President-elect Donald Trump's reelection was credited for emboldening a group of people waving Nazi flags in Michigan over the weekend.

WLNS reported that the flags were seen in two cities, including at a Jewish play.

According to the report, "many people" were seen displaying flags with swastikas on Saturday night as the Fowlerville Community Theater performed the "Diary of Anne Frank." The same group was also seen outside the American Legion Post in Howell.

"It was upsetting," cast member Becky Frank said. "You know, just knowing the character I was playing, knowing a lot of the research that I did on my character."

Witnesses said the protest began in Howell before moving to Fowlerville. Protesters were seen wearing masks with the number 1488, a white supremacist symbol.

"There was a group of people at the four-way intersection in downtown that had swastika flags and American flags," witness Alex Sutfill told WLNS. "They were sticking their arms up and yelling hail Hitler and Hail Trump and everything like that."

Peter Damerow said the group told him to go back to his country.

"They looked at me and one of them said," Damerow recalled. "No this is Pureville now, and we're here to make sure it stays pure."

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By Matt Solomon Published: November 11th, 2024

By Keegan Kelly Published: November 11th, 2024

By Tara Ariano Published: November 12th, 2024

(Shortlink to this post: https://debbieohi.link/goodnight-ganesha)

I met Nadia Salomon through the SCBWI and am also familiar with her online. I love her enthusiasm, positive outlook, and the support she has shown fellow members of the kidlit community over the years! I was excited to get a sneak peek of GOODNIGHT GANESHA, her debut as a picture book author. The bedtime story celebrates nigthtime rituals as two young children visit their grandparents in India. SUCH gorgeous illustrations by Poonam Mistry. Thanks to both Nadia and Poonam for answering some questions about the book as well as their advice for young writers and illustrators!

Nadia Salomon lives in northern California with her family. Nadia writes picture book, middle-grade, and graphic novel manuscripts with themes of South Asian and Caribbean culture, STEM, non-fiction, and humor. Nadia is the winner of the 2020 SCBWI Service Award and the 2019 SCBWI WOOP Honor Award for work of outstanding progress on her non-fiction, picture book manuscript, MYRLIE: A VOICE OF HOPE. You can find out more about Nadia on her website, Twitter, Facebook, Instagram and YouTube. You can sign up for her newsletter here.

Poonam Mistry is a freelance illustrator living in the UK and graduated in 2010 with a degree in Graphic Design and Illustration at the University of Hertfordshire. Poonam creates her beautifully intricate images by hand using fine liners and then digitally alters them. You can find out more about Poonam on her website, Twitter, and Instagram.

Synopsis of GOODNIGHT GANESHA (Philomel, Aug. 31, 2021):

"As nighttime falls over the city, two children visiting their grandparents in India find there’s so much fun to be had! Whether it’s listening to epic stories or observing rituals in the puja room, there are many moments that make this time together special. In this beautiful, rhyming ode to bedtime, the only thing more universal than getting ready for bed and saying goodnight is the love between children and their grandparents."

Inspiration photo from Poonam Mistry.

Q. What was your path to publication?

Nadia: I'm a #PitMad success story. I landed my amazing agent, Ammi-Joan Paquette, through twitter pitching! That's about three years after joining SCBWI. But my debut, GOODNIGHT GANESHA, is not the story she faved, but instead what I call a 'hot potato' idea inspired by my child. I wrote the draft in October of 2017. I sent it to several editors and agents I had connected with through conferences, but received lots of champagne rejections before shelving it. It was one of 21 manuscripts I shared with my agent in March of 2018. She loved the concept, but asked me to write the story in lyrical prose. After rounds of revisions, in January of 2019, she finally accepted the manuscript. She sent it out on sub. Six months later, in July of 2019, we sold the manuscript to Liza Kaplan, a senior editor at Philomel Books. I am now traditionally published. From concept to release will be 3 years, 10 months, 14 days to be exact.

