The findings come from Third Sector’s inaugural Charity Employer Index

• Risks to the jobs market have remain unchanged or have fallen
• Fed may be on the 'last mile' to price stability, inflation expected to converge to 2% over the medium term
• Monetary policy well posited, Fed can 'judiciously and patiently' judge income data to decide on further rate cuts
• Strong economy on track for a 'solid' fourth quarter
• Growth is broad-balanced and driven by consumption, income growth, productivity, supportive financial conditions and wealth effects
• Recent high productivity could prove durably structural but that remains uncertain
• Core inflation remain elevated
• Pressure in services industries slowly abating

This is the third Fed official who has floated some more-hawkish hints. It's hardly a signal of a pause in December but early 2025 is going to be interesting. There are meetings in January, March and May. Assuming a cut in Dec, there is one cut fully priced in for that period (and a smidge more).

That sounds about right based on the comments and data but that's going to swing based on the next set of numbers and beyond.

More hawkish comments from the St Louis Fed President

• Inflation data is also stronger but has not yet changed view that policy is on a path to neutral
• There is likely space for a gradual easing of policy towards neutral rate
• Stronger data likely pushing Treasury yields higher
• Too soon to understand new administration
• Rising bond yields also offer a sense of higher inflation risk and some sense the Fed may not cut as much

One really great thing to do every day of the week by Megan Seling WEDNESDAY 11/13  

Secret SIFF Staff Benefit Screening!

(FILM/FUNDRAISER) Days after getting our souls ripped out and stomped on by more than 75 million Americans on November 5, SIFF had to break even more bad news: SIFF Cinema Egyptian will be closed for the foreseeable future due to a “significant pipe leak.” It happened Tuesday evening. I blame Trump for this, somehow. This sucks for moviegoers, of course, but it’s an even bigger blow to the workers whose future employment has been put into upheaval. Tonight, SIFF supporters have organized a super secret screening and fundraiser at Northwest Film Forum to raise funds for the staffers impacted by the closure. What movie? It’s a surprise! They promise it is “VERY good.” It’s free, but hopefully, you can kick at least a few bucks into the SIFF Cinema Workers Union Fundraiser on GoFundMe. And if you show your proof of donation at the concession stand, you get a free small popcorn! (Northwest Film Forum, 1515 12th Ave, 7 pm, free) MEGAN SELING

The Blood Brothers

(MUSIC) Like any fan of Seattle hardcore band the Blood Brothers, I have found myself at a show, pressed up against a wall of people, shouting the wrong lyrics to their songs. For instance, on their hit "USA NAILS," there's a hook where you think you're singing a cheer-style "one, one, and two!" but the lyrics are actually: "These pigs locked me up to see what color I'd rot into!" When I sat down to talk to Johnny Whitney, who fronts the band with fellow singer/screamer/guttural whisperer Jordan Blilie, he noted that plenty of lyrics websites list incorrect verses for Blood Brothers songs. "It's hilarious how wrong some of them are," Whitney said. "The lyrics on Spotify are not even close to what I'm actually saying. Just buy the fucking CD, and look it up. Come on, people." Read the full interview here. (The Showbox, 1426 First Ave, Nov 14-15, 8 pm, Thurs is all ages, Fri is 21+) SUZETTE SMITH

Babe Fest 2

(PARTY) During a time that feels both politically glum and literally glum outside, join your fellow babes to let loose in a sparkly sea of positive energy. DJ Wax Witch (the mastermind behind Seattle's girl-powered DJ series Babe Night) will host the second annual Babe Fest, featuring a therapeutic blend of '90s pop, Y2K dance, and Euro house bops. Fellow spinderellas SofiiaK, Abbie, Reverend Dollars, and Ten Billion Jules will join the fun in addition to live sets from friendship-focused bands Who Is She? and THEM (full disclosure: my sister is in this band, but I’d think they’re great even without blood relation, I promise!). Proceeds from ticket sales will be donated to Rain City Rock Camp, a local nonprofit that empowers creativity in femmes and gender-nonconforming individuals through music with sliding-scale rock camps and education. (Baba Yaga, 124 S Washington St, 7 pm, $15-$20, 21+) AUDREY VANN

