sex Same Sex Attraction and Three Desert Fathers By www.ancientfaith.com Published On :: 2023-08-28T20:56:22+00:00 We live in a generation that has been taught to tie their personal identity to their imagined sexual preferences. Consequently, it is difficult to help people who struggle with sexual passions to find hope and repentance. However, the teaching of holy fathers such as St. Isaac the Syrian and St. Barsanuphius of Gaza provide a very helpful alternative to the world’s way of thinking about such passions. For these saints, same-sex attraction is a passion like any other. It is not part of one’s identity, but is a parasitical passion, resisted and struggled against as all other passions are. Full Article
sex Same-Sex Marriage and Homosexuality By www.ancientfaith.com Published On :: 2015-11-05T17:37:10+00:00 In this episode, Fr John Parker address same-sex marriage and homosexuality, in response to the frenzy of discussion on these topics today in the public sphere. Full Article
sex Of Gay Sex and Leaven By www.ancientfaith.com Published On :: 2017-06-28T19:51:46+00:00 What does the Orthodox Church think about gay sex? The official answer is not hard to find. Full Article
sex Pope Francis’ "Fiducia Supplicans" and Same-Sex Union By www.ancientfaith.com Published On :: 2024-01-31T06:00:01+00:00 I have just read two fascinating pieces about Pope Francis’ recent and controversial document Fiducia Supplicans, which officially allows Roman Catholic priests to bless persons in same-sex relationships, one by an Orthodox and the other by a Roman Catholic. Full Article
sex Sex and Political Action By www.ancientfaith.com Published On :: 2016-02-23T03:44:50+00:00 Fr. Philip LeMasters, Dean of the School of Social Sciences and Religion at McMurry University, tries to account for why homosexuality has become the defining issue of our time, arguing that it was the civil rights movement and the sexual revolution that has turned us all into political hedonists. Full Article
sex Christianity and Same-Sex Attraction By www.ancientfaith.com Published On :: 2014-03-15T21:03:02+00:00 Dr. Philip Mamalakis and Andrew Williams, the creators and facilitators of “Finding the freedom to live in the image of God,” a new therapeutic program based on Orthodox principles for sexual addictions and sex-related issues. Full Article
sex Same-Sex Marriage: Separation of Church-State Issue, or a Moral Problem We Must Oppose? By www.ancientfaith.com Published On :: 2014-03-15T21:03:25+00:00 Guests: Father John Whiteford (ROCOR) and David J. Dunn, PhD, author of the Huffington Post article, “Gay marriage: An Eastern Orthodox Perspective.” Full Article
sex Michael McMonagle jailed for child sex offences By www.bbc.com Published On :: Fri, 08 Nov 2024 16:09:05 GMT Michael McMonagle has been sentenced to nine months in custody and a further nine months on licence. Full Article
sex Trafficker jailed for forcing women into sex work By www.bbc.com Published On :: Fri, 08 Nov 2024 12:40:29 GMT A human trafficker who lured women from Thailand and forced them into the sex trade is jailed Full Article
sex Church 'colluded' with sex abuse bishop By www.bbc.co.uk Published On :: Former bishop Peter Ball was jailed for sex offences against 18 teenagers and young men. Full Article England
sex Sex worker guilty of luring man to fatal stabbing By www.bbc.com Published On :: Mon, 11 Nov 2024 16:11:15 GMT Rebecca Moore, 25, is found guilty of her role in the murder of Sacad Ali in Sheffield on 9 March. Full Article
sex Middlesex sign ex-Gloucestershire all-rounder Gohar By www.bbc.com Published On :: Tue, 05 Nov 2024 12:19:55 GMT Spin bowling all-rounder Zafar Gohar signs a two-year deal with Middlesex following his departure from Gloucestershire. Full Article
sex Inside an abandoned Essex RAAC school By www.bbc.co.uk Published On :: Tue, 12 Nov 2024 13:47:00 GMT St Andrew's Junior School in Hatfield Peverel might not be completely rebuilt until 2028. Full Article
sex The Sex Myth: extract and first interview By belledejour-uk.blogspot.com Published On :: Fri, 13 Apr 2012 15:05:00 +0000 The Telegraph have now printed an extract and the first interview about The Sex Myth. Positively chuffed to see "be an ally" in print. (Especially on Friday the 13th, which is fast becoming the date when sex work allies are urged to speak out.)If you'd like to find out more about the book, and would like your copy of The Sex Myth signed, why not join me in London or Nottingham next week? Full Article interview writing
