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Recent advances of nanomedicines for liver cancer therapy

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J. Mater. Chem. B, 2020, 8,3747-3771
DOI: 10.1039/C9TB02871D, Review Article
Xiaoqin Chi, Kun Liu, Xiangjie Luo, Zhenyu Yin, Hongyu Lin, Jinhao Gao
This review highlights recent advancements in nanomedicines for liver cancer therapy.
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Alendronate/folic acid-decorated polymeric nanoparticles for hierarchically targetable chemotherapy against bone metastatic breast cancer

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J. Mater. Chem. B, 2020, 8,3789-3800
DOI: 10.1039/D0TB00046A, Paper
Shih-Hong Chen, Te-I Liu, Cheng-Lin Chuang, Hsin-Hung Chen, Wen-Hsuan Chiang, Hsin-Cheng Chiu
Through hierarchically targeting bone matrix and tumor cells, PTX-carrying ALN/FA-nanoparticles substantially accumulate in bone metastases and improve mice survival rate.
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Tumor-mediated shape-transformable nanogels with pH/redox/enzymatic-sensitivity for anticancer therapy

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J. Mater. Chem. B, 2020, 8,3801-3813
DOI: 10.1039/D0TB00143K, Paper
Dong Zhou, Sainan Liu, Yongjun Hu, Shiwei Yang, Bing Zhao, Kaikai Zheng, Yuhong Zhang, Peixin He, Guoyan Mo, Yulin Li
Tumor-mediated shape-cleavable nanogels can release drug-carrying ultrasmall nanovesicles through tumor tissue depth, which together with their pH/redox/enzymatic-multistimulative drug release smartness results in a synergistic antitumor efficacy.
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Fluorescence resonance energy transfer-based drug delivery systems for enhanced photodynamic therapy

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J. Mater. Chem. B, 2020, 8,3772-3788
DOI: 10.1039/D0TB00262C, Review Article
Yu Huang, Feng Qiu, Rongjun Chen, Deyue Yan, Xinyuan Zhu
In this Review, recent advances in fluorescence resonance energy transfer-based drug delivery systems for enhanced photodynamic therapy are described, and the current challenges and perspectives in this emerging field are also discussed.
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Modified gaphene oxide (GO) particles in peptide hydrogels: a hybrid system enabling scheduled delivery of synergistic combinations of chemotherapeutics

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J. Mater. Chem. B, 2020, 8,3852-3868
DOI: 10.1039/D0TB00064G, Paper
John D. Schneible, Kaihang Shi, Ashlyn T. Young, Srivatsan Ramesh, Nanfei He, Clay E. Dowdey, Jean Marie Dubnansky, Radina L. Lilova, Wei Gao, Erik Santiso, Michael Daniele, Stefano Menegatti
Composite material enabling the delivery of synergistic combination of doxorubicin and gemcitabine against breast cancer with molar and kinetic precision.
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Macrocyclic polyamine [12]aneN3 modified triphenylamine-pyrazine derivatives as efficient non-viral gene vectors with AIE and two-photon imaging properties

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J. Mater. Chem. B, 2020, 8,3869-3879
DOI: 10.1039/D0TB00321B, Paper
Le-Le Ma, Ming-Xuan Liu, Xu-Ying Liu, Wan Sun, Zhong-Lin Lu, Yong-Guang Gao, Lan He
[12]aneN3 modified triphenylamine-pyrazines as non-viral gene vectors with AIE and two-photon imaging properties.
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Redox-responsive amphiphilic camptothecin prodrug nanoparticles for targeted liver tumor therapy

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J. Mater. Chem. B, 2020, 8,3918-3928
DOI: 10.1039/D0TB00285B, Paper
Lu Lu, Bing Li, Chuanchuan Lin, Ke Li, Genhua Liu, Zengzilu Xia, Zhong Luo, Kaiyong Cai
A redox-responsive drug carrier with asialoglycoprotein receptor (ASGPR) targeting is fabricated for liver tumor therapy.
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Biodegradable MnFe-hydroxide nanocapsules to enable multi-therapeutics delivery and hypoxia-modulated tumor treatment