World Toilet Day

(COMMUNITY) In honor of the United Nations' World Toilet Day on November 19, the Gates Discovery Center invites toilet users of all stripes for a day of activities and exhibits highlighting the importance of the porcelain throne. You can make your own "pooparium," a terrarium filled with biosolid compost, or stop by the water bar to see if you can taste the difference between tap, bottled, and filtered water. I think even the most stoic of us won't be able to resist giggling while playing poop-into-toilet-themed corn hole—and who doesn't need a laugh right now? (Bill & Melinda Gates Foundation Discovery Center, 11 am-3 pm, free, all ages) SHANNON LUBETICH

STÖR

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(VISUAL ART) If you assume STÖR is a parody of a certain meatball-serving Swedish mega-retailer, you'd be right—but it's more than that, too. The labyrinthine Base Camp Studios project was imagined as an "immersive rebrand of how we experience, consume, and purchase art." That means you can explore and shop the STÖR space while contemplating the confluence of commerce and artistic production. Mary Anne Carter, Lilia Deering, and over 25 other participating artists have outfitted the installation with "surreal reinterpretations" of mass-produced home goods and decor. (Base Camp Studios, 1901 Third Ave, through Jan 10, $15 suggested donation) LINDSAY COSTELLO

Katie Gavin

(MUSIC) As a devoted stan of queer indie pop icons, Gayotic podcasters, and self-proclaimed "greatest band in the world" MUNA, I've enjoyed watching member Katie Gavin step into her solo side project. She cites Alanis Morissette, Fiona Apple, Ani DiFranco, Tracy Chapman, Tori Amos, and Sarah McLachlan as influences on her debut album What a Relief, which was largely written on acoustic guitar over the course of seven years, and their raw honesty shines through on nostalgic '90s-tinged singles like "Aftertaste" (a sweet, woozy ode to the vulnerability of a nascent crush) and "Casual Drug Use" (a compassionate affirmation in the face of substance abuse issues, penned in the wake of a breakup in 2016). (Neumos, 925 E Pike St, 7 pm, $39-$45, all ages) JULIANNE BELL

Matty Matheson

(FOOD/BOOKS) You might already know the boisterous, tattooed, foul-mouthed Canadian chef Matty Matheson for his role as handyman Neil Fak on FX's The Bear (which he also executive produces) or for his joyfully chaotic cooking channel on YouTube. His latest cookbook Soups, Salads, Sandwiches involves all three of the holy comfort food triad, with recipes like crab congee, "Everyone's Mom's Macaroni and Tuna Salad," and Cubanos. Best of all, the book's commentary stays true to his signature raucous, jovial voice. He'll chat with Little Fat Boy food writer and photographer Frankie Gaw about the release. (Town Hall Seattle, 1119 Eighth Ave, 7:30 pm, $7-$139, all ages) JULIANNE BELL

Actor Dick Van Dyke, who turns 99 next month, suggested he would happily not be around to see the next four years under President-elect Donald Trump's second term in the White House.

The post Watch: Dick Van Dyke Suggests He’d Rather Die Than See Another Four Years of Trump appeared first on Breitbart.

The roughly six-hour flyby in 1986 revealed Uranus' protective magnetic field was strangely empty. Now, researchers say that the data could have been affected by a solar wind event

The study showed that people without the SI gene may have a hard time digesting sugary foods, making them dislike it.

Fox News legal editor Kerri Urbahn told 'The Story with Martha McCallum that Trump could force a pardon from Gov. Hochul by threatening to withhold federal funds to New York unless she pardons his 34 felonies.

This shouldn't come as a surprise since Urbahn was the Director of Public Affairs for the Department of Justice under Attorney General Bill Barr during the first Trump administration.

This segment was prompted by the judge delaying a decision on Trump's 34 felony convictions for another week.

MACCALLUM: Governor Hochul could also pardon President Trump on these charges because it is a state charge, right?

URBAHN: Yeah that's right and look she needs to really be thinking through this because New York state needs federal money and they get a lot of it.

