According to the latest "Energy Infrastructure Update" report from the Federal Energy Regulatory Commission's Office of Energy Projects, solar, biomass, wind, geothermal, and hydropower "units" provided 394 MW — or 100 percent — of all new electrical generation placed in-service in November 2013. There was no new capacity during the month from natural gas, coal, oil, or nuclear power. Renewable energy sources also provided 99 percent of all new electrical generating capacity in October.

Learn how Canadian utility SaskPower integrated its hydro and non-hydro generating assets under one management system using Hatch's Vista Decision Support System.

The Treasury Select Committee’s report highlights the recent calls for meaningful reform to the business rates system.  The concerns have been growing, culminating most recently in a letter signed by over 50 retail bosses to the Chancello...

From 20 March, UK pubs, restaurants and cafes have been closed as part of the government response to COVID-19. In an effort to stay afloat many food businesses are looking to diversify, with some offering takeaway and pick up services for the first ...

Summary The UK Government has recently announced the zero-rating for supplies of PPE equipment and E-Publications from 1 May 2020.  E-Publications means electronically supplied books, brochures, pamphlets, newspapers, magazines, journals a...

The approval rating of the Moon Jae-in government has hit a low of 67.1 percent largely due to North Korea nuclear issues. The rating has fallen for three consecutive weeks. As for the approval rating of the ruling Minjoo Party has declined for four weeks in a row to 49.3 percent. Pollster Realmeter said on September 18 that a survey commissioned by CBS-TV revealed that the ratio of those who thought positively about the way the current government has performed was 67.1 percent, down by 2.0 p...

China’s securitisation has been developing rapidly. To date, China’s securitisation market is already the largest in Asia and second largest in the world. Our structured finance partner Kingsley Ong (who is also the Secretary-General of ...

(MENAFN - EIN Presswire) Coronavirus - Africa: Commemorating Smallpox Eradication � a legacy of hope, for COVID-19 and other�diseases [To enable links... ......

(MENAFN - African Press Organization) [To enable links in your articles, contact MENAFN Click here ] [To enable links in your articles, contact MEN... ......

Download logo On 8 May 1980, the 33rd World Health Assembly officially declared: ‘The world and all its peoples have won freedom from smallpox.’ The declaration marked the end of a disease that had plagued humanity for at least 3 000 years, killing 300 million people in the 20th century alone. It was ended, thanks to a 10-year global effort, spearheaded by the World Health Organization, that involved thousands of health workers around the world to administer half a billion vaccinations to stamp out smallpox. The US$ 300m price-tag to eradicate smallpox saves the world well over US$ 1 billion every year since 1980. Speaking at a virtual event hosted at WHO-HQ, involving key...

Standard & Poor's rating agency on  May 6 affirmed Turkey’s long-term foreign currency sovereign credit rating at B+ and long-term local currency sovereign credit rating at BB-. 

[WHO] Geneva -On 8 May 1980, the 33rd World Health Assembly officially declared: 'The world and all its peoples have won freedom from smallpox.'

We can understand why the world is so apt to overlook the rest of Christ’s incarnation at Christmas. But are we, as God’s people, any better? Are we faithfully contemplating and celebrating the Lord in His fullness? Or are we, like the world, too caught up in the seasonal festivities to consider the rest of the story when it comes to Christ’s birth?

Rachier has refused to comment on the matter due to conflict of interest.

RAWALPINDI: The countrywide protests by the Geo-Jang Group workers against the deteriorating media environment, disrupting circulation of dailies Jang and The News and incarcerating Editor-in-Chief Mir Shakil-ur-Rahman on fabricated charges continued on Friday.The countrywide protests by the...

President Moon Jae-in's approval rating has stood at over 60 percent for a third week running despite the dire state of the economy.Moon, who marks his third year in office this weekend, seems to owe his recovered popularity to the relatively smooth handling of the coronavirus epidemic. But it also ...

ADB has approved a $100 million loan to help supply renewable energy to Mongolia by installing its first large-scale advanced battery energy storage system.

According to a study by India Ratings, lack of credit availability and ongoing economic slowdown in India due to the coronavirus pandemic could lead to the residential sector witnessing weak demand in the fiscal year 2020-21.  Residential demand could remain muted in the next financial year, 2020-21 due to the increasing risks to India’s growth in case the economic impact of coronavirus continues beyond the first quarter.   Moreover, the housing sector faces a liquidity crunch and refinancing challenges due to increasing uncertainty over the availability of credit in the market, coupled with poor demand. This is in the backdrop of the recent meltdown in the financial market and rising risk […]

Title: No One-Size-Fits-All for Hydrating During Sports
Category: Health News
Created: 4/30/2018 12:00:00 AM
Last Editorial Review: 5/1/2018 12:00:00 AM

On March 13, 2020, the National Science and Technology Advisors from a dozen countries, including the United States, called on publishers to voluntarily agree to make their COVID-19 and coronavirus-related publications and associated data immediately accessible in PubMed Central (PMC) and other appropriate public repositories to support the ongoing public health emergency response efforts.

