moral Moral pressure and human rights compliance By www.thehindu.com Published On :: Thu, 22 Aug 2024 00:16:00 +0530 There is a need to establish the undeniable centrality of human rights in a rapidly changing world that is facing prejudice and fanaticism Full Article Lead
moral Suspects in Kokkallur ‘moral policing case’ still on the run By www.thehindu.com Published On :: Wed, 30 Oct 2024 19:23:24 +0530 The alleged assault took place at Kokkallur near Balussery in Kozhikode on Monday Full Article Kozhikode
moral Narratives, Imperatives, and Moral Reasoning [electronic journal]. By encore.st-andrews.ac.uk Published On :: National Bureau of Economic Research Full Article
moral Moral Hazard and the Property Rights Approach to the Theory of the Firm [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
moral A minimal moral hazard central stabilisation capacity for the EMU based on world trade [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
moral Adverse Selection and Moral Hazard in the Leasing Market: Are Buybacks the Solution? [electronic journal]. By encore.st-andrews.ac.uk Published On :: Full Article
moral Nyx, Excellent Lass and Balmoral shine By www.thehindu.com Published On :: Tue, 15 Oct 2024 16:33:55 +0530 Full Article Races
moral Del Aviz, Southern Force, Balmoral, Nyx, Chotipari and Macron excel By www.thehindu.com Published On :: Wed, 23 Oct 2024 18:09:59 +0530 Full Article Races
moral Morale and the Italian army during the First World War [electronic resource] / Vanda Wilcox. By darius.uleth.ca Published On :: Cambridge : Cambridge University Press , 2016. Full Article
moral Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00600C, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Gennaro Sanità, Maria Laura Alfieri, Barbara Carrese, Serena Damian, Vincenza Mele, Gaetano Calì, Brigida Silvestri, Sebastiano Marra, Susan Mohammadi, Giuseppina Luciani, Paola Manini, Annalisa LambertiBiological assays carried out on melanoma and breast cancer cells highlighted the role of light in boosting the cytotoxic effect of a ruthenium complex featuring a dihydroisoquinoline ligand suggesting applications in photodynamic therapy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
moral Mental health is a moral and ethical issue By www.thehindu.com Published On :: Thu, 10 Oct 2024 12:53:31 +0530 The greatest gap in mental health interventions has been in understanding the lived experiences of suffering Full Article Comment
moral Chief Minister Siddaramaiah has no moral right to seek resignation of Prime Minister Narendra Modi, says Union Minister By www.thehindu.com Published On :: Tue, 12 Nov 2024 07:00:00 +0530 Pralhad Joshi was responding to a challenge by Mr. Siddaramaiah to the PM to prove charges of corruption in Karnataka or resign. Full Article Karnataka
moral Sugar-coated moral lessons By www.thehindu.com Published On :: Thu, 01 Sep 2016 22:48:26 +0530 The four plays staged at “Hriday Manch-2016” were comic expositions exuding local flavour and style, writes Diwan Singh Bajeli Full Article Friday Review
moral Self-adjuvanted L-arginine-modified dextran-based nanogels for sustained local antigenic protein delivery to antigen-presenting cells and enhanced cellular and humoral immune responses By pubs.rsc.org Published On :: Biomater. Sci., 2024, 12,1771-1787DOI: 10.1039/D3BM01150J, PaperJin Teng Chung, Mehrnoosh Rafiei, Ying ChauAntigens are delivered in self-adjuvanted arginine-modified dextran-based nanogels to the dendritic cells in promoting antigen specific cellular immunity.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
moral Zaida Morales-Martínez wins mentoring award By cen.acs.org Published On :: 28 Jul 2018 10:21:14 +0000 Full Article
moral Newcastle takeover: Moral values should prevail, Khashoggi's fiancee says By www.bbc.co.uk Published On :: Sat, 09 May 2020 23:01:47 GMT The fiancee of murdered journalist Jamal Khashoggi says Newcastle United and the Premier League must put moral values ahead of financial gains. Full Article
moral 'Moral values should prevail on Newcastle takeover' By www.bbc.co.uk Published On :: Sat, 09 May 2020 23:01:47 GMT The fiancee of murdered journalist Jamal Khashoggi says Newcastle United and the Premier League must put moral values ahead of financial gains. Full Article