Q. What interaction did you have with the illustrator, if any, during the process?

Nadia: Poonam and I interacted behind the scenes, but we NEVER discussed GOODNIGHT GANESHA or the art for the book. I trusted her whole-heartedly. All work related communications went through our editor. We became friends behind the scenes - coping through the pandemic, bonding over shared culture, family, and everything else in between, but we NEVER had convos as she worked on the book. The one time was at the end, when Poonam completed the art and asked me, "DID YOU SEE THE FINAL ART YET?" And I was like, "Uhm...NO." She was so excited. She said she put a lot of extra details and hoped I liked it. I was so antsy, but stayed calm. A few days later I received the final art. It was just incredible! We had a good cry messaging back and forth over the final art and what this project meant to each of us. We're about to contribute a piece of Telugu Culture and Kalamkari art into kidlit; we're ecstatic and proud of what we created together.

Q. What was your illustration process for GOODNIGHT GANESHA?

Poonam: For Goodnight Ganesha, I began by actually taking photographs around my parent's house. They have a lot of decorative ornaments and wall hangings all around their home so this was the perfect starting point for the book. Nadia's text is so poetic and beautiful so I sketched the imagery I felt best represented each spread and would really showcase her words- usually I have several versions for each part of the text and pick the ones I like the most. Once this was approved, I sketched out larger versions on thick cartridge paper and used black ink to draw in the designs in neat. This is where I added all the patterns and details. Mostly I took inspiration from traditional Indian art such Kalamkari textiles and Madhubani art. I layered the patterned very much like you would see on sarees and fabrics. After completing the drawing, I used Photoshop to add colour and additional patterns to finish it off. Some of the spreads have a patterned border- this was because I wanted them to look like wall hangings and Kalamkari textile pieces- big pieces of art!

Q. What advice do you have for young writers?

Nadia: Read, read, read. Write your stories. Make writing a habit. Write, write, write. Use the power of storytelling to change the world through joy. Explore your emotions, your memories, and create new classics. There's someone out there, an adult, another child, a pair of hands waiting to read your story that may impact or influence their life. No matter your age, your size, your voice - your words have value.

Q. What advice do you have for young illustrators?

Poonam: My biggest piece of advice is to do art that is true to yourself. My style is a real reflection of the things I love and what makes me who I am. It is my visual voice. Also always keep drawing and be experimental in the media you use. Although my work is mostly digital, I love painting in my style!

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For more insights from book creators, see my Inkygirl Interview Archives.

You shop local and buy organic when you can, but how can you tell if your farmers market produce is really organic? There have been a few scandals in recent years where farmers market vendors were found to be purchasing and reselling grocery store produce labeled as locally grown. So how can you tell? Here's how to find a great farmers market vendor or food co-op for organic produce.[...]

If you love pasta, but don’t often find suitable gluten-free alternatives in restaurants, Charlie's Table gluten-free products may be the answer for you. In fact, this craft pasta and pasta flour blend not only caters to the gluten intolerant, but is free of the top nine food allergens.[...]

From droughts to flooding and heat waves, the weather has been tough all across the country recently. Did you know that pests can significantly reduce your garden yield? According to the Connecticut State Agricultural Experiment Station, you could be dealing with several kinds of pests that drastically impact your garden. [...]

Flagstaff, Arizona draws outdoorsy folks and is known as one of Arizona’s more progressive and laidback towns — which bodes well for vegans. I spent a few days in Flagstaff and didn’t run out of delicious, plant-based places to eat. It’s an attractive town to visit in its own right, though many people find themselves here on their way to the Grand Canyon, which is an hour and a half away. Here are some of the top places for vegans to get a good meal.[...]

The clonal quaking aspen known as Pando is between 16,000 and 80,000 years old.

A special, triple-bean, vegan chili inspired by Jess Damuck’s new cookbook. It’s bold, flavor-packed and uses a technique to achieve the best texture of any chili I’ve eaten. It’s time to schedule a big chili night.

