Toronto, ON – The co-founders of Toronto-based start-up Exact Media, who are graduates of the Rotman Commerce program at the University of Toronto, have been named to the 2017 Forbes 30 Under 30 list of the young innovators redefining marketing and advertising. Daniel Rodic, BCom’12, and Elena Sahakyan, BCom’09, are two of the three co-founders […]

NASA's Kepler space telescope recently made the news by finding a planet that orbits a double-star system, a situation that brought to mind the fictional planet Tatooine of the movie Star Wars. On such a planet, if it had a solid surface, you could see a double sunset. This worksheet explores the orbital mechanics of such a system.

With a little ingenuity, HVAC contractors could come out on top in the smart homes market for years to come.

Guest Daniel Corbett discusses how to scale your application with the help of load balancing. Hear details on HAProxy and the load balancing ecosystem as a whole.

Sergey Gorbunov of Axelar discusses blockchain interoperability, a technology that enables decentralized applications to work across multiple blockchain ecosystems. Host Philip Winston spoke with Gorbunov about programmable blockchains, distributed vs. centralized changes, the Ethereum virtual machine, Axelar's Cross-Chain Gateway Protocol and Cross-Chain Transfer Protocol, security issues, delegated proof of stake...

this is 100% dead-on

N-Sorb leverages Aptar CSP Technologies’ proven 3-Phase Activ-Polymer™ platform technology to address the pressing issue of N-nitrosamine impurities in pharmaceuticals.

Abstracts from the Journal of Clinical Psychology, Journal of Clinical Experimental Neuropsychology, and other journals about estimating premorbid intelligence.

Regression equations for estimating premorbid intelligence.

TricorBraun has entered into a definitive stock purchase agreement with funds managed by Ares Management Corporation’s Private Equity Group and Ontario Teachers’ Pension Plan Board, both of which will acquire a majority interest in the Company.

The new and improved AGELESS provides a timely packaging solution for customers navigating the PFAS regulatory landscape.

 Police Innovations LLC eliminates damage in transit with orbital wrapper.

Wrapper prevents loads from sliding off the pallet and adds protection from damage in transit.

New rackable pallet supports heavy loads, provides load stability and features unique design qualities to streamline operations.

Manufactured through a process of Structural Foam Injection, the pallet boasts exceptional durability and reliability, making it an optimal choice for use within the industrial and automotive sectors.

https://www.politico.eu/article/climate-world-diplomats-donald-trump-victory-clean-energy-fossil-fuels-greenhouse-emissions/ By Karl Mathiesen, Sara Schonhardt and Zia Weise Green stocks wobble as officials rush to respond and activists brace for the unknown. ‘It’s going to suck,’ one said. Their worst nightmare is now a burning reality. Climate diplomats and top-ranking activists on Wednesday struggled to project calm as it became inevitable: Donald Trump is returning to the White […]

https://www.politico.eu/article/keep-using-fossil-fuels-hungarys-orban-tells-cop29-climate-summit/ Excerpt: BAKU, Azerbaijan — Let’s continue using oil and gas, Hungarian Prime Minister Viktor Orbán told world leaders at the United Nations climate summit today. “We must continue advancing the green transition while also maintaining our use of natural gas, oil and nuclear energy,” Orbán said. His remarks stand in stark contrast to the […]

New Technology Delivers Flawless Dolby Atmos Sound Over Your Power Lines  Forbes

The 10 Most Important Banking And Financial Technology Trends That Will Shape 2025  Forbes

The "Machete" star voices a new AI assistant.

Su libro recrea la vida diaria de seis astronautas orbitando en la Estación Espacial Internacional, con una prosa poética y científica a partes iguales Leer

El precio de la vivienda sigue al alza y se aproxima a los 3.255 euros por metro cuadrado, récord histórico alcanzado en 2011. Euskadi da ayudas a 40.000 vascos para pagar su alquiler y otras 27.000 familias viven en VPO de alquiler protegido. El consejero multiplica sus retoques a la política de Vivienda y confía que las "zonas tensionadas" enfríen un mercado de alquiler disparado Leer

Magyar leads mass protest against Orbán’s rule

Location: Electronic Resource- 

Jessica Harris watches a TV play revived for the stage.

Eureka Forbes reported an 83.2% YoY rise in Q2 net profit to Rs 46.67 crore, with revenues up 27.6% to Rs 672.87 crore. Growth was driven by product innovation, increased marketing, and early festive season demand.

Samantha Harvey talks about her new Booker Prize-winning novel Orbital. It follows a day in the life of astronauts aboard the International Space Station.

The two richest Black Americans are in finance and tech.

Commissioner of Police Stephen Corbishley has responded to a report about rape statistics in Bermuda. “A recent report shared on Facebook suggested that Bermuda sits 5th in the world in relation to offences of rape,” Commissioner Corbishley said. “The BPS and many other partner agencies in Bermuda are there to support victims of rape and […]

The Bermuda Tourism Authority [BTA] is aiming to enroll 300 new participants in its AnchorBDA programme before the end of 2024. A spokesperson said, “The Bermuda Tourism Authority has launched a bold challenge, aiming to enroll 300 new participants in its AnchorBDA programme before the end of 2024. “This initiative seeks to enhance the skills […]

The public can now step into the future of lunar exploration at Space Center Houston by entering an early mockup for Northrop Grumman's Gateway astronaut accommodations around the moon.

