Simple things are often the best, and never more so than in cooking. Although it's tempting to gild the lily, sometimes the best thing you can do with beautiful ingredients is keep things as simple as possible - and this light, refreshing sorbet is a case in point. The flavours are true and clear, and it needs nothing more than a few orange segments and strawberry slices to finish it off.

This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, shared by Alice Zaslavsky, author of Alice's Food A-Z.

Institute of Ophthalmology., producer.

Dogs -- Breeding -- Great Britain -- History -- 19th century.

Paris : J.-B. Baillière, 1880.

Dessau : Rot, 1908.

Wien : Doll, 1817-

Edinburgi : Apud Balfour et Smellie, 1781.

Bonnae : Typis Joan. Frid. Abshoven, 1790.

Viennæ : Typis Christiani Friderici Wappler, 1788-92.

Viennae : Apud Rudolphum Graeffer, 1783.

Viennae : Apud Rudolphum Graeffer, 1783.

Paris : A. Delahaye, 1872.

Paris : Société d’éditions scientifiques, 1901.

Berkeley, California : Tabor Sarah Books, 1988.

(Common Object Request Broker Architecture) Pioneering integration architecture. Developed during the 1990s by the Object Management Group (OMG), CORBA was the first major attempt to define a platform-neutral architecture for combining heterogenous software resources across a network. A forerunner of today's service-oriented architectures, CORBA was designed for high-end, transaction-heavy, enterprise deployments, and thus it works best for tight coupling of software resources written in traditional programming languages such as C, C++, Java, Smalltalk and COBOL. Although the addition of IIOP (Internet Inter-ORB Protocol) extended CORBA to run over the Internet, it is less flexible than today's more loosely coupled SOAs, which are based on the exchange of XML documents using web services.

We can adapt flexibly to environment changes and search for the most appropriate rule to a context. The orbital prefrontal cortex (PFo) has been associated with decision making, rule generation and maintenance, and more generally has been considered important for behavioral flexibility. To better understand the neural mechanisms underlying the flexible behavior, we studied the ability to generate a switching signal in monkey PFo when a strategy is changed. In the strategy task, we used a visual cue to instruct two male rhesus monkeys either to repeat their most recent choice (i.e., stay strategy) or to change it (i.e., shift strategy). To identify the strategy switching-related signal, we compared nonswitch and switch trials, which cued the same or a different strategy from the previous trial, respectively. We found that the switching-related signal emerged during the cue presentation and it was combined with the strategy signal in a subpopulation of cells. Moreover, the error analysis showed that the activity of the switch-related cells reflected whether the monkeys erroneously switched or not the strategy, rather than what was required for that trial. The function of the switching signal could be to prompt the use of different strategies when older strategies are no longer appropriate, conferring the ability to adapt flexibly to environmental changes. In our task, the switching signal might contribute to the implementation of the strategy cued, overcoming potential interference effects from the strategy previously cued. Our results support the idea that ascribes to PFo an important role for behavioral flexibility.

SIGNIFICANCE STATEMENT We can flexibly adapt our behavior to a changing environment. One of the prefrontal areas traditionally associated with the ability to adapt to new contingencies is the orbital prefrontal cortex (PFo). We analyzed the switching related activity using a strategy task in which two rhesus monkeys were instructed by a visual cue either to repeat or change their most recent choice, respectively using a stay or a shift strategy. We found that PFo neurons were modulated by the strategy switching signal, pointing to the importance of PFo in behavioral flexibility by generating control over the switching of strategies.

The associations between food insecurity and child well-being have been well studied on the basis of household levels of food insecurity, as reported by heads of households.

Household measures, however, may not capture gender biases in food insecurity and morbidity. This study assessed adolescents' own experience with food insecurity and how it was associated with morbidity and the effect of gender in this process. (Read the full article)

Although China has the largest birth population in the world and a number of multicenter studies of neonatal respiratory failure are reported, there is a paucity of data regarding outcome measurement of very premature neonates requiring respiratory care and surfactant therapy.

