gen

QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism




gen

NF-kappa B interacting long noncoding RNA enhances the Warburg effect and angiogenesis and is associated with decreased survival of patients with gliomas




gen

Tumor-selective delivery of antisense oligomers (antimiRs) against oncogenic microRNAs

miRNA-targeted antimiRs conjugated to a peptide with a low pH–induced transmembrane structure (pHLIP) could help treat solid tumors.




gen

Globohexaosylceramide (globo-H); stage-specific embryonic antigen-3 (SSEA-3); SSEA-4

Mouse studies suggest chemically modified carbohydrate conjugates could be useful as antigens for the development of cancer vaccines.




gen

Cyclin dependent kinase 7 (CDK7); v-myc myelocytomatosis viral related oncogene neuroblastoma derived (MYCN; NMYC)

In vitro and mouse studies suggest THZ1, a covalent CDK7 inhibitor, could help treat neuroblastoma and other cancers driven by MYCN and other c-MYC (MYC)-family oncoproteins.




gen

Estrogen receptor; LYN kinase (LYN); phosphoinositide 3-kinase (PI3K)

Studies in mice and human samples suggest inhibiting LYN could help treat estrogen receptor–positive breast cancers resistant to anti-estrogen therapy.




gen

Genocea's mark on malaria

Genocea has identified an immunological imprint in patients with malaria and is using a $1.2 million grant from the Gates Foundation to turn the findings into a vaccine.




gen

FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome




gen

MicroRNA binding site polymorphism in inflammatory genes associated with colorectal cancer: literature review and bioinformatics analysis




gen

Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice




gen

Cancer Gene Therapy




gen

Machine intelligence lights up imaging




gen

Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy




gen

Evaluating the impact of trauma and PTSD on epigenetic prediction of lifespan and neural integrity




gen

New insights into K<sub>ATP</sub> channel gene mutations and neonatal diabetes mellitus




gen

Decelerated epigenetic aging associated with mood stabilizers in the blood of patients with bipolar disorder




gen

Single-cell RNA sequencing reveals the heterogeneity of liver-resident immune cells in human




gen

Efficient generation of mouse models with the prime editing system




gen

Mendelian neurodegenerative disease genes involved in autophagy




gen

Expert opinion—management of chronic myeloid leukemia after resistance to second-generation tyrosine kinase inhibitors




gen

Genomic characterization of patients with polycythemia vera developing resistance to hydroxyurea




gen

An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders




gen

Monogenic small vessel diseases — rare but still important




gen

Predicting brain-disorder risk genes




gen

Generational trends in US opioid-overdose deaths




gen

Age and generational patterns of overdose death risk from opioids and other drugs




gen

Getting Smart on Pandemics: Intelligence in the Wake of COVID-19

This episode of Horns of a Dilemma touches on whether the failure to properly anticipate and warn about the novel coronavirus constitutes an intelligence failure, what changes might be required in the intelligence community in the wake of the pandemic, and what type of investigation or inquiry might be appropriate in order to learn lessons and incorporate changes for both the intelligence community and the whole of government moving forward.




gen

Comments on “The role of appetite-related hormones, adaptive thermogenesis, perceived hunger and stress in long-term weight-loss maintenance: a mixed-methods study”




gen

Getting Smart on Pandemics: Intelligence in the Wake of COVID-19

This episode of Horns of a Dilemma touches on whether the failure to properly anticipate and warn about the novel coronavirus constitutes an intelligence failure, what changes might be required in the intelligence community in the wake of the pandemic, and what type of investigation or inquiry might be appropriate in order to learn lessons and incorporate changes for both the intelligence community and the whole of government moving forward.




gen

Carmen Reinhart Says Argentina’s Debt Workout Won’t Be Its Last

Argentina’s latest effort to restructure its overseas debt probably won’t be its last, according to Harvard University economist Carmen Reinhart, who has sounded alarms over coming emerging markets crises in Venezuela and Turkey.




gen

Restructuring Argentina’s Private Debt is Essential

Argentina's creditors are being asked to accept a proposal that would reduce their revenue stream but make it sustainable. A responsible resolution will set a positive precedent, not only for Argentina, but for the international financial system as a whole.




