MARIO Lemina wants to remain at Galatasaray beyond the end of the season.

Political conflict can be both helpful and harmful to local government. According to a new study, which it is depends on the nature of the conflict. A Northern Illinois University researcher surveyed city councils and other municipal bodies to examine two types of conflict. Political Science Chair Scot Schraufnagel said "policy conflict" is when lawmakers have differences of opinion on specific issues and laws. “Policy conflict does not detract from governing board effectiveness," he said. "In fact, there’s a positive relationship between higher policy conflict and the perception of a better functioning legislature.” The other type is "relational conflict." “People sabotaging someone else’s legislative initiative just simply because they don’t like them, or so forth," he said, "so it’s about personalities, and not about policy." This, according to Schraufnagel, leads to a win-at-all-costs mentality and actively prevents cooperation. He said the study’s conclusions could have strong

House Speaker Nancy Pelosi thinks the Democratic National Convention should be moved to a much bigger stadium so party faithful have space to social distance for Joe Biden's nomination. 

Here are interesting correlations between the seriousness of podcasts and the hosting companies they use.

Middle school spans those tween and early teenage years when, for many, puberty hits. Bullies seem to reign supreme. And we begin to grow into ourselves. Like most, writer and reporter Judith Warner was once a middle schooler. She's also the mother of two former middle schoolers. In her new book, And Then They Stopped Talking To Me , she investigates why the middle-school years can be so awful — and what we can do to help make them a little bit better. Interview Highlights On asking people what words come to their mind when thinking of middle school Soul crushing. Shattering. A rush of nausea. Any variation on the word misery that you can come up with. By and large, the answers were so powerful. And yet then there were a couple of people who had good memories too. And that was something that was important for me to hold on to and listen to in more detail. On deciding to write the book It really grew out of a kind of random thought one day when my daughter was in middle school and I

Middle school spans those tween and early teenage years when, for many, puberty hits. Bullies seem to reign supreme. And we begin to grow into ourselves. Like most, writer and reporter Judith Warner was once a middle schooler. She's also the mother of two former middle schoolers. In her new book, And Then They Stopped Talking To Me , she investigates why the middle-school years can be so awful — and what we can do to help make them a little bit better. Interview Highlights On asking people what words come to their mind when thinking of middle school Soul crushing. Shattering. A rush of nausea. Any variation on the word misery that you can come up with. By and large, the answers were so powerful. And yet then there were a couple of people who had good memories too. And that was something that was important for me to hold on to and listen to in more detail. On deciding to write the book It really grew out of a kind of random thought one day when my daughter was in middle school and I

With a James Beard Foundation survey indicating that only one in five restaurant owners think they can keep their businesses viable, Seattle Times food writer Bethany Jean Clement takes a look at what we stand to lose.

The decision by Americans to hunker down during the coronavirus pandemic has been heavily influenced by pronouncements from national and local leaders, according to data released Monday by the Centers for Disease Control and Prevention. The report offers the most robust information to date showing the relationship between people’s behavior and official policies announced by […]

Knight has written a series of books about "mental decluttering" — her latest is called F*ck No! "Most people will take no for an answer much more easily than you think they will," she says.

The Venezuelan military defector identified as the ringleader of the botched coup attempt in Venezuela was likely working as a "double agent" for the same man he allegedly attempted to overthrow, socialist narco-dictator Nicolás Maduro, Breitbart News has learned.

Gold's Gym filed for Chapter 11 bankruptcy this week and 24 Hour Fitness is exploring the same option.

The author of And Then They Stopped Talking To Me tells NPR, "I expected middle schoolers to be these sorts of monsters. And they weren't. They were just kids."

The author of And Then They Stopped Talking To Me tells NPR, "I expected middle schoolers to be these sorts of monsters. And they weren't. They were just kids."

Justin Turner has an idea to help limit the toll on players during a shortened season: a home run derby to decide a winner when a game is tied after 10 innings.

It's surprisingly easy to learn the best techniques that help you get the most out of the simple act of breathing.

A new study by Stanford University, using antibody blood tests, estimates that the number of cases in Santa Clara County may be 50 to 85 times greater than what was previously known.

School won't be the same when it resumes after coronavirus closures. There could be staggered start times, reconfigured classes and no assemblies.

Since 1998, the city of Carmel has spent more than $250 million to build 126 roundabouts in the city. But data doesn't prove safety claims.

