National Bureau of Economic Research

Each and every minute detail of Allu Arjun's Pushpa has left the fans super excited, ever since the inception. The movie is said to be an action thriller, wherein Allu Arjun will be seen doing some high-octane action sequences. Well, if

Tune into our new show Fox League Live on Channel 502 Monday to Friday at 6.30pm and on Saturday at 3pm and Sunday at 5pm.

The world’s consumption of raw materials is set to nearly double by 2060 as the global economy expands and living standards rise, placing twice the pressure on the environment that we are seeing today, according to a new OECD report.

‌07/09/2017 - Flooding is one of the most common, wide-reaching and destructive natural perils, affecting on average about 250 million people around the world each year. OECD work on the financial management of flood risk has identified a number of ways that policy makers can improve the way they manage the financial implications of floods.

Tackling climate change may be costly, but not tackling it will cost even more. And the longer we wait to act, the more our environment, our health and our economies will be damaged. Find out more about the likely impacts of rising GHG concentrations on global temperature, and how that will affect all of us.

The consequences of degradation of environmental quality as well as the consequences of environmental policies are typically unevenly distributed. In general, poorer countries and lower income households are more severely affected by environmental degradation and at the same time have less capacity to adapt.

This report provides an analysis of how climate change damages may affect international trade in the coming decades and how international trade can help limit the costs of climate change. It analyses the impacts of climate change on trade considering both direct effects on infrastructure and transport routes and the indirect economic impacts resulting from changes in endowments and production.

The world’s consumption of raw materials is set to nearly double by 2060 as the global economy expands and living standards rise, placing twice the pressure on the environment that we are seeing today, according to a new OECD report.

Workers can be mismatched by qualifications while their skills are, in fact, adequate for their jobs. This situation, ‘apparent’ qualification mismatch is more common in certain fields of study than in others and speaks to the need of strengthening the links between employers, education providers and students to share information on the true skills, to avoid true skills mismatch.

When writing CSS for markup with weird class or id attribute values, you need to consider some rules. For example, you can’t just use ## { color: #f00; } to target the element with id="#". Instead, you’ll have to escape the weird characters (in this case, the second #). Doing so will cancel the meaning of special CSS characters and allows you to refer to characters you cannot easily type out, like crazy Unicode symbols.

Having recently written about character references in HTML, I figured it would be interesting to look into JavaScript character escapes as well.

The performance of automated model building in crystal structure determination usually decreases with the resolution of the experimental data, and may result in fragmented models and incorrect side-chain assignment. Presented here are new methods for machine-learning-based docking of main-chain fragments to the sequence and for their sequence-independent connection using a dedicated library of protein fragments. The combined use of these new methods noticeably increases sequence coverage and reduces fragmentation of the protein models automatically built with ARP/wARP.

Fragment-based molecular-replacement methods can solve a macromolecular structure quasi-ab initio. ARCIMBOLDO, using a common secondary-structure or tertiary-structure template or a library of folds, locates these with Phaser and reveals the rest of the structure by density modification and autotracing in SHELXE. The latter stage is challenging when dealing with diffraction data at lower resolution, low solvent content, high β-sheet composition or situations in which the initial fragments represent a low fraction of the total scattering or where their accuracy is low. SEQUENCE SLIDER aims to overcome these complications by extending the initial polyalanine fragment with side chains in a multisolution framework. Its use is illustrated on test cases and previously unknown structures. The selection and order of fragments to be extended follows the decrease in log-likelihood gain (LLG) calculated with Phaser upon the omission of each single fragment. When the starting substructure is derived from a remote homolog, sequence assignment to fragments is restricted by the original alignment. Otherwise, the secondary-structure prediction is matched to that found in fragments and traces. Sequence hypotheses are trialled in a brute-force approach through side-chain building and refinement. Scoring the refined models through their LLG in Phaser may allow discrimination of the correct sequence or filter the best partial structures for further density modification and autotracing. The default limits for the number of models to pursue are hardware dependent. In its most economic implementation, suitable for a single laptop, the main-chain trace is extended as polyserine rather than trialling models with different sequence assignments, which requires a grid or multicore machine. SEQUENCE SLIDER has been instrumental in solving two novel structures: that of MltC from 2.7 Å resolution data and that of a pneumococcal lipoprotein with 638 residues and 35% solvent content.

