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Rethinking 'The Economic Consequences of the Peace'




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Thematic review series: The Pathogenesis of Atherosclerosis. Effects of infection and inflammation on lipid and lipoprotein metabolism mechanisms and consequences to the host

Weerapan Khovidhunkit
Jul 1, 2004; 45:1169-1196
Thematic Reviews




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Counter-terrorism measures and sanctions: How to avoid negative consequences for humanitarian action?

Counter-terrorism measures and sanctions: How to avoid negative consequences for humanitarian action? 9 September 2021 — 2:00PM TO 3:30PM Anonymous (not verified) 21 July 2021 Online

Exploring current endeavours to address the tensions between counter-terrorism measures, sanctions and humanitarian action.

Counter-terrorism measures  address broad forms of support to terrorist acts. Their expansion, internationally and domestically, has given rise to new points of friction with international humanitarian law. Unless the measures include adequate safeguards, they  can impede humanitarian action. Country-specific sanctions imposed for other objectives, such as ending conflicts or protecting civilians, raise similar challenges for humanitarian action. 

These problems are not new, but solutions at international and national level remain elusive. 

At this panel event, which marks the launch of a new Chatham House research paper, panellists explore current endeavours to address the tensions between counter-terrorism measures, sanctions and humanitarian action.

  • What are the current dynamics and developments at Security Council level?  
  • What are the opportunities now that the UK is developing its independent sanctions strategy? 
  • What challenges do counter-terrorism requirements in funding agreements for humanitarian action  pose? 
  • What is necessary to make progress?




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Unconditional Cesàro convergence of sequences of super-reflexive valued random variables

Abdessamad Dehaj and Mohamed Guessous
Theor. Probability and Math. Statist. 111 (), 1-8.
Abstract, references and article information




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A Systematic Structure-Function Characterization of a Human Mutation in Neurexin-3{alpha} Reveals an Extracellular Modulatory Sequence That Stabilizes Neuroligin-1 Binding to Enhance the Postsynaptic Properties of Excitatory Synapses

α-Neurexins are essential and highly expressed presynaptic cell-adhesion molecules that are frequently linked to neuropsychiatric and neurodevelopmental disorders. Despite their importance, how the elaborate extracellular sequences of α-neurexins contribute to synapse function is poorly understood. We recently characterized the presynaptic gain-of-function phenotype caused by a missense mutation in an evolutionarily conserved extracellular sequence of neurexin-3α (A687T) that we identified in a patient diagnosed with profound intellectual disability and epilepsy. The striking A687T gain-of-function mutation on neurexin-3α prompted us to systematically test using mutants whether the presynaptic gain-of-function phenotype is a consequence of the addition of side-chain bulk (i.e., A687V) or polar/hydrophilic properties (i.e., A687S). We used multidisciplinary approaches in mixed-sex primary hippocampal cultures to assess the impact of the neurexin-3αA687 residue on synapse morphology, function and ligand binding. Unexpectedly, neither A687V nor A687S recapitulated the neurexin-3α A687T phenotype. Instead, distinct from A687T, molecular replacement with A687S significantly enhanced postsynaptic properties exclusively at excitatory synapses and selectively increased binding to neuroligin-1 and neuroligin-3 without changing binding to neuroligin-2 or LRRTM2. Importantly, we provide the first experimental evidence supporting the notion that the position A687 of neurexin-3α and the N-terminal sequences of neuroligins may contribute to the stability of α-neurexin–neuroligin-1 trans-synaptic interactions and that these interactions may specifically regulate the postsynaptic strength of excitatory synapses.




