urea

Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus

RSC Med. Chem., 2024, 15,3395-3417
DOI: 10.1039/D4MD00334A, Research Article
Vu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh Thanh
D-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.
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Rational design and in vitro testing of new urease inhibitors to prevent urinary catheter blockage

RSC Med. Chem., 2024, 15,3597-3608
DOI: 10.1039/D4MD00378K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Rachel A. Heylen, Nicola Cusick, Tom White, Emily J. Owen, Bethany L. Patenall, Martin Alm, Peter Thomsen, Maisem Laabei, A. Toby A. Jenkins
In silico identification of urease inhibitors based on thiourea, tested to determine IC50 and tested on a catheterised in vitro bladder model, showing efficacy in reducing catheter blockage.
The content of this RSS Feed (c) The Royal Society of Chemistry




urea

Telangana Cyber Security Bureau conducts digital awareness campaign for senior citizens




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Telangana State Cyber Security Bureau nabbed 165 cyber criminals involved in 795 cases in last six months

45% fraudsters are either graduates or post-graduates; indulge in crime due to peer pressure and for easy money, says data




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Reaction of unsymmetrical α-bromo-1,3-diketones with N-substituted thioureas: regioselective access to 2-(N-arylamino)-5-acyl-4-methylthiazoles and/or rearranged 2-(N-acylimino)-3-N-aryl-4-methylthiazoles

RSC Adv., 2024, 14,35585-35600
DOI: 10.1039/D4RA05436A, Paper
Open Access
Ranjana Aggarwal, Shilpa Sharma, Naman Jain, Dionisia Sanz, Rosa M. Claramunt, Patricia Delgado, M. Carmen Torralba
Hantzsch's [3 + 2] cyclic condensation of α-bromo-1,3-diketones with N-substituted thioureas.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Accelerating the reaction kinetics of Ni1−xO/Ni(OH)2/NF by defect engineering for urea-assisted water splitting

Dalton Trans., 2024, Advance Article
DOI: 10.1039/D4DT02871F, Paper
Yuan Rui, Zong Li, Miaohui Wang, Yunxia Liu, Haiping Lin, Peipei Huang, Qing Li
The reaction kinetics of Ni1-xO/Ni(OH)2/NF are accelerated through a defect engineering strategy by combining Zn doping and acid etching, leading to improved intrinsic activities for UOR.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Nobel laureate Geim urges young scientists to embrace curiosity and break routine

Prof Geim addressed the 15th Convocation of Hindustan Institute of Technology and Science (HITS).




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Bis-thiourea and macrocyclic polyamines as binary organocatalysts for the ROP of lactide

Catal. Sci. Technol., 2024, Advance Article
DOI: 10.1039/D4CY00952E, Paper
Open Access
Assunta D'Amato, Maria Voccia, Filippo Bruno, Sara D'Aniello, Lucia Caporaso, Francesco De Riccardis, Irene Izzo, Giorgio Della Sala, Mina Mazzeo
New binary catalysts formed by a bis-thiourea and a series of flexible polyaza-macrocycles are revealed to be efficient catalysts for the ring opening polymerization (ROP) of L-lactide.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Nobel Laureates Paul D. Boyer and Jens C. Skou die at 99

Biochemists were two of three who shared 1997 prize for work related to adenosine triphosphate




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Nobel laureates Jens C. Skou and Paul D. Boyer die at 99

Biochemists were two of three who shared 1997 prize for work related to adenosine triphosphate




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Synthesis of axially chiral thiourea by NHC-catalyzed desymmetrizative amidation

Green Chem., 2024, 26,10940-10949
DOI: 10.1039/D4GC03113J, Paper
Yingtao Wu, Xin Guan, Kehan Jiao, Huaqiu Zhao, Mingrui Li, Jiaqiong Sun, Guangfan Zheng, Qian Zhang
NHC-catalyzed desymmetrization amidation of biaryl dialdehydes has been developed for NH-free axially chiral thiourea. Sequential kinetic resolution enhances the chirality induction of the desymmetrization strategy, expanding the applicable scope.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Engineering high-valence nickel sites in Ni3S2/Ni3Se2 architectures enabling urea-assisted hydrogen evolution reactions

