sex Sex Offender Brittonie Taylor To Be Released By bernews.com Published On :: Thu, 08 Oct 2020 14:25:08 +0000 The Government has issued a public notice that convicted sex offender Brittonie Lloyd Taylor will be released from prison on October 9th. A government spokesperson said, “The Minister of Legal Affairs, the Hon. Kathy Lynn Simmons, JP, MP today issued a public notice of the impending release, of sex offender Brittonie Lloyd Taylor, who will […] Full Article All Crime News #BrittonieTaylor #SexOffenderNotice #SexualAssault
sex Court: Sex Offender Challenges Deportation By bernews.com Published On :: Mon, 01 Nov 2021 10:32:08 +0000 Convicted sex offender Brittonie Taylor is making a legal challenge against being deported, with the Court ruling making an “order for a temporary stay of the Deportation Order.’ The court document noted that the applicant stated that he is a Jamaican national who has lived in Bermuda since 2000 and he has Bermudian children “In 2012 […] Full Article All Crime News #BermudaImmigration #BrittonieTaylor #CrimeInBermuda #MagistratesAndSupremeCourt #SexualAssault
sex Sex Offender TeWolde Selassie To Be Released By bernews.com Published On :: Fri, 18 Feb 2022 15:23:25 +0000 The Government has issued a public notice that convicted sex offender TeWolde Mathin Selassie will be released from prison on February 21st. A Government spokesperson said, “The Minister of Legal Affairs and Constitutional Reform, the Hon. Kathy Lynn Simmons, JP, MP, today issued a public notice of the impending release, of sex offender TeWolde Mathin […] Full Article All Crime News #CrimeInBermuda #SexOffenderNotice #SexualAssault
sex Sex Offender Devaun Cox To Be Released By bernews.com Published On :: Tue, 25 Apr 2023 23:31:54 +0000 The Attorney-General and Minister of Legal Affairs Kathy Lynn Simmons has issued a public notification that convicted sex offender Devaun Cox is set to be released, with the 38-year-old due to be released on April 27th. Photo provided by the Government The full Public Notice follow below [PDF here]: Related Stories Govt Advisory: Sex Offender […] Full Article All Crime News #CrimeInBermuda #SexOffenderNotice #SexualAssault
sex Govt Advisory: Sex Offender To Be Released By bernews.com Published On :: Wed, 30 Aug 2023 14:15:50 +0000 The Minister of Legal Affairs has issued a public notification that convicted sex offender Neville Craig Richardson is set to be released, with the 54-year-old due to be released on August 31st. Photo provided by the Government The full Public Notice follow below [PDF here]: Related Stories Sex Offender Devaun Cox To Be Released Sex […] Full Article All Crime News #CrimeInBermuda #SexOffenderNotice #SexualAssault
sex Ministry Statement On Sex Offender Devaun Cox By bernews.com Published On :: Wed, 10 Jan 2024 14:59:06 +0000 The Ministry of Legal Affairs and the Ministry of National Security addressed public concerns over sex offender Devaun Cox, noting that he was recently remanded in custody. A Government spokesperson said, “The Ministry of Legal Affairs and Ministry of National Security remain committed to addressing the concerns raised by residents regarding the recent release of repeat sex […] Full Article All Crime News #BermudaGovernment #CrimeInBermuda #SexualAssault
sex Police Investigate Video: Public Sex At Cup Match By bernews.com Published On :: Sat, 01 Aug 2015 19:21:07 +0000 The police said they are “aware of a video clip currently circulating on social media purporting to show two persons engaging in sexual activity in public at Cup Match,” and said they are looking into the matter, and reminded the public “that offenses under the telecommunications act are committed even when only sharing material such […] Full Article All News technology #BermudaPolice #CupMatch #CupMatchSexVideo #Offbeat #SexInPublic #SocialMedia
sex Bruce Springsteen’s Best Sex Jokes From the ‘Stand Up for Heroes’ Fundraiser By www.cracked.com Published On :: Tue, 12 Nov 2024 15:30:00 -0800 By Matt Solomon Published: November 12th, 2024 Full Article
sex Why a sex tape leak could actually be a ploy for power in Equatorial Guinea By www.bbc.com Published On :: Sun, 10 Nov 2024 01:36:21 GMT Dozens of videos involving a senior civil servant in Equatorial Guinea have flooded social media, shocking people in the country. Full Article