And there is a lot that the federal government could do in terms of pulling funding from both the city and the state of New York. There's a bunch of ways to do it through the Justice Department and other places, and you know, at the end of the day it's all politics.

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Samsung is reportedly working on a tri-fold smartphone, expected to arrive sometime next year. An earlier report suggested that Samsung display's partners have finished developing components for the tri-fold model. Now, the latest development reveals Samsung has already filed a patent

If you think so, or at least want to explore the idea, SCORE and our mentors are ready to assist you confidentially and at no charge. It’s a long, winding road to entrepreneurial success. The more advocates you have, the better chance you have to realize your dream.

Do not go into business if you know little or nothing about it.

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In a new study that expands our understanding of how humans contribute to global warming, scientists have discovered that human activity has dramatically changed the terrestrial biosphere to make it a significant contributor to climate change...

Washington – Designating a single government agency to direct safety, health and environmental research efforts on nanomaterials could help accelerate progress, a new National Research Council report suggests.

Chicago — The lung tissue of contemporary coal miners contains higher levels of respirable crystalline silica dust than was found in miners of past generations – which may explain an ongoing surge in cases of the most severe form of black lung disease, researchers at University of Illinois Chicago say.

Chicago — Spontaneous activity, such as moving your feet back and forth, while seated can burn more calories than using a standing workstation, according to the results of a recent study.

Almonds are a key ingredient that can help broaden dietary options in snack products through their wide variety of forms that help introduce new flavor experiences and offer many health benefits.

Microsoft's Word program now recommends replacing the term "maternity leave" with more “inclusive” language.

[International] :
Russian President Vladimir Putin has suggested that Russia could hold military drills with North Korea.  According to Reuters and the Russian state news agency TASS, Putin mentioned the possibility during a plenary session of the annual meeting of the Valdai International Discussion Club in ...

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The Azotobacter vinelandii FeSII protein forms an oxygen-resistant complex with the nitrogenase MoFe and Fe proteins. FeSII is an adrenodoxin-type ferredoxin that forms a dimer in solution. Previously, the crystal structure was solved [Schlesier et al. (2016), J. Am. Chem. Soc. 138, 239–247] with five copies in the asymmetric unit. One copy is a normal adrenodoxin domain that forms a dimer with its crystallographic symmetry mate. The other four copies are in an `open' conformation with a loop flipped out exposing the 2Fe–2S cluster. The open and closed conformations were interpreted as oxidized and reduced, respectively, and the large conformational change in the open configuration allowed binding to nitrogenase. Here, the structure of FeSII was independently solved in the same crystal form. The positioning of the atoms in the unit cell is similar to the earlier report. However, the interpretation of the structure is different. The `open' conformation is interpreted as the product of a crystallization-induced domain swap. The 2Fe–2S cluster is not exposed to solvent, but in the crystal its interacting helix is replaced by the same helix residues from a crystal symmetry mate. The domain swap is complicated, as it is unusual in being in the middle of the protein rather than at a terminus, and it creates arrangements of molecules that can be interpreted in multiple ways. It is also cautioned that crystal structures should be interpreted in terms of the contents of the entire crystal rather than of one asymmetric unit.

Robin Heilweil, 6, wears a mask while swinging around with her kindergarten class this month at Kenter Canyon School in Los Angeles.; Credit: Sarah Reingewirtz/Los Angeles Daily News/Southern California News Group via Getty Images

New research released Friday by the Centers for Disease Control and Prevention reinforces an old message: COVID-19 spreads less in schools where teachers and staff wear masks. Yet the study arrives as states and school districts across the country have begun scaling back or simply dropping their masking requirements for staff and students alike.

With the majority of school-age children still too young to qualify for vaccination, Friday's research is the latest salvo in a simmering fight between public health officials and politicians — with parents lining up on both sides.

The new study comes from Georgia and compares COVID-19 infection rates across 169 K-5 schools. Some schools required teachers, staff and sometimes students to wear masks; some did not.

Between Nov. 16 and Dec. 11, researchers found that infection rates were 37% lower in schools where teachers and staff members were required to wear masks. The difference between schools that did and did not require students to wear masks was not statistically significant.

