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Statement by Attorney General Eric Holder on the Office of the Inspector General’s Report on Operation Fast and Furious

Attorney General Eric Holder released the following statement today on the Department of Justice’s Office of the Inspector General’s report on Operation Fast and Furious.



  • OPA Press Releases

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Acting Associate Attorney General Tony West Speaks at the Permanent Mission of the Republic of South Africa High-level Breakfast Meeting on “Access to Criminal Legal Aid”

"But if the arc of history bends toward justice -- and I believe it does -- then it bends not by it's own weight but by the hands of those who dare to reach," said Acting Associate Attorney General West.




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Assistant Attorney General Lisa Monaco Speaks at the ABA Standing Committee on Law and National Security Breakfast Event

“Above all, our goal is to serve as practical problem solvers on the operational, legal, and policy questions we confront with our partners, and to keep pace with an evolving threat, while ensuring that we do so consistent with the rule of law and civil liberties,” said Assistant Attorney General Monaco.




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Medifast Recalls Optavia Oatmeal For Undeclared Milk

Baltimore, Maryland-based Medifast, Inc. is recalling certain Optavia Oatmeal products citing undeclared milk, a known allergen, the U.S. Food and Drug Administration said in a statement. The recall involves around 24,923 boxes of OPTAVIA Essential Old Fashioned Maple & Brown Sugar Oatmeal. The product is packaged in yellow and white cardboard boxes with the brand name.




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DSM Insight Series: 1 in 4 Consumers Prepare, Consume Breakfast in Less Than 5 Minutes

DSM today published the first part of a new report in its Global Insight Series, focused on breakfast habits and behavior in Europe and the US.




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No difference found in caffeine's effects on exercise power among 'fast' or 'slow' metabolizers

A recent study looking at the effects of caffeine on brief, high intensity exercise found the substance improved performance, regardless of genetic variations in how subjects metabolized caffeine.




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PTO Cancer Immunotherapy Fast Track

In response to President Obama’s National Cancer Moonshot initiative to eliminate cancer, the USPTO has launched the “Cancer Immunotherapy Pilot Program.” The Pilot Program provides an accelerated review for applications related to cancer immunotherapy and is set to launch in July 2016. According to the USPTO, this initiative: aims to cut the time it takes to...… Continue Reading




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Coldest Canadian Arctic communities face greatest reductions in shorefast sea ice




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Coldest Canadian Arctic communities face greatest reductions in shorefast sea ice





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Ultrafast optical response and ablation mechanisms of molybdenum disulfide under intense femtosecond laser irradiation




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Author Correction: Enhanced energy coupling for indirect-drive fast-ignition fusion targets




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Extinction watch: Amber eyes, dwindling fast

As of December 2017, fewer than 50 individuals are thought to be remaining in three subpopulations that are scattered over 140,000 square km in Iran’s central plateau. The cats have been nearly wiped out by excessive hunting, habitat degradation and scarcity of prey species.




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Code the web faster with Adobe Edge Code preview

See the latest features in Adobe Edge Code preview: live development, code hinting for HTML and CSS, inline colors, and quick code editing in context. (3:51)




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Hamilton beats Red Bulls to fastest times

Lewis Hamilton lead the way in the afternoon practice session at Interlagos




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Hamilton fast but wild in final practice

Lewis Hamilton led the way in the final practice session ahead of qualifying for the Australian Grand Prix, although the session wasn't without a few wild moments for the reigning world champion




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Rosberg fastest as Hamilton has engine trouble

Nico Rosberg set the fastest time in the opening practice session at the Malaysian Grand Prix as Mercedes team-mate Lewis Hamilton had his session cut short by an engine problem




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Rosberg fastest ahead of qualifying

Nico Rosberg set the pace in the final practice session for the Malaysian Grand Prix ahead of qualifying, although Mercedes stranglehold on the top appeared to loosen slightly as six cars managed to lap within a second over the hour




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To fast or not to fast—that is the coronavirus question for Ramadan

       




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We shouldn’t have to wait for FedNow to have faster payments

America’s payment system seems more like it belongs to a developing nation than to one of the wealthiest countries on the planet. U.S. banks can still take three days or longer to grant customers access to their own deposits. That delay costs real money to many of this country’s poorest citizens, causing them to resort to high-interest…

       




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Faster, more efficient innovation through better evidence on real-world safety and effectiveness


Many proposals to accelerate and improve medical product innovation and regulation focus on reforming the product development and regulatory review processes that occur before drugs and devices get to market. While important, such proposals alone do not fully recognize the broader opportunities that exist to learn more about the safety and effectiveness of drugs and devices after approval. As drugs and devices begin to be used in larger and more diverse populations and in more personalized clinical combinations, evidence from real-world use during routine patient care is increasingly important for accelerating innovation and improving regulation.