sex Why Scotland should not make sex work illegal By belledejour-uk.blogspot.com Published On :: Mon, 18 Jun 2012 09:14:00 +0000 UPDATE: MSPs have voted that Grant's bill will have to go to consultation and will not be fast-tracked. Which is good news. But the fight is not over, and expect more to come when the consultation hits. At the same time that the Moratorium 2012 campaign kicks off in London, spearheading a common-sense approach to sex work, there appears a bid in Scotland to try to make prostitution illegal. Just to recap: soliciting, running a brothel, and kerb crawling are already illegal (as too are trafficking and sexual exploitation of children). Exchanging sex for money at this point is not. Not yet. Labour MSP Rhoda Grant claims "Scotland should become an unattractive market for prostitution and therefore other associated serious criminal activities, such as people trafficking for sexual exploitation, would be disrupted." Grant is, unfortunately, badly informed and wrong. I'm going to keep this one short and sweet because the points are pretty straightforward... Scotland does not have a sex trafficking epidemic Sex trafficking is the excuse frequently given these days to harass and criminalise sex workers. Problem is, it's not remotely the "epidemic" they would have you believe. If you're not already up to speed on the whys and wherefores, I highly recommend reading Laura Agustin's work on this. Or if I may be so cheeky to suggest you could also buy my book. Specifically, it is not happening in Scotland. “In Scotland, to the best of my knowledge, we don't have a conviction for human trafficking,” said police constable Gordon Meldrum. Meldrum had previously claimed research “proved” the existence of 10 human trafficking groups north of the border, and 367 organised crime groups with over 4000 members. “We had one case which was brought to court previously but was abandoned. My understanding is it was abandoned due to a lack of evidence, essentially.” Strange how the evidence seemed to disappear precisely when someone was asked to produce all these fantasy baddies, isn't it? It's not only Scotland where the trafficking hype falls flat though: investigation throughout the UK has comprehensively failed to find any supposed sex trafficking epidemic. Not convinced by the evidence? Then consider this: criminalising sex workers and their clients removes the most reliable information sources police have for investigating abuses. Police don't have a great track record on this: In interviews by the Sex Workers Project with 15 trafficking survivors who experienced police raids, only one had been asked by law enforcement if she was coerced, and only after she was arrested. SWOP-NYC make this case clearly. Criminalising sex work has been shown in Scotland to make criminal activity worse Criminalisation has all kinds of effects on the behaviour of sex workers, but unfortunately, none of those effects are good. Fear of police forces sex workers to get into clients’ cars quickly, and possibly be unable to avoid dangerous attackers posing as clients. When vigilantes and police roam the pavements, sex workers wait until the wee hours to come out, making them more isolated and vulnerable to harm. Such an approach can also result in a transfer of activity from streetwalking to other ways of getting money. High-profile crackdown results in repeated arrests of prostitutes, which translate to fines that sex workers, now burdened with criminal records, are unable to pay except by more prostitution or by fraud, shoplifting, and dealing drugs. Take Aberdeen, for instance. From 2001 onward, the city had an established tolerance zone for sex workers around the harbour. That ended with passage of the Prostitution (Public Places) (Scotland) Act in 2007. In the following months the city centre experienced an influx of streetwalkers and an increase in petty crimes. Quay Services, which operates a drop-in centre for streetwalkers, reported that sex workers became more afraid to seek assistance, and the number of women coming to the centre dropped to “just a handful”. There was also evidence that displacing sex workers led to more activity in the sex trade, not less – convictions for solicitation tripled. This kind of ‘crime shuffling’ takes prostitution out of one area and dumps it on another. It only resembles an improvement if you fail to look at the full picture. Prohibition never works There is a lot of talk in the political sphere about the need for “evidence based policy”. This means rejecting approaches that are moralistic and manipulative. Sex workers have suffered the tragic consequences of prejudicial social attitudes that lead to bad policy. The prohibition approach has not worked. It will never work. The people who endorse this view are putting people in danger and should not be guiding public opinion any longer. Disliking sex work is not a good enough argument to justify criminalising it. Is there any public interest served by preventing adults from engaging in a consensual transaction for sexual services? No, there is not. Bit like the war on drugs: making the business profitable only to criminals, awaiting the inevitably grim results, then claiming that it’s the drugs themselves, not the laws, wot caused it. Few reasonable people believe that line of argument when it comes to drugs. Why does anyone believe it when it comes to sex? Moral disapproval is a bad basis for policymaking. I don't find the idea of taking drugs at all appealing, but I don't assume my own preferences should be the basis for law. The condescension heaped on people who do sex work is embarrassingly transparent. All this mealy-mouthed, 'oh but we want to help them, really’. How’s that again? By saddling people with criminal records and taking away their children? Do me a favour. As well as the happy prostitutes there are unhappy sex workers in need of