sex How a hologram is being used to solve a sex worker's murder By www.bbc.com Published On :: Sun, 10 Nov 2024 01:22:20 GMT The fatal stabbing of a Hungarian teenager, killed shortly after she gave birth, has baffled police for 15 years. Full Article
sex Diddy's private jet is available for rent amid his sex trafficking case By www.businessinsider.com Published On :: Tue, 12 Nov 2024 21:38:18 +0000 Sean Combs is trying to sell the private jet, which prosecutors have said makes him a flight risk. Full Article Law Entertainment Media Transportation sean-combs diddy private-jet sexual-assualt
sex Dutch police hope to solve cold-case murder of sex worker using hologram By www.upi.com Published On :: Sun, 10 Nov 2024 13:53:31 -0500 A hologram of a sex worker who was murdered in Amsterdam more than a decade ago could help solve the cold case, investigators hope. Full Article
sex Dominatrices Are Showing People How to Have Rough Sex Safely By www.scientificamerican.com Published On :: Fri, 16 Feb 2024 21:30:00 GMT Research shows rough sex is becoming more common. Dominatrices are helping the general public catch up. Full Article Mind & Brain Sexuality
sex Watch: Ben Stiller teaches kids sex ed in 'Nutcrackers' By www.upi.com Published On :: Tue, 12 Nov 2024 15:02:04 -0500 Hulu released the trailer for "Nutcrackers" Tuesday. The Ben Stiller holiday comedy premieres Nov. 29. Full Article
sex Texas education board set to revise sex education curriculum By www.edweek.org Published On :: 2020-11-23T08:45:49-05:00 Full Article Education
sex Are Schools Prepared to Respond to Sex Abuse? Latest Probe Reveals Shortcomings By www.edweek.org Published On :: Tue, 24 Sep 2019 00:00:00 +0000 A federal investigation of Chicago's failures to respond to sexual violence in schools raises troubling questions for school districts nationwide. Full Article Illinois
sex Penticton, B.C., city councillor faces more historical sex offence charges in Ontario, police say By www.cbc.ca Published On :: Tue, 12 Nov 2024 21:14:53 EST A Penticton city councillor who was arrested and charged with historical sexual offences this summer is facing new charges after more victims were identified, say police in Sarnia, Ont. Full Article News/Canada/British Columbia
sex Church of England head Justin Welby resigns after sex abuse coverup controversy By www.cbc.ca Published On :: Tue, 12 Nov 2024 09:28:54 EST An investigation found that he failed to inform police about serial physical and sexual abuse by a volunteer at Christian summer camps as soon as he became aware of it. Full Article News/World
sex Wessex Water pumps innovation into equipment designs with SOLIDWORKS software By www.solidworks.com Published On :: Wed, 28 Nov 2007 00:00:00 -0500 The U.K. 's No. 1 water utility uses 3D CAD software to achieve right-first-time design Full Article
sex Sensex Rises By 305 Points, Nifty By 103 In Early Market Trade By www.ndtv.com Published On :: Wed, 29 Nov 2023 10:02:34 +0530 Equity benchmark indices rallied in early trade on Wednesday amid continuous foreign fund inflows along with buying in heavyweight IT stocks, Reliance Industries and HDFC Bank. Full Article
sex Nifty Hits All-Time High After Upbeat Growth Data, Sensex Up 300 Points By www.ndtv.com Published On :: Fri, 01 Dec 2023 09:44:28 +0530 Nifty hit a fresh record high on Friday, as faster-than-expected economic growth in the September-quarter added to optimism over the global interest rate outlook. Full Article
sex AG Jennings, ATF, DSP Announce 91 Felony Charges Against Sussex County Straw Purchasers By news.delaware.gov Published On :: Wed, 16 Feb 2022 20:45:48 +0000 Guns used in Dover homicide, New Castle County suicide; many remain unrecovered Attorney General Kathy Jennings joined law enforcement and prosecutors Wednesday to announce that the DOJ has secured 87 felony charges against five defendants who are collectively charged with illegally purchasing and providing to others more than 60 firearms, including guns recovered at the […] Full Article Department of Justice Department of Justice Press Releases News
sex DOJ Seeks Public’s Assistance in Sussex County Sexual Abuse Case By news.delaware.gov Published On :: Thu, 31 Mar 2022 17:22:28 +0000 Prosecutors seek additional victims of Ellendale pastor The Delaware Department of Justice is seeking the public’s assistance in the prosecution of a Sussex County pastor indicted for Unlawful Sexual Contact, and is requesting that any additional victims contact law enforcement. Major Foster, a Lincoln man who at the time was employed as pastor of Ellendale’s […] Full Article Department of Justice Department of Justice Press Releases News