Green Chem., 2024, Advance Article
DOI: 10.1039/D4GC04318A, Paper
Taotao Ai, Miaomiao Bai, Weiwei Bao, Jie Han, Xueling Wei, Xiangyu Zou, Jungang Hou, Lizhai Zhang, Zhifeng Deng, Yuxin Zhang
Bifunctional Ni3S2@Ni3Se2 electrocatalysts were constructed for urea-assisted hydrogen evolution. In the HER/UOR two-electrode system, the heterogeneous interface modulates the electronic structure and thus improves the catalytic performance.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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urea

(B,P,Co,Fe)-Ni Modified on Nanowood for Boosting Seawater Urea Electro-Oxidation

Green Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4GC05156D, Paper
Hongjiao Chen, Kewei Zhang, Yanzhi Xia, Jian Li, Bin Hui
Coupling urea oxidation reaction (UOR) and hydrogen evolution reaction (HER) in seawater is desirable to produce sustainable and green hydrogen due to the reduced energy consumption. However, developing high-performance UOR/HER...
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Crystalline/amorphous c-NiMo/a-NiMoOx nanoarrays for urea-assisted energy-saving H2 production in alkaline seawater

Green Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4GC05042H, Paper
Dongxue Guo, Yi Ping, Chuanjiao Wang, Changan Hou, Danhong Wang
Electrocatalytic seawater splitting is regarded as the most effective method for producing green hydrogen (H2), but it faces issues of high energy consumption and harmful chlorine evolution side reactions. Replacing...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Bureaucrat-turned-politician Zende is NCP candidate in Purandar friendly fight




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Indians’ foreign visa obsession: From bureaucrats’ kids to Gulf workers, why is talent leaving?




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Weather Warnings for South Australia. Issued by the Australian Bureau of Meteorology




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Weather Warnings for South Australia - marine areas. Issued by the Australian Bureau of Meteorology




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Weather Warnings for Tasmania - land areas. Issued by the Australian Bureau of Meteorology




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Which one of Abhijit Banerjee’s Twitter profiles is real? Nobel laureate economist answers

Several noted personalities such as Ramchandra Guha, Mahua Moitra, among others have now said that the Indian-origin economist does not have any Twitter profile.




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As States Race to Woo MNCs Shifting Out of China, Will Beaureacuracy Rise to Occasion?

The Prime Minister Narendra Modi-led government is of the opinion that the negative image of China in the international community may help in getting investment worth Rs 25 lakh crore, if the cards are played well.





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As States Race to Woo MNCs Shifting Out of China With Labour Reforms, Will Beaureacuracy Rise to Occasion?

The Prime Minister Narendra Modi-led government is of the opinion that the negative image of China in the international community may help in getting investment worth Rs 25 lakh crore, if the cards are played well.





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As States Race to Woo MNCs Shifting Out of China, Will Beaureacuracy Rise to Occasion?

The Prime Minister Narendra Modi-led government is of the opinion that the negative image of China in the international community may help in getting investment worth Rs 25 lakh crore, if the cards are played well.







urea

As States Race to Woo MNCs Shifting Out of China, Will Beaureacuracy Rise to Occasion?

The Prime Minister Narendra Modi-led government is of the opinion that the negative image of China in the international community may help in getting investment worth Rs 25 lakh crore, if the cards are played well.




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Weather Warnings for New South Wales / Australian Capital Territory - land areas. Issued by the Australian Bureau of Meteorology




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Weather Warnings for Australian Capital Territory. Issued by the Australian Bureau of Meteorology




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Top bureaucrat sustains minor injuries in accident

Top bureaucrat sustains minor injuries in accident




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Punjab Vigilance Bureau ties up with District Administration to combat COVID-19




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The synthesis and crystal structure of bis­[3,3-diethyl-1-(phenyl­imino-κN)thio­urea-κS]silver hexa­fluorido­phosphate