Orbit equation and orbital precession General Relativity explains gravity as Space-Time curvature and orbits of planets as geodesics of curved Space-Time. However, this concept is extremely hard to understand and geodesics hard to compute. If we can find an analytical orbit equation for planets like Newtonian orbit equation, relativistic gravity will become intuitive and straightforward...

Samantha Harvey has won the 2024 Booker Prize for her science fiction novel Orbital. The novel follows six international astronauts as they orbit the Earth for one day of their nine-month space mission.

Samantha Harvey's Orbital wins the Booker Prize. The 136-page space novel explores astronauts' reflections on Earth, touching on mourning, desire, and the climate crisis.

Junyi Xie
J. Amer. Math. Soc. 38 (), 1-62.
Abstract, references and article information

Jesper V. Olsen
Dec 1, 2005; 4:2010-2021
Technology

Jian Li
Proc. Amer. Math. Soc. 152 (), 5207-5217.
Abstract, references and article information

The recent structural elucidation of ex vivo Drosophila Orb2 fibrils revealed a novel amyloid formed by interdigitated Gln and His residue side chains belonging to the prion-like domain. However, atomic-level details on the conformational transitions associated with memory consolidation remain unknown. Here, we have characterized the nascent conformation and dynamics of the prion-like domain (PLD) of Orb2A using a nonconventional liquid-state NMR spectroscopy strategy based on 13C detection to afford an essentially complete set of 13Cα, 13Cβ, 1Hα, and backbone 13CO and 15N assignments. At pH 4, where His residues are protonated, the PLD is disordered and flexible, except for a partially populated α-helix spanning residues 55–60, and binds RNA oligos, but not divalent cations. At pH 7, in contrast, His residues are predominantly neutral, and the Q/H segments adopt minor populations of helical structure, show decreased mobility and start to self-associate. At pH 7, the His residues do not bind RNA or Ca2+, but do bind Zn2+, which promotes further association. These findings represent a remarkable case of structural plasticity, based on which an updated model for Orb2A functional amyloidogenesis is suggested.

Gorbachev's complex legacy is beyond the popular belief Expert comment NCapeling 3 September 2022

The last major figure with a decisive Cold War role, Mikhail Gorbachev was not as bad as Putin’s Russia portrays him, but also not as heroic as the West thinks.

Arguably the worst year of the Cold War since the Cuban Missile Crisis was 1983, with three major incidents which escalated East-West tensions – and any one of them could have led to a full-scale war.

The first was the Korean Airline KAL007 being shot down by an SU15 fighter aircraft for straying into Soviet airspace, killing all 269 passengers and crew. Then came the identification of signals from Soviet satellites as being incoming US intercontinental ballistic missiles – Colonel Stanislav Petrov, going against all protocols, thankfully decided to report them as a false alarm before he could be sure.

The third was perhaps the most dangerous, being the misinterpretation of a live-fire NATO exercise which was believed by some in both East Germany and Russia to be a front for an imminent attack.

All three incidents occurred in the few months following the infamous March 1983 ‘Star Wars’ speech by US president Ronald Reagan, in which he talked about nuclear arms control and laid out the US case for a ballistic missile defence programme.

At that time Mikhail Sergeyevich Gorbachev was the youngest serving member of the USSR Politburo, known to be a favourite of Soviet leader Yuri Andropov, and it is highly likely he had been aware of these close calls and was part of discussions within Kremlin decision-making circles.

A changemaker both inside and outside the USSR

Following the deaths of Andropov in 1984 and his replacement Konstantin Chernenko in 1985, Gorbachev’s appointment as general secretary of the Communist Party saw him immediately begin to change the Soviet Union from within – and also change relationships with the major Western powers, especially the US, Germany, and the UK.

His policies of glasnost (openness) and perestroika (restructuring) were primarily aimed at internal reforms but translated into a major reset of international relations and international security. During his six years as leader, Gorbachev initiated many arms control negotiations which resulted in treaties and increased both the transparency and the confidence between the USSR and the US.

These included the 1986 Stockholm Accord which emanated from the Helsinki Process and allowed for the observation and inspection of large-scale military exercises, the 1985 resumption of the Strategic Arms Reduction Talks which lead to START I, and the 1987 INF Treaty in which the USSR ‘out-yessed’ the US – the most open and transparent disarmament treaty in terms of notification and verification measures ever agreed.

There was also a reciprocal moratorium on nuclear weapons tests starting from 1985 – which laid the groundwork for the 1996 CTBT – the 1991 Chemical Weapons Convention, and the 1990 Conventional Forces in Europe (CFE) Treaty.

The most dramatic moment of all was when Gorbachev and Reagan met at a summit in Reykjavik and came close to deciding to eliminate nuclear weapons – but the initiative failed to reach agreement, mainly because Reagan could not drop his commitment to ballistic missile defences and Gorbachev could not accept the offer of joint development.