moral Bolivian voters nix Morales plan for 4th term By america.aljazeera.com Published On :: 2016-02-24T03:55:00Z Voters in Bolivia rejected by a slim margin a constitutional amendment that would have allowed Morales to run again Full Article
moral Don't Forget a Hearty Dash of Morals By feedproxy.google.com Published On :: Tue, 26 Jul 2011 19:52:49 -0700 Full Article creative process flow chart stephenie meyer twilight
moral Moral bathwater, dance-bar babes By indiatogether.org Published On :: Sun, 01 May 2005 00:00:00 +0000 Why are our publicly held/debated notions of morality limited to a few things such as the world of those castigated as sexual outliers? Partly, the fault lies in our public discourse - a discourse that has turned conversations about morality itself into rare events. The India Together editorial. Full Article
moral A moral breach in the dam By indiatogether.org Published On :: Fri, 14 Apr 2006 00:00:00 +0000 As the demands for justice draw embarrassingly close to the PM, the decision to raise the height of the Sardar Sarovar dam is being reviewed. But promises are nothing new, and officials have always known that they can be broken with impunity. Should we expect anything different this time? The India Together editorial. Full Article
moral Paradise Papers: The moral dilemmas of tax avoidance By www.hardnewsmedia.com Published On :: Wed, 08 Nov 2017 12:54:59 +0000 Mohan Guruswamy The tranche of documents uncovered recently has not only brought several stalwarts of Indian politics, cinema industry, and business tycoons under scanner but has also thrown up pertinent questions over the moral dilemmas of avoiding tax The paradise in the Paradise Papers refers to tax havens of low or even no taxation. Such havens usually are shadowy and sleazy little countries and principalities such as the Cayman Islands, Lichtenstein and Monaco, and sometimes entities within countries like Jersey, Guernsey, Bermuda in the UK and Delaware and Puerto Rico in the USA. Then there are low taxation countries like Switzerland, Singapore and Dubai that assure secretive rich people of their privacy. Essentially a tax haven exists to cheat sovereign states of their lawful incomes. The Tax Justice Network campaign group estimates that corporate tax avoidance costs governments $500bn a year, while personal tax avoidance costs $200bn a year. This in effect means that anywhere between $20-30 trillion of business transactions are sheltered from taxations. Moody’s estimated that in 2016 giant American technology companies such as Google, Microsoft and Apple were hoarding about $1.84 trillion cash in offshore havens. Clearly they are avoiding tax and as bending the rules of the tax system is not illegal unlike tax evasion; they are operating within the letter, but perhaps not the spirit, of the law. In the early 1980’s, shaken up by the number of scandals in Wall Street, and by the number of its MBA graduates who were found wanting in ethical and moral values, the Harvard Business School made a course on “Leadership and Corporate Accountability” a core requirement. I am sure Jayant Sinha, a Harvard MBA, had to do this course and would have scored a high grade in it. Such courses now are in the core curriculum of the business schools attended by the other two young politicians also named in the Paradise Papers or capers if you will. Sachin Pilot graduated from the famous Wharton School of Business and Karti Chidambaram took his business masters from Texas and a law degree from Cambridge to boot. Doing the required ethics course is one thing but it is quite something else to be able to resolve moral dilemmas of what John Kenneth Galbraith described as the “HBS’s ethical view of capitalism which derives straight out of the Protestant ethic and its transformational view of money, in which the ability to accumulate wealth is a reflection of one’s character.” The charge against Jayant Sinha is that while acting as an Omidyar Network representative was on the board of a California company that made a loan to that company’s Cayman subsidiary. Usually such a loan to such a subsidiary suggests a fiddle. Whether Sinha knew this or did not know it is something else? Clearly the evidence does not suggest any malfeasance. But clearly there is room for skepticism. Omidyar Network proclaims its belief: “Just as eBay created the opportunity for millions of people to start their