BDMS already owns a 25% stake in Bumrungrad Hospital.

The post Thai hospital operator BDMS makes $3b buyout offer for Bumrungrad appeared first on DealStreetAsia.

Thailand’s third-largest life insurer by assets met last month with potential advisers on the proposed share sale.

The post Thai Life seeks bank pitches for $700m IPO plan appeared first on DealStreetAsia.

• Dresden players sent home after two test positive
• ‘We are not changing our plans,’ says Christian Seifert

The Bundesliga is keen to press ahead with plans to restart the season for the top two tiers next weekend, despite Dynamo Dresden’s squad being quarantined for two weeks.

Dresden’s players were sent home after two tested positive for coronavirus. This means the second tier club cannot play their first two games of the restart – against Hannover on 17 May and against Fürth the following weekend.

United Arab Emirates-based group anticipates strong growth next year

Over 25 states and union territories, including Maharashtra, Gujarat, Uttar Pradesh, Assam and Delhi, have banned the use of smokeless tobacco produc

1. Anticoagulants Could Help Hospitalized COVID-19 Patient Survival, Research Finds  The Daily Wire
2. Most Covid patients may lose sense of smell by third day of infection: Study  The Newsopedia
3. View Full coverage on Google News

Mary Pratt, who played for the Rockford Peaches and Kenosha Comets in the All-American Girls Professional Baseball League, has died

random5erendipity:

CHINA

Check out travel recommendations at Wanderfly!

Twitter | Facebook | Tumblr

travel5erendipity:

ICELAND

Check out travel recommendations at Wanderfly!

Twitter | Facebook | Tumblr

HELENA (April 23, 2020) – Today, U.S. Environmental Protection Agency (EPA) Region 8 Deputy Regional Administrator Deb Thomas recognized students and staff from Capital High School in Helena for winning the ‘See a Bloom, Give It Room’ High School Video Challenge.

The C train reached its last stop just after 9 a.m. Saturday at the Euclid Ave. station in East New York when the man insisted he needed five more minutes before he could leave the car.

The C train reached its last stop just after 9 a.m. Saturday at the Euclid Ave. station in East New York when the man insisted he needed five more minutes before he could leave the car.

Prior to joining the Boilermakers, Elliott Cribby served as pitching coach and recruiting coordinator at Seattle University.

The road to Indianapolis: Why Colts fell in love with Michael Pittman Jr.

The road to Indianapolis: Why Colts fell in love with Michael Pittman Jr.

Deaths and hospitalizations related to COVID-19 could increase dramatically in Montreal if social distancing measures are lifted, according to a new study.

Lethal infections by strains of the highly-pathogenic avian influenza virus (HPAIV) H5N1 pose serious threats to both the poultry industry and public health worldwide. A lack of confirmed HPAIV epitopes recognized by cytotoxic T lymphocytes (CTLs) has hindered the utilization of CD8+ T-cell–mediated immunity and has precluded the development of effectively diversified epitope-based vaccination approaches. In particular, an HPAIV H5N1 CTL-recognized epitope based on the peptide MHC-I–β2m (pMHC-I) complex has not yet been designed. Here, screening a collection of selected peptides of several HPAIV strains against a specific pathogen-free pMHC-I (pBF2*1501), we identified a highly-conserved HPAIV H5N1 CTL epitope, named HPAIV–PA123–130. We determined the structure of the BF2*1501–PA123–130 complex at 2.1 Å resolution to elucidate the molecular mechanisms of a preferential presentation of the highly-conserved PA123–130 epitope in the chicken B15 lineage. Conformational characteristics of the PA123–130 epitope with a protruding Tyr-7 residue indicated that this epitope has great potential to be recognized by specific TCRs. Moreover, significantly increased numbers of CD8+ T cells specific for the HPAIV–PA123–130 epitope in peptide-immunized chickens indicated that a repertoire of CD8+ T cells can specifically respond to this epitope. We anticipate that the identification and structural characterization of the PA123–130 epitope reported here could enable further studies of CTL immunity against HPAIV H5N1. Such studies may aid in the development of vaccine development strategies using well-conserved internal viral antigens in chickens.

Protease-activated receptor 2 (PAR-2) is activated by secreted proteases from immune cells or fungi. PAR-2 is normally expressed basolaterally in differentiated nasal ciliated cells. We hypothesized that epithelial remodeling during diseases characterized by cilial loss and squamous metaplasia may alter PAR-2 polarization. Here, using a fluorescent arrestin assay, we confirmed that the common fungal airway pathogen Aspergillus fumigatus activates heterologously-expressed PAR-2. Endogenous PAR-2 activation in submerged airway RPMI 2650 or NCI–H520 squamous cells increased intracellular calcium levels and granulocyte macrophage–colony-stimulating factor, tumor necrosis factor α, and interleukin (IL)-6 secretion. RPMI 2650 cells cultured at an air–liquid interface (ALI) responded to apically or basolaterally applied PAR-2 agonists. However, well-differentiated primary nasal epithelial ALIs responded only to basolateral PAR-2 stimulation, indicated by calcium elevation, increased cilia beat frequency, and increased fluid and cytokine secretion. We exposed primary cells to disease-related modifiers that alter epithelial morphology, including IL-13, cigarette smoke condensate, and retinoic acid deficiency, at concentrations and times that altered epithelial morphology without causing breakdown of the epithelial barrier to model early disease states. These altered primary cultures responded to both apical and basolateral PAR-2 stimulation. Imaging nasal polyps and control middle turbinate explants, we found that nasal polyps, but not turbinates, exhibit apical calcium responses to PAR-2 stimulation. However, isolated ciliated cells from both polyps and turbinates maintained basolateral PAR-2 polarization, suggesting that the calcium responses originated from nonciliated cells. Altered PAR-2 polarization in disease-remodeled epithelia may enhance apical responses and increase sensitivity to inhaled proteases.

