's reaction isn't a ban. The office appears to believe it might be able to work through this. “While we believe Mr. Patton’s remorse is sincere and believe people can change, we feel it’s best to suspend use of Banjo technology by the Utah attorney general’s office while we implement a third-party audit and advisory committee to address issues like data privacy and possible bias,” Piatt said. “We recommend other state agencies do the same.” It's refreshing to hear a prosecutor state that it's possible for former criminals to turn their lives around and become positive additions to their communities, but one gets the feeling this sort of forgiveness is only extended to ex-cons who have something to offer law enforcement agencies. Everyone else is just their rap sheet for forever, no matter how many years it's been since their last arrest. The other problem here is the DA's office's tacit admission it did not take data privacy or possible bias into account before granting Banjo access to the state's surveillance equipment, allowing it to set up servers in government buildings, and giving it free rein to dust everything with its unaudited AI pixie dust. These are all steps that should have taken place before any of this was implemented, even if the state had chosen to do business with a company with a less controversial CEO. This immediate reaction is the right step to take, but a little proactivity now and then would be a welcome change. Full Article
actor From Playing Games to Committing Crimes: A Multi-Technique Approach to Predicting Key Actors on an Online Gaming Forum By www.lightbluetouchpaper.org Published On :: Mon, 27 Jan 2020 15:01:00 +0000 I recently travelled to Pittsburgh, USA, to present the paper “From Playing Games to Committing Crimes: A Multi-Technique Approach to Predicting Key Actors on an Online Gaming Forum” at eCrime 2019, co-authored with Ben Collier and Alice Hutchings. The accepted version of the paper can be accessed here. The structure and content of various underground … Continue reading From Playing Games to Committing Crimes: A Multi-Technique Approach to Predicting Key Actors on an Online Gaming Forum → Full Article Academic papers Cybercrime
actor Retrograde nerve growth factor signaling abnormalities in familial dysautonomia By www.jci.org Published On :: Familial dysautonomia (FD) is the most prevalent form of hereditary sensory and autonomic neuropathy (HSAN). In FD, a germline mutation in the Elp1 gene leads to Elp1 protein decrease that causes sympathetic neuron death and sympathetic nervous system dysfunction (dysautonomia). Elp1 is best known as a scaffolding protein within the nuclear hetero-hexameric transcriptional Elongator protein complex, but how it functions in sympathetic neuron survival is very poorly understood. Here, we identified a cytoplasmic function for Elp1 in sympathetic neurons that was essential for retrograde nerve growth factor (NGF) signaling and neuron target tissue innervation and survival. Elp1 was found to bind to internalized TrkA receptors in an NGF-dependent manner, where it was essential for maintaining TrkA receptor phosphorylation (activation) by regulating PTPN6 (Shp1) phosphatase activity within the signaling complex. In the absence of Elp1, Shp1 was hyperactivated, leading to premature TrkA receptor dephosphorylation, which resulted in retrograde signaling failure and neuron death. Inhibiting Shp1 phosphatase activity in the absence of Elp1 rescued NGF-dependent retrograde signaling, and in an animal model of FD it rescued abnormal sympathetic target tissue innervation. These results suggest that regulation of retrograde NGF signaling in sympathetic neurons by Elp1 may explain sympathetic neuron loss and physiologic dysautonomia in patients with FD. Full Article
actor (H)Elping nerve growth factor: Elp1 inhibits TrkA’s phosphatase to maintain retrograde signaling By www.jci.org Published On :: Nerve growth factor (NGF) regulates many aspects of neuronal biology by retrogradely propagating signals along axons to the targets of those axons. How this occurs when axons contain a plethora of proteins that can silence those signals has long perplexed the neurotrophin field. In this issue of the JCI, Li et al. suggest an answer to this vexing problem, while exploring why the Elp1 gene that is mutated in familial dysautonomia (FD) causes peripheral neuropathy. They describe a distinctive function of Elp1 as a protein that is required to sustain NGF signaling by blocking the activity of its phosphatase that shuts off those signals. This finding helps explain the innervation deficits prominent in FD and reveals a unique role for Elp1 in the regulation of NGF-dependent TrkA activity. Full Article
actor The neonatal microenvironment programs innate γδ T cells through the transcription factor STAT5 By www.jci.org Published On :: IL-17–producing RORγt+ γδ T cells (γδT17 cells) are innate lymphocytes that participate in type 3 immune responses during infection and inflammation. Herein, we show that γδT17 cells rapidly proliferate within neonatal lymph nodes and gut, where, upon entry, they upregulate T-bet and coexpress IL-17, IL-22, and IFN-γ in a STAT3- and retinoic acid–dependent manner. Neonatal expansion was halted in mice conditionally deficient in STAT5, and its loss resulted in γδT17 cell depletion from all adult organs. Hyperactive STAT5 mutant mice showed that the STAT5A homolog had a dominant role over STAT5B in promoting γδT17 cell expansion and downregulating gut-associated T-bet. In contrast, STAT5B preferentially expanded IFN-γ–producing γδ populations, implying a previously unknown differential role of STAT5 gene products in lymphocyte lineage regulation. Importantly, mice lacking γδT17 cells as a result of STAT5 deficiency displayed a profound resistance to experimental autoimmune encephalomyelitis. Our data identify that the neonatal microenvironment in combination with STAT5 is critical for post-thymic γδT17 development and tissue-specific imprinting, which is essential for infection and autoimmunity. Full Article
actor Not Just the End of IT, the End of IT Contractors By www.cringely.com Published On :: Mon, 30 Mar 2020 20:10:12 +0000 Earlier this week I predicted the demise of conventional IT caused by the wide adoption of SD-WAN and SASE, accelerated by the emergency demands of everyone working from home. Now that Congress has passed a $2.2 trillion COVID-19 bail-out, let’s throw-in the implications of that legislation to see what effect it is all likely to have on what used to be IT. The short version is to expect an even bigger bloodbath as IT employees at all levels are let go forever. Please understand that some version of this bloodbath was going to happen anyway. What matters right now is how we respond to it. While my previous column was generally about turning lower-level IT nerds into Uber drivers, this one goes a little further […] Digital Branding Web Design Marketing Full Article 2020 cloud computing computer networks Predictions strategy COVID-19 economics IBM recession SASE SD-WAN
actor Actors By fun-movie-trivia.blogspot.com Published On :: Wed, 09 Oct 2013 16:04:00 +0000 Full Article Filmmaking Terms