This is one more study showing that masking, among other mitigation efforts, "can reduce infections and ultimately save lives," said Dr. Sean O'Leary, a professor of pediatrics at the University of Colorado and vice chair of the Committee on Infectious Diseases for the American Academy of Pediatrics.

O'Leary points to a previous CDC study, of schools in Florida, that also found "a strong association with student mask requirements and lower rates of infections in students."

Like any study, Friday's release comes with caveats. Only 12% of schools invited to share their data did so. And it's always worth remembering: Correlation is not causation. Still, the results offer an important warning to states and school districts that are now lifting their school-based mask requirements, especially for adults: It's safer if you don't.

The latest, and perhaps broadest effort to change schools' masking policies comes from Texas, where Republican Gov. Greg Abbott issued an executive order Tuesday banning all mask mandates in the state's public schools. After June 4, the order says, "no student, teacher, parent or other staff member or visitor may be required to wear a face covering."

For Abbott, and many opponents of mask mandates, the move is about restoring a balance between safety and freedom. "We can continue to mitigate COVID-19 while defending Texans' liberty to choose whether or not they mask up," he said in announcing the order.

Zeph Capo, president of the Texas American Federation of Teachers, called the move "unconscionable" in a statement. "The governor's new verdict takes a blanket approach to addressing what is still extremely dangerous for some Texans — a return to school unmasked."

And Texas isn't alone. On Thursday, Iowa's Republican governor, Kim Reynolds, also signed a law banning schools from requiring masks. The justification is similar: "I am proud to be a governor of a state that values personal responsibility and individual liberties," Reynolds said in a statement.

"Whether a child wears a mask in school is a decision that should be left only to a student's parents," South Carolina Gov. Henry McMaster said last week as he issued an executive order allowing parents to opt their children out of school-based mask requirements.

Public health experts have been quick to sound the alarm.

"All along in this pandemic, we have seen the tragic consequences when politics start to play a role in public health decisions. And to me, this kind of maneuver smells like politics — to ban the requirements that are ultimately there to save lives," O'Leary said. "The body of evidence shows us that masks work."

And Dr. Aaron Milstone, a professor of pediatric infectious diseases at Johns Hopkins, likens the banning of mask mandates to having a variable speed limit.

"Unfortunately, with contagious diseases the decisions I make impact someone else," Milstone said. "It would be like saying: You can drive 55 mph if you think that's safe for you, but if someone else thinks they can safely drive 90 mph, their choice may wind up risking your life."

While the CDC recently scaled back its masking guidance for people who are fully vaccinated, the agency also reiterated that schools should continue to require universal masking, at least through the end of the current school year. Though one vaccine has been approved for use for 12- to 15-year-olds, those kids won't be considered fully vaccinated for another month.

Milstone said it's simply too early to talk about schools without masking. "Until vaccines are eligible for all children, it's hard to abandon the practices that we know work the best to prevent the spread of COVID."

Dr. Anthony Fauci, chief medical adviser to the White House, told CNBC this week that it is conceivable the CDC could recommend that middle and high schools be mask-free in the fall — if, that is, enough students 12 years of age and older get vaccinated.

This content is from Southern California Public Radio. View the original story at SCPR.org.

The Telecom Regulatory Authority of India (TRAI) has recommended that linear set-top boxes (STBs) be included in the PLI scheme to promote local manufacturing in the television broadcasting sector. The TRAI has also suggested conducting periodic reviews of indigenous components, factoring in local components in determining localisation levels under the PLI scheme, and reviewing investment outlays required for MSME manufacturing for selected equipment.

According to Dr Eric Chun-Pu Chu, DC PhD, of Chiropractic Doctors Association of Hong Kong (CDAHK), people spend about 6 hours a day gazing at their mobile phones, which can cause major text-neck aches and numbness.

Grime Squad Offers a Solution to Improve Curb Appeal and Boost Home Value

Chainlink fences are a good option for creating safe outdoor spaces for tiny dogs, bunnies, and ferrets according to residential North Vancouver fencing company.