sex DCRPT Secures Prison Sentence in Sussex County Hate Crime By news.delaware.gov Published On :: Tue, 03 May 2022 12:54:59 +0000 A Sussex County man has been sentenced to two years in prison for a hate crime involving a neighbor. James Raab, of Laurel, was sentenced on April 22 after pleading guilty to felony Hate Crime, Possession of a Deadly Weapon During the Commission of a Felony, Aggravated Menacing, and Resisting Arrest. Raab, 38, was arrested […] Full Article Department of Justice Department of Justice Press Releases News
sex DOJ Secures Conviction Against Recidivist Sex Offender By news.delaware.gov Published On :: Mon, 05 Dec 2022 15:10:13 +0000 A Magnolia man has pleaded guilty to two counts of Unlawful Sexual Conduct Against a Child and two counts of Human Trafficking a Minor. George Curtis, 31, was arrested following an investigation that found that he, while serving as the photographer for an illicit photoshoot prearranged on social media, repeatedly made unwanted sexual contact with […] Full Article Criminal Division Department of Justice Press Releases
sex Delaware DOL Secy. Gilliam-Johnson visits Kent, Sussex farms in review of Migrant Seasonal Farm Worker program By news.delaware.gov Published On :: Tue, 10 Oct 2017 17:25:22 +0000 October 10, 2017 As part of its ongoing work monitoring and tracking the state’s Foreign Labor Certification and Migrant Seasonal Farm Worker activities, officials from the Delaware Department ofLabor paid a recent visit to Kent and Sussex County farms enrolled in the programs. DOL Secretary Dr. Patrice Gilliam-Johnson was joined by Deputy Secretary Karryl McManus, Division […] Full Article Department of Labor
sex Sussex County Farm Family Receives Delaware Secretary’s Award for Agriculture By news.delaware.gov Published On :: Thu, 10 Jun 2021 17:08:39 +0000 Recently, Delaware Secretary of Agriculture Michael T. Scuse took a road trip down to Sussex County to make a surprise presentation to a family farm in Laurel. Scuse recognized the Vincent Family for their commitment to Delaware through agricultural production and equipment sales, for providing gainful employment to community members, and for continuing to alleviate hunger through their participation in the USDA Farmers to Families Food Box Program. Full Article Department of Agriculture Delaware Secretary of Agriculture Michael T. Scuse farm family Secretary's Award for Distinguished Service to Delaware Agriculture USDA Farmers to Families Food Box Program Vincent Farms
sex After arriving in Delaware in 2017, spotted lanternfly now confirmed in Sussex County By news.delaware.gov Published On :: Tue, 12 Jul 2022 14:48:09 +0000 Five years after the first confirmed spotted lanternfly was found in New Castle County in 2017, the spotted lanternfly has made its way to Sussex County, creating a statewide quarantine for this invasive pest. Full Article Department of Agriculture News Delaware Department of Agriculture insect invasive pest Invasive species Plant Industries Section quarantine spotted lanternfly Spotted Lanternfly Program Sussex County
sex Delaware Forest Service Joins Daughters of the American Revolution to Establish Memorial Forest in Sussex County By news.delaware.gov Published On :: Mon, 22 Apr 2024 17:03:12 +0000 DOVER, Del. (April 22, 2024) – The Delaware Forest Service hosted the Daughters of the American Revolution (DAR), Col. John Haslet Chapter in Dover, and other volunteers to establish a memorial plot dedicated to former State Forester Walter F. Gabel, who served in this role from 1974 to 1991. “We are excited about this DAR […] Full Article Department of Agriculture Forest Service afforestation Daughters of the American Revolution Delaware Forest Service memorial Redden State Forest tree tree planting
sex DPH Announces First Human Case Of West Nile Virus Of The Year In Sussex County Man By news.delaware.gov Published On :: Wed, 31 Aug 2022 16:14:29 +0000 DOVER, DE (Aug. 31, 2022) – The Division of Public Health (DPH) is announcing this year’s first human case of West Nile Virus (WNV), in a 78-year-old Sussex County man. West Nile Virus is a mosquito-borne illness that can cause serious health problems. In addition to the first human WNV case, there also have been confirmed cases in a horse in New Castle County, and in […] Full Article Division of Public Health dawn and dusk Delaware virus dnrec DPH first human in delaware mosquito public health West Nile Virus WNV