support. Society should protect the unwilling and underage from sexual exploitation and provide outreach for those who need and want it. We already have laws and services for that. Maybe the laws should be more intelligently enforced and the services better supported. But prosecuting the victimless crimes does neither of these. It helps no one. The potential existence of abuses does not mean such work should be automatically criminalised if for no other reason than doing so makes the lives of people in sex work worse, not better. Criminalisation is the very opposite of compassion. Rhoda Grant is hiding behind an "end demand" approach that will not achieve what she claims it will, but will punish sex workers and send those with already chaotic lives further into a downward spiral. If that isn't punishing them with no hope for change then I don't know what is. It's time we started acting like grownups and stopped pretending that making something illegal makes it cease to exist. Full Article crime prostitution Scotland trafficking
sex BREAKING NEWS: I was a sex worker. By belledejour-uk.blogspot.com Published On :: Sun, 11 Aug 2013 12:21:00 +0000 This morning I awoke to find a claim published in the Mail that I was not a sex worker. It is a direct attack on my integrity as a writer, to claim that I lied. And I have been prepared. When the case goes to trial, I will have to present evidence that I was a sex worker. Starting with this - an Archive.org snap of my first escorting ad from October 2003 (link NSFW). (Readers of the first book may recall this was the session with the grumpy photographer I wrote about. As I have often said, it was that experience - being made to wear terrible lingerie, awkward poses, all the rest - that first made me think, 'hey, I should be blogging this.' And if you read the third book, I made a reference to a restaurant on Old Compton Street that has the same name as my working name - that is, of course, Taro.) I will also be presenting my bank records from 2003-04, showing the cash deposits from the money I earned as an escort, and tax records from the same years showing that this income was declared to HMRC and tax paid. Here is a sample: I also have the notebook in which I recorded details of appointments, etc. In several instances I have been able to piece together entries from the notebook, deposits to my accounts, and the corresponding entries in the book. If pressed, I will name a client, but only as a last resort. The Mail also claims I didn't own nice enough clothes so couldn't have been an escort! That's from December 2003, and is the same red silk top I wore to meet the manager for the first time (as written about in the first book). The next is at Henley Regatta in July 2004, suit is from Austin Reed, the bracelet was a gift from a client. The Mail claims I was in Sheffield when writing the blog, but I moved to London in September 2003 and started escorting in October, starting blogging a few weeks later. All of which is easy - trivial, even - to prove. Oh, and the "former landlady in Sheffield, who did not wish to be named", where I supposedly lived for three years? Who apparently saw me in 'Oxfam jumpers'? Hmm... I lived one year in university accommodation (St George's Flats), one year in a shared flat with an absentee landlord I never met (Hawthorne Road), and one year on my own in a house let through an agency (Loxley New Road). All well before moving to London. So either the landlady is lying about the timing of my tenancy and having met me, or (shock, horror) they made it up. There's much more but it would be boring to put it all here. It's amazing to me the MoS made no effort at all to match anything they printed against things that are easy to find and in the public domain. But that's by the by, and will come out in due course. It matters because this is a concerted and direct attack on my work as a writer. When I was anonymous, being real was my main - my only - advantage. The Mail on Sunday have made some frankly nonsense claims, and I will be going to town on this. Because I know people do not trust the word of a sex worker, that is why I saved everything. I look forward to the opportunity to rebut all claims in court. (The MoS claim the trial is expected "within weeks." In fact it is scheduled for June 2015.) Full Article lawsuit Scotland
sex Church of England head Justin Welby resigns over handling of sex abuse scandal By www.washingtontimes.com Published On :: Tue, 12 Nov 2024 09:38:11 -0500 Archbishop of Canterbury Justin Welby, head of the Church of England and spiritual leader of the global Anglican Communion, resigned Tuesday after an investigation found that he failed to tell police about serial physical and sexual abuse by a volunteer at Christian summer camps as soon as he became aware of it. Full Article
sex Now in my 70s, I want a better sex life By www.boston.com Published On :: Thu, 09 May 2024 12:58:35 +0000 I am now getting to a point where I want to explore my sexuality. I have a bucket list of things I want to try. The post Now in my 70s, I want a better sex life appeared first on Boston.com. Full Article Love Letters Dating Dating Sex + Relationships Health ???? Sex ????