own businesses, we believe market forces can be a potent driver for positive social change.” Grand words but that hardly conceals the true goal that is to make bucks, sometimes fast ones too. Again as Galbraith put it: “The modern conservative is engaged in one of man’s oldest exercises in moral philosophy; that is, the search for a superior moral justification for selfishness.” Jayant, then fresh out of one of the IIT’s, worked with me way back in the mid 1980’s on a paper that proposed the mass construction of smokeless challahs for rural homes as a profitable employment for hundreds of thousands of rural workers. I remember it as a bit of an elaborate scheme that also computed the savings due to improved health results. It was published in this newspaper and the then Prime Minister Rajiv Gandhi took note of it. I was impressed enough to write a recommendation when he applied for a Masters in Energy Management at Pennsylvania. I next met him when I was serving as his fathers Advisor in the Finance Ministry. Jayant and his wife were both working with foreign companies investing in Indian stocks. He was apprehensive about a proposal made by me to disinvest PSU stocks by selling them to the governments banks for onward restructure and disinvestment. The minister had clearly spoken to him. At that time too I wondered if the HBS’s core business ethics course would have seen conflict of interest issues in it? The minister however had plenty of flex in him. To my mind tax avoidance is just as reprehensible as tax evasion. Sinha was too junior in the Finance Ministry to have expressed views on this. It would have been unlikely though for that is not the HBS way. The previous Finance Minister, himself a Harvard MBA, would not have any left footprints for young Sinha to tread on. Neither would the present lawyer Finance Minister. CorruptionParadise PapersPanama PapersGovernment of IndiaLead Image: Full Article
moral Whole Foods' John Mackey on Obamacare, fascism and capitalism's moral code By www.mnn.com Published On :: Fri, 18 Jan 2013 16:35:29 +0000 The granola guru John Mackey has a new book and is once again making waves with his outspoken views. Full Article Sustainable Business Practices
moral 7 'universal moral rules' found around the world By www.mnn.com Published On :: Tue, 26 Feb 2019 16:45:57 +0000 Researchers say they've identified a universal code of human morality. Full Article Responsible Living
moral What is moral grandstanding and are you guilty of it? By www.mnn.com Published On :: Sat, 11 Jan 2020 14:14:59 +0000 When it comes to political or personal conversations, it's always good to avoid this type of superiority posturing. Full Article Arts & Culture
moral The case for fossil fuel divestment is economic, not just moral By www.mnn.com Published On :: Wed, 17 Feb 2016 16:04:10 +0000 In the long run, fossil fuel investments are an increasingly risky bet. And investors are beginning to take note. Full Article Energy
moral American Morality - A Glimmer of Hope on the Horizon By www.articlegeek.com Published On :: Has the United States lost it's basic principle of morality? Has the United States moved away from the guiding principles that this country was founded on? In this article, I will address these and other questions, with the hope that by examining these issues, we can as a society, move in a direction our founding fathers had envisioned. Full Article
moral Jesus Morales Celebrated for Dedication to the Food Industry By www.24-7pressrelease.com Published On :: Tue, 25 Feb 2020 07:00:00 GMT Mr. Morales has become reputable with his Nicaraguan cuisine as the general manager of La Bella Managua Full Article
moral Whole Foods’ John Mackey on Capitalism’s Moral Code By hbr.org Published On :: Thu, 17 Jan 2013 17:23:19 -0500 John Mackey, co-CEO of Whole Foods Market and coauthor of "Conscious Capitalism: Liberating the Heroic Spirit of Business." Full Article
moral SCCM Pod-411 Clinical Moral Distress By sccm-audio.s3.amazonaws.com Published On :: Wed, 08 Apr 2020 12:45:00 -0500 Margaret M. Parker, MD, MCCM, and Christopher S. Parshuram, MBChB, PhD, discuss clinician moral distress in Canadian pediatric and neonatal intensive care units. Full Article Medicine