Novel FFPE proteomics method suggests prolactin induced protein as hormone induced cytoskeleton remodeling spatial biomarker | Communications Biology  Nature.com

Toronto, ON – Handwipes aren’t just for germs anymore.  Their uses may extend to more flexible thinking and reorienting one’s priorities. A pair of researchers at the University of Toronto’s Rotman School of Management has found the physicality of cleaning one’s hands acts to shift goal pursuit, making prior goals less important and subsequent goals more […]

Toronto, ON – Super-computer modelling of Earth’s crust and upper-mantle suggests that ancient geologic events may have left deep ‘scars’ that can come to life to play a role in earthquakes, mountain formation, and other ongoing processes on our planet. This changes the widespread view that only interactions at the boundaries between continent-sized tectonic plates […]

Suggests similar evolution occurs on separate islandsToronto, ON – A University of Toronto-led team has reported the discovery of a new lizard in the middle of the most- visited island in the Caribbean, strengthening a long-held theory that communities of lizards can evolve almost identically on separate islands. The chameleon-like lizard – a Greater Antillean […]

In a period where budgets are extremely tight and layoffs are being made, many companies find it difficult to justify assigning resources to innovation.

https://justthenews.com/politics-policy/energy/left-thought-voters-loved-climate-agenda-trumps-victory-suggests-its-not By Kevin Killough Kamala Harris hoped to secure the White House with a platform that vaguely appeared moderate on one hand, while cozying up to radical climate activists on the other. Donald Trump has repeatedly called climate change a “hoax,” something Democrats hammered the Republican candidate on for years, and promised voters America would “drill, baby, drill” if […]

One Really Great Way to Cope Every Day of the Week by Megan Seling WEDNESDAY 11/6  

Drink Sad Girl Shots and Eat Cheese at Situ Tacos

(SHOCK) In a state of post-election shock? Me, too. Lean into the overwhelm with a bracing gulp of el Jimador tequila and a salty cube of Tillamook cheese—otherwise known as the Sad Girl Shot. Situ Tacos owner Lupe Flores claims this combination got her through the pandemic, and it’s likely an ideal salve for our current despondent situation, too. I generally try not to suggest alcohol as an antidote to despair—as wine writer Marissa A. Ross wrote in the wake of Anthony Bourdain’s death, “Drink to celebrate life, not to deal with loss”—but the Sad Girl Shot is just too perfect an invention. Plus, Situ Tacos is also hosting Floaters, an exhibition of artist Devin Liston’s bubbly, surreal, Dali-esque paintings of everyday objects like billiard balls, in their glitzy gold back bar Tilda’s Lounge tonight. Instead of doom-scrolling, go feast your eyes on art and knock back a few drinks, and if you’d prefer to abstain from booze, you can always skip the shots and opt for a tub of Situ’s divine queso. Best of all, 25 percent of the night’s proceeds will go to the Lebanese Red Cross, so you’ll be fighting nihilism by supporting a worthy cause. Sad girls por vida! (Situ Tacos, 5239 Ballard Ave NW, Sad Girl Shots are $6, chips and queso are $10) JULIANNE BELL

Go to Another World with SIFF’s Cinema Italian Style Film Festival

(DENIAL) What’s America? You don’t live there. In fact, you’ve never even heard of the United States. You live in a bubble. Your days are steeped in simplicity and unbroken serenity, untouched by the ever-looming threat of Christofascism and student loan repayment. Your life is bliss. And what you have heard of are the sun-dappled olive groves of Italy. Consider snagging a seat at one of SIFF's chic Cinema Italian Style screenings, particularly if you’re into guised critiques of the bourgeoisie. Or amp up the distraction factor at Art of Studio Ghibli, which celebrates the legendary Japanese animation studio’s poetic, intelligent approach to nature and the more-than-human world. (Thanks, Miyazaki—you’re giving us a reason to live right now.) Sean Baker’s Anora, which follows a sex worker who marries a Russian oligarch, might feel a little too “real world-y” at the moment, but his clear-eyed approach and lush visuals are always a draw. (See full film listings on EverOut) LINDSAY COSTELLO