Prevention of aberrant cutaneous wound repair and appropriate regeneration of an intact and functional integument require the coordinated timing of fibroblast and keratinocyte migration. Here, we identified a mechanism whereby opposing cell-specific motogenic functions of a multifunctional intracellular and extracellular protein, the receptor for hyaluronan-mediated motility (RHAMM), coordinates fibroblast and keratinocyte migration speed and ensures appropriate timing of excisional wound closure. We found that, unlike in WT mice, in Rhamm-null mice, keratinocyte migration initiates prematurely in the excisional wounds, resulting in wounds that have re-surfaced before the formation of normal granulation tissue, leading to a defective epidermal architecture. We also noted aberrant keratinocyte and fibroblast migration in the Rhamm-null mice, indicating that RHAMM suppresses keratinocyte motility but increases fibroblast motility. This cell context–dependent effect resulted from cell-specific regulation of extracellular signal-regulated kinase 1/2 (ERK1/2) activation and expression of a RHAMM target gene encoding matrix metalloprotease 9 (MMP-9). In fibroblasts, RHAMM promoted ERK1/2 activation and MMP-9 expression, whereas in keratinocytes, RHAMM suppressed these activities. In keratinocytes, loss of RHAMM function or expression promoted epidermal growth factor receptor–regulated MMP-9 expression via ERK1/2, which resulted in cleavage of the ectodomain of the RHAMM partner protein CD44 and thereby increased keratinocyte motility. These results identify RHAMM as a key factor that integrates the timing of wound repair by controlling cell migration.

The operator Jamaica’s two largest airports wants to scrap or delay non-essential capital projects. It forms part of a wider halt of capital projects by the Grupo Aeroportuario del Pacífico – which translate to Pacific Airport Group, or GAP –...

The total number of cases in the province remains 284, with 30 now considered active.

Epithelial cells are held together and connected by several different types of structures that form cell-cell contacts.

George Mason University professor Elise Miller-Hooks and her team have been studying and modeling the flow of patients through American hospitals in times of crisis since 2014.

Danes haven’t built a “socialist” country. Just one that works.

As refugee numbers soar locally, the local government in Sid, Serbia, asks OM to help them again. OM gets their tent out again.

Scotland will not adopt the Prime Minister's new coronavirus slogan which drops the 'stay at home' message, Nicola Sturgeon has confirmed.

An OM worker in Bosnia shares how the enduring faith of two elderly women of God has inspired her to also persevere to the end.

Yamaha and Suzuki both have pulled out of the 110cc scooter space in India and this has left only five players to compete in the space.

The government on Friday announced that a "limited" lockdown, including suspension of inter-state travel, air and train services, will continue to remain in force for another two weeks throughout the country from May 4, but some activities would be allowed after classifying areas into red, orange and green zones.

On MCX, gold June futures rose Rs 37 to Rs 45,788 per 10 grams. Similarly, silver July futures were trading Rs 403 or 0.96 per cent higher at Rs 42,299 per kg

The Food Corporation of India (FCI) has been able to buy half of its wheat procurement target of 40.7 million tonne by Wednesday despite a delayed start this year as Punjab has exceeded expectation by purchasing nearly 75% of its target in only 22 days.

Wipro has signed a memorandum of understanding with the Maharashtra government under which it will repurpose one of its information technology campuses at Hinjewadi in Pune to a 450-bed intermediary care Covid-19 hospital in four weeks and hand it over to the state government by May 30.

Startups must maintain their financial health by conserving cash, cutting down on costs and renegotiating their existing contracts.

The ratings agency explained that private sector is dominated by small doctor-run facilities in terms of number of facilities and number of beds.

Aggregate recast loans worth around Rs 50,000 crore (Rs 49,332 crore) failed at the corporate debt restructuring (CDR) cell in FY17, taking total failures since the inception of the cell in 2001 to Rs 1.37 lakh crore.

As APHS concludes its capex cycle and loss-making ventures breakeven, the stage is set for APHS to double Ebitda and reduce capex to one-third over FY19–21.

However, the High Court rejected this invocation of Rule 165, ruling that the it specified only the payability conditions of fees, and not the chargeability of it.

Lack of PPE & shortage of testing kits is a real issue.

The Katoch committee, in 2015, had proposed several measures like setting up parks for API, providing capex, and subsidised loans to boost domestic production of APIs.

At least one person has died and dozens were evacuated following a fire at a Moscow hospital which has been treating coronavirus patients.
Read Full Article at RT.com

As Elon Musk sues Californian authorities for stopping a Tesla factory from reopening, he has found a somewhat novel way of dealing with his critics – dismissing them with short Russian insults.
Read Full Article at RT.com

Nirmala Sitharaman’s office on Thursday had tweeted that PSBs sanctioned loans worth Rs 5.66 lakh crore for over 41.81 lakh accounts in MSME, retail, agriculture and corporate sectors during March-April 2020.

Tremors of the earthquake were felt in the afternoon in parts of Delhi and NCR right after a dust storm and rains lashed south and east Delhi. Authorities have not reported any damage to life and property yet.