BackgroundOrlistat is recommended as an adjunct to diet and exercise for weight loss in the treatment of type 2 diabetes mellitus (T2DM).AimTo explore associations between patient characteristics and orlistat prescribing, and to determine associations of orlistat with weight loss in T2DM and prediabetes.Design and settingCohort study using anonymised health records from a UK database of general practice.MethodThe UK Clinical Practice Research Datalink (CPRD) Aurum database was searched to compile a cohort of patients aged ≥18 years, first diagnosed with T2DM or prediabetes in 2016 or 2017. Once the data had been collated, multivariable logistic regression models were used to determine associations with starting orlistat and stopping it early (<12 weeks of prescriptions) and orlistat’s associations with weight loss in those who had not been prescribed second-line antidiabetic medications.ResultsOut of 100 552 patients with incident T2DM or prediabetes, 655 (0.8%) patients with T2DM and 128 (0.7%) patients with prediabetes were prescribed orlistat. Younger people, females, those in areas of deprivation, current smokers, those coprescribed metformin, and those recorded as having hypertension were statistically significantly more likely to be prescribed orlistat; higher baseline glycated haemoglobin levels were associated with early stopping. In comparison with patients not on orlistat, those who continued using it for ≥12 weeks were more likely to lose ≥5% weight (adjusted odds ratio [AOR] 1.69, 95% confidence interval [CI] = 1.07 to 2.67) but those who stopped orlistat early were less likely to lose ≥5% weight (AOR 0.56, 95% CI = 0.29 to 1.09).ConclusionOrlistat was significantly associated with weight loss in patients with T2DM and prediabetes when taken for at least 12 weeks; however, it was infrequently prescribed and often taken for <12 weeks. Orlistat may be a useful adjunct to lifestyle modifications for patients with T2DM and prediabetes, but barriers to continued use means it may not be effective for everyone in managing weight loss.

The discovery of a new prime number highlights the rising price of mathematical gold

Armin Strom Cognac Watch � the watch with a drop of 1762 Gautier Cognac

The Nutrilite� Power of 5 Campaign engaged over 260,000 people worldwide to �raise their hand� to fight childhood malnutrition and accomplished a GUINNESS WORLD RECORDS� title for Largest collage of cutout handprints.

Mary Murphy partners with Osteo Bi-Flex�

Karnataka Health Minister Dinesh Gundu Rao revealed that Bengaluru has recorded 4,427 medlinkdengue/medlink cases this year. He also announced the launch of a monitoring app for these cases.

In Europe in 2022, around 1,300 locally acquired human cases of medlinkWest Nile virus/medlink infection have been recorded (!--ref1--). They

The Ministry of Agriculture in Japan confirmed a highly pathogenic avian influenza outbreak at a poultry farm in the eastern prefecture of Ibaraki. This

Announcement Number: TN-20-EI-00895-MP
Closing Date: 06 June 2020

Guinness World Record: 69 വർഷം പിന്നിടുന്ന ഗിന്നസ് റെക്കോർഡ്സിന്റെ ചരിത്രത്തിൽ ഇതുവരെ ലോകത്താകമാനമായി 53, 000 പേർക്കാണ് ഈ ഗിന്നസ് ടൈറ്റിൽ ലഭിച്ചിട്ടുള്ളത്.

Samsung Health is expanding its role as a personal health management tool with the latest app update, allowing users to view their medical records alongside new features for tracking medications and food. This enhancement marks a major step forward in making

After two years of struggles, Hamilton ended his long winless run at the British Grand Prix with a record ninth home triumph at Silverstone

Despite this positive trend, industry experts caution that the current demand environment remains uncertain, and graduates have expressed frustrations over delayed joining dates 

Elizabeth Montoya and Chrissy Fernandez from Guinness World Records take the WIRED Autocomplete Interview and answer the Internet's most searched questions about the Guinness World Records. How does Guinness World Records make money? How is the tallest person in the world? Who has the longest fingernails? Elizabeth and Chrissy answer all these questions and much more!

We visit Jack White's Third Man Records vinyl pressing plant in Detroit, Michigan to find out exactly what goes into the creation of a vinyl record; from cutting and pressing to making sure they sound great. Find out more here: https://thirdmanpressing.com https://www.instagram.com/thirdmanpressing/ Director: Katherine Wzorek Director of Photography: Kevin Hewitt Editor: Louis Lalire Talent: Broc Barnes, Warren Defever, Ed Gillis Line Producer: Joseph Buscemi Associate Producer: Samantha Vélez Production Manager: Eric Martinez Production Coordinator: Fernando Davila Camera Operator: Kevin Ward Audio: Frank Biondo Production Assistant: Ryan Hewitt Post Production Supervisor: Alexa Deutsch Post Production Coordinator: Ian Bryant Supervising Editor: Doug Larsen Assistant Editor: Justin Symonds

This decision comes as the existing contract with the current vendor, TerraCIS, is set to expire on November 30, 2024