Nonetheless, all these nuclear arms control treaties led the way for their descendants which have kept nuclear weapons in check ever since and are still in place in the form of the New START agreement.

But despite these outstanding achievements, Gorbachev had blind spots – such as enabling rather than destroying the USSR bioweapons programme, unlike the US which had dismantled its own bioweapons offensive capability by 1973.

And it is now known that, despite negotiating the Chemical Weapons Convention, Russia withheld information on new chemical weapons agents – Novichoks – which have since been used to lethal effect by Russia in Salisbury and against figures opposing the current regime.

His misguided faith in a Soviet future

Gorbachev was markedly different to his predecessors as secretary general. He was neither as decrepit nor as hardline, and he understood from the outset that the Soviet Union was, by the 1980s, finally dying.

Using the intellectual abilities of Aleksandr Yakovlev, he forced through the reforms which simultaneously captured the imagination of the free world and liberated his countrymen and women.

But although he built solid relationships – even friendships – with the world’s major heads of state and improved the USSR’s human rights, releasing dissidents such as Andrei Sakharov, but many – especially Ukrainian dissidents – continued to languish in camps.

The greatest disappointment in Gorbachev’s legacy was he completely believed the USSR could be reformed and still survive as an entity while others, such as Boris Yeltsin and Ronald Reagan, understood it had to be dismantled.

This shortcoming is especially uncomfortable as today’s Russia continues to insist it has a given right to control other former Soviet states, to the extent it is willing to destroy them if they do not concede.

Preclinical data have shown that ¹⁶¹Tb-labeled peptides targeting the somatostatin receptor are therapeutically more effective for peptide receptor radionuclide therapy than are their ¹⁷⁷Lu-labeled counterparts. To further substantiate this enhanced therapeutic effect, we performed cellular dosimetry to quantify the absorbed dose to the cell nucleus and compared dose–response curves to evaluate differences in relative biological effectiveness in vitro. Methods: CA20948 cell survival was assessed after treatment with [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTATATE (agonist) and with [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTA-LM3 (antagonist) via a clonogenic assay. Cell binding, internalization, and dissociation assays were performed up to 7 d to acquire time-integrated activity coefficients. Separate S values for each type of particle emission (Auger/internal conversion [IC] electrons and β^– particles) were computed via Monte Carlo simulations, while considering spheric cells. Once the absorbed dose to the cell nucleus was calculated, survival curves were fitted to the appropriate linear or linear-quadratic model and corresponding relative biological effectiveness was evaluated. Results: Although the radiopeptide uptake was independent of the radionuclide, [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 delivered a 3.6 and 3.8 times higher dose to the nucleus, respectively, than their ¹⁷⁷Lu-labeled counterparts on saturated receptor binding. This increased nucleus-absorbed dose was mainly due to the additional emission of IC and not Auger electrons by ¹⁶¹Tb. When activity concentrations were considered, both [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 showed a lower survival fraction than did labeling with ¹⁷⁷Lu. When the absorbed dose to the nucleus was considered, no significant difference could be observed between the dose–response curves for [¹⁶¹Tb]Tb- and [¹⁷⁷Lu]Lu-DOTATATE. [¹⁶¹Tb]Tb-DOTA-LM3 showed a linear-quadratic dose response, whereas [¹⁶¹Tb]Tb-DOTATATE showed only a linear dose response within the observed dose range, suggesting additional cell membrane damage by Auger electrons. Conclusion: The IC, rather than Auger, electrons emitted by ¹⁶¹Tb resulted in a higher absorbed dose to the cell nucleus and lower clonogenic survival for [¹⁶¹Tb]Tb-DOTATATE and [¹⁶¹Tb]Tb-DOTA-LM3 than for the ¹⁷⁷Lu-labeled analogs. In contrast, [¹⁶¹Tb]Tb-DOTATATE showed no higher dose response than [¹⁷⁷Lu]Lu-DOTATATE, whereas for [¹⁶¹Tb]Tb-DOTA-LM3 an additional quadratic response was observed. Because of this quadratic response, potentially caused by cell membrane damage, [¹⁶¹Tb]Tb-DOTA-LM3 is a more effective radiopeptide than [¹⁶¹Tb]Tb-DOTATATE for labeling with ¹⁶¹Tb.

SpaceX on Saturday successfully launched a Falcon 9 rocket carrying a payload of 22 Starlink Internet communications satellite from Cape Canaveral in Florida, marking a state record 73rd orbital rocket launch this year.

SpaceX successfully launched Wednesday a new batch of Starlink satellites into orbit to further its mission to expand Internet access to the global population in now more than 200 space missions.

SpaceX launched another batch of 23 Starlink V2 Mini satellites into low Earth orbit aboard a Falcon 9 rocket from Cape Canaveral Space Force Station Thursday at 3:19 p.m. EST.

Much more than you’d think – and it’s whirling around at dangerously high speeds

A ring could explain a mysterious arrangement of impact craters near the equator and might even have caused an ice age, according to a new study