sex I didn’t know enough about sex therapy, either By www.boston.com Published On :: Tue, 28 May 2024 20:42:20 +0000 Sex therapists — including the one in today’s episode of the Love Letters podcast — say that a lot of people don’t really understand the range of the work. The post I didn’t know enough about sex therapy, either appeared first on Boston.com. Full Article Culture Commentary Dating Sex + Relationships Love Letters
sex Pimloc Helps Sussex Police Enhance Law Enforcement Through AI Redaction Technology By www.sdmmag.com Published On :: Fri, 27 Sep 2024 18:00:00 -0400 The collaboration helps to make multimedia redaction for subject access requests and digital evidence faster and more accurate through the implementation of artificial intelligence technologies, which marks the start of an exciting business development for Pimloc. Full Article
sex Pharmactive Biotech Products: Boost Sex Drive, Function By www.preparedfoods.com Published On :: Fri, 28 Oct 2022 12:30:00 -0400 Pharmactive Biotech Products, S.L.U., launches Liboost®, a novel botanical extract of Damiana (Turnera diffusa), as the first formulation to help enhance sexual function in both men and women. Its sexual performance boosting capabilities have been confirmed in a consumer study conducted by the company yielding impressive results. Full Article
sex ‘It is a kind of marriage’: When Denmark held the first ever same-sex civil unions By ifp.nyu.edu Published On :: Wed, 09 Oct 2024 22:03:19 +0000 The post ‘It is a kind of marriage’: When Denmark held the first ever same-sex civil unions was curated by information for practice. Full Article History
sex “A little love is enough for me to live my life…”: Precarity and resilience among older sex workers in India By ifp.nyu.edu Published On :: Tue, 05 Nov 2024 03:32:32 +0000 Volume 36, Issue 5, September-October 2024, Page 410-426. Read the full article › The post “A little love is enough for me to live my life…”: Precarity and resilience among older sex workers in India was curated by information for practice. Full Article Journal Article Abstracts
sex Basic Black LIVE: President Obama, Same-Sex Marriage, and the Black Vote By www.wgbh.org Published On :: Sat, 12 May 2012 00:00:00 EST (Originally broadcast May 11, 2012) President Obama surprised the world yesterday when his stance on same-sex marriage finished "evolving" and he came out in support of it. Will his position hurt or help his chances at re-election? How will it affect his relationship with black clergy? Will it alter his support in the black community? Our panelists: - Callie Crossley, host and executive editor, The Callie Crossley Show - Kim McLarin, author and assistant professor of creative writing, Emerson College - Phillip Martin, senior reporter, 89.7 WGBH Radio - Lionel McPherson, associate professor of philosophy, Tufts University Full Article
sex R. Kelly calls accusers 'liars' in sex abuse case By minnesota.publicradio.orghttps Published On :: Wed, 06 Mar 2019 08:46:33 -0600 The singer, out on bail following his Feb. 22 arrest in Chicago, said he has done "lots of things wrong" when it comes to women, but said he has apologized. He denies doing anything against their will. Full Article
sex R. Kelly arrested again in Chicago on federal sex charges By minnesota.publicradio.orghttps Published On :: Fri, 12 Jul 2019 04:57:18 -0500 Singer R. Kelly, already facing sexual abuse charges brought by Illinois prosecutors, was arrested in Chicago Thursday on a federal grand jury indictment listing 13 counts including sex crimes and obstruction of justice. Full Article
sex Therapists urge churches to offer more than celibacy for people with unwanted same-sex attraction By www.christianpost.com Published On :: Tue, 22 Oct 2024 13:36:52 -0400 People suffering as a result of unwanted same-sex attraction or gender confusion should be allowed to seek professional help, and the Church must offer a more hopeful message than simply telling them to be celibate for the rest of their lives. Full Article
sex Sex after vaccination is good, Russian doctor says By english.pravda.ru Published On :: Fri, 09 Jul 2021 12:09:00 +0300 There is nothing wrong with having sex after vaccination against COVID-19, Vladislav Zhemchugov, Doctor of Medical Sciences, specialist in especially dangerous infections, said in an interview with RIA Novosti. According to him, sex is an energy-intensive process. However, according to the doctor, everything depends on the person. “I think that on the contrary, a higher emotional background contributes to an increase in immunity,” the specialist said. Full Article Health
sex Prosecutors Seek Four-Year Sentence for Footballer Who Admitted Secretly Filming Sex Acts By world.kbs.co.kr Published On :: Wed, 16 Oct 2024 13:47:54 +0900 [Sports] : Prosecutors are seeking a four-year prison term for football forward Hwang Ui-jo, who has admitted to filming sexual encounters without his partners’ consent. The 32-year-old footballer, who plays for the Turkish Süper Lig club Alanyaspor, entered the guilty plea Wednesday at the Seoul Central District ...[more...] Full Article Sports