moral Why universal basic health care is both a moral and economic imperative By feedproxy.google.com Published On :: Thu, 07 May 2020 07:03:33 PDT Several hundred cars were parked outside a food bank in San Antonio on Good Friday — the food bank fed 10,000 people that day. Such scenes, increasingly common across the nation and evocative... Full Article Guest Columnist
moral Why universal basic health care is both a moral and economic imperative By www.thegazette.com Published On :: Thu, 7 May 2020 10:03:33 -0400 Several hundred cars were parked outside a food bank in San Antonio on Good Friday — the food bank fed 10,000 people that day. Such scenes, increasingly common across the nation and evocative of loaves and fish, reflect the cruel facts about the wealthiest nation in the world: 80 percent of Americans live paycheck to paycheck, and 100 percent of Americans were unprepared for the COVID-19 pandemic. People are hungry due to macroeconomic and environmental factors, not because they did something wrong. Although everyone is at risk in this pandemic, the risk is not shared equally across socioeconomic classes. Universal basic health care could resolve this disparity and many of the moral and economic aspects associated with the pandemic.Increases in the total output of the economy, or the gross domestic product (GDP), disproportionately benefit the wealthy. From 1980 to 2020, the GDP increased by 79 percent. Over that same time, the after-tax income of the top 0.01 percent of earners increased by 420 percent, while the after-tax income of the middle 40 percent of earners increased by only 50 percent, and by a measly 20 percent for the bottom 50 percent of earners. At present, the top 0.1 percent of earners have the same total net worth as the bottom 85 percent. Such income inequality produces poverty, which is much more common in the U.S. than in other developed countries. Currently 43 million Americans, or 12.7 percent of the population, live in poverty. At the same time, 30 million Americans are uninsured and many more are underinsured with poorly designed insurance plans. The estimated total of uninsured and underinsured Americans exceeds 80 million. In addition, most of the 600,000 homeless people and 11 million immigrants in the U.S. lack health care coverage. Immigrants represent an especially vulnerable population, since many do not speak English and cannot report hazardous or unsafe work conditions. Furthermore, many immigrants avoid care due to fear of deportation even if they entered the country through legal channels.Most people in poverty and many in the middle class obtain coverage from federal programs. On a national level, Medicaid is effectively a middle-class program and covers those living in poverty, 30 percent of adults and 60 percent of children with disabilities as well as about 67 percent of people in nursing homes. In Iowa, 37 percent of children and 48 percent of nursing home residents use Medicaid. Medicaid also finances up to 20 percent of the care provided in rural hospitals. Medicare, Medicaid and the Children’s Hospital Insurance Program (CHIP) together cover over 40 percent of Americans. In addition to facilitating care, health care policy must also address the “social determinants of health,” since the conditions in which people live, work, and play dictate up to 80 percent of their health risks and outcomes. This means that health care reform requires programs in all facets of society. Winston Churchill first conceptualized such an idea in the early 20th century as a tool to prevent the expansion of socialism, arguing that inequality could persist indefinitely without social safety nets. Since that time most developed countries have implemented such social programs, but not the US.All developed countries except the U.S. provide some type of universal basic health care for their residents. Universal basic health care refers to a system that provides all people with certain essential benefits, such as emergency services (including maternity), inpatient hospital and physician care, outpatient services, laboratory and radiology services, treatment of mental illness and substance abuse, preventive health services (including vaccinations), rehabilitation, and medications. Providing access to these benefits, along with primary care, dramatically improves the health of the community without imposing concerns regarding payment. Perhaps not coincidentally, the U.S. reports a lower life