A well-preserved fossilised tail from Spinosaurus suggests this massive dinosaur may have been able to propel itself and hunt for prey in the water

Chinese e-commerce company Alibaba set the stage for the biggest IPO ever as it looks to raise $21 billion sometime in September. Conway G. Gittens reports.

A well-preserved fossilised tail from Spinosaurus suggests this massive dinosaur may have been able to propel itself and hunt for prey in the water

Neiman Marcus Group filed for bankruptcy protection on Thursday, marking one of the highest-profile collapses yet among retailers forced to temporarily close stores in response to the COVID-19 pandemic. Freddie Joyner has more.

Title: Tailoring Exercise to Your Age
Category: Health News
Created: 4/29/2019 12:00:00 AM
Last Editorial Review: 4/29/2019 12:00:00 AM

ABSTRACT

Pathogenicity islands and plasmids bear genes for pathogenesis of various Escherichia coli pathotypes. Although there is a basic understanding of the contribution of these virulence factors to disease, less is known about variation in regulatory networks in determining disease phenotypes. Here, we dissected a regulatory network directed by the conserved iron homeostasis regulator, ferric uptake regulator (Fur), in uropathogenic E. coli (UPEC) strain CFT073. Comparing anaerobic genome-scale Fur DNA binding with Fur-dependent transcript expression and protein levels of the uropathogen to that of commensal E. coli K-12 strain MG1655 showed that the Fur regulon of the core genome is conserved but also includes genes within the pathogenicity/genetic islands. Unexpectedly, regulons indicative of amino acid limitation and the general stress response were also indirectly activated in the uropathogen fur mutant, suggesting that induction of the Fur regulon increases amino acid demand. Using RpoS levels as a proxy, addition of amino acids mitigated the stress. In addition, iron chelation increased RpoS to the same levels as in the fur mutant. The increased amino acid demand of the fur mutant or iron chelated cells was exacerbated by aerobic conditions, which could be partly explained by the O₂-dependent synthesis of the siderophore aerobactin, encoded by an operon within a pathogenicity island. Taken together, these data suggest that in the iron-poor environment of the urinary tract, amino acid availability could play a role in the proliferation of this uropathogen, particularly if there is sufficient O₂ to produce aerobactin.

IMPORTANCE Host iron restriction is a common mechanism for limiting the growth of pathogens. We compared the regulatory network controlled by Fur in uropathogenic E. coli (UPEC) to that of nonpathogenic E. coli K-12 to uncover strategies that pathogenic bacteria use to overcome iron limitation. Although iron homeostasis functions were regulated by Fur in the uropathogen as expected, a surprising finding was the activation of the stringent and general stress responses in the uropathogen fur mutant, which was rescued by amino acid addition. This coordinated global response could be important in controlling growth and survival under nutrient-limiting conditions and during transitions from the nutrient-rich environment of the lower gastrointestinal (GI) tract to the more restrictive environment of the urinary tract. The coupling of the response of iron limitation to increased demand for amino acids could be a critical attribute that sets UPEC apart from other E. coli pathotypes.

BACKGROUND AND OBJECTIVES:

A previous single-county study found that retail stores usually asked young-looking tobacco customers to show proof-of-age identification, but a large proportion of illegal tobacco sales to minors occurred after the customers had shown identification proving they were too young to purchase tobacco. We sought to investigate these findings on a larger scale.

Jack Nguyen and Meir M. Barak

Cortical bone remodeling is an ongoing process triggered by microdamage, where osteoclasts resorb existing bone and osteoblasts deposit new bone in the form of secondary osteons (Haversian systems). Previous studies revealed regional variance in Haversian systems structure and possibly material, between opposite cortices of the same bone. As bone mechanical properties depend on tissue structure and material, it is predicted that bone mechanical properties will vary in accordance with structural and material regional heterogeneity. To test this hypothesis, we analyzed the structure, mineral content and compressive stiffness of secondary bone from the cranial and caudal cortices of the white-tailed deer proximal humerus. We found significantly larger Haversian systems and canals in the cranial cortex but no significant difference in mineral content between the two cortices. Accordingly, we found no difference in compressive stiffness between the two cortices and thus our working hypothesis was rejected. Seeing that the deer humerus is curved and thus likely subjected to bending during habitual locomotion, we expect that similar to other curved long bones, the cranial cortex of the deer humerus is likely subjected primarily to tensile strains and the caudal cortex is likely subject primarily to compressive strains. Consequently, our results suggest that strain magnitude (larger in compression) and sign (compression vs. tension) affect differently the osteoclasts and osteoblasts in the BMU. Our results further suggest that osteoclasts are inhibited in regions of high compressive strains (creating smaller Haversian systems) while osteoblasts’ osteoid deposition and mineralization is not affected by strain magnitude and sign.

SUMMARY:

The cerebral ventricles have been studied since the fourth century BC and were originally thought to harbor the soul and higher executive functions. During the infancy of neuroradiology, alterations to the ventricular shape and position on pneumoencephalography and ventriculography were signs of mass effect or volume loss. However, in the current era of high-resolution cross-sectional imaging, variation in ventricular anatomy is more easily detectable and its clinical significance is still being investigated. Interpreting radiologists must be aware of anatomic variations of the ventricular system to prevent mistaking normal variants for pathology. We will review of the anatomy and development of the lateral ventricles and discuss several ventricular variations.