The structure of the title complex, [Ag(C11H15N3S)2]PF6, has monoclinic (P21/c) symmetry, and the silver atom has a distorted square-planar geometry. The coordination complex crystallized from mixing silver hexa­fluorido­phosphate with a concentrated tetra­hydro­furan solution of N,N-di­ethyl­phenyl­azo­thio­formamide [ATF; systematic name: 3,3-diethyl-1-(phenyl­imino)­thio­urea] under ambient conditions. The resultant coordination complex exhibits a 2:1 ligand-to-metal ratio, with the silver(I) atom having a fourfold AgN2S2 coordination sphere, with a single PF6 counter-ion. In the crystal, however, one sulfur atom from an ATF ligand of a neighboring complex coordinates to the silver atom, with a bond distance of 2.9884 (14) Å. This creates a polymeric zigzag chain propagating along the c-axis direction. The chains are linked by C—H⋯F hydrogen bonds, forming slabs parallel to the ac plane.




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3,3-Bis(2-hy­droxy­eth­yl)-1-(4-methyl­benzoyl)thio­urea: crystal structure, Hirshfeld surface analysis and computational study

In the title tri-substituted thio­urea derivative, C13H18N2O3S, the thione-S and carbonyl-O atoms lie, to a first approximation, to the same side of the mol­ecule [the S—C—N—C torsion angle is −49.3 (2)°]. The CN2S plane is almost planar (r.m.s. deviation = 0.018 Å) with the hy­droxy­ethyl groups lying to either side of this plane. One hy­droxy­ethyl group is orientated towards the thio­amide functionality enabling the formation of an intra­molecular N—H⋯O hydrogen bond leading to an S(7) loop. The dihedral angle [72.12 (9)°] between the planes through the CN2S atoms and the 4-tolyl ring indicates the mol­ecule is twisted. The experimental mol­ecular structure is close to the gas-phase, geometry-optimized structure calculated by DFT methods. In the mol­ecular packing, hydroxyl-O—H⋯O(hydrox­yl) and hydroxyl-O—H⋯S(thione) hydrogen bonds lead to the formation of a supra­molecular layer in the ab plane; no directional inter­actions are found between layers. The influence of the specified supra­molecular inter­actions is apparent in the calculated Hirshfeld surfaces and these are shown to be attractive in non-covalent inter­action plots; the inter­action energies point to the important stabilization provided by directional O—H⋯O hydrogen bonds.




urea

3,3-Bis(2-hy­droxy­eth­yl)-1-(4-nitro­benzo­yl)thio­urea: crystal structure, Hirshfeld surface analysis and computational study

In the title compound, C12H15N3O5S, a tris­ubstituted thio­urea derivative, the central CN2S chromophore is almost planar (r.m.s. deviation = 0.018 Å) and the pendant hy­droxy­ethyl groups lie to either side of this plane. While to a first approximation the thione-S and carbonyl-O atoms lie to the same side of the mol­ecule, the S—C—N—C torsion angle of −47.8 (2)° indicates a considerable twist. As one of the hy­droxy­ethyl groups is orientated towards the thio­amide residue, an intra­molecular N—H⋯O hydrogen bond is formed which leads to an S(7) loop. A further twist in the mol­ecule is indicated by the dihedral angle of 65.87 (7)° between the planes through the CN2S chromophore and the 4-nitro­benzene ring. There is a close match between the experimental and gas-phase, geometry-optimized (DFT) mol­ecular structures. In the crystal, O—H⋯O and O—H⋯S hydrogen bonds give rise to supra­molecular layers propagating in the ab plane. The connections between layers to consolidate the three-dimensional architecture are of the type C—H⋯O, C—H⋯S and nitro-O⋯π. The nature of the supra­molecular association has been further analysed by a study of the calculated Hirshfeld surfaces, non-covalent inter­action plots and computational chemistry, all of which point to the significant influence and energy of stabilization provided by the conventional hydrogen bonds.