expectancy and higher rates of infant mortality, suicide and homicide compared to other developed countries. Countries such as Canada, Great Britain, Denmark, Germany, Switzerland, Australia, and Japan all produce better health care outcomes than the U.S. at a much lower cost. In fact the U.S. spends about twice the percentage of its GDP on health care compared to these countries. With that being said, the Affordable Care Act of 2010 (ACA), which facilitated a decrease in the rate of the uninsured in the U.S. from 20 percent to 12 percent, also decreased the percentage of the GDP spent on health care from 20.2 percent to 17.9 percent in just 10 years. For this reason, most economists agree that universal basic health care would not cost more than the current system, and many would also argue that the total costs of the health care system cannot be further reduced unless everyone has access to basic care.Achieving successful universal basic health care requires a serious long-term commitment from the federal government — contributing to Medicaid and financing its expansion are not enough. It requires courage from our elected leaders. The ACA took several important steps toward this goal by guaranteeing coverage for preexisting conditions, banishing lifetime maximums for essential services, and mandating individual coverage for everyone, though Congress repealed this final provision in 2017. At present, the ACA requires refinement and a public option, thereby preserving private and employer-based plans for those who want them.Without universal basic health care the people living at the margins of society have no assurances that they will have access to basic health care services, especially during times of pandemic. Access to food and medications is less reliable, large families live together in small spaces, and public transportation facilitates frequent exposure to others. Childhood diseases such as asthma, chronic diseases such as diabetes, and diseases related to smoking such as COPD and cancer are all likely to worsen. Quarantine protocols also exacerbate the mental health crisis, further increasing rates of domestic violence, child abuse, substance abuse, depression, and suicide. In the last six weeks over 30 million Americans have applied for unemployment benefits, and as people become unemployed, many will lose health insurance. Access to basic health care without economic or legal consequences would greatly enhance all aspects of pandemic management and response, from tracing contacts and quarantining carriers to administering tests and reinforcing supply chains. The COVID-19 pandemic has disproportionately affected minorities and the impoverished in both mortality and livelihood. Universal basic health care helps these vulnerable populations the most, and by reducing their risk it reduces the risk for everyone. In this way, universal basic health care supports the best interests of all Americans. Like a living wage, universal basic health care aligns with the Christian tradition of social justice and is a moral and economic imperative for all Americans. Nurses, doctors, and other health care providers often observe a sharp contrast between the haves and have-nots when seeing patients. The homeless, the hungry, the unemployed, the working poor, the uninsured; people without families, patients with no visitors, those who live alone or lack support systems; refugees and immigrants — all of these people deserve the fairness and dignity provided by universal basic health care and programs which improve the social determinants of their health. The ACA moved U.S. toward this goal, but now it requires refinement and a public option. The COVID-19 pandemic highlights the urgency of this imperative by demonstrating how universal basic health care could decrease the risks to those less fortunate, thus significantly decreasing the risks to everyone. James M. Levett, MD, serves on the board of Linn County Public Health and is a practicing cardiothoracic surgeon with Physicians’ Clinic of Iowa. Pramod Dwivedi, MS, DrPH (c), is the health director of Linn County Public Health. Full Article Guest Columnist
moral How Spokane Bishop Thomas Daly wrestled with the moral dilemma of canceling Mass for coronavirus By www.inlander.com Published On :: Fri, 20 Mar 2020 13:44:00 -0700 This is hardly the first time the Catholic Church has to deal with a plague. Spokane Bishop Thomas Daly knows that well.… Full Article News/Local News