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Alan Yang’s film about the lack of understanding between generations strikes a chord, and is so relevant as coronavirus racism spreads

• Read all the Lockdown watch films here
• The best arts and entertainment during self-isolation

Inflamed by President Trump’s casual phrase “Chinese virus”, anti-Asian sentiment is erupting all over the world. As a British-Vietnamese person who has been spat on because of the colour of her skin, the film Tigertail is a glimmer of hope – a way of showing the truth, and connecting Asian communities at a time when panic and misinformation serve to break us apart. Alan Yang’s multi-generational love story Tigertail weaves in Yang’s cultural self-discovery and features memories of Taiwan, as experienced by the protagonist Pin-Jui. Weighted against the present tide of anti-Asian bigotry, this tender story about honesty and lost love is more relevant than ever.

“American culture has been negligent in portraying Asian-American people as fully realised human beings,” Yang told the Deadline podcast. Yang, who worked on Parks and Recreation before co-creating Master of None, recalled the trepidation he felt in the early days of his career, in a cultural landscape where east Asians were rarely represented, or stereotyped as hardworking automatons. Yang said he had felt restricted to using only white characters in his early pilots, fearing that all-Asian or Asian-American scripts would never be accepted. But this was before the film successes of Crazy Rich Asians, The Farewell and Parasite brought real Asian faces to mainstream culture.

Required for Comet Lake processors

GRANT SHAPPS announced the Government is introducing a £2 billion travel scheme to encourage Britons to use alternative transport as the UK slowly relaxes lockdown measures.

Brookfield, known for its contrarian bets on malls, will take minority stakes in struggling retailers

A recent study has described new states that can be found in super-cold atom experiments, which could have applications for quantum technology.

The following is a brief roundup of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.

Warning from head of High Street chain comes as retailers across the UK feel the financial pinch of coronavirus restrictions

A fifth of high street stores plan to stay closed permanently after the coronavirus lockdown lifts, retail leaders have told MPs.

A new biography of Harry and Meghan will "go beyond the headlines" and "reveal unknown details" of the couple's life together.

Brits will be left in the lurch unless ministers set out a clear path for lifting the Covid-19 lockdown, a former prime minister's think tank said.

Ex-official alleges cronyism, says warnings about supply shortages were ignored.

Imaging specialist produces clearest pictures yet from dramatic Nasa mission

Apple's over-ear headphones may be called 'AirPods Studio' & retail for $349  AppleInsiderView Full coverage on Google News

Consumers can reach out to their preferred retailers via Tecno's website and enter their PIN code details. The microsite with a store locator will assist in mapping the retailer and the contact details, and the device will be delivered to their doorsteps by their nearest retailer.

Toronto-Dominion Bank says it expects to take a provision for credit losses related to its U.S. retail banking business of roughly $1.1 billion (US$800 million) in its second quarter due to the pandemic.

Florida health officials have halted the publication of up-to-the-minute death statistics related to the coronavirus pandemic that have, by law, been compiled by medical examiners in the state.

A small flock of shorebirds contaminated with oil after touching down on a northern Alberta tailings pond is expected to be released back into the wild within a week.

The moon has seen a lot in its 4.5 million years of life, and a detailed new geologic map serves as testament.

The actress and her husband, Tom Hanks, were both hospitalised with the deadly virus

The actor and his wife both tested positive for the virus in Australia

Star-studded stories from the silver screen

Harry Winks has given an insight into how Tottenham players are keeping fit during the coronavirus lockdown.

Football fans will have the chance to embark upon a nostalgic journey over the next few weeks as ITV screen the 1996 European Championships in their entirety.

Fifty years ago, on May 9, 1970, The Guess Who became the first-ever Canadian rock band to top Billboard's Hot 100 chart.

In what would have been big news at the coronavirus-postponed Game Developer's Conference, Sony's streamed event, along with Microsoft's announcement, heats up the video game wars.

The Real Housewives of Cheshire star joined the Loose Women panel via a video call to talk about how children with autism have been affected by the pandemic

A recent study at the Okinawa Institute of Science and Technology Graduate University has described new states that can be found in super-cold atom experiments, which could have applications for quantum technology.

The update comes after Prime Minister Boris Johnson confirmed he would set out a lockdown exit strategy on Sunday.

ITV News has seen correspondence from Debenhams’ administrator to Bangladeshi suppliers demanding a 90% discount on garments orders.

Closures dragged total sales down, despite a 109.6% jump in online retail sales for the month – the highest increase on record.

Supermarket and grocery store turnover leapt 22 per cent in March on panic buying of toilet paper and food but sales are expected to fall as stockpiling subsides and major retailers, including Myer, extend shutdowns.

An easing of coronavirus restrictions means non-essential shopping has the green light from this weekend, but that doesn't mean all the stores are ready to throw open their doors immediately.

The local share market closes lower, despite some retail stocks rallying after sales surged in March, while the corporate regulator warns of the dangers of day trading for individual investors.

Neiman Marcus, the 112-year-old storied luxury department store chain, has filed for Chapter 11 bankruptcy protection, the first department store chain to be toppled by the coronavirus pandemic.

The Duchess of Cambridge has been keeping a secret – there's another baby in her...

Fernandes and Pogba are yet to feature in the same Man Utd side due to the Frenchman's rotten luck with injuries this season, but a partnership is on the horizon now he is back to full fitness

Federal indictments were down 75 percent in April and 25 percent in march as prosecutors and investigators were forced to curtail operations in response to coronavirus.