Held along the Saryu River’s 55 ghats, including Ram ki Paidi, over 25.12 lakh diyas were lit, with 1,121 participants performing ‘aarti’ in unison

According to a press release, the ambient air quality monitored by the Puducherry Pollution Control Committee (PPCC) at Reddiyarpalayam, Mudaliarpet, and Anna Nagar in the city found PM (10) and PM (2.5) levels to be on the higher side

Easterly to north-easterly flows starting to rebuild after being scattered by severe cyclone Dana over the Bay

The airport logged 1,538 air traffic movements, significantly up from 1,433 in September 2024

Mohammed Ameen and Mohammed Jaseel, Plus Two students from KKM Higher Secondary School, Cheekkode in Malappuram, contested the same event in the previous edition and finished exactly in the same positions

JIPMER in Puducherry will be closed until 2:30 p.m. due to the consecration of Ram temple in Uttar Pradesh’s Ayodhya

Srinagar district’s poll percentage was 27.9% in the 2014 Assembly election and recorded 29.24% this time; J&K Chief Electoral Officer says Srinagar saw an increase of 5% compared to voter turnout of the recent Lok Sabha polls

The first One-Day International between India and Sri Lanka witnessed important milestones being set and new records being made.

Usain Bolt’s superhuman effort of 9.58 seconds (100m) and 19.19 seconds (200m) at the 2009 World Championships in Berlin have not been threatened ever since.

The company attributed this growth to increased volumes across modalities, which drove operational leverage

Square Yards said gross transaction value has risen to Rs 22,870 crore, a 67 per cent increase year-on-year, while the number of transactions has doubled

Tamilnadu Petroproducts blames global uncertainty for dip in profitability

Moka Vijay Kumar’s painting celebrates cultural unity across Andhra Pradesh, Odisha, and Chhattisgarh

'We focus on the masses, to watch a film while clapping, dancing and whistling.''But there should be strong content.''Every dialogue in the film has a thought process, which people can relate to.'

Four XUV700s entered the challenge and all four recorded over 4000 km in 24 hours, says Rajesh Karkera.

Many in the region had to dust off their snow shovels for at least one more dig out on Saturday morning after a polar vortex blasted parts of the province, catching many off guard.

The new cases bring the total number of confirmed COVID-19 cases in Kwara to 28.

The post Kwara records first COVID-19 death appeared first on Premium Times Nigeria.

The Kwara State Government, on Saturday, recorded the death of a COVID-19 case. This was confirmed in a statement signed by Rafiu Ajakaye, Chief Press Secretary to the Governor/Spokesman, Kwara State Technical Committee on COVID-19. He disclosed that the COVID-19 patient arrived in Kwara from Lagos with a child and has since been receiving treatment. […]

Kwara records first COVID-19 death

Nigeria on Saturday recorded the most coronavirus deaths in a single day. The Nigeria Center for Disease Control, NCDC, on Saturday reported 11 fatalities. As of Friday, the total number of deaths resulting from COVID-19 was 117. But according to the data released on Saturday, the total number of deaths in the country stood at […]

Nigeria records highest COVID-19 deaths in 24 hours

Hong Kong recorded at least one new imported coronavirus case on Sunday, ending a string of three days with no reported infections. The tally of confirmed Covid-19 cases now moves to at least 1,045. The last time the city recorded new infections was on Thursday, when four imported cases were revealed. At least eight new infections have been recorded so far this month, all imported – cases involving people with recent travel history. Health authorities have previously said the deadly…

A miniseries about the rise of the late Andre Harrell’s Uptown Records is still in the works and moving ahead at BET following the veteran music executive’s death. But with production throughout the television business shut down due to the coronavirus pandemic, no premiere date or timetable for the start of shooting has been set. […]

Earlier this year, Toronto-based indie label Royal Mountain Records (PUP, Mac DeMarco, Alvvays, U.S. Girls) created a first-of-its-kind fund to support its artists’ mental health. Each act on the label now has access to $1,500 each – completely confidential and non-recoupable – to use on mental health wellness and addiction treatment.

The label is run by Hollerado frontman Menno Versteeg, who joins us this week to talk about the fund’s creation and, more generally, mental health in the music community. Menno is open and honest about how his own history as a touring musician inspired the fund, and why labels, managers, agents, and others who earn their living off of musicians need to do more to support artists’ well-being.

And since Hollerado just released their final album and will soon embark on their last tour, we also fit in a quick chat about the band.

The popular saying "April showers bring May flowers" might not be the case this year. The northeastern United States is experiencing an unusual Mother's Day weekend as most restaurants remain closed amid coronavirus concerns and a historic polar vortex packing snow shatters temperature records. Freeze watches and warnings along with frost advisories were put into effect Friday night for many places across parts of the Midwest, down into the Southeast and into the Northeast.

As the music world today is reeling from the news of Andre Harrell’s death at the age of 59, his colleagues and friends are celebrating the career of the Uptown Records founder. Harrell’s milestone career and personal story also are the subject of Uptown, a three-part original scripted miniseries, which was greenlighted by BET Networks […]