Continue reading Health Nut Vegan Chili on 101 Cookbooks

Princeton University will present the honors at Alumni Day, scheduled for Feb. 22, 2025.

Download links (Spotify, YouTube, Apple) here. Learn more about the Pagan History Project here.

Let the velvet-voiced Dr. Puca explains how the festival of Samhain gained its present form — and remember, Samhain is a season, a -“tide.”

Morgan's paper on plate tectonics revolutionized the field of geology in the late 1960s. He taught at Princeton from 1966 to 2004.

Improving organic traffic can sometimes be challenging, but if you apply the correct SEO strategies, the hard work will eventually pay off. Search engine traffic is great because it’s relevant and targeted. For most websites, organic traffic converts much better than traffic from social media or other sources. Another great advantage is that visits from […]

The post 10 Smart Ways To Increase Organic Traffic To A Website appeared first on RSSground.com.

Natural Bonds is not only a home for animals, however: It is also a home for people. 

Cate Blanchett intepreta Catherine Ravenscroft, uma famosa jornalista investigativa que recebe anonimamente um romance no qual ela é, indiscutivelmente, a personagem central

By Hailey Gomez Popular podcast host Joe Rogan threw his full support behind former President Donald Trump on Monday, just one day before the election. In recent weeks, the popular podcast host has separately interviewed Trump and his running mate, Republican Ohio Sen. J.D. Vance, to discuss their policy platform and thoughts on the campaign. […]

The post Joe Rogan Endorses Trump On Election Eve appeared first on Liberty Unyielding.

Fans congratulate the Transformers star, who's spoken about a previous pregnancy ending in miscarriage.

They are accused of hate speech as rights groups say the law is being used to restrict freedoms.

Wigan Athletic goalkeeper Tom Watson saves all three penalties in a shootout victory over Nottingham Forest U21s to send them through to the EFL Trophy knockout phase.

Scotland call up Stuart Armstrong for the games against Croatia and Poland as Che Adams and Lewis Morgan withdraw from the squad.

The CEO of a California gay charity has been charged with embezzling almost a million bucks of the organization’s money. The charity official, Jacob Joseph Aaron Rostovsky, has been charged with 53 felony counts including fraudulent claims, grand theft, misappropriation of public funds, insurance fraud, perjury and money laundering, according to KTLA-TV. The DA said […]

The post CEO of Gay Nonprofit Charged for Stealing Organization’s Money appeared first on The Lid.

This is how disgusting Democrats are… the man who tried to murder Ronald Reagan in 1981 is now telling Democrats to stop asking him to assassinate Donald Trump. If you are a Democrat, you can’t be hated enough. Hinkley had to tell Democrats to stop with their negativity on social media, WAVY-TV reported. “I’m a […]

The post Would-Be Reagan Assassin John Hinkley Tells Leftists to Stop Asking Him to Murder Donald Trump appeared first on The Lid.

The United States on Tuesday banned all civilian flights to Haiti for a month, a day after a jetliner was shot at on approach to the capital and as a new prime minister took the reins of a nation ravaged by poverty and gang violence.

Morgan Stanley analysts say Tesla will surge if it can expand to be an AI giant, which may be more likely if Elon Musk exerts influence in a second Trump term.

There is a reason Joe Rogan became the world's largest podcaster. He doesn't take his audience -- or his guests -- for granted. He wants MEANINGFUL conversations.

The post Joe Rogan Officially Backs A Candidate… Could Be The Biggest Endorsement Yet appeared first on Clash Daily.

Rassie Erasmus' 7-1 variation of the Bomb Squad used against Scotland on Sunday set off a few tremors in the north, with Times writer Stephen Jones the latest to criticise the "dangerous" and "arrogant" tactic.