sex Quick Prison Response To Medical Emergency Gives Sussex Correctional Institution Inmate A New Lease On Life By news.delaware.gov Published On :: Wed, 07 Dec 2022 20:35:30 +0000 Georgetown, DE – This past week the Delaware Department of Correction (DOC) recognized Correctional Officers and medical professionals for saving the life of a Sussex Correctional Institution (SCI) inmate who experienced a sudden life-threatening cardiac arrest earlier this year. On August 14, 2022 a 62 year-old inmate was working in the SCI kitchen when he exhibited […] Full Article Department of Correction reentry
sex AT&T 911 cell outage in Kent & Sussex Counties By news.delaware.gov Published On :: Sun, 11 Oct 2020 15:19:49 +0000 AT&T cell phone subscribers in Kent and Sussex Counties are experiencing difficulties when dialing and texting 911. In case of an emergency, please call the following emergency numbers: Kent County 911 Admin (302)734-6050 Dover PD Admin (302)736-7111 Sussex County 911 (302)855-2970 Rehoboth Beach (302)227-2577 Full Article Department of Safety and Homeland Security News
sex Kent/Sussex 911 restored for AT&T customers By news.delaware.gov Published On :: Sun, 11 Oct 2020 18:22:21 +0000 Kent/Sussex Counties, DE – 911 Services are fully restored for AT&T subscribers. If you have an emergency, you can now call or text 911. If you experience any problems, please call the following administrative lines: Kent County 911 (302) 734-6050 Dover PD (302) 736-7111 Sussex County 911 (302) 855-2970 Rehoboth Beach PD (302) 227-2577 Full Article Department of Safety and Homeland Security News
sex Governor Surveys Sussex County Tornado Damage By news.delaware.gov Published On :: Sun, 02 Apr 2023 23:01:36 +0000 Governor John C. Carney, Jr. joined State and Sussex County officials to tour areas near Bridgeville today after a confirmed tornado tore through the region on Saturday night, April 1. Preliminary estimates show more than 60 structures were damaged or destroyed along a 14-mile-long path through the communities of Bridgeville, Greenwood, and Ellendale. The survey also included a DelDOT maintenance yard on Newton Road where several buildings were damaged and destroyed, including one where winds pulled a wooden beam out of the ground, shifting the concrete footing. Full Article Delaware Emergency Management Agency Department of Safety and Homeland Security Governor John Carney News
sex Recovery Resources for Sussex County Tornado By news.delaware.gov Published On :: Fri, 07 Apr 2023 19:08:11 +0000 To aid in the ongoing recovery process, the Delaware Emergency Management Agency (DEMA) is announcing the following resources and assistance available to those affected by the recent deadly tornado in Sussex County on April 1. Full Article Delaware Emergency Management Agency Delaware Health and Social Services Department of Safety and Homeland Security News Office of the Governor Sussex County
sex Archbishop resigns over lack of action on sex abuse scandal By www.iol.co.za Published On :: Wed, 13 Nov 2024 03:00:24 GMT Full Article
sex Church of England head Justin Welby resigns over handling of sex abuse scandal By www.voanews.com Published On :: Tue, 12 Nov 2024 10:36:02 -0500 London — Archbishop of Canterbury Justin Welby, head of the Church of England and spiritual leader of the global Anglican Communion, resigned Tuesday after an investigation found that he failed to tell police about serial physical and sexual abuse by a volunteer at Christian summer camps as soon as he became aware of it. Pressure on Welby had been building since Thursday, when release of the inquiry's findings kindled anger about a lack of accountability at the highest reaches of the church. Helen-Ann Hartley, the bishop of Newcastle, said Monday that his position was "untenable" after some members of the church's national assembly started a petition calling on Welby to step down because he had "lost the confidence of his clergy." "I believe that stepping aside is in the best interests of the Church of England, which I dearly love and which I have been honored to serve," Welby said in a statement. The strongest outcry came from the victims of John Smyth, a prominent attorney who abused teenage boys and young men at Christian summer camps in Britain, Zimbabwe and South Africa over five decades. Andrew Morse, who was repeatedly