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J. Mater. Chem. B, 2020, 8,3929-3938
DOI: 10.1039/D0TB00243G, Paper
Linhua Liao, Dong Cen, Yike Fu, Bin Liu, Chao Fang, Yifan Wang, Xiujun Cai, Xiang Li, Hao Bin Wu, Gaorong Han
Fine nanocapsules based on MnFe hydroxides, showing high loading capacity, O2 induction and biodegradation, were synthesized for effective synergistic therapies.
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A near-infrared light-responsive multifunctional nanocomposite hydrogel for efficient and synergistic antibacterial wound therapy and healing promotion

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J. Mater. Chem. B, 2020, 8,3908-3917
DOI: 10.1039/D0TB00361A, Paper
Na Yang, Ming Zhu, Guochao Xu, Ning Liu, Cong Yu
A multifunctional nanocomposite hydrogel for synergistic antibacterial wound therapy and healing promotion.
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Molecular simulations and understanding of antifouling zwitterionic polymer brushes

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J. Mater. Chem. B, 2020, 8,3814-3828
DOI: 10.1039/D0TB00520G, Paper
Yonglan Liu, Dong Zhang, Baiping Ren, Xiong Gong, Lijian Xu, Zhang-Qi Feng, Yung Chang, Yi He, Jie Zheng
Zwitterionic materials demonstrate the strong surface hydration to empower their antifouling property.
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New forms of electrospun nanofiber materials for biomedical applications

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J. Mater. Chem. B, 2020, 8,3733-3746
DOI: 10.1039/D0TB00271B, Review Article
Shixuan Chen, Johnson V. John, Alec McCarthy, Jingwei Xie
This review article discusses new forms of electrospun nanofiber materials and their biomedical applications.
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“Watson–Crick GC”-inspired supramolecular nanodrug of methotrexate and 5-fluorouracil for tumor microenvironment-activatable self-recognizing synergistic chemotherapy

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J. Mater. Chem. B, 2020, 8,3829-3841
DOI: 10.1039/D0TB00468E, Paper
Meijin Chen, Shiduan Chen, Fukai Zhu, Fanfan Wang, Haina Tian, Zhongxiong Fan, Sunkui Ke, Zhenqing Hou, Yang Li
The “Watson–Crick G≡C”-inspired carrier-free nanodrug have excellent tumor microenvironment-triggered active self-targeting ability and enhanced synergistic chemotherapeutic effects.
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Tunable layer-by-layer films containing hyaluronic acid and their interactions with CD44

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J. Mater. Chem. B, 2020, 8,3880-3885
DOI: 10.1039/D0TB00407C, Paper
Sara Amorim, Iva Pashkuleva, Celso A. Reis, Rui L. Reis, Ricardo A. Pires
We developed hyaluronic acid (HA):poly-L-lysine (PLL) layer-by-layer (LbL) constructs whose viscoelastic properties and bioactivity can be finely tuned by using polyanions of different molecular weight and/or crosslinking.
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Human serum albumin-based doxorubicin prodrug nanoparticles with tumor pH-responsive aggregation-enhanced retention and reduced cardiotoxicity

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J. Mater. Chem. B, 2020, 8,3939-3948
DOI: 10.1039/D0TB00327A, Paper
Boya Zhang, Shiyu Wan, Xinyu Peng, Mingying Zhao, Sai Li, Yuji Pu, Bin He
A nano-assembly of pH-sensitive doxorubicin prodrug and human serum albumin shows tumor pH-responsive aggregation, enhanced tumor retention and reduced cytotoxicity.
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H2S-Donating trisulfide linkers confer unexpected biological behaviour to poly(ethylene glycol)–cholesteryl conjugates

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J. Mater. Chem. B, 2020, 8,3896-3907
DOI: 10.1039/C9TB02614B, Paper
Francesca Ercole, Yuhuan Li, Michael R. Whittaker, Thomas P. Davis, John F. Quinn
A comprehensive in vitro study into trisulfide-bearing PEG-conjugates was conducted. For these materials the combination of a cholesteryl group and an H2S donating moiety is required to confer cytoprotective and ROS-mitigating effects.
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Ternary hydrogels with tunable mechanical and self-healing properties based on the synergistic effects of multiple dynamic  bonds

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/C9TB02885D, Paper
Kun Li, Jingxi Wang, Ping Li, Yubo Fan
Ternary hydrogels with tunable mechanical properties were prepared based on the synergistic effects of hydrogen bonds and imine bonds.
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Platelet membrane-coated nanoparticles for targeted drug delivery and local chemo-photothermal therapy of orthotopic hepatocellular carcinoma