Break Shit

<a href="https://file13records.bandcamp.com/album/hamburgers-ep">Hamburgers - EP by Atom & His Package</a>

(ANGER) Ever since I saw Bob Trevino Likes It at SIFF this year, I’ve wanted to visit a “rage room,” especially as a woman who, like the main character in the film, has always been taught to be kind and polite, never violent. Lucky for us, we have our own version up in Lake City that invites you to smash glasses, sledgehammer a toilet, and more. We recommend emptying your mind and listening to this absurd little song while you do it. If you’re not into destruction, you can punch out your anger at Cappy’s Boxing Gym in Central District or Seattle Boxing Gym in Interbay (they both offer your first class free!). And if you’d rather drink a beer while throwing sharp objects, there’s always axe throwing in Capitol Hill and White Center. (Rage Industry, 13333 Lake City Way NE, sessions start at $40) SHANNON LUBETICH

Have You Tried Being Less of an Asshole?

(BARGAINING) DO BETTER. It’s the directive that has echoed through social media comments for years as the quick quip that critics post anytime anyone does anything that even mildly rocks their delicate sensibilities. It usually (understandably) is met with eye rolls. But… have you tried it? Have you actually tried to do better? Maybe if we’re all the best versions of ourselves, we can cancel out some of the 72 million selfish bigots who voted for the racist rapist and preserve some goodwill in this world. Lead with kindness. Have patience. Smile at dogs. Randomly text your pals and tell them that they’re the most gorgeous and hilarious beings on the planet. Offer to bring a meal to a sick friend or rake up leaves for an elderly neighbor. Hold open a door, pay for someone’s coffee, and don’t laugh when a tourist falls off their rented scooter. Be everything those 72 million (and counting!) motherfuckers are too selfish to be. Fake it ‘til you make it—or uncontrollably collapse into a crying, shaking heap of blood, guts, and flesh on the floor—baby! MEGAN SELING

Live That “Two Benadryl and a Lifetime Movie” Life

(DEPRESSION) Several years ago, I heard about “Two Benadryl and a Lifetime Movie” on the C-Word podcast and never forgot it. The depression cocktail has since become the remedy I give to myself and my loved ones who are experiencing insurmountable amounts of sadness. While it doesn’t necessarily need to be those little pink pills and Lifetime’s Ladies of the '80s: A Divas Christmas (although it’s a great combination, TBH), pick any mind-numbing film or television show and pair it with an indulgent (but safe) amount of sleep-inducing potion. Other variations include two cups of chamomile tea and an Adam Sandler movie, two hits of weed and a Martha Stewart Living marathon, or two bowls of ice cream and an old season of Project Runway. Personally, I will be taking two melatonin and watching Lifetime’s adaptation of Flowers in the Attic before drifting into a sweet slumber (or dissociative oblivion, we’ll see). AUDREY VANN

Go for a Long Walk and Discover Who You Are Now

(TESTING) This is my cure-all for when I feel out of control and need to take back my agency because it’s simple, and you set all the parameters. You control when you walk, how fast you walk, how long you walk, and how many steep inclines you choose to brave or creatively avoid. You can break out into a run or sit down on a wet park bench in the morning drizzle to absorb the book, podcast, or music you’re listening to. Counting steps is nice if you’re into goal setting, but so is leaving your phone at home and soaking in the quiet. Let disinhibition lead you. Screw the clock. Fuck obligations. Clear your schedule and just go. Walking is one of the simplest ways to connect with your autonomy and the human spirit, whatever that means to you. Turn home when your legs ache, and when you get that restless, sick feeling, get your ass off the couch and go walk again. VIVIAN MCCALL