sex How And Why Was Bill Cosby’s Sex Assault Conviction Overturned? By www.scpr.org Published On :: Wed, 30 Jun 2021 10:52:59 -0700 Bill Cosby exits the Montgomery County Courthouse in Norristown, Pa., Saturday, June 17, 2017. ; Credit: Matt Rourke/AP AirTalkPennsylvania’s highest court overturned. Bill Cosby’s sex assault conviction Wednesday after finding an agreement with a previous prosecutor prevented him from being charged in the case. Cosby has served more than two years of a three- to 10-year sentence at a state prison near Philadelphia. He had vowed to serve all 10 years rather than acknowledge any remorse over the 2004 encounter with accuser Andrea Constand. We dive into how this all happened, through the lens of law, celebrity and the MeToo movement. With files from the Associated Press Guests: Ambrosio Rodriguez, former prosecutor; he is currently a criminal defense attorney at The Rodriguez Law Group in Los Angeles; he led the sex crimes team and was in the homicide unit in the Riverside D.A.’s office; he tweets at @aer_attorney Laurie L. Levenson, professor of criminal law at Loyola Law School in Los Angeles and former federal prosecutor This content is from Southern California Public Radio. View the original story at SCPR.org. Full Article
sex Hot Vax Summer? How Sex And Relationships In America Are Changing With Vaccines Widely Available By www.scpr.org Published On :: Tue, 06 Jul 2021 09:19:11 -0700 In this photo taken on February 10, 2020 a 'love kit' is seen on the bed in a room at the Dragonfly hotel in Mumbai.; Credit: PUNIT PARANJPE/AFP via Getty Images AirTalkA new survey shows that in the era of widespread vaccine availability, American couples are more satisfied in their relationships -- and some are even getting more experimental than they have been. Led by Indiana University Kinsey Institute researcher Justin Lehmiller in collaboration with the website Lovehoney, which describes itself as “global sexual happiness experts,” the report looked at responses from 2,000 U.S. adults age 18-45, including an oversample of 200 who identified as LGBTQ, and among the major findings of the survey were that more than half (51 percent) of respondents said their sexual interests had changed during the pandemic, and many of those said they’d started trying things they hadn’t before. It also found that 44 percent of people surveyed said they were communicating better with their partner, and among singles surveyed 52 percent say they’re less interested in casual sex and more than a third of them said they weren’t interested in having sex on the first date. Today on AirTalk, we’ll talk with Professor Lehmiller about the survey, its findings and how the pandemic impacted Americans’ views on relationships and sex. Guest: Justin Lehmiller, social psychologist and research fellow at Indiana University’s Kinsey Institute who conducted the “Summer of Love” survey; author of “Tell Me What You Want: The Science of Sexual Desire and How It Can Help You Improve Your Sex Life” (Hachette Go, July 2020); host of the “Sex and Psychology” podcast; he tweets @JustinLehmiller This content is from Southern California Public Radio. View the original story at SCPR.org. Full Article
sex NICHOLS KASTER AND CALIFORNIA CIVIL RIGHTS LAW GROUP FILE SEX AND SEXUAL ORIENTATION DISCRIMINATION CLASS ACTION AGAINST GEICO, UNITED HEALTHCARE SERVICES, AND UNITEDHEALTH GROUP By www.24-7pressrelease.com Published On :: Mon, 29 Jan 2024 08:00:00 GMT The complaint alleges that this policy was unfair and facially discriminated on the basis of sex and/or sexual orientation. Full Article
sex SARS2/COVID 19 in Middlesex County, Massachusetts: A Pilot Community Report By www.24-7pressrelease.com Published On :: Fri, 06 Sep 2024 08:00:00 GMT A data driven report on the spread of COVID 19 in Middlesex County, Massachusetts Full Article
sex COVID19/SARS2 in Middlesex County, Massachusetts: A Pilot Community Report, vaccines vs. antiviral response By www.24-7pressrelease.com Published On :: Wed, 11 Sep 2024 08:00:00 GMT Considering the major societal disruptions brought on by government mandates responding to the COVID19 pandemic, all communities owe their residents an objective review of the mandates imposed. Full Article
sex Sport, Sex and Identity Symposium - U of T experts to discuss how sport shapes identity and reflects humanity By media.utoronto.ca Published On :: Wed, 30 Mar 2016 12:40:48 +0000 U of T experts to discuss how sport shapes identity and reflects humanityToronto, ON — How can sport act as a platform to promote human rights and break down barriers? How can it reflect and define our cultural identity and shape gender roles? Join U of T’s Faculty of Kinesiology and Physical Education for Sport, […] Full Article Education Event Advisories Kinesiology and Physical Education Media Releases University of Toronto