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00735H, Paper
Long Wu, Wei Xie, Hui-Ming Zan, Zhongzhong Liu, Ganggang Wang, Yanfeng Wang, Wei Liu, Wenfei Dong
Specific targeted drug delivery and controllable release of drugs at tumor regions are two of the main challenges for hepatocellular carcinoma (HCC) therapy, particularly post metastasis.
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Synthetic mycomelanin thin films as emergent bio-inspired interfaces controlling the fate of embryonic stem cells

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00623H, Paper
Paola Manini, Valeria Lucci, Valeria Lino, Stefania Sartini, Francesco Rossella, Geppino Falco, Cinzia Chiappe, Marco d’Ischia
Mycomelanin thin films from 1,8-dihydroxynaphthalene can serve as a biointerface inducing adhesion and proliferation of ESCs and promoting their differentiation towards endodermal lineages.
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Boron-based nanosheets for combined cancer photothermal and photodynamic therapy

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00070A, Paper
Yong Kang, Xiaoyuan Ji, Zhengjun Li, Zhiguo Su, Songping Zhang
Tumor phototherapy is of great significance for the expansion and advancement of cancer treatment methods.
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A fiber-shaped neural probe with alterable elastic moduli for direct implantation and stable electronic–brain interfaces

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00508H, Communication
Chengqiang Tang, Songlin Xie, Mengying Wang, Jianyou Feng, Zhengqi Han, Xiaoying Wu, Liyuan Wang, Chuanrui Chen, Jiajia Wang, Liping Jiang, Peining Chen, Xuemei Sun, Huisheng Peng
A fiber-shaped neural probe with alterable elastic moduli allows direct implantation and enables adaptive electronic–tissue interfaces post implantation.
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Discrimination of cysteamine from mercapto amino acids through isoelectric point-mediated surface ligand exchange of β-cyclodextrin-modified gold nanoparticles

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00462F, Paper
Quanbao Ma, Xun Fang, Junting Zhang, Lili Zhu, Xiabing Rao, Qi Lu, Zhijun Sun, Huan Yu, Qunlin Zhang
A pI-mediated R6G-β-CD@AuNPs system was designed for the first time for the discrimination of CA from GSH/Cys/Hcy in human serum samples.
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Nanoscale dual-enzyme cascade metal–organic frameworks through biomimetic mineralization as ROS generators for synergistic cancer therapy

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00357C, Paper
Shuiling Jin, Lanling Weng, Zhi Li, Zhenzhen Yang, Lili Zhu, Jianxiang Shi, Wenxue Tang, Wang Ma, Hong Zong, Wei Jiang
Chemodynamic therapy (CDT) has been critically challenged by insufficient H2O2 in cancer tissues and inefficient reactive oxygen species (ROS) production.
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A bio-inspired injectable hydrogel as a cell platform for real-time glycaemic regulation

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00561D, Paper
Yu Zhang, Jun Yang, Jun Zhang, Shuangwen Li, Lisi Zheng, Yanlong Zhang, Huipeng Meng, Xinge Zhang, Zhongming Wu
A bio-inspired injectable hydrogel as a cell platform for real time glycemic regulation by mimicking the function of native islet β cells.
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One-pot synthesis of trypsin-based magnetic metal–organic frameworks for highly efficient proteolysis

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/C9TB02315A, Paper
Chao Zhong, Zhixian Lei, Huan Huang, Mingyue Zhang, Zongwei Cai, Zian Lin
A facile approach was developed for one-pot synthesis of trypsin-based magnetic ZIF-8, which could be applied as an immobilized enzyme microreactor for rapid digestion of proteins.
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Shape memory materials for electrically-powered soft machines

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00392A, Review Article
Xiaonan Huang, Michael Ford, Zach J. Patterson, Masoud Zarepoor, Chengfeng Pan, Carmel Majidi
We review the recent progress of electrically-powered artificial muscles and soft machines using shape memory alloy and liquid crystal elastomer.
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Preparation and biological evaluations of collagen-like hierarchical Ti surface with superior osteogenic capabilities

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00799D, Paper
Weiwei Lao, Qiaojie Luo, Yadong Chen, Wei Yao, Jiajia Xu, Lijie Fan, Xiaodong Li
The construction of multiscale Ti surfaces of high osteogenic ability always attracts numerous attentions in oral implantology and implantable biomaterial field. However, so far, the absence of solid understanding of...
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Molecular imaging of extracellular vesicles in vitro via Raman metabolic labelling