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Crystal engineering of exemestane to obtain a co-crystal with enhanced urease inhibition activity

Co-crystallization is a phenomenon widely employed to enhance the physio-chemical and biological properties of active pharmaceutical ingredients (APIs). Exemestane, or 6-methyl­ideneandrosta-1,4-diene-3,17-dione, is an anabolic steroid used as an irreversible steroidal aromatase inhibitor, which is in clinical use to treat breast cancer. The present study deals with the synthesis of co-crystals of exemestane with thio­urea by liquid-assisted grinding. The purity and homogeneity of the exemestane–thio­urea (1:1) co-crystal were confirmed by single-crystal X-ray diffraction followed by thermal stability analysis on the basis of differential scanning calorimetry and thermogravimetric analysis. Detailed geometric analysis of the co-crystal demonstrated that a 1:1 co-crystal stoichiometry is sustained by N—H⋯O hydrogen bonding between the amine (NH2) groups of thio­urea and the carbonyl group of exemestane. The synthesized co-crystal exhibited potent urease inhibition activity in vitro (IC50 = 3.86 ± 0.31 µg ml−1) compared with the API (exemestane), which was found to be inactive, and the co-former (thio­urea) (IC50 = 21.0 ± 1.25 µg ml−1), which is also an established tested standard for urease inhibition assays in vitro. The promising results of the present study highlight the significance of co-crystallization as a crystal engineering tool to improve the efficacy of pharmaceutical ingredients. Furthermore, the role of various hydrogen bonds in the crystal stability is successfully analysed quantitatively using Hirshfeld surface analysis.




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catena-Poly[[[aquacopper(II)]-μ-(biphenyl-2,2'-dicarboxylato)-μ-[N,N'-bis(pyridin-4-yl)urea]] 1.25-hydrate]

In the title compound, {[Cu(C14H8O4)(C11H10N4O)(H2O)]·1.25H2O}n, the CuII cations are coordinated in a square-pyramidal fashion by trans carboxylate O-atom donors from two diphenate (dip) ligands, trans pyridyl N-atom donors from two bis(4-pyridyl)urea (bpu) ligands, and a ligated water molecule in the apical position. [Cu(H2O)(dip)(bpu)]n coordination polymer layer motifs are oriented parallel to (overline{1}02). These layer motifs display a standard (4,4) rectangular grid topology and stack in an AAA pattern along the a-axis direction to form the full three-dimensional crystal structure of the title compound, mediated by N—H...O and O—H...O hydrogen bonding patterns involving the water molecules of crystallization.




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NAS, NAE, and NAM Presidents Honor American 2017 Nobel Laureates

NAS President Marcia McNutt, NAE President C. D. Mote, Jr., and NAM President Victor J. Dzau honored U.S. 2017 Nobel Prize recipients Barry Barish, Joachim Frank, Michael Rosbash, Kip Thorne, and Michael Young at a reception on Capitol Hill on Wednesday, April 18. U.S. Senators Lamar Alexander (R-Tenn.) and Christopher Coons (D-Del.) co-hosted the event.




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Improvements Needed to Achieve More Efficiency, Quality of Census Bureau’s Annual Economic Surveys

The U.S. Census Bureau should develop a detailed concept and implementation plan for an Annual Business Survey System (ABSS) to replace the current suite of largely separate annual economic surveys, says a new report by the National Academies of Sciences, Engineering, and Medicine.




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NAS Honors 10 U.S. Nobel and Kavli Prize Laureates

From revolutionizing cancer care to modeling the economic impact of climate change, recent winners of Nobel and Kavli Prizes have explored virtually every angle of science.




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Urea fertilisation of the sea for CO2 removal: Issues for consideration

One method that has been proposed for removing carbon dioxide (CO2) from the atmosphere is to ‘fertilise’ the ocean to encourage phytoplankton (algae) blooms. A recent study has outlined the environmental, legal and social implications of large-scale fertilisation of the sea with urea in the Sulu Sea off the coast of the Philippines.




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"We Don't Know What We are Talking About" - Nobel Laureate David Gross

Science has reached an enormous impasse. From biology to physics, astronomy to genetics, the scientific community is reaching the limits of understanding which often presage a complete rethinking of long-accepted theories. So characteristic of this new apex of modern arrogance is the inability to comprehend the obvious in physics: That we don't know what we are talking about.




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Better Business Bureau Recognizes Terry Bryant Accident & Injury Law with Winner of Distinction Award

This marks the 3rd consecutive award the Houston personal injury firm has received for the quality of service it offers clients.