To celebrate the 10th anniversary of researchers producing the first complete human genome sequence — the genetic blueprint of the human body — the Smithsonian’s National Museum of Natural History, will open a new high-tech, high-intensity exhibition in 2013.

The post 2013 exhibition to celebrate first complete human genome sequence appeared first on Smithsonian Insider.

“Ignition Sequence,” 1968, Vincent Cavallaro, oil on canvas. The power of the ignition and launch sequence of a NASA rocket is portrayed in an abstract […]

The post “Ignition Sequence,” by Vincent Cavallaro appeared first on Smithsonian Insider.

An elementary method is described for finding the coordination sequences for a tiling, based on coloring the underlying graph. The first application is to the two kinds of vertices (tetravalent and trivalent) in the Cairo (or dual-32.4.3.4) tiling. The coordination sequence for a tetravalent vertex turns out, surprisingly, to be 1, 4, 8, 12, 16, …, the same as for a vertex in the familiar square (or 44) tiling. The authors thought that such a simple fact should have a simple proof, and this article is the result. The method is also used to obtain coordination sequences for the 32.4.3.4, 3.4.6.4, 4.82, 3.122 and 34.6 uniform tilings, and the snub-632 tiling. In several cases the results provide proofs for previously conjectured formulas.

An operationally simple and time-efficient approach has been developed for the synthesis of racemic N-substituted 3-(2-aryl-2-oxoeth­yl)-3-hy­droxy­indolin-2-ones by a piperidine-catalysed aldol reaction between aryl methyl ketones and N-alkyl­isatins. These aldol products were used successfully as strategic inter­mediates for the preparation of N-substituted (E)-3-(2-hetaryl-2-oxo­ethyl­idene)indolin-2-ones by a stereoselective dehydration reaction under acidic conditions. The products have all been fully characterized by 1H and 13C NMR spectroscopy, by mass spectrometry and, for a representative selection, by crystal structure analysis. In each of (RS)-1-benzyl-3-hy­droxy-3-[2-(4-meth­oxy­phen­yl)-2-oxoeth­yl]indolin-2-one, C24H21NO4, (Ic), and (RS)-1-benzyl-3-{2-[4-(di­methyl­amino)­phen­yl]-2-oxoeth­yl}-3-hy­droxy­indolin-2-one, C25H24N2O3, (Id), inversion-related pairs of mol­ecules are linked by O—H⋯O hydrogen bonds to form R22(10) rings, which are further linked into chains of rings by a combination of C—H⋯O and C—H⋯π(arene) hydrogen bonds in (Ic) and by C—H⋯π(arene) hydrogen bonds in (Id). The mol­ecules of (RS)-1-benzyl-3-hy­droxy-3-[2-oxo-2-(pyridin-4-yl)eth­yl]indolin-2-one, C22H18N2O3, (Ie), are linked into a three-dimensional framework structure by a combination of O—H⋯N, C—H⋯O and C—H⋯π(arene) hydrogen bonds. (RS)-3-[2-(Benzo[d][1,3]dioxol-5-yl)-2-oxoeth­yl]-1-benzyl-3-hy­droxy­indolin-2-one, C24H19NO5, (If), crystallizes with Z' = 2 in the space group Poverline{1} and the mol­ecules are linked into com­plex sheets by a combination of O—H⋯O, C—H⋯O and C—H⋯π(arene) hydro­gen bonds. In each of (E)-1-benzyl-3-[2-(4-fluoro­phen­yl)-2-oxo­ethyl­idene]indolin-2-one, C23H16FNO2, (IIa), and (E)-1-benzyl-3-[2-oxo-2-(thiophen-2-yl)ethylidene]indolin-2-one, C21H15NO2S, (IIg), the mol­ecules are linked into simple chains by a single C—H⋯O hydrogen bond, while those of (E)-1-benzyl-3-[2-oxo-2-(pyridin-4-yl)ethyl­idene]indolin-2-one, C22H16N2O2, (IIe), are linked by three C—H⋯O hydrogen bonds to form sheets which are further linked into a three-dimensional structure by C—H⋯π(arene) hydrogen bonds. There are no hydrogen bonds in the structures of either (E)-1-benzyl-3-[2-(4-meth­oxy­phen­yl)-2-oxo­ethyl­idene]indolin-2-one, C24H19NO3, (IIc), or (E)-1-benzyl-5-chloro-3-[2-(4-chloro­phen­yl)-2-oxo­ethyl­idene]indolin-2-one, C23H15Cl2NO2, (IIh), but the mol­ecules of (IIh) are linked into chains of π-stacked dimers by a combination of C—Cl⋯π(arene) and aromatic π–π stacking inter­actions.