This study is the largest survey, to date, in a Chinese network of 55 NICUs that presents the incidence, morbidity, and mortality rates, with risk factors of neonatal respiratory failure, with special emphasis on surfactant-treated very immature infants. (Read the full article)

Infants weighing 501 to 1500 g are at high risk for mortality and for neonatal morbidities associated with both short- and long-term adverse consequences.

Mortality and major neonatal morbidity in survivors decreased for infants 501 to 1500 g between 2000 and 2009. However, in 2009, a high proportion of these infants still either died or survived after experiencing ≥1 major neonatal morbidity. (Read the full article)

Moderately preterm-born children (32–35^6/7 weeks’ gestation) are at risk for both neonatal morbidities after birth and developmental delays in early childhood. It is unknown whether neonatal morbidities contribute to the developmental delays of this particular group.

Of all neonatal morbidities commonly seen in moderately preterm-born children, only hypoglycemia increased the risk of developmental delay after moderately preterm birth. A concerted effort to prevent hypoglycemia after birth might enhance developmental outcome in this group. (Read the full article)

Mortality of very low birth weight infants varies widely between regions and countries; however, the variation in morbidities after adjusting for confounders has not been adequately studied.

Composite outcome of mortality or short-term morbidity for very low birth weight infants was lower in Japan than in Canada. However, marked variations in mortality and individual morbidity exist, revealing areas for improvement in each country. (Read the full article)

Randomized controlled trials have shown that zinc supplementation during diarrhea substantially reduces the incidence and severity. However, the effect of short-course prophylactic zinc supplementation has been observed only in children >12 months of age.

The current study was able to show that short-course prophylactic zinc supplementation significantly reduced diarrhea morbidity in apparently healthy infants of 6 to 11 months even after 5 months of follow-up. (Read the full article)

Individuals with autism spectrum disorders have a higher comorbidity burden than the general pediatric population, including higher rates of seizures, psychiatric illness, and gastrointestinal disorders.

Comorbidities do not occur evenly. Our clustering analysis reveals subgroups characterized by seizure, psychiatric disorders, and complex multisystem disorders including auditory and gastrointestinal disorders. Correlations between seizure, psychiatric disorders, and gastrointestinal disorders are validated on a sample from a second hospital. (Read the full article)

Infants with trisomy 13 (T13) or trisomy 18 (T18) are known to have poor survival. Little is known about how very low birth weight (VLBW) impacts survival and morbidities among infants with T13 or T18.

We examined the risks of mortality and neonatal morbidities for VLBW infants with T13 or T18 compared with VLBW infants with trisomy 21 and VLBW infants without birth defects in a 16-year cohort from the Neonatal Research Network. (Read the full article)

In addition to seizures, school-aged children with epilepsy can have coexisting cognitive and behavioral difficulties, but the spectrum and prevalence of such difficulties are uncertain.

This study provides population-based data on the prevalence of common comorbid cognitive impairments and factors associated with such diagnoses in school-aged children with "active" epilepsy. (Read the full article)

Universal use of conjugated pneumococcal vaccines has resulted in dramatic decline in vaccine-type invasive pneumococcal disease. However, disease is not evenly distributed, and children with underlying clinical conditions are disproportionately represented, especially among children >5 years of age.

Invasive pneumococcal disease among children with comorbidity results in higher morbidity and mortality, and a large proportion of disease is due to serotypes not included in current conjugate vaccines. (Read the full article)

Although there is evidence regarding comorbidity of physical and mental disorders from clinical samples of specific disorders and treatment registries, there is limited evidence from systematic samples of youth with comprehensive information on the full range of mental and physical disorders.

This report is the first study to investigate the specificity of associations between a broad range of mental and physical conditions by using a large, systematically obtained pediatric sample with enriched information from electronic medical records and direct interviews. (Read the full article)

Studies on the risk of mortality and morbidities of extremely preterm infants of multiple gestation births have shown inconsistent results. Perinatal antecedents, admission status and severity of illness after birth can adversely affect outcomes of the extremely premature infants.