For more information on which publishers have responded to this call and how to discover COVID-19 and coronavirus-related publications in PMC, see the main COVID-19 Initiative page.

A FAQ is also available. If you have questions not addressed in the FAQ, please contact pmc-phe@ncbi.nlm.nih.gov.

You can learn more about how this initiative fits into the wider NLM response to the current public health emergency in Dr. Patti Brennan's post, "How Does a Library Respond to a Global Crisis?"

ABSTRACT

Staphylococcus aureus is a major concern in human health care, mostly due to the increasing prevalence of antibiotic resistance. Intracellular localization of S. aureus plays a key role in recurrent infections by protecting the pathogens from antibiotics and immune responses. Peptidoglycan hydrolases (PGHs) are highly specific bactericidal enzymes active against both drug-sensitive and -resistant bacteria. However, PGHs able to effectively target intracellular S. aureus are not yet available. To overcome this limitation, we first screened 322 recombineered PGHs for staphylolytic activity under conditions found inside eukaryotic intracellular compartments. The most active constructs were modified by fusion to different cell-penetrating peptides (CPPs), resulting in increased uptake and enhanced intracellular killing (reduction by up to 4.5 log units) of various S. aureus strains (including methicillin-resistant S. aureus [MRSA]) in different tissue culture infection models. The combined application of synergistic PGH-CPP constructs further enhanced their intracellular efficacy. Finally, synergistically active PGH-CPP cocktails reduced the total S. aureus by more than 2.2 log units in a murine abscess model after peripheral injection. Significantly more intracellular bacteria were killed by the PGH-CPPs than by the PGHs alone. Collectively, our findings show that CPP-fused PGHs are effective novel protein therapeutics against both intracellular and drug-resistant S. aureus.

IMPORTANCE The increasing prevalence of antibiotic-resistant bacteria is one of the most urgent problems of our time. Staphylococcus aureus is an important human pathogen that has acquired several mechanisms to evade antibiotic treatment. In addition, S. aureus is able to invade and persist within human cells, hiding from the immune response and antibiotic therapies. For these reasons, novel antibacterial strategies against these pathogens are needed. Here, we developed lytic enzymes which are able to effectively target drug-resistant and intracellular S. aureus. Fusion of these so-called enzybiotics to cell-penetrating peptides enhanced their uptake and intracellular bactericidal activity in cell culture and in an abscess mouse model. Our results suggest that cell-penetrating enzybiotics are a promising new class of therapeutics against staphylococcal infections.

There are roughly 48,000 deaths caused by influenza annually and an estimated 200,000 people who have undiagnosed human immunodeficiency virus (HIV). These are examples of acute and chronic illnesses that can be identified by employing a CLIA-waived test. Pharmacies across the country have been incorporating CLIA-waived point-of-care tests (POCT) into disease screening and management programs offered in the pharmacy. The rationale behind these programs is discussed. Additionally, a summary of clinical data for some of these programs in the infectious disease arena is provided. Finally, we discuss the future potential for CLIA-waived POCT-based programs in community pharmacies.

Brain-infiltrating leukocytes contribute to multiple sclerosis (MS) and autoimmune encephalomyelitis and likely play a role in traumatic brain injury, seizure, and stroke. Brain-infiltrating leukocytes are also primary targets for MS disease-modifying therapies. However, no method exists for noninvasively visualizing these cells in a living organism. 1-(2'-deoxy-2'-¹⁸F-fluoroarabinofuranosyl) cytosine (¹⁸F-FAC) is a PET radiotracer that measures deoxyribonucleoside salvage and accumulates preferentially in immune cells. We hypothesized that ¹⁸F-FAC PET could noninvasively image brain-infiltrating leukocytes. Methods: Healthy mice were imaged with ¹⁸F-FAC PET to quantify if this radiotracer crosses the blood–brain barrier (BBB). Experimental autoimmune encephalomyelitis (EAE) is a mouse disease model with brain-infiltrating leukocytes. To determine whether ¹⁸F-FAC accumulates in brain-infiltrating leukocytes, EAE mice were analyzed with ¹⁸F-FAC PET, digital autoradiography, and immunohistochemistry, and deoxyribonucleoside salvage activity in brain-infiltrating leukocytes was analyzed ex vivo. Fingolimod-treated EAE mice were imaged with ¹⁸F-FAC PET to assess if this approach can monitor the effect of an immunomodulatory drug on brain-infiltrating leukocytes. PET scans of individuals injected with 2-chloro-2'-deoxy-2'-¹⁸F-fluoro-9-β-d-arabinofuranosyl-adenine (¹⁸F-CFA), a PET radiotracer that measures deoxyribonucleoside salvage in humans, were analyzed to evaluate whether ¹⁸F-CFA crosses the human BBB. Results: ¹⁸F-FAC accumulates in the healthy mouse brain at levels similar to ¹⁸F-FAC in the blood (2.54 ± 0.2 and 3.04 ± 0.3 percentage injected dose per gram, respectively) indicating that ¹⁸F-FAC crosses the BBB. EAE mice accumulate ¹⁸F-FAC in the brain at 180% of the levels of control mice. Brain ¹⁸F-FAC accumulation localizes to periventricular regions with significant leukocyte infiltration, and deoxyribonucleoside salvage activity is present at similar levels in brain-infiltrating T and innate immune cells. These data suggest that ¹⁸F-FAC accumulates in brain-infiltrating leukocytes in this model. Fingolimod-treated EAE mice accumulate ¹⁸F-FAC in the brain at 37% lower levels than control-treated EAE mice, demonstrating that ¹⁸F-FAC PET can monitor therapeutic interventions in this mouse model. ¹⁸F-CFA accumulates in the human brain at 15% of blood levels (0.08 ± 0.01 and 0.54 ± 0.07 SUV, respectively), indicating that ¹⁸F-CFA does not cross the BBB in humans. Conclusion: ¹⁸F-FAC PET can visualize brain-infiltrating leukocytes in a mouse MS model and can monitor the response of these cells to an immunomodulatory drug. Translating this strategy into humans will require exploring additional radiotracers.