moral Femoral condylar radius gage By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT An instrument and method for determining the location of the anatomical epicondylar axis between the condyles of a femur is provided. The instrument includes first and second gauges each for measuring a radius of a femoral condyle and a frame. At least one of the gauges is movably connected to the frame. The method includes positioning the measuring end of each gauge against a separate condyle of a femur, actuating a pivoting member of each gauge to determine the radius of each condyle, measuring the distance between the condyles, and determining the location of the anatomical epicondylar axis of the femur. A measurement can be taken from a measuring scale provided on the gauge and from another scale provided on the frame. Determining the location of the axis can further include performing a calculation utilizing the radii of the condyles and the distance between the condyles. Full Article
moral #650 - Carmen Morales By thechurchofwhatshappeningnow.libsyn.com Published On :: Thu, 17 Jan 2019 03:14:12 +0000 Carmen Morales, a comedian, the second doorgirl in the history of The Comedy Store and host of the "No Sir I Don't Like It" podcast, joins Joey Diaz and Lee Syatt LIVE in studio. This podcast is brought to you by: My Bookie - Join now and MYBookie will match your deposit with up to a 50% bonus of your first deposit up to $1,000. www.mybookie.ag. Use Promo code CHURCH to activate the offer. Onnit.com. Use Promo code CHURCH for a 10% discount at checkout. Recorded live on 01/16/2019. Full Article
moral Moral Injury By kutpodcasts.org Published On :: Sat, 02 May 2020 19:52:32 +0000 On this edition of Two Guys on Your Head, Dr. Art Markman and Dr. Bob Duke talk about the psychology of moral injury. Full Article Two Guys on Your Head COVID-19 frontline Guilt Moral Injury Pandemic podcast psychology
moral George Steiner on morality, his love of books and the marvels of language By www.cbc.ca Published On :: Fri, 7 Feb 2020 15:30:43 EST Eleanor Wachtel revisits her 1995 conversation with the American literary critic and writer about the power of human speech. He died on Feb. 3, 2020. Full Article Radio/Writers & Company
moral From Soviet Russia to Trump's America, Masha Gessen on the nature of power and morality By www.cbc.ca Published On :: Fri, 27 Mar 2020 15:31:40 EDT The Russian-American journalist, author, translator and activist spoke with Eleanor Wachtel about the abuse of power and rise of modern totalitarianism. Full Article Radio/Writers & Company
moral Loren Linto sees the Harrow Balmoral football netball club as a vital ingredient for successful and prosperous communities in the two rural towns. By www.abc.net.au Published On :: Sat, 14 Sep 2019 12:05:00 +1000 Full Article ABC Wimmera westernvic Australia:VIC:Harrow 3317
moral Harrow Balmoral's C Grade team is just one of three senior sides stacked with professional women. By www.abc.net.au Published On :: Sat, 14 Sep 2019 12:05:00 +1000 Full Article ABC Wimmera westernvic Rural:Rural Women:All Sport:Netball:All Australia:VIC:Harrow 3317
moral Harrow-Balmoral's C Grade team is stacked with professional women By www.abc.net.au Published On :: Sat, 14 Sep 2019 12:05:00 +1000 Full Article ABC Wimmera westernvic Rural:Community Development:All Rural:Rural Women:All Sport:Netball:All Australia:VIC:Harrow 3317
moral AI and moral intuition: use it or lose it? By www.abc.net.au Published On :: Sun, 29 Mar 2020 17:30:00 +1100 Artificial intelligence is helping us to make all sorts of decisions these days, and this can be hugely useful. But if we outsource our moral intuition to AI, do we risk becoming morally de-skilled? Full Article Ethics Philosophy
moral Whales and our own morality By www.abc.net.au Published On :: Sat, 09 May 2020 08:45:00 +1000 A thought provoking examination of our relationship with whales and the environment. Full Article
moral Bleak outlook for Home Affairs morale, as staff report dissatisfaction with work and leadership By www.abc.net.au Published On :: Thu, 29 Aug 2019 15:28:00 +1000 The results of this year's public service survey show only a third of Home Affairs staff think it is a good place to work. Full Article ABC Radio Canberra canberra Government and Politics:All:All Government and Politics:Public Sector:All Australia:ACT:All Australia:ACT:Canberra 2600 Australia:All:All