Preterm multiple gestation infants have increased risk of mortality but similar risk of major morbidities compared with singletons. Outcomes improved over time and all adverse outcomes, including mortality, were comparable between multiples and singletons in the most recent 5-year epoch. (Read the full article)

Meropenem/vaborbactam resistance in Klebsiella pneumoniae is associated with loss of function mutations in the OmpK35 and OmpK36 porins. Here we identify two previously unknown loss of function mutations that confer cefuroxime resistance in K. pneumoniae. The proteins lost were NlpD and KvrA; the latter is a transcriptional repressor controlling capsule production. We demonstrate that KvrA loss reduces OmpK35 and OmpK36 porin production, which confers reduced susceptibility to meropenem/vaborbactam in a KPC-3 producing K. pneumoniae isolate.

Peroxidases are a group of heterogeneous family of enzyme that plays diverse biological functions. Ascorbate peroxidase is a redox enzyme that is reduced by trypanothione, which plays a central role in the redox defence system of Leishmania. In view of developing new and novel therapeutics, we have performed in silico studies in order to search for ligand library and identification of new drug candidates and its physiological role against promastigotes and intracellular amastigotes of Leishmania donovani. Our results demonstrated that the selected inhibitor ZINC96021026 has significant anti-leishmanial effect and effectively killed both free and intracellular forms of the parasite. ZINC96021026 was found to be identical to ML-240, a selective inhibitor of Valosin-containing protein (VCP) or p97, a member of AAA-ATPase protein family which was derived from the scaffold of DBeQ, targeting the D2-ATPase domain of the enzyme. ZINC96021026 (ML-240) thus have broad range of cellular functions, thought to be derived from its ability to unfold proteins or disassemble protein complexes besides inhibiting the ascorbate peroxidase activity. ML-240 may inhibits the parasite's ascorbate peroxidase leading to extensive apoptosis and inducing generation of reactive oxygen species. Taken together, our results demonstrated that ML-240 could be an attractive therapeutic option for treatment against leishmaniasis.

Jeffrey D. Horbar
Jun 1, 2012; 129:1019-1026
ARTICLES

Jeffrey D. Horbar
Jul 1, 2002; 110:143-151
ARTICLES

This hearty broth comprises goodness of chicken, lemon, coriander, ginger and garlic. This shorba is all things soothing and flavourful

The discovery was announced by the Minor Planet Center on Tuesday. So far, the astronomers do not have enough data to establish what the minimoon is made of.

The experimental spaceship was launched without crew by China's new large carrier rocket Long March-5B from the Wenchang Space Launch Centre in Hainan on Tuesday.

East Tennessee State University is promoting Jason Shay to be head coach of the men's basketball team, replacing Steve Forbes, who left for Wake Forest last week. Shay was on Forbes' staff the past five seasons.

visit News18 Urdu for latest news, breaking news, news headlines and updates from Porbander on politics, sports, entertainment, cricket, crime and more.

visit News18 Urdu for latest news, breaking news, news headlines and updates from Korba on politics, sports, entertainment, cricket, crime and more.

When I was a boy growing up in the Bronx, I would often stay at my Aunt Gloria and Uncle Mike’s apartment when I got home from school until my mom got home from work. They lived on the ground floor of the same apartment building that my family lived in. My Grandpa Corbin lived with them. It was a wonderful neighborhood of many different nationalities and many wonderful cooking smells! Sometimes when turning the corner to our block, I would be greeted by the unmistakable aroma of Grandpa’s Codfish Cakes! Once, being the little chubby piggy kid that I was I ate the last two Codfish cakes from the day before. Aunt Gloria quickly scooted me outside to play, but I could hear Grandpa yell “Who ate the last codfish cakes!!” After he cooled off – Grandpa had a temper – I apologized, but I could tell he was still pretty angry. Not long after, I turned the corner to the smell of Codfish Cakes! There sat Grandpa with a glint in his eye. “I made these codfish cakes the way I really like them! It might keep you from eating them all!” He handed me one with a smile on his face. I took a bite and thought my head might explode! But I think that started my love of hot foods! I finished and asked for another through the tears. He laughed and handed me another – this one wasn’t quite so hot – I do think the first one was specially made just for me. Over the years I tried to duplicate Grandpa’s Cod Fishcakes – without any success – thinking it was an English recipe. It wasn’t until I found out that Grandpa Corbin was born in Barbados and I found a recipe from there that tasted almost like I remembered. With some adjustments over the years, I think I finally have it! -- posted by Billy R.