Ligand bias is the ability of ligands to differentially activate certain receptor signaling responses compared with others. It reflects differences in the responses of a receptor to specific ligands and has implications for the development of highly specific therapeutics. Whereas ligand bias has been studied primarily for G protein–coupled receptors (GPCRs), there are also reports of ligand bias for receptor tyrosine kinases (RTKs). However, the understanding of RTK ligand bias is lagging behind the knowledge of GPCR ligand bias. In this review, we highlight how protocols that were developed to study GPCR signaling can be used to identify and quantify RTK ligand bias. We also introduce an operational model that can provide insights into the biophysical basis of RTK activation and ligand bias. Finally, we discuss possible mechanisms underpinning RTK ligand bias. Thus, this review serves as a primer for researchers interested in investigating ligand bias in RTK signaling.

Staphylococcus aureus adhesion to the host's skin and mucosae enables asymptomatic colonization and the establishment of infection. This process is facilitated by cell wall-anchored adhesins that bind to host ligands. Therapeutics targeting this process could provide significant clinical benefits; however, the development of anti-adhesives requires an in-depth knowledge of adhesion-associated factors and an assay amenable to high-throughput applications. Here, we describe the development of a sensitive and robust whole cell assay to enable the large-scale profiling of S. aureus adhesion to host ligands. To validate the assay, and to gain insight into cellular factors contributing to adhesion, we profiled a sequence-defined S. aureus transposon mutant library, identifying mutants with attenuated adhesion to human-derived fibronectin, keratin, and fibrinogen. Our screening approach was validated by the identification of known adhesion-related proteins, such as the housekeeping sortase responsible for covalently linking adhesins to the cell wall. In addition, we also identified genetic loci that could represent undescribed anti-adhesive targets. To compare and contrast the genetic requirements of adhesion to each host ligand, we generated a S. aureus Genetic Adhesion Network, which identified a core gene set involved in adhesion to all three host ligands, and unique genetic signatures. In summary, this assay will enable high-throughput chemical screens to identify anti-adhesives and our findings provide insight into the target space of such an approach.

This article is by Toni Šušnjar.

Strategy and Enemies

The structure of an army will depend on the strategy, as strategy will determine the army’s role and tasks. A state which carries out expansion through outright territorial conquest will have large numbers of heavy infantry, combat engineers and artillery, and possibly some heavy cavalry as well (e.g. Roman Empire, 10th century Byzantine Empire). If conquest is done by slowly destroying an opponent’s economic and social structures through constant raiding (such as chevauchee or razzia / ghazw), then majority of the army will be light cavalry, with some heavy cavalry support (e.g. Seljuk and Ottoman Empires), and light infantry will be used if terrain is unsuitable for cavalry. If a state is defending against cavalry raids, then light cavalry will be dominant (e.g. 15th century Hungary), whereas heavy cavalry will predominate if enemy raiders are primarily infantry. If enemy armies are too powerful to face in the field, light and heavy cavalry will be used to harass the invading army and cut off its supplies and foraging. In terrain unsuitable for cavalry operations, heavy infantry will be used instead.

Raiding — as a strategy — is generally preferred against a peer opponent, especially if a state cannot have a developed logistical support system.

Continue reading Building a Fantasy Army — Strategy & Organization at Mythic Scribes.

Expert

Webinar: Gandhi's Vision for India 15 June 2020 — 12:00PM TO 12:45PM Anonymous (not verified) 9 June 2020

In 1931, Mahatma Gandhi visited Chatham House as part of his campaign for Indian independence. Addressing an overflowing hall, he described the poverty and the religious conflict that plagued India at the time.

Today, India is the world’s fifth largest economy and more than 270 million people have been lifted out of poverty in just a decade. But poverty in India remains widespread and the outbreak of the COVID-19 pandemic is only expected to exacerbate the situation. Meanwhile, the communal violence that erupted in Delhi earlier this year reflects intensifying religious tensions under Prime Minister Narendra Modi.

In this webinar, the speakers discuss Gandhi’s global legacy and to what extent we are seeing a re-awakening of his principles across modern India.