A new report from the National Academies of Sciences, Engineering, and Medicine provides a comprehensive assessment of economic and demographic trends of U.S. immigration over the past 20 years, its impact on the labor market and wages of native-born workers, and its fiscal impact at the national, state, and local levels.

We urge the U.S. Department of Homeland Security to immediately stop separating migrant children from their families, based on the body of scientific evidence that underscores the potential for lifelong, harmful consequences for these children and based on human rights considerations.

A recent study has examined the implications of CO2 leaking from storage sites under a variety of scenarios over 100,000 years. The findings suggest that ocean storage of CO2 (prohibited in the EU) would lead to long-term warming of the atmosphere, higher sea levels and acidification and dead zones in the ocean. In contrast, geological storage with low-leakage rates (1 per cent per 1000 years) would lead to conditions similar to a low-emissions future. This implies that

Interactions between population growth, consumption and the use of natural products and services have created an unsustainable pressure on the environment. New research has provided a detailed investigation into the relationships between these three trends, providing insight into how to alleviate these pressures. It concludes they cannot be addressed by market mechanisms or technological advances alone.

Research into future climate scenarios suggest that by 2100, climate change could lead to annual damages in the EU from river flooding alone of €14 billion to €21.5 billion, with more people affected than today, and a reduction in household welfare.

Implementation of technology to clean the flue gases of coal-fired power plants has significantly reduced sulphur and fine particle emissions that cause environmental damage. However, recent research suggests that plants applying this technology would emit more ultrafine particles (1-10 nanometer (nm) diameter) that affect the formation of clouds, with the unintended consequence of changing the amount and intensity of rainfall downwind of fossil fuel power installations.

Researchers have assessed the phyto-toxic effects of copper nanoparticles on vegetables grown within urban gardens, comparing increasing doses of these nanoparticles to simulate potential aerial deposition to extreme pollution of CuO-NP in a range of increasing exposure periods. Lettuce and cabbage absorbed high amounts of copper nanoparticles, after 15 days of exposure, which interfered with photosynthesis, respiration and also reduced growth. Under the specific exposure conditions of the study the researchers indicate that metal nanoparticles could lead to potential health risks to humans from the contamination of crops from pollution.

Grey is back on the internet, Myke is upset about mischief, and they both got some new devices.

The Rainforest Alliance's new video suggests what it would be like if the environmental consequences of your food choices happened in your own backyard.

It's amazing how closely the powerful swirls of a hurricane match the Fibonacci sequence.

Effects include people traveling more, in bigger cars (EV sales are flat), and a dip in public transit.

Climate change is forcing tropical fish to migrate, and they threaten to mow down their new terrain.

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