Forbes magazine has announced the top 25 highest grossing Turkish TV series of the year. Click through for the full list...

In the lead-up to the Truth Matters conference in October, we will be focusing our attention on the sufficiency, authority, and clarity of Scripture. Of our previous blog series, none better embodies that emphasis than Frequently Abused Verses. The following entry from that series originally appeared on September 16, 2015. -ed.

Love, don’t judge.

For many people in the church, that simple slogan has become the kneejerk defense in the face of criticism and confrontation. At some point, believers decided that careful discernment and agapē love are diametrically opposed; that judgment is always a threat to our unity in Christ. And with no regard for the quality or content of the exhortation, too many Christians speedily deploy Matthew 7:1 as an all-purpose, get-out-of-jail-free card: “Do not judge so that you will not be judged.”

Writing thirty years ago in his commentary on Matthew’s gospel, John MacArthur explained how that verse is routinely misapplied as a shield against confrontation and conflict in the church.

This passage has erroneously been used to suggest that believers should never evaluate or criticize anyone for anything. Our day hates absolutes, especially theological and moral absolutes, and such simplistic interpretation provides a convenient escape from confrontation. Members of modern society, including many professing Christians, tend to resist dogmatism and strong convictions about right and wrong. Many people prefer to speak of all-inclusive love, compromise, ecumenism, and unity. To the modern religious person those are the only “doctrines” worth defending, and they are the doctrines to which every conflicting doctrine must be sacrificed. ^[1] John MacArthur, The MacArthur New Testament Commentary: Matthew 1-7 (Chicago, IL: Moody Press, 1985), 430.

In the intervening decades, the church’s appetite for criticism, conflict, and confrontation has only further diminished. And in that same time, the misunderstanding and misapplication of this verse and others like it (cf. Luke 6:37; John 3:17) has taken root in the church, skewing its perspective on discipline and judgment, and insulating its people from rebuke and exhortation.

In fact, many in the church today behave as if confrontation and discerning judgment are forbidden. Any confrontation—whether it’s a question of personal holiness or doctrinal disagreement—is seen as prideful overstepping and an attack on the unity of God’s people. As John MacArthur explains,

In many circles, including some evangelical circles, those who hold to strong convictions and who speak up and confront society and the church are branded as violators of this command not to judge, and are seen as troublemakers or, at best, as controversial. ^[2] The MacArthur New Testament Commentary: Matthew 1-7, 431.

But Matthew 7:1 has nothing to do with avoiding conflict in favor of unity, or ignoring doctrinal or moral error in the name of love. As with many of the abused verses we’ll examine in this series, a simple look at the context makes the original intent of Christ’s words abundantly clear.

The seventh chapter of Matthew’s gospel represents the end of Christ’s Sermon on the Mount—His most extensive teaching on living as a citizen of the kingdom of God. Woven throughout that sermon is an exposé of the hypocrisy of the religious leaders of His day. Jesus upends the system of works-righteousness they had inflicted on God-fearing people throughout Israel.

During Christ’s life and ministry, the Jewish faith had been reduced to a heavy-handed list of dos and don’ts. The religious elite had obliterated God’s original intent in giving His law to His people, replacing it with a burdensome system of works righteousness. And they held the entire nation to their corrupt, man-made standard.

In his commentary, John MacArthur explains how the focus of Christ’s Sermon on the Mount makes it clear that the Lord was not prohibiting judgment, but promoting discernment.

If this greatest sermon by our Lord teaches anything, it teaches that His followers are to be discerning and perceptive in what they believe and in what they do, that they must make every effort to judge between truth and falsehood, between the internal and the external, between reality and sham, between true righteousness and false righteousness—in short, between God’s way and all other ways. ^[3] The MacArthur New Testament Commentary: Matthew 1-7, 431.