(Louisiana State University Health Sciences Center) A study conducted at LSU Health New Orleans has shown for the first time that chronic exposure to inhaled nicotine alone increases blood pressure in both the body's general circulation and in the lungs that can lead to pulmonary hypertension. The study also found that nicotine-induced pulmonary hypertension is accompanied by changes in the size, shape and function (remodeling) of the blood vessels in the lung and the right lower chamber of the heart.

(Taylor & Francis Group) Over 80% of people surveyed in a study do not plan to conceive during the COVID-19 crisis, perhaps putting to rest suggestions that the lockdown could lead to rise in birth numbers.

David E. Cummings
Aug 1, 2001; 50:1714-1719
Rapid Publications

While safe third-country agreements appear to hold the potential of deterring new asylum claims, experience suggests this may be a false promise. As the Trump administration explores the possibility of such agreements with Mexico and Guatemala, this commentary examines the evidence of safe third-country arrangements in Europe, finding them difficult to enforce and playing little role in deterring new claims.

Leaders across the United States should plan for a worst-case scenario, second wave to the COVID-19 pandemic, including no vaccine availability or herd immunity, say experts at the University of Minnesota.

As European asylum systems are tested again by the COVID-19 pandemic, which has injected the need for social distancing during processing and in reception centers, it appears lessons learned during the 2015-16 migration and refugee crisis may be fading. Chief among them: A number of Member States have phased out their buffer capacity. This MPI Europe commentary explores the diametrically different approaches taken to asylum during the pandemic.

Hepatocyte growth factor (HGF) is a multifunctional protein that signals through the MET receptor. HGF stimulates cell proliferation, cell dispersion, neuronal survival, and wound healing. In the inner ear, levels of HGF must be fine-tuned for normal hearing. In mice, a deficiency of HGF expression limited to the auditory system, or an overexpression of HGF, causes neurosensory deafness. In humans, noncoding variants in HGF are associated with nonsyndromic deafness DFNB39. However, the mechanism by which these noncoding variants causes deafness was unknown. Here, we reveal the cause of this deafness using a mouse model engineered with a noncoding intronic 10 bp deletion (del10) in Hgf. Male and female mice homozygous for del10 exhibit moderate-to-profound hearing loss at 4 weeks of age as measured by tone burst auditory brainstem responses. The wild type (WT) 80 mV endocochlear potential was significantly reduced in homozygous del10 mice compared with WT littermates. In normal cochlea, endocochlear potentials are dependent on ion homeostasis mediated by the stria vascularis (SV). Previous studies showed that developmental incorporation of neural crest cells into the SV depends on signaling from HGF/MET. We show by immunohistochemistry that, in del10 homozygotes, neural crest cells fail to infiltrate the developing SV intermediate layer. Phenotyping and RNAseq analyses reveal no other significant abnormalities in other tissues. We conclude that, in the inner ear, the noncoding del10 mutation in Hgf leads to developmental defects of the SV and consequently dysfunctional ion homeostasis and a reduction in the EP, recapitulating human DFNB39 nonsyndromic deafness.

SIGNIFICANCE STATEMENT Hereditary deafness is a common, clinically and genetically heterogeneous neurosensory disorder. Previously, we reported that human deafness DFNB39 is associated with noncoding variants in the 3'UTR of a short isoform of HGF encoding hepatocyte growth factor. For normal hearing, HGF levels must be fine-tuned as an excess or deficiency of HGF cause deafness in mouse. Using a Hgf mutant mouse with a small 10 bp deletion recapitulating a human DFNB39 noncoding variant, we demonstrate that neural crest cells fail to migrate into the stria vascularis intermediate layer, resulting in a significantly reduced endocochlear potential, the driving force for sound transduction by inner ear hair cells. HGF-associated deafness is a neurocristopathy but, unlike many other neurocristopathies, it is not syndromic.

The ancient throwing stick may have been used by Neanderthals or an even earlier hominin

The city's residents sorted waste materials for reuse in future projects, according to new research

Its paddle-like tail, unearthed in Morocco, suggests the Cretaceous carnivore ventured into the water to hunt

Buried in a mass grave in Mexico City, the trio may have been part of the first generation abducted from their homeland and brought to the New World

Alcohol industry groups were successful in getting the Yukon government to pull labels warning of the connection between alcohol and cancer from liquor store shelves, but the strategy may have ultimately backfired, researchers suggest.

Taking mom out for Mother's Day brunch is a tradition for many. But with people staying home and restaurants closed except for delivery or pick-up, this year's Mother's Day will be a little bit different. Food columnist Andrew Coppolino looks at options.