First, further evidence development from medical product use in large populations can allow providers to better target and treat individuals, precisely matching the right drug or device to the right patients. As genomic sequencing and other diagnostic technologies continue to improve, postmarket evidence development is critical to assessing the full range of genomic subtypes, comorbidities, patient characteristics and preferences, and other factors that may significantly affect the safety and effectiveness of drugs and devices. This information is often not available or population sizes are inadequate to characterize such subgroup differences in premarket randomized controlled trials.

Second, improved processes for generating postmarket data on medical products are necessary for fully realizing the intended effect of premarket reforms that expedite regulatory approval. The absence of a reliable postmarket system to follow up on potential safety or effectiveness issues means that potential signals or concerns must instead be addressed through additional premarket studies or through one-off postmarket evaluations that are more costly, slower, and likely to be less definitive than would be possible through a better-established infrastructure. As a result, the absence of better systems for generating postmarket evidence creates a barrier to more extensive use of premarket reforms to promote innovation.

These issues can be addressed through initiatives that combine targeted premarket reforms with postmarket steps to enhance innovation and improve evidence on safety and effectiveness throughout the life cycle of a drug or device. The ability to routinely capture clinically relevant electronic health data within our health care ecosystem is improving, increasingly allowing electronic health records, payer claims data, patient-reported data, and other relevant data to be leveraged for further research and innovation in care. Recent legislative proposals released by the House of Representatives’ 21st Century Cures effort acknowledge and seek to build on this progress in order to improve medical product research, development, and use. The initial Cures discussion draft included provisions for better, more systematic reporting of and access to clinical trials data; for increased access to Medicare claims data for research; and for FDA to promulgate guidance on the sources, analysis, and potential use of so-called Real World Evidence. These are potentially useful proposals that could contribute valuable data and methods to advancing the development of better treatments.

What remains a gap in the Cures proposals, however, is a more systematic approach to improving the availability of postmarket evidence. Such a systematic approach is possible now. Biomedical researchers and health care plans and providers are doing more to collect and analyze clinical and outcomes data. Multiple independent efforts – including the U.S. Food and Drug Administration’s Sentinel Initiative for active postmarket drug safety surveillance, the Patient-Centered Outcomes Research Institute’s PCORnet for clinical effectiveness studies, the Medical Device Epidemiology Network (MDEpiNet) for developing better methods and medical device registries for medical device surveillance and a number of dedicated, product-specific outcomes registries – have demonstrated the potential for large-scale, systematic postmarket data collection. Building on these efforts could provide unprecedented evidence on how medical products perform in the real-world and on the course of underlying diseases that they are designed to treat, while still protecting patient privacy and confidentiality.

These and other postmarket data systems now hold the potential to contribute to public-private collaboration for improved population-based evidence on medical products on a wider scale. Action in the Cures initiative to unlock this potential will enable the legislation to achieve its intended effect of promoting quicker, more efficient development of effective, personalized treatments and cures.

What follows is a set of both short- and long-term proposals that would bolster the current systems for postmarket evidence development, create new mechanisms for generating postmarket data, and enable individual initiatives on evidence development to work together as part of a broad push toward a truly learning health care system.

Downloads

      




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If you can’t keep hackers out, find and remove them faster

In the wake of recent intrusions into government systems, it is difficult to identify anyone who believes defenders have the advantage in cyberspace. Digital adversaries seem to achieve their objectives at will, spending months inside target networks before someone, usually a third party, discovers the breach. Following the announcement, managers and stakeholders commit to improving…

       




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To fast or not to fast—that is the coronavirus question for Ramadan

       




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McDonald's To Offer Fast-Food "McWeddings" in Hong Kong

If soaring wedding costs have you wondering how you can afford it all (and yet, you couldn't be bothered with the effort to put on a more eco-conscious wedding) then McDonald's may have the answer for you.