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The Hippocampus Preorders Movements for Skilled Action Sequences

Plasticity in the subcortical motor basal ganglia–thalamo–cerebellar network plays a key role in the acquisition and control of long-term memory for new procedural skills, from the formation of population trajectories controlling trained motor skills in the striatum to the adaptation of sensorimotor maps in the cerebellum. However, recent findings demonstrate the involvement of a wider cortical and subcortical brain network in the consolidation and control of well-trained actions, including a brain region traditionally associated with declarative memory—the hippocampus. Here, we probe which role these subcortical areas play in skilled motor sequence control, from sequence feature selection during planning to their integration during sequence execution. An fMRI dataset (N = 24; 14 females) collected after participants learnt to produce four finger press sequences entirely from memory with high movement and timing accuracy over several days was examined for both changes in BOLD activity and their informational content in subcortical regions of interest. Although there was a widespread activity increase in effector-related striatal, thalamic, and cerebellar regions, in particular during sequence execution, the associated activity did not contain information on the motor sequence identity. In contrast, hippocampal activity increased during planning and predicted the order of the upcoming sequence of movements. Our findings suggest that the hippocampus preorders movements for skilled action sequences, thus contributing to the higher-order control of skilled movements that require flexible retrieval. These findings challenge the traditional taxonomy of episodic and procedural memory and carry implications for the rehabilitation of individuals with neurodegenerative disorders.




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The World's Oldest Cheese Was Buried in a Chinese Tomb 3,600 Years Ago. Now, Scientists Have Sequenced Its DNA

New research has revealed that the mysterious white substance found alongside three ancient mummies was once a soft cheese called kefir




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Hamilton building collapse at downtown park could've had 'terrifying' consequences, mayor says

Two buildings collapsed on Hamilton’s Gore Park early Monday morning after being boarded up for over a decade. The fire department says no one was injured and the city has issued an emergency demolition order.



  • News/Canada/Hamilton

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In Another Likely Consequence of Pandemic, Delaware Overdose Deaths Increase 15% in 2021

Division of Forensic Science Annual Report Finds Fentanyl Still Involved in More Than 80% of Deaths; Cocaine Link on the Rise NEW CASTLE (May 24, 2022) – In what health officials fear is another consequence of the uncertainty associated with the COVID-19 pandemic, Delaware’s overdose deaths increased more than 15% in 2021 to a record […]



  • Delaware Health and Social Services
  • Department of Safety and Homeland Security
  • Division of Public Health
  • Division of Substance Abuse and Mental Health
  • News
  • Addiction
  • Delaware Hope Line
  • DHSS Secretary Molly Magarik
  • HelpIsHere
  • substance use disorder

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Tree Planting and Cooking Fuel in Vietnam: A Case of Unintended Consequences

Tree Planting and Cooking Fuel in Vietnam: A Case of Unintended Consequences Tree Planting and Cooking Fuel in Vietnam: A Case of Unintended Consequences
Anonymous (not verified) Tue, 05/21/2019 - 12:44

East-West Wire

Tagline
News, Commentary, and Analysis
East-West Wire

The East-West Wire is a news, commentary, and analysis service provided by the East-West Center in Honolulu. Any part or all of the Wire content may be used by media with attribution to the East-West Center or the person quoted. To receive East-West Center Wire media releases via email, subscribe here.

For links to all East-West Center media programs, fellowships and services, see www.eastwestcenter.org/journalists.

Explore

East-West Wire

Tagline
News, Commentary, and Analysis
East-West Wire

The East-West Wire is a news, commentary, and analysis service provided by the East-West Center in Honolulu. Any part or all of the Wire content may be used by media with attribution to the East-West Center or the person quoted. To receive East-West Center Wire media releases via email, subscribe here.

For links to all East-West Center media programs, fellowships and services, see www.eastwestcenter.org/journalists.

Explore





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Egypt: Consequences of Morsi's Removal

The Egyptian Armed Forces' removal of President Morsi has created a number of challenges related to democracy, political stability and the role of Islam.




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Iraq: Consequence of Military Training

Decades of Western military intervention and training have stoked the fires of sectarianism and warfare in Iraq and the broader region.




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War’s hidden casualties: Mideast conflict unleashes severe environmental consequences


The current conflict in the Middle East will leave a lasting environmental impact, prompting calls for urgent restoration and cross-border cooperation.