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POKE ME: Government, get out of skilling. Motivate the bureaucracy to create the right ecosystem instead

What we need before Skill India is perhaps a Skill Government mission. And what’s more, in this Budget season, a visionary leader can do this without much fund allocation.




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Bureau of Reclamation News Release: Water experiment to be conducted along the Colorado River while maintaining hydropower production this summer

From May 1 through August 31, the Department of the Interior will conduct a Macro-invertebrate Production Flow at Glen Canyon Dam. This experiment, also known as a Bug Flow, aims to improve egg-laying conditions for aquatic insects, which are the primary food source for endangered and native fish in the Colorado River. https://www.nps.gov/grca/learn/news/bor-news-water-experiment-to-be-conducted-along-the-colorado-river-while-maintaining-hydropower-production-this-summer.htm




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Aryloxyurea compound and pest control agent

The present invention provides a pest control agent, acaricide or fungicide that contains, as the active ingredient thereof, at least one type of compound selected from the aryloxyurea compounds represented by formula (V) (wherein R1 to R5 each independently represents an alkyl group or the like, X is a halogen atom or the like, n is an integer of 0 to 5, and Z is an oxygen atom or sulfur atom) or salts thereof.




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Aminoethylation process having improved yield of aryloxyalkylene amine compounds and reduced urea by-products

Disclosed is a process for preparing an aryloxyalkylene amine compound via an aminoethylation reaction comprising: a) reacting an aromatic hydroxyl compound in the presence of a basic catalyst with a 2-oxazolidinone compound of the formula II to form an intermediate reaction product; wherein R3 is selected from the group consisting of hydrogen or lower alkyl having 1 to 6 carbon atoms, R4 is selected from the group consisting of hydrogen, straight or branched chain alkyl having from one to six carbon atoms, phenyl, alkaryl, or arylalkyl; and b) reacting the intermediate product of step a) with a polyalkylene polyamine.




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Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pryimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea

The present application is directed to solid forms of compounds of formula I: and pharmaceutically acceptable salts thereof, that inhibit bacterial gyrase and/or Topo IV and pharmaceutical compositions comprising said compounds and salts. These compounds and salts are useful in treating bacterial infections.




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Hydroswellable, segmented, aliphatic polyurethanes and polyurethane ureas

Hydroswellable, absorbable and non-absorbable, aliphatic, segmented polyurethanes and polyurethane-urea capable of swelling in the biological environment with associated increase in volume of at least 3 percent have more than one type of segments, including those derived from polyethylene glycol and the molecular chains are structurally tailored to allow the use of corresponding formulations and medical devices as carriers for bioactive agents, rheological modifiers of cyanoacrylate-based tissue adhesives, as protective devices for repairing defective or diseased components of articulating joints and their cartilage, and scaffolds for cartilage tissue engineering.




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Method for minimizing the diameter of a urea solution, urea solution and use of a surfactant in urea solution

A mixture of surfactants from alkylene oxide adducts with different degrees of alkoxylation is used in a urea solution to be added to an exhaust stream for reduction of nitrous gases.




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Substituted phenylcarbamoyl alkylamino arene compounds and N,N'-BIS-arylurea compounds

Substituted phenylcarbamoyl alkylamino arenes; substituted phenylthiocarbamyl alkylamino arenes; substituted phenylcarbamoyl alkylamino heteroarenes; substituted phenylthiocarbamyl alkylamino heteroarenes; N-substituted aryl, N'-substituted aryl urea compounds; N-substituted aryl, N'-substituted heteroaryl urea compounds; N-substituted aryl, N'-substituted aryl thiourea compounds and N-substituted aryl, N'-substituted heteroaryl thiourea compounds are provided and may find use as androgen receptor modulators. The compounds may find particular use in treating prostate cancer, including castration-resistant prostate cancer and/or hormone-sensitive prostate cancer.




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Use of diazolidinyl urea for anti-clumping of biological samples

The present invention provides methods for preventing clumping of cells in microfluidic devices by addition of diazolidinyl urea (DU). DU can be added to samples at the time of collection or can be added to samples post-collection. DU can also be pre-added to sample collection devices.