This event is part of a series, held in the context of the Chatham House Centenary in 2020, bringing together historians, practitioners and current policymakers to discuss contemporary problems of international relations.

Kenta Suzuki of the Massachusetts Institute of Technology (MIT) is awarded the 2025 American Mathematical Society (AMS)-Mathematical Association of America (MAA)-Society for Industrial and Applied Mathematics (SIAM) Frank and Brennie Morgan Prize for his extraordinary research in the representation theory of $p$-adic groups. His papers, including two solo works, represent significant progress in different areas of the field.

From the citation

Suzuki worked on deep problems in representation theory, and he has authored and coauthored six research papers. In particular, he has made important contributions to the representation theory of $p$-adic groups. His results include asymptotics for the dimension of spaces fixed by a congruence subgroup in an admissible representation of $GL(n).$ His joint works include working out the local Langlands correspondence for several rank two $p$-adic groups, and the determination of canonical bases in the subregular quotient of the affine Hecke algebra and its antispherical module, along with their “coherent” categorifications.

Response of Kenta Suzuki

It is an honor for me to receive the Frank and Brennie Morgan Prize. I thank the Morgan family and the AMS, MAA, and SIAM for their generosity. I thank my mentors throughout the years, Toshihiko Nakazawa, Li Li, Michael Zieve, and Colin Hinde, for kindling my interest in mathematics. Toshihiko Nakazawa patiently explored mathematics with me from a young age and continues to inspire me with his insights. I thank Roman Bezrukavnikov, Wei Zhang, Zhiwei Yun, Ivan Losev, Vasily Krylov, and Calder Morton-Ferguson for further stimulating my interest in mathematics at MIT and introducing me to the many wonders of representation theory. Wei Zhang’s unwavering support has motivated me to explore many areas of mathematics. I leave every conversation with Roman Bezrukavnikov with new ideas, and he has helped me grow as a researcher by encouraging me to pursue even my most ambitious ideas. The mathematical community at MIT and Harvard have been supportive and taught me so much, both mathematical and nonmathematical. Finally, I thank my parents, particularly my mother, for supporting me throughout my journey in every possible way. She has been my role model and is one of the most intelligent and charismatic people I know.

Biographical sketch of Kenta Suzuki

Kenta Suzuki is a fourth-year undergraduate at MIT from Tokyo, Japan, and Plymouth, Michigan. Suzuki’s work focuses on the representation theory of $p$-adic groups and geometric representation theory. Suzuki is particularly interested in applying geometric methods to solve problems of representation theory. In his free time, he runs, reads, and is (slowly) learning how to cook.

About the prize

The AMS-MAA-SIAM Frank and Brennie Morgan Prize for Outstanding Research in Mathematics by an Undergraduate Student is awarded annually to an undergraduate (or students for joint work) for outstanding research in mathematics. The prize recipient's research can include more than one paper, however, the paper or papers to be considered for the prize must be completed while the student is an undergraduate. Publication of research is not required.

Established in 1995, the prize is entirely endowed by a gift from Mrs. Frank (Brennie) Morgan. The current prize amount is $1,200.

The prize will be presented at the 2025 Joint Mathematics Meetings in Seattle.

Learn more about the prize and previous recipients.

Contact: AMS Communications

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The American Mathematical Society is dedicated to advancing research and connecting the diverse global mathematical community through our publications, meetings and conferences, MathSciNet, professional services, advocacy, and awareness programs.

A growing number of motor vehicle crashes across Jamaica has been attributed to drivers operating the vehicles under the influence of marijuana, according to Health Minister Dr Christopher Tufton. "The data is clear, we are seeing more people...

Twenty-eight-year-old labourer Michael Ennis, of Manning's Hill district in Manchester, has been charged with smoking ganja in a public place following an incident in May Pen, Clarendon on Monday.