beaten by Smyth over a period of five years, said that resigning was a chance for Welby to start repairing the damage caused by the church's handling of historical abuse cases more broadly. "I believe that now is an opportunity for him to resign,'' Morse told the BBC before Welby stepped down. "I say opportunity in the sense that this would be an opportunity for him to stand with the victims of the Smyth abuse and all victims that have not been treated properly by the Church of England in their own abuse cases." Welby's resignation comes against the backdrop of widespread historical sexual abuse in the Church of England. A 2022 report by the Independent Inquiry Child Sexual Abuse found that deference to the authority of priests, taboos surrounding the discussion of sexuality and a culture that gave more support to alleged perpetrators than their victims helped make the Church of England Church of England "a place where abusers could hide." Full Article Europe
sex Church of England head Justin Welby resigns over handling of sex abuse scandal By www.euronews.com Published On :: Tue, 12 Nov 2024 23:48:51 +0100 Church of England head Justin Welby resigns over handling of sex abuse scandal Full Article
sex Amendment J: Removing ban on same-sex marriage from Colorado Constitution up in early voting By www.denverpost.com Published On :: Tue, 05 Nov 2024 22:00:36 +0000 Colorado voters will decide whether to repeal the state constitution's now-defunct marriage definition that only recognizes unions between a man and a woman. Full Article Election Latest Headlines National News News Politics election Election 2024 gay marriage LGBTQ National Politics same-sex marriage U.S. Supreme Court
sex Breast Cancer Treatment Effects on Sex Life a Hidden Burden By www.medicinenet.com Published On :: Tue, 9 Aug 2022 00:00:00 PDT Title: Breast Cancer Treatment Effects on Sex Life a Hidden BurdenCategory: Health NewsCreated: 8/8/2022 12:00:00 AMLast Editorial Review: 8/9/2022 12:00:00 AM Full Article
sex Girls Lose Friends for Having Sex But Boys Don't, Study Shows By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Girls Lose Friends for Having Sex But Boys Don't, Study ShowsCategory: Health NewsCreated: 8/24/2015 12:00:00 AMLast Editorial Review: 8/24/2015 12:00:00 AM Full Article
sex Sex Lives Best When Couples Share Child Care Duties, Survey Shows By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Sex Lives Best When Couples Share Child Care Duties, Survey ShowsCategory: Health NewsCreated: 8/23/2015 12:00:00 AMLast Editorial Review: 8/24/2015 12:00:00 AM Full Article
sex Could an Estrogen Patch Boost Women's Sex Lives in Menopause? By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Could an Estrogen Patch Boost Women's Sex Lives in Menopause?Category: Health NewsCreated: 8/28/2017 12:00:00 AMLast Editorial Review: 8/29/2017 12:00:00 AM Full Article
sex Ex-CDC Director Frieden Arrested on Sex Charges By www.medicinenet.com Published On :: Mon, 29 Aug 2022 00:00:00 PDT Title: Ex-CDC Director Frieden Arrested on Sex ChargesCategory: Health NewsCreated: 8/25/2018 12:00:00 AMLast Editorial Review: 8/27/2018 12:00:00 AM Full Article
sex Many Older Women Have Active Sex Lives, But Menopause Can Interfere By www.medicinenet.com Published On :: Thu, 19 May 2022 00:00:00 PDT Title: Many Older Women Have Active Sex Lives, But Menopause Can InterfereCategory: Health NewsCreated: 5/18/2022 12:00:00 AMLast Editorial Review: 5/19/2022 12:00:00 AM Full Article
sex Vaginal or C-Section, Method of Childbirth Won't Affect a Couple's Sex Life Later By www.medicinenet.com Published On :: Thu, 25 Aug 2022 00:00:00 PDT Title: Vaginal or C-Section, Method of Childbirth Won't Affect a Couple's Sex Life LaterCategory: Health NewsCreated: 8/24/2022 12:00:00 AMLast Editorial Review: 8/25/2022 12:00:00 AM Full Article