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Largest genome sequenced so far is 30 times bigger than a human's

The South American lungfish has a whopping 180 gigabases of DNA in each cell, compared with 6 gigabases in human cells




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You can turn any random sequence of events into a clock

A set of mathematical equations can help turn apparently random observations into a clock – and then measure its accuracy




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Rapid SARS-CoV-2 surveillance using clinical, pooled, or wastewater sequence as a sensor for population change [METHODS]

The COVID-19 pandemic has highlighted the critical role of genomic surveillance for guiding policy and control. Timeliness is key, but sequence alignment and phylogeny slow most surveillance techniques. Millions of SARS-CoV-2 genomes have been assembled. Phylogenetic methods are ill equipped to handle this sheer scale. We introduce a pangenomic measure that examines the information diversity of a k-mer library drawn from a country's complete set of clinical, pooled, or wastewater sequence. Quantifying diversity is central to ecology. Hill numbers, or the effective number of species in a sample, provide a simple metric for comparing species diversity across environments. The more diverse the sample, the higher the Hill number. We adopt this ecological approach and consider each k-mer an individual and each genome a transect in the pangenome of the species. Structured in this way, Hill numbers summarize the temporal trajectory of pandemic variants, collapsing each day's assemblies into genome equivalents. For pooled or wastewater sequence, we instead compare days using survey sequence divorced from individual infections. Across data from the UK, USA, and South Africa, we trace the ascendance of new variants of concern as they emerge in local populations well before these variants are named and added to phylogenetic databases. Using data from San Diego wastewater, we monitor these same population changes from raw, unassembled sequence. This history of emerging variants senses all available data as it is sequenced, intimating variant sweeps to dominance or declines to extinction at the leading edge of the COVID-19 pandemic.




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Improved functions for nonlinear sequence comparison using SEEKR [ARTICLE]

SEquence Evaluation through k-mer Representation (SEEKR) is a method of sequence comparison that uses sequence substrings called k-mers to quantify the nonlinear similarity between nucleic acid species. We describe the development of new functions within SEEKR that enable end-users to estimate P-values that ascribe statistical significance to SEEKR-derived similarities, as well as visualize different aspects of k-mer similarity. We apply the new functions to identify chromatin-enriched lncRNAs that contain XIST-like sequence features, and we demonstrate the utility of applying SEEKR on lncRNA fragments to identify potential RNA-protein interaction domains. We also highlight ways in which SEEKR can be applied to augment studies of lncRNA conservation, and we outline the best practice of visualizing RNA-seq read density to evaluate support for lncRNA annotations before their in-depth study in cell types of interest.




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International Survey Released for World Meningitis Day Shows Parents Feel They Don't Know Enough About the Disease and its Consequences - Lenine Cunha, Portuguese Paralympian and Win for Meningitis campaign ambassador

Lenine Cunha, Portuguese Paralympian and Win for Meningitis campaign ambassador




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The consequences are painful




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Wildfires Of No Consequence 

Billowing menace, acrid scents  Old growth, saplings charring together  While out of sight, fawns distressed race And the owl’s perch succumbs.  Golden hordes breaching firebreaks  Rapine alight windswept, rapacious, desiccation stoked   Consuming canopies, no quarter given While rooted tributaries blazing course underfoot.  Slight deluges, drawn from placid lakes Lofted by fraught metaled battalions Plunge pityingly […]

The post Wildfires Of No Consequence  appeared first on Waiter Rant.




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Scalable design of uniform oligourethanes for impact study of chain length, sequence and end groups on thermal properties

Polym. Chem., 2024, 15,4319-4326
DOI: 10.1039/D4PY01001A, Paper
Open Access
Jens Van Hoorde, Nezha Badi, Filip E. Du Prez
A bidirectional growth-based protocol is used for the synthesis of a series of sequence-defined oligourethanes in large scale (50 g). The effect of chain length, sequence and end group functionalities on the thermal properties is evaluated.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Sequence-defined structural transitions by calcium-responsive proteins

Polym. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4PY00907J, Paper
Marina Chang, Winnie Huang, Gatha Shambharkar, Kenny Hernandez, Danielle Jamie Mai
Biopolymer sequences dictate their functions, and protein-based polymers are a promising platform to establish sequence–function relationships for novel biopolymers. To efficiently explore vast sequence spaces of natural proteins, sequence repetition...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Structural determination of fructooligosaccharides and raffinose family oligosaccharides using logically derived sequence tandem mass spectrometry