Recent studies have suggested that innate immune responses exhibit characteristics associated with memory linked to modulations in both vertebrates and invertebrates. However, the diverse evolutionary paths taken, particularly within the invertebrate taxa, should lead to similarly diverse innate immunity memory processes. Our understanding of innate immune memory in invertebrates primarily comes from studies of the fruit fly Drosophila melanogaster, the generality of which is unclear. Caenorhabditis elegans typically inhabits soil harboring a variety of fatal microbial pathogens; for this invertebrate, the innate immune system and aversive behavior are the major defensive strategies against microbial infection. However, their characteristics of immunological memory remains infantile. Here we discovered an immunological memory that promoted avoidance and suppressed innate immunity during reinfection with bacteria, which we revealed to be specific to the previously exposed pathogens. During this trade-off switch of avoidance and innate immunity, the chemosensory neurons AWB and ADF modulated production of serotonin and dopamine, which in turn decreased expression of the innate immunity-associated genes and led to enhanced avoidance via the downstream insulin-like pathway. Therefore, our current study profiles the immune memories during C. elegans reinfected by pathogenic bacteria and further reveals that the chemosensory neurons, the neurotransmitter(s), and their associated molecular signaling pathways are responsible for a trade-off switch between the two immunological memories.

The dimeric ectonucleotidase CD73 catalyzes the hydrolysis of AMP at the cell surface to form adenosine, a potent suppressor of the immune response. Blocking CD73 activity in the tumor microenvironment can have a beneficial effect on tumor eradication and is a promising approach for cancer therapy. Biparatopic antibodies binding different regions of CD73 may be a means to antagonize its enzymatic activity. A panel of biparatopic antibodies representing the pairwise combination of 11 parental monoclonal antibodies against CD73 was generated by Fab-arm exchange. Nine variants vastly exceeded the potency of their parental antibodies with ≥90% inhibition of activity and subnanomolar EC50 values. Pairing the Fabs of parents with nonoverlapping epitopes was both sufficient and necessary whereas monovalent antibodies were poor inhibitors. Some parental antibodies yielded potent biparatopics with multiple partners, one of which (TB19) producing the most potent. The structure of the TB19 Fab with CD73 reveals that it blocks alignment of the N- and C-terminal CD73 domains necessary for catalysis. A separate structure of CD73 with a Fab (TB38) which complements TB19 in a particularly potent biparatopic shows its binding to a nonoverlapping site on the CD73 N-terminal domain. Structural modeling demonstrates a TB19/TB38 biparatopic antibody would be unable to bind the CD73 dimer in a bivalent manner, implicating crosslinking of separate CD73 dimers in its mechanism of action. This ability of a biparatopic antibody to both crosslink CD73 dimers and fix them in an inactive conformation thus represents a highly effective mechanism for the inhibition of CD73 activity.

Peter Lasch
Dec 1, 2020; 19:2125-2138
Technological Innovation and Resources

Protein biosynthesis is fundamental to cellular life and requires the efficient functioning of the translational machinery. At the center of this machinery is the ribosome, a ribonucleoprotein complex that depends heavily on Mg2+ for structure. Recent work has indicated that other metal cations can substitute for Mg2+, raising questions about the role different metals may play in the maintenance of the ribosome under oxidative stress conditions. Here, we assess ribosomal integrity following oxidative stress both in vitro and in cells to elucidate details of the interactions between Fe2+ and the ribosome and identify Mn2+ as a factor capable of attenuating oxidant-induced Fe2+-mediated degradation of rRNA. We report that Fe2+ promotes degradation of all rRNA species of the yeast ribosome and that it is bound directly to RNA molecules. Furthermore, we demonstrate that Mn2+ competes with Fe2+ for rRNA-binding sites and that protection of ribosomes from Fe2+-mediated rRNA hydrolysis correlates with the restoration of cell viability. Our data, therefore, suggest a relationship between these two transition metals in controlling ribosome stability under oxidative stress.