Fabric with tiny vibrating motors elicits sensations associated with clouds, water and rocks on the skin and has been made into a dress that could improve emotions

For the first time, astronomers have spotted an exoplanet by detecting radio waves generated by interactions with its parent star

These are the Star Wars hydrating face masks from Japanese beauty product manufacturer Isshin Do. They come in Darth Vader, Stormtrooper, Darth Maul, C-3PO and Chewbacca varieties, and each contains water, glycerin, hyaluronic acid, collagen, and vitamin C to make your face feel softer than a baby Yoda's butt. For those living in Japan, you can pick up the masks for around $4 apiece from a variety of beauty retailers. For those of us not living in Japan, you can buy a 3-pack of any character for $31 from the Japan Trend Shop which, I wouldn't even kid myself, my face is not worth. I don't even buy sunscreen, I just use old spray paint I find in the garage. Also, how long you think it'll take before these are being used by couples for lewd sex acts? "Already happened." FACT. Keep going for a shot of each while I try to pretend I didn't just imagine some Chewbacca on C-3PO bedroom role playing.

On a Mother's Day unlike previous ones, here are a few ideas to help you celebrate, whether your mom is near, far, or socially isolating.

New surveys out Thursday show President Donald Trump’s approval rating for his handling of the coronavirus pandemic is underwater in four critical states while governors receive high marks.

Coronavirus: the symptoms Read our LIVE updates on the coronavirus here

Fitch on Friday said it has withdrawn the ratings on Reliance Capital as the company has decided to stop participating.

Prabhudas Lilladher has a ‘reduce’ rating on Infosys Technologies as it feels that the outlook for the company and the software industry is quite weak in the near-term.

Watch a professional (non-gaming) illustrator adapting to a new medium.

Celebrity TV chef from MKR has been repeatedly criticised by scientific and medical groups over his views on health and nutrition

The controversial reality TV chef Pete Evans will exit My Kitchen Rules, Seven’s defining show of the decade which slumped badly in the ratings this year.

Evans, a self-styled health guru held one of the most lucrative jobs in television despite a series of controversies related to his views on health and nutrition.

Former soap star was forced to defend his recent ITV programme On The NHS Frontline this month

Draper has been in hospital with Covid-19 since late March

If you were born in March or April, our condolences ...

Heinz release jigsaw with all pieces coloured in its signature red hue

Jimmy Kimmel and Stephen Colbert have criticised President Trump for not concentrating on helping Americans during the coronavirus pandemic.

Steve Howey believes deal is good for owner Mike Ashley, the prospective buyers, and the fans Amnesty International UK​ says move is 'PR tool' for Saudi Arabia to 'sportswash​' human rights image

Shorebirds are increasingly under pressure around Australia, as the nation's wetlands and coastal estuaries continue to be swallowed by housing.

Donald Trump has in recent days turned the war against COVID-19 into a war against the states, in a desperate effort to shirk responsibility for his pandemic denialism.

Citrus growers say under a proposed change, the health star rating for 100 per cent orange juice could drop from the current five stars to as low as 2.5 stars.

AWARD-WINNING musician and singer Vince Jones is among the top-notch jazz talent set to entertain audiences at the Tanks Arts Centre this year.

Learn how digital tech is accelerating medical breakthroughs by registering your team to attend Xcelerating Life Sciences Boston: Biopharma’s Future in Digital Health. While some content focuses on the Boston ecosystem, we’re confident the forum – and virtual networking – will be valuable to a national audience. The May 13, 2020 event will explore the […]