sex Perseverance and collaboration: How a new clinical trial aims to determine whether sex matters when matching blood products to patients By www.blood.ca Published On :: Thu, 31 Oct 2024 17:26:59 +0000 Perseverance and collaboration: How a new clinical trial aims to determine whether sex matters when matching blood products to patients Transfusion Blood Thursday, October 31, 2024 Abby Wolfe As the Principal Investigator for the SexMatters trial described in this blog, Dr. Mickey Zeller is an Associate Professor in the Department of Medicine at McMaster University. She is also a Medical Officer at Canadian Blood Services. Around 2018, Dr. Mickey Zeller's grandmother asked her a question that she couldn’t fully answer at the time. It’s a question that Dr. Zeller continues to keep top-of-mind in her roles as an Associate Professor at McMaster University and a Medical Officer at Canadian Blood Services. Having sustained a pelvic fracture at the age of 94, she asked her granddaughter, “If I need a blood transfusion, could it come from a man... and if it does, would that be safe?”. As Dr. Zeller describes, “I looked at her and, in that moment, I said, ‘Grandma, no one knows! But it’s on my list to find out!’.” In fact, questions about whether selecting products based on the sex of donor and recipient could improve outcomes following blood transfusions have been around for years. However, there is not yet been enough evidence to definitively answer whether this strategy would help optimize hospital and blood operator practices. After much perseverance, collaboration with researchers across Canadian Blood Services’ extended research network, and a successful bid for CIHR funding, a research team led by Dr. Zeller is embarking on a new research journey they hope will finally provide the evidence to answer questions about whether sex matters in red blood cell transfusion. What will the study focus on and why is it needed? When a patient requires a transfusion of red blood cells (RBCs), the matching of product to patient is based on compatibility testing that looks at whether the blood is group A, B, AB or O, whether it is Rh positive or negative, and what other antibodies are present. Canadian Blood Services’ Rare Blood Program also helps ensure patients with specific combinations of antigens – proteins that appear on the surface of red blood cells – can be matched with appropriate blood components. Laboratory studies on donor factors such as age and sex have looked at their impact on characteristics of RBCs in terms of hematocrit, cell volume, hemoglobin content, and deformability – that is, the flexibility or “squeeze-ability” of the cells. However, currently available evidence has not demonstrated a need for red blood cells for transfusion to be matched based on the sex of either donor or recipient. The principal research question being posed by this study is: In adults admitted to the ICU who require RBC transfusions, do donor-recipient sex-matched RBC transfusions result in improved 30-day mortality compared with sex-mismatched RBC transfusions? Answering this question has a large potential for impact because of the substantial number of blood transfusions that occur throughout Canada every year. “If there was a risk identified [from the sex of the donor and recipient], even moving the needle a little bit to improve the matching of blood product to recipient could add another layer of safety to current practices,” Dr. Zeller explains. What had to happen to make this study possible? While it seems like a basic question to remain unanswered, Dr. Zeller acknowledges the investments of energy, expertise, and funding to get the study to this point. “Sometimes these basic questions remain for a long time because it is challenging to get the funding and infrastructure in place to be able to answer them in a scientifically rigorous way; even if they’re basic-level questions, it’s only by investing that you are able to gather the evidence to answer the question.” Dr. Zeller says. That’s part of the reason why Canadian Blood Services’ investments in networks like CTTG are important. The Canadian Transfusion Trials Group (CTTG) is funded by Canadian Blood Services with the aim of supporting and accelerating clinical trials that can inform best practices in transfusion medicine in Canada. CTTG reviewed and endorsed this SexMatters study and provided support through its development, making it the second RCT since CTTG’s inception to earn CIHR funding following participation in their review process. "I had the opportunity to present to CTTG twice and receive feedback that improved this study design and my application to CIHR for its funding. Having it reviewed by people like Dr. Donald Arnold, Dr. Jeannie Callum, Dr. Nadine Shehata – people with world-recognized expertise in this area – really led to the success of this application,” Dr. Zeller says. “We were able to have really rich discussions on tough questions about study design and impact, including details like how we would account for patients that are pre-transfused entering the study.” Dr. Mickey Zeller, Principal Investigator for the SexMatters clinical trial, and Dr. Donald Arnold, Co-Director of the CTTG network, discuss aspects of the newly funded