gen

Getting Smart on Pandemics: Intelligence in the Wake of COVID-19

This episode of Horns of a Dilemma touches on whether the failure to properly anticipate and warn about the novel coronavirus constitutes an intelligence failure, what changes might be required in the intelligence community in the wake of the pandemic, and what type of investigation or inquiry might be appropriate in order to learn lessons and incorporate changes for both the intelligence community and the whole of government moving forward.




gen

Genome-wide selection and genetic improvement during modern maize breeding




gen

Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease




gen

Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers




gen

Tracking genetic discrimination




gen

Nature Genetics




gen

ZBP1 (DAI/DLM-1) promotes osteogenic differentiation while inhibiting adipogenic differentiation in mesenchymal stem cells through a positive feedback loop of Wnt/β-catenin signaling




gen

Correction to: AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs




gen

Covid-19 tweeting in English: Gender differences

Thelwall, Mike and Thelwall, Saheeda Covid-19 tweeting in English: Gender differences. El profesional de la información, 2020, vol. 29, n. 3. [Journal article (Unpaginated)]




gen

Carmen Reinhart Says Argentina’s Debt Workout Won’t Be Its Last

Argentina’s latest effort to restructure its overseas debt probably won’t be its last, according to Harvard University economist Carmen Reinhart, who has sounded alarms over coming emerging markets crises in Venezuela and Turkey.




gen

Restructuring Argentina’s Private Debt is Essential

Argentina's creditors are being asked to accept a proposal that would reduce their revenue stream but make it sustainable. A responsible resolution will set a positive precedent, not only for Argentina, but for the international financial system as a whole.




gen

Genome-wide association study of semen volume, sperm concentration, testis size, and plasma inhibin B levels




gen

Analyses of breakpoint junctions of complex genomic rearrangements comprising multiple consecutive microdeletions by nanopore sequencing




gen

Genome-wide association study identifies zonisamide responsive gene in Parkinson’s disease patients




gen

Correction to ‘Genotyping of Malaysian G6PD-deficient neonates by reverse dot blot flow-through hybridisation’




gen

Journal of Human Genetics




gen

Geopolitical and Market Implications of Renewable Hydrogen: New Dependencies in a Low-Carbon Energy World

To accelerate the global transition to a low-carbon economy, all energy systems and sectors must be actively decarbonized. While hydrogen has been a staple in the energy and chemical industries for decades, renewable hydrogen is drawing increased attention today as a versatile and sustainable energy carrier with the potential to play an important piece in the carbon-free energy puzzle. Countries around the world are piloting new projects and policies, yet adopting hydrogen at scale will require innovating along the value chains; scaling technologies while significantly reducing costs; deploying enabling infrastructure; and defining appropriate national and international policies and market structures.

What are the general principles of how renewable hydrogen may reshape the structure of global energy markets? What are the likely geopolitical consequences such changes would cause? A deeper understanding of these nascent dynamics will allow policy makers and corporate investors to better navigate the challenges and maximize the opportunities that decarbonization will bring, without falling into the inefficient behaviors of the past.




gen

Geopolitical and Market Implications of Renewable Hydrogen: New Dependencies in a Low-Carbon Energy World

To accelerate the global transition to a low-carbon economy, all energy systems and sectors must be actively decarbonized. While hydrogen has been a staple in the energy and chemical industries for decades, renewable hydrogen is drawing increased attention today as a versatile and sustainable energy carrier with the potential to play an important piece in the carbon-free energy puzzle. Countries around the world are piloting new projects and policies, yet adopting hydrogen at scale will require innovating along the value chains; scaling technologies while significantly reducing costs; deploying enabling infrastructure; and defining appropriate national and international policies and market structures.

What are the general principles of how renewable hydrogen may reshape the structure of global energy markets? What are the likely geopolitical consequences such changes would cause? A deeper understanding of these nascent dynamics will allow policy makers and corporate investors to better navigate the challenges and maximize the opportunities that decarbonization will bring, without falling into the inefficient behaviors of the past.




gen

Mechanisms governing autophagosome biogenesis