Prepare for Battle

(ACCEPTANCE) This is here. It’s real. Donald Trump will be the 47th President of the United States. A lot of bad shit is going to happen, so we need to donate and fight and organize. Don’t get complacent in our blue state. I know a lot of you out there will legitimately be fine, but don’t let your privilege get in the way of seeing that many, many others will not. Donate to the ACLU. Donate to abortion funds in Florida, Nebraska, and South Dakota. Donate to the National Immigrant Justice Center. Do whatever Pramila Jayapal tells you to do. Organize a friend group to attend this talk at Town Hall on Thursday about taking collective action and building civic community. Join a mutual aid group (like Super Familia, South & East King County, and Homies Helping Homies). Give food to a community fridge. Volunteer. Foster dogs. Do literally anything to give back to your community. Tell people you love them, and mean it. It’s time to show the fuck up, Seattle. SHANNON LUBETICH

Union Minister calls on domestic toy industry to back artisans and foster creativity at Toy CEO Meet. Global players like Walmart and Amazon join hands for collaborations. Government measures boost local manufacturing. Stakeholders discuss investment opportunities in India's growing toy market.

The clonal quaking aspen known as Pando is between 16,000 and 80,000 years old.

1. iPhone SE 4 expected to launch in March 2025, supply chain data suggests  Business Standard
2. iPhone SE4 is likely to launch soon and here are 5 big upgrades we are expecting  India Today
3. Apple iPhone SE 4 to launch next year, likely to become the cheapest iPhone to support Apple Intelligence...  Moneycontrol
4. iPhone SE 4 may spell trouble for iPhone 16 and premium Android phones, here’s why  Hindustan Times
5. iPhone SE 4 Camera Production to Begin Soon Ahead of Anticipated Debut in March 2025: Report  Gadgets 360

VAR2CSA is the placental-malaria–specific member of the antigenically variant Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family. It is expressed on the surface of Plasmodium falciparum-infected host red blood cells and binds to specific chondroitin-4-sulfate chains of the placental proteoglycan receptor. The functional ∼310 kDa ectodomain of VAR2CSA is a multidomain protein that requires a minimum 12-mer chondroitin-4-sulfate molecule for specific, high affinity receptor binding. However, it is not known how the individual domains are organized and interact to create the receptor-binding surface, limiting efforts to exploit its potential as an effective vaccine or drug target. Using small angle X-ray scattering and single particle reconstruction from negative-stained electron micrographs of the ectodomain and multidomain constructs, we have determined the structural architecture of VAR2CSA. The relative locations of the domains creates two distinct pores that can each accommodate the 12-mer of chondroitin-4-sulfate, suggesting a model for receptor binding. This model has important implications for understanding cytoadherence of infected red blood cells and potentially provides a starting point for developing novel strategies to prevent and/or treat placental malaria.

Nutritional supplements that contain curcumin -- a natural anti-inflammatory compound -- may protect the eyes from the development and progression of age-related macular degeneration, a new study suggests.

Virtual yoga can be a successful and accessible way to manage chronic low back pain -- a common ailment with major consequences, a new study suggests.

New DNA analysis adds to growing research indicating the famous Pacific island did not collapse from overuse of resources before the arrival of Europeans

A new paper analyzes three decades of fatalities around the world and predicts how "superbugs" will affect human health in the future

Scientists converted the patient’s own cells into blood sugar-regulating cell clusters before injecting them back into her abdomen—and one year later, she still doesn't need insulin injections

Scientists used EEG headsets, MRI machines and eye trackers to study volunteers' responses to five paintings housed at the Mauritshuis museum in the Netherlands

A scientist used at-home experiments to test whether cats hesitated when moving through increasingly shorter or narrower openings

Unlike other birds, which get pigments from their diets, parrots produce their own—but scientists never fully understood the underlying mechanisms, until now

Mary, a 54-year-old Asian elephant at the Berlin Zoo, is the “queen of showering,” but her companion Anchali seems to have figured out how to exploit that habit to play pranks

The ancient burial structures, strikingly similar all across Europe and the mediterranean, have puzzled scientists and historians for centuries

Philanthropies may be moving away from big new investments with a K-12 academic focus and toward areas like social and emotional learning and wraparound services, Grantmakers in Education finds.

Mentoring a student-teacher won't hurt a teacher's district evaluation score—in fact, it might even give it a boost, according to a working study.

The film was originally set for 2022, but was delayed multiple times by the pandemic and SAG-AFTRA actors strike. It's now scheduled to be released on May 23, 2025.