clinical trial. Says Dr. Zeller, “Each time the application went through reviews, I could present to these colleagues to essentially say, 'Here are the criticisms it has received and here’s how I’ve handled them.' And they would provide me advice and encouragement to resubmit. It is really valuable having people across the country who are cheering for you, and who are hand-in-hand with you to celebrate your success!” “It’s an absolute privilege to do high quality research because you have to be surrounded by an incredible group of humans. Academic curiosity and commitment by those that have mentored me have enabled me to do this work. It’s out of a generosity of spirit that people have shared their expertise with me for this work, and it takes a lot of time and effort.” Dr. Mickey Zeller, Principal Investigator for the SexMatters trial What other research has informed this study? Before this study received CIHR support, the research team undertook an exploratory analysis, a systematic review and meta-analysis, and a pilot trial which took place in 2022 across five Ontario-based hospitals to establish feasibility of the randomized controlled trial. Findings of retrospective observational studies indicated potential association between sex-mismatched transfusions and mortality, but some aspects remained unclear due to low certainty of evidence, inconsistencies or contradictory subgroup analyses in the available literature. Much previous research involving Canadian Blood Services researchers has also supported the need for this randomized controlled trial. This includes: research undertaken in the lab of Canadian Blood Services Senior Scientist, Dr. Jason Acker, which has investigated impacts of various factors (including age and sex) on red blood cell storage and other factors of quality; the iTADs clinical trial (short for “An innovative Trial Assessing Donor Sex on Recipient Mortality") undertaken by Canadian Blood Services Adjunct Scientist Dr. Dean Fergusson and colleagues that signalled there may be increased risks with blood from younger, female donors; as well as research by Canadian Blood Services Adjunct Scientists Nancy Heddle and Dr. Donald Arnold at McMaster University’s Michael G. DeGroote Centre for Transfusion Research (formerly known as the McMaster Centre for Transfusion Research) which was supported through Canadian Blood Services’ Transfusion Medicine Research Program Support Award. Read the Research Unit summarizing some of MCTR’s research on blood.ca (2019): Sex-mismatched red blood cell transfusions and mortality | Canadian Blood Services Earlier publications involving these and other researchers have also investigated the impact that blood donor age and sex have on outcomes for transfusion recipients, summarized evidence related to sex-matched versus mismatched transfusions and mortality, and the biological mechanisms implicated in adverse outcomes of sex-mismatched transfusions. There is still room for more investigation to build on this previously completed research, and that aligns with Canadian Blood Services' emphasis on the importance of research that spans the continuum from bench-to-bedside to continuously improve our processes, products and services. As Dr. Zeller describes: “There are biological studies and retrospective data, but we only have one existing RCT. There’s a real importance to pursue a prospective, RCT so we can look forward as opposed to looking back.” “As every blood donor is unique, the challenge we have is to understand which donor-specific factors can be better matched to improve patient outcomes. Differences in the biology of blood cells from male and female blood donors are well defined, but what we do not understand is if these differences affect health outcomes in transfused patients. This is very important question that the SexMatters clinical trial is proposing to address.” Dr. Jason Acker, Co-Investigator in the SexMatters trial How will the study work and why the focus on transfusions in the ICU? Focusing on transfusions in the ICU is a significant distinguishing feature of this study. The iTADS trial was completed as a multicentre, double-blind trial, but it looked at mortality rates across the whole hospital. This new trial will look at transfusions received by patients in the intensive care unit (ICU) specifically. “In the hospital, we know that mortality rate is much higher in a transfused ICU patient compared to a patient in another part of the hospital,” Dr. Zeller says. “We’ve chosen to focus this study on the sickest population of patients – those in the ICU – with the idea that any impact will be seen most prominently in this group. The analysis will include consideration to dosage so we can adjust for the specific number of units transfused to each patient.” The study is also designed so that participants will not know whether a blood transfusion is matched or mismatched based on the sex of donor or recipient – a method used to prevent potential bias in the trial. “At the hospital, you always get a list with each shipment of blood product that says what