sex De novo genome assemblies of two cryptodiran turtles with ZZ/ZW and XX/XY sex chromosomes provide insights into patterns of genome reshuffling and uncover novel 3D genome folding in amniotes [RESEARCH] By genome.cshlp.org Published On :: 2024-10-29T06:46:07-07:00 Understanding the evolution of chromatin conformation among species is fundamental to elucidate the architecture and plasticity of genomes. Nonrandom interactions of linearly distant loci regulate gene function in species-specific patterns, affecting genome function, evolution, and, ultimately, speciation. Yet, data from nonmodel organisms are scarce. To capture the macroevolutionary diversity of vertebrate chromatin conformation, here we generate de novo genome assemblies for two cryptodiran (hidden-neck) turtles via Illumina sequencing, chromosome conformation capture, and RNA-seq: Apalone spinifera (ZZ/ZW, 2n = 66) and Staurotypus triporcatus (XX/XY, 2n = 54). We detected differences in the three-dimensional (3D) chromatin structure in turtles compared to other amniotes beyond the fusion/fission events detected in the linear genomes. Namely, whole-genome comparisons revealed distinct trends of chromosome rearrangements in turtles: (1) a low rate of genome reshuffling in Apalone (Trionychidae) whose karyotype is highly conserved when compared to chicken (likely ancestral for turtles), and (2) a moderate rate of fusions/fissions in Staurotypus (Kinosternidae) and Trachemys scripta (Emydidae). Furthermore, we identified a chromosome folding pattern that enables "centromere–telomere interactions" previously undetected in turtles. The combined turtle pattern of "centromere–telomere interactions" (discovered here) plus "centromere clustering" (previously reported in sauropsids) is novel for amniotes and it counters previous hypotheses about amniote 3D chromatin structure. We hypothesize that the divergent pattern found in turtles originated from an amniote ancestral state defined by a nuclear configuration with extensive associations among microchromosomes that were preserved upon the reshuffling of the linear genome. Full Article
sex Chronic Administration of Cannabinoid Agonists ACEA, AM1241, and CP55,940 Induce Sex-Specific Differences in Tolerance and Sex Hormone Changes in a Chemotherapy-Induced Peripheral Neuropathy [Special Section: Cannabinoid Signaling in Human Health and Dise By jpet.aspetjournals.org Published On :: 2024-10-18T07:04:15-07:00 Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of chemotherapy treatment, routinely manifesting as increased pain sensitivity (allodynia) in distal extremities. Despite its prevalence, effective treatment options are limited. Cannabinoids are increasingly being evaluated for their ability to treat chronic pain conditions, including CIPN. While previous studies have revealed sex differences in cannabinoid-mediated antinociception in acute and chronic pain models, there is a paucity of studies addressing potential sex differences in the response of CIPN to cannabinoid treatment. Therefore, we evaluated the long-term antiallodynic efficacy of cannabinoid receptor type 1 (CB1)-selective, cannabinoid receptor type 2 (CB2)-selective, and CB1/CB2 mixed agonists in the cisplatin CIPN model, using both male and female mice. CB1 selective agonism was observed to have sex differences in the development of tolerance to antiallodynic effects, with females developing tolerance more rapidly than males, while the antiallodynic effects of selective CB2 agonism lacked tolerance development. Compound-specific changes to the female estrous cycle and female plasma estradiol levels were noted, with CB1 selective agonism decreasing plasma estradiol while CB2 selective agonism increased plasma estradiol. Chronic administration of a mixed CB1/CB2 agonist resulted in increased mRNA expression of proinflammatory cytokines and endocannabinoid regulatory enzymes in female spinal cord tissue. Ovarian tissue was noted to have proinflammatory cytokine mRNA expression following administration of a CB2 acting compound while selective CB1 agonism resulted in decreased proinflammatory cytokines and endocannabinoid regulatory enzymes in testes. These results support the need for further investigation into the role of sex and sex hormones signaling in pain and cannabinoid-mediated antinociceptive effects. SIGNIFICANCE STATEMENT CIPN is a common side effect of chemotherapy. We have found that both CB1 and CB2 receptor agonism produce antinociceptive effects in a cisplatin CIPN model. We observed that tolerance to CB1-mediated antinociception developed faster in females and did not develop for CB2-mediated antinociception. Additionally, we found contrasting roles for CB1/CB2 receptors in the regulation of plasma estradiol in females, with CB1 agonism attenuating estradiol and CB2 agonism enhancing estradiol. These findings support the exploration of cannabinoid agonists for CIPN. Full Article