moral Nazi memorabilia auction in Western Australian city condemned as 'morally repugnant' by Jewish group By www.abc.net.au Published On :: Mon, 24 Jun 2019 09:35:00 +1000 Private collectors snap up dozens of artefacts from the Third Reich at an auction, showing the popularity and value of Nazi military memorabilia is on the rise. Full Article ABC Central West NSW centralwest melbourne goldfields Community and Society:History:World War 1 Community and Society:History:World War 2 Defence and National Security:Defence Forces:Army Government and Politics:Social Policy:All Unrest Conflict and War:All:All Australia:NSW:Bathurst 2795 Australia:VIC:Melbourne 3000 Australia:WA:Kalgoorlie 6430
moral Cortes-Ramos v. Martin-Morales By feeds.findlaw.com Published On :: 2018-06-28T08:00:00+00:00 (United States First Circuit) - Reversed the order to dismiss the plaintiff's copyright and trademark claims stemming from a songwriting contest. Plaintiff entered a songwriting competition and agreed to the terms of the contest rules including an arbitration provision. Plaintiff did not win the contest, but alleges that the song he submitted was used by defendant for a music video. The court held that defendant was not a party to the arbitration agreement and could not invoke its provisions. Full Article Copyright Trademark Dispute Resolution & Arbitration
moral Cortes-Ramos v. Martin-Morales By feeds.findlaw.com Published On :: 2018-06-28T08:00:00+00:00 (United States First Circuit) - Reversed the order to dismiss the plaintiff's copyright and trademark claims stemming from a songwriting contest. Plaintiff entered a songwriting competition and agreed to the terms of the contest rules including an arbitration provision. Plaintiff did not win the contest, but alleges that the song he submitted was used by defendant for a music video. The court held that defendant was not a party to the arbitration agreement and could not invoke its provisions. Full Article Copyright Trademark Dispute Resolution & Arbitration
moral Pathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model By www.jci.org Published On :: Seizures often herald the clinical appearance of gliomas or appear at later stages. Dissecting their precise evolution and cellular pathogenesis in brain malignancies could inform the development of staged therapies for these highly pharmaco-resistant epilepsies. Studies in immunodeficient xenograft models have identified local interneuron loss and excess glial glutamate release as chief contributors to network disinhibition, but how hyperexcitability in the peritumoral microenvironment evolves in an immunocompetent brain is unclear. We generated gliomas in WT mice via in utero deletion of key tumor suppressor genes and serially monitored cortical epileptogenesis during tumor infiltration with in vivo electrophysiology and GCAMP7 calcium imaging, revealing a reproducible progression from hyperexcitability to convulsive seizures. Long before seizures, coincident with loss of inhibitory cells and their protective scaffolding, gain of glial glutamate antiporter xCT expression, and reactive astrocytosis, we detected local Iba1+ microglial inflammation that intensified and later extended far beyond tumor boundaries. Hitherto unrecognized episodes of cortical spreading depolarization that arose frequently from the peritumoral region may provide a mechanism for transient neurological deficits. Early blockade of glial xCT activity inhibited later seizures, and genomic reduction of host brain excitability by deleting MapT suppressed molecular markers of epileptogenesis and seizures. Our studies confirmed xenograft tumor–driven pathobiology and revealed early and late components of tumor-related epileptogenesis in a genetically tractable, immunocompetent mouse model of glioma, allowing the complex dissection of tumor versus host pathogenic seizure mechanisms. Full Article
moral It’s Morally Intolerable for the Privileged to Profit from this Emergency By robertreich.org Published On :: Mon, 23 Mar 2020 21:00:40 -0400 Societies gripped by cataclysmic wars, depressions, or pandemics can become acutely sensitive to... Full Article coronavirus