Analyst, 2024, Advance Article
DOI: 10.1039/D4AN00872C, Paper
Chia Yen Liew, Wun-Long Li, Chi-Kung Ni
Logical procedures for structural determination of fructooligosaccharides and raffinose family oligosaccharides.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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McLaren warns of 'massive consequences' if Red Bull broke rules

Red Bull have confirmed the presence of a ride-height device in their cars but said it could not be accessed once the cars were fully assembled




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Consequences of twisting of the flexible arms of imidazole-derived urea in zinc-dicarboxylate coordination polymers

CrystEngComm, 2024, 26,1976-1985
DOI: 10.1039/D4CE00005F, Paper
Satyendra Verma, Rinki Brahma, Jubaraj B. Baruah
A semi-flexible imidazole-based urea ligand, 1-(3-(1H-imidazol-1-yl)propyl)-3-phenylurea, and three zinc-dicarboxylate coordination polymers possessing the ligand were synthesized and characterized.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A Highly Diastereoselective One-Pot Ugi/Radical Spirocyclization/Aza-Michael Addition Sequence

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00610K, Communication
Chandra Volla, Salman Khan, Abhradeep Chatterjee, Akshay Murali Nair
We hereby report a highly diastereoselective synthesis of chalcogenated azaspirotricycles via a one-pot Ugi/spirocyclization/ aza-Michael addition sequence. The reaction proceeded via a key visible light mediated spirocyclization step under mild,...
The content of this RSS Feed (c) The Royal Society of Chemistry




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World Stroke Day: NIMHANS study finds that part of sleep apnoea burden is a consequence of stroke

Most patients with stroke are not evaluated for sleep apnea; this is an issue that needs to be addressed by the scientific community, doctors at NIMHANS, Bengaluru said




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Lead in turmeric can cause severe health consequences in kids, adults: Experts




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UN summit approves fund to share benefits of nature's sequenced genetic data

The issue had been a bone of contention at the 16th Conference of Parties (COP16) to the UN's Convention on Biological Diversity (CBD)




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What are the Consequences of Global Banking for the International Transmission of Shocks? A Quantitative Analysis [electronic journal].

National Bureau of Economic Research




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Weak States: Causes and Consequences of the Sicilian Mafia [electronic journal].

National Bureau of Economic Research




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Using the Sequence-Space Jacobian to Solve and Estimate Heterogeneous-Agent Models [electronic journal].

National Bureau of Economic Research




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UNINTENDED CONSEQUENCES OF THE GLOBAL DERIVATIVES MARKET REFORM [electronic journal].




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Unequal Consequences of Covid 19 across Age and Income: Representative Evidence from Six Countries [electronic journal].




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Terror and Tourism: The Economic Consequences of Media Coverage [electronic journal].




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States and Wars: China's Long March towards Unity and its Consequences, 221 BC - 1911 AD [electronic journal].




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The Rise of Agribusiness and the Distributional Consequences of Policies on Intermediated Trade [electronic journal].




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Redistributive Consequences of Abolishing Uniform Contribution Policies in Pension Funds [electronic journal].




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Potential consequences of post-Brexit trade barriers for earnings inequality in the UK [electronic journal].




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Men. Roots and Consequences of Masculinity Norms [electronic journal].




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Macroeconomic Consequences of Tariffs [electronic journal].

National Bureau of Economic Research




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Longer-run Economic Consequences of Pandemics [electronic journal].

National Bureau of Economic Research




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Interlinked Firms and the Consequences of Piecemeal Regulation [electronic journal].




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The Intergenerational Behavioural Consequences of a Socio-Political Upheaval [electronic journal].




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Individual Consequences of Occupational Decline [electronic journal].




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High-Quality Versus Low-Quality Growth in Turkey - Causes and Consequences [electronic journal].




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Fiscal and Monetary Stabilization Policy at the Zero Lower Bound: Consequences of Limited Foresight [electronic journal].

National Bureau of Economic Research




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Emigration during the French Revolution: Consequences in the Short and Longue Durée [electronic journal].

National Bureau of Economic Research




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The Economic Consequences of Hospitalizations for Older Workers across Countries [electronic journal].