sex Sex Differences in the Neural and Behavioral Effects of Acute High-Dose Edible Cannabis Consumption in Rats [Special Section: Cannabinoid Signaling in Human Health and Disease] By jpet.aspetjournals.org Published On :: 2024-10-18T07:04:15-07:00 The consumption of 9-tetrahydrocannabinol (THC)- or cannabis-containing edibles has increased in recent years; however, the behavioral and neural circuit effects of such consumption remain unknown, especially in the context of ingestion of higher doses resulting in cannabis intoxication. We examined the neural and behavioral effects of acute high-dose edible cannabis consumption (AHDECC). Sprague-Dawley rats (six males, seven females) were implanted with electrodes in the prefrontal cortex (PFC), dorsal hippocampus (dHipp), cingulate cortex (Cg), and nucleus accumbens (NAc). Rats were provided access to a mixture of Nutella (6 g/kg) and THC-containing cannabis oil (20 mg/kg) for 10 minutes, during which they voluntarily consumed all of the provided Nutella and THC mixture. Cannabis tetrad and neural oscillations were examined 2, 4, 8, and 24 hours after exposure. In another cohort (16 males, 15 females), we examined the effects of AHDECC on learning and prepulse inhibition and serum and brain THC and 11-hydroxy-THC concentrations. AHDECC resulted in higher brain and serum THC and 11-hydroxy-THC levels in female rats over 24 hours. AHDECC also produced: 1) Cg, dHipp, and NAc gamma power suppression, with the suppression being greater in female rats, in a time-dependent manner; 2) hypolocomotion, hypothermia, and antinociception in a time-dependent manner; and 3) learning and prepulse inhibition impairments. Additionally, most neural activity and behavior changes appear 2 hours after ingestion, suggesting that interventions around this time might be effective in reversing/reducing the effects of AHDECC. SIGNIFICANCE STATEMENT The effects of high-dose edible cannabis on behavior and neural circuitry are poorly understood. We found that the effects of acute high-dose edible cannabis consumption (AHDECC), which include decreased gamma power, hypothermia, hypolocomotion, analgesia, and learning and information processing impairments, are time and sex dependent. Moreover, these effects begin 2 hours after AHDECC and last for at least 24 hours, suggesting that treatments should target this time window in order to be effective.: Full Article
sex Self-Reported PrEP Use and Risk of Bacterial STIs Among Ontarian Men Who Are Gay or Bisexual or Have Sex With Men [Original Research] By www.annfammed.org Published On :: 2024-09-23T14:00:14-07:00 PURPOSE HIV pre-exposure prophylaxis (PrEP) may increase rates of bacterial sexually transmitted infections (STIs) among gay, bisexual, and other men who have sex with men (GBM) through risk compensation (eg, an increase in condomless sex or number of partners); however, longitudinal studies exploring the time-dependent nature of PrEP uptake and bacterial STIs are limited. We used marginal structural models to estimate the effect of PrEP uptake on STI incidence. METHODS We analyzed data from the iCruise study, an online longitudinal study of 535 Ontarian GBM from July 2017 to April 2018, to estimate the effects of PrEP uptake on incidence of self-reported bacterial STIs (chlamydia, gonorrhea, and syphilis) collected with 12 weekly diaries. The incidence rate was calculated as the number of infections per 100 person-months, with evaluation of the STIs overall and individually. We used marginal structural models to account for time-varying confounding and quantitative bias analysis to evaluate the sensitivity of estimates to nondifferential outcome misclassification. RESULTS Participating GBM were followed up for a total of 1,623.5 person-months. Overall, 70 participants (13.1%) took PrEP during the study period. Relative to no uptake, PrEP uptake was associated with an increased incidence rate of gonorrhea (incidence rate ratio = 4.00; 95% CI, 1.67-9.58), but not of chlamydia or syphilis, and not of any bacterial STI overall. Accounting for misclassification, the median incidence rate ratio for gonorrhea was 2.36 (95% simulation interval, 1.08-5.06). CONCLUSIONS We observed an increased incidence rate of gonorrhea associated with PrEP uptake among Ontarian GBM that was robust to misclassification. Although our findings support current guidelines for integrating gonorrhea screening with PrEP services, additional research should consider the long-term impact of PrEP among this population. Annals Early Access article Full Article