units you have received from the blood operator”, Dr. Zeller explains. “As part of this study’s protocol, participating hospitals will see an additional colour-coding noted on this inventory, and this is what will be used when it comes time for us to do our analysis.” Who could benefit from this knowledge and what are the next steps? Dr. Zeller is glad to have Canadian Blood Services involved in this research, acknowledging that changing policy related to matching of blood products would be a significant change for hospitals and blood suppliers, requiring strong evidence from RCTs like this one. “This study will help to inform health-care professionals who prescribe and administer blood products, along with patients, donors, and the blood operator, too. One of the important questions if it does turn out to have a significant difference is ‘Then what?’ We already divide our inventory by group (ABO) and by Rh status (+/-). Would the need to be matching by sex further impact inventory? We don’t know yet, but that’s why it’s important to have the blood supplier involved,” Dr. Zeller says. The study will require a total sample size of approximately 11,000 patients across an expected nine hospital sites in Ontario. “We’ve designed this study to be very efficient; it’s got components of what would be considered a pragmatic study design,” Dr. Zeller says. “In terms of the products, Canadian Blood Services does not have to provide anything different than they already do for this study (other than the colour-coded markers) and we will use electronic capture to pull data, so we don’t need to collect study information at bedside. These were processes leveraged from the earlier iTADS study as the iTADS research team was very supportive of us learning from what they did.” “Whether transfusions should be matched for donor sex is a question that has been percolating in people’s minds for many years. Dr. Zeller has had the courage and perseverance to tackle this important question, which could have important policy implications. I’m excited for Dr. Zeller to embark on this journey and advance knowledge on best transfusion practices.” Dr. Donald Arnold, Co-Director of CTTG and Co-Investigator in the SexMatters trial Canadian Blood Services – Driving world-class innovation Through discovery, development and applied research, Canadian Blood Services drives world-class innovation in blood transfusion, cellular therapy and transplantation—bringing clarity and insight to an increasingly complex healthcare future. Our dedicated research team and extended network of partners engage in exploratory and applied research to create new knowledge, inform and enhance best practices, contribute to the development of new services and technologies, and build capacity through training and collaboration. Find out more about our research impact. The opinions reflected in this post are those of the author and do not necessarily reflect the opinions of Canadian Blood Services nor do they reflect the views of Health Canada or any other funding agency. Related blog posts Does sex matter in red blood cell transfusions? Monday, December 23, 2019 Tricia Abe When doctors select compatible red blood cell units for transfusion into a patient, they don’t consider the sex of the patient and whether the donor is the same (sex-matched) or opposite sex (sex-mismatched). But a study led by Dr. Michelle Zeller, Canadian Blood Services medical officer and assistant professor in the department of medicine at McMaster University, suggests that the role of donor sex in red blood cell compatibility may be worth a closer look. Transfusion Blood Read full story, Does sex matter in red blood cell transfusions? All blood is not the same Wednesday, October 04, 2017 Dr. Jeannie Callum In this six-part series, Dr. Jeannie Callum, a hospital-based transfusion specialist, shares her real-life experience witnessing the impact of blood donation on patient lives. She provides some fascinating insight into blood transfusion, past and present, and emphasizes the need for male donors and why some donors may be safer for patients. Read the complete series here. Transfusion Blood Read full story, All blood is not the same Canadian Blood Services research collaborate with BEST to understand how donor age impacts red blood cell quality Tuesday, September 26, 2023 Dr. Travis Sztainert Recent research involving Canadian Blood Services researchers highlights the relationship between donor age and the quality of blood products like red blood cells, while considering the complex interplay between storage conditions, oxidative stress, and genetic factors. Though the clinical implications remain uncertain, these findings underscore the importance of ongoing research in optimizing blood storage practices and continuing to improve the efficacy of blood transfusions for patients in need. Transfusion Blood Read full story, Canadian Blood Services research collaborate with BEST to understand how donor age impacts red blood cell quality Full Article
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