With that in mind, the prohibition against judgment takes on completely different nuance. Christ was condemning a very specific kind of self-righteous judgment—the kind we see on display in His parable about the Pharisee and the tax collector.

And He also told this parable to some people who trusted in themselves that they were righteous, and viewed others with contempt: “Two men went up into the temple to pray, one a Pharisee and the other a tax collector. The Pharisee stood and was praying this to himself: ‘God, I thank You that I am not like other people: swindlers, unjust, adulterers, or even like this tax collector. I fast twice a week; I pay tithes of all that I get.’ But the tax collector, standing some distance away, was even unwilling to lift up his eyes to heaven, but was beating his breast, saying, ‘God, be merciful to me, the sinner!’ I tell you, this man went to his house justified rather than the other; for everyone who exalts himself will be humbled, but he who humbles himself will be exalted.” (Luke 18:9-14)

Like many professing believers today, the Pharisees put on a good show of public holiness, and loved looking down on anyone who didn’t. As John explains,

Jesus here is talking about the self-righteous, egotistical judgment and unmerciful condemnation of others practiced by the scribes and Pharisees. Their primary concern was not to help others from sin to holiness, but to condemn them to eternal judgment because of actions and attitudes that did not square with their own worldly, self-made traditions. ^[4] The MacArthur New Testament Commentary: Matthew 1-7, 432.

Jesus’ words in Matthew 7:1 were a reminder to the religious elite that they were not the final judges—that they too would stand before God, and that they would not want to be held to their own rigorous, self-righteous standard (Matthew 7:2). Believers today need to heed that warning as well, and avoid the same kind of hypocritical hubris regarding our own holiness, and how it corresponds to other believers’.

We also need to consider how to biblically discern, confront, and rebuke when necessary. Fortunately for us, Christ addressed that very issue in His subsequent statements.

Why do you look at the speck that is in your brother’s eye, but do not notice the log that is in your own eye? Or how can you say to your brother, “Let me take the speck out of your eye,” and behold, the log is in your own eye? You hypocrite, first take the log out of your own eye, and then you will see clearly to take the speck out of your brother’s eye. (Matthew 7:3-5)

Confrontation and criticism are not forbidden in the church, but they must be undergirded with humility and purity. We need to humbly submit to the Lord, shining the light of His Word into the dark corners of our own hearts instead of arrogantly pointing it in someone else’s face. It’s only when we’ve dealt faithfully and biblically with our own sin that we can help a brother see his own. And as John explains, even in the midst of confrontation, we need to maintain a spirit of humility.

All confrontation of sin in others must be done out of meekness, not pride. We cannot play the role of judge—passing sentence as if we were God. We cannot play the role of superior—as if we were exempt from the same standards we demand of others. We must not play the hypocrite—blaming others while we excuse ourselves. ^[5] The MacArthur New Testament Commentary: Matthew 1-7, 437.

We do a great disservice to the Body of Christ when we confront and judge one another in arrogance and self-righteousness. But, as John MacArthur writes, we also do damage to the church if we fail to exercise godly judgment and discernment when it’s warranted.

There is also danger, however, even for the truly humble and repentant believer. The first danger . . . is of concluding that we have no right to oppose wrong doctrine or wrong practices in the church, lest we fall into judgmental self-righteousness. We will then not be willing to confront a sinning brother as the Lord clearly calls us to do. The second danger is closely related to the first. If we are afraid to confront falsehood and sin in the church, we will be inclined to become undiscriminating and undiscerning. The church, and our own lives, will become more and more in danger of corruption. Realizing the impact of sin in the assembly (1 Peter 4:15), Peter made a powerful call for a confrontive, critical church when he said, “For it is time for judgment to begin with the household of God” (1 Peter 4:17). Believers must be discerning and make proper judgment when it is required. ^[6] The MacArthur New Testament Commentary: Matthew 1-7, 437.

Discernment does not have to lead to division. If we faithfully follow the pattern Christ gave us, we will be able to confront one another out of love and humility, not arrogance and self-righteousness. And we’ll be able to humbly accept the input of others without rushing to defensive arguments and judgmental retaliation.