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Asthma Inhalers' Green Upgrade Deadline Fast Approaching

Good news: The ban on CFC-based asthma inhalers is rapidly approaching. Inhalers are going green and by December 31, all inhalers must be powered by hydrofluoroalkane (HFA) instead of the ozone-harming chlorofluorocarbons (CFCs).




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Breakfast (as we know it) is a lie!

Why are we eating cardboard-like cereal and bland yogurt when we could be having a sensational meal?




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TEDxOilSpill: An Idea More Powerful Than a Faster Horse

Innovation may be a fundamental part of




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Why Towns With Good Transit Options Are Recovering Faster From the Recession

Cities and towns with good public-transit options offer more convenience for residents and are, of course, more environmentally friendly places to live. Now it




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Teenager invents faster way to clean up toxic tar sands waste using sand and bacteria

The breakthrough also scored 18-year-old Hayley Todesco a Google Science Fair Award.




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Iran's Lake Urmia Is Drying Up Fast

About 100 years ago, my grandfather emigrated to the United States from a village near Lake Urmia, in what is now northwestern Iran. He died long before I was born, leaving me with




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Bed bugs: Better, stronger, faster!

Research reveals that bed bugs develop resistance to widely used chemical treatments, potentially paving the way for super bed bugs.




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White Castle becomes first fast food chain to serve plant-based Impossible Burger

The so-called "bleeding" veggie burger is bleedin' everywhere these days.




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Occasional fasting may be a fast fix for our health

Many people swear by the value of periodically fasting for a day or a couple days at a time. Science backs them up




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UK government refuses to crack down on fast fashion

It has rejected recommendations that could divert some of the 300,000 tonnes of clothing that go to landfill each year.




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Tableware for the Slow Food Movement: Plate Tells You When You Are Eating Too Fast

The Mandometer was originally developed to treat eating disorders like anorexia and bulimia nervosa; it was developed to "teach patients how to eat and recognize hunger and satiety." There are clinics using the technology in Sweden, the USA and




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Why is the world's population growing faster than expected?

If the latest projections prove to be accurate, we need to plan for about a 10% increase in the needed supply of food, drinking water, and energy, and in carbon dioxide emissions by 2050.




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Europe is warming faster than climate models projected

More than 90 percent of weather stations studied showed the climate was warming, a percentage too high to purely be from natural climate variability, say researchers




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Antarctic peninsula melting at fastest rate in 1,000 years

By analyzing a 364-meter ice core, researchers have been able to go back in time and track the freezing and melting cycles of Antarctica's peninsula.




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Fast Food Furniture is a worrisome trend

Do we really want our furniture to be inspired by burgers and hot dogs? We prefer Slow Food.




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Why you should avoid "fast furniture"

From the chemicals to the lifespan to the landfill, it suffers many of the same problems as fast fashion.




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'We Are the Weather: Saving the Planet Begins at Breakfast' (book review)

Jonathan Safran Foer argues convincingly that changing our diets is the most effective way to fight the climate crisis.




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Arctic sea ice cover keeps shrinking fast!

The graph says it all...




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6 big-batch breakfasts for holiday entertaining

House full of guests? These recipes will make your mornings go much smoother.




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Is flying dying? No, it is growing faster than ever

It's expected that by 2037 the number of people flying will double.




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Would you do a carbon fast for Lent?

Climate Caretakers offers a 7-week guide to reducing your carbon footprint.




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Denmark allows fast and heavy "speed pedelecs" in the bike lanes. What were they thinking?

We always write "Learn from Denmark." We take it back.




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Is It True That Farmers Feed Antibiotics To Livestock To Make Them Grow Faster?

I always thought the 'it makes them grow faster' reasoning for why they put antibiotics in animal feed was a myth and that the truth was more complex. Farmers found they could crowd animals




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Low-clearance Rapid Transit: Cheaper than subways, faster than trolleys

It has its ups and downs, but Harald Buschbacher's idea might be the best of both transit worlds.




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Fast food is fueling Brazilian wildfires

When you buy a burger, it could be from a cow raised on Brazilian soy feed. That's a problem.




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Does Living Near Fast Food Restaurants Mean You’re More Likely to Be Fat?

Fast food is the enemy of green food, so why does an overweight America still eat so much fast food?