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00620C, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Conor C. Horgan, Anika Nagelkerke, Thomas E. Whittaker, Valeria Nele, Lucia Massi, Ulrike Kauscher, Jelle Penders, Mads S. Bergholt, Steve R. Hood, Molly M. Stevens
Molecular imaging of extracellular vesicles in vitro via Raman metabolic labelling.
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Covalent Organic Framework as Nanocarrier for Synergistic Phototherapy and Immunotherapy

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00679C, Paper
Ying Zhou, Sainan Liu, Chunling Hu, Lihan Cai, Maolin Pang
As traditional cancer treatment methods, photodynamic therapy (PDT) and photothermal therapy (PTT) can eliminate primary tumor, but can't inhibit tumor extensive metastasis and local recurrence. Herein, in order to prevent...
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Coaxial mussel-inspired biofibers: Making of a robust and efficacious depot for cancer drug delivery

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00052C, Paper
Javad Foroughi, Sepehr Talebian , In Kyoung Shim, Kara Vine, Song Cheol Kim, Geoffrey M Spinks
Biopolymer-based hydrogels have emerged as promising platforms for drug delivery systems (DDSs) due to their inherent biocompatibility, tunable physical properties and controllable degradability. Yet, drug release in majority of these...
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Surface functionalization strategies of extracellular vesicles

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J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00744G, Review Article
Sagar Rayamajhi, Santosh Aryal
Physical, biological, and chemical strategies of surface functionalization can add vital functionality in extracellular vesicles (EVs) for diverse biomedical applications.
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The Circadian Clock Gene PER2 Enhances Chemotherapeutic Efficacy in Nasopharyngeal Carcinoma When Combined with a Targeted Nanosystem

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00595A, Paper
Li Hou, Hailiang Li, Haiyan Wang, Dede Ma, Jing Liu, liqiong Ma, Zhihua Wang, Zhihua Yang, Faxuan Wang, Hechun Xia
Treatment failure occurs in more than 40% of advanced nasopharyngeal carcinoma (NPC) patients including local recurrence and distant metastasis due to chemoradioresistance. Circadian clock genes were identified as regulating cancer...
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Ag@S-nitrosothiols core-shell nanoparticles for chemo and photothermal synergistic tumor target therapy

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00734J, Paper
Xinlin Yang, Tuanwei Liu, Xiao Li, Jinan Wang, Ping Zhang, Xiaoying Huang, Zhide Zhang, Dian-Shun Guo
Along with development of the controlled delivery systems for target therapy, ‘single-strategy’ therapy often fails to achieve the desired performance in real body internal environment. In such case, it is...
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Hydrogels toughened by biominerals as energy-dissipative sacrificial bonds

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00833H, Communication
Kazuki Fukao, Kazuki Tanaka, Ryuji Kiyama, Takayuki Nonoyama, Jian Ping Gong
Inspired by bone tissues, hydrogels toughened by hydroxyapatite (HAp) working as energy-dissipative sacrifical bonds is created. The contribution of dissipated energy from HAp mineral was over 500 % higher than...
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Diblock Copolypeptoids: A Review of Phase Separation, Self-Assembly and Biological Applications

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00477D, Review Article
Sunting Xuan, Ronald N Zuckermann
Polypeptoids are biocompatible, synthetically accessible, chemically and enzymatically stable, chemically diverse, and structurally controllable. As a bioinspired and biomimetic material, it has attracted considerable attention due to its great potential...
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High-performance non-enzymatic glucose detection: using conductive Ni-MOF as an electrocatalyst

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J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00131G, Communication
Yanxia Qiao, Qian Liu, Siyu Lu, Guang Chen, Shuyan Gao, Wenbo Lu, Xuping Sun
Conductive metal−organic frameworks (MOFs) are studied extensively in applications like water electrolysis, gas storage, and supercapacitors due to their high conductivity and large pore volume, etc. In this communication, we...
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Br(e)aking the news : journalism, politics and new media / Janey Gordon, Paul Rowinski and Gavin Stewart (eds)

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Psychoanalysis and ethics in documentary film / Agnieszka Piotrowska

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Piotrowska, Agnieszka, author


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The interplay of influence : news, advertising, politics, and the Internet / Kathleen Hall Jamieson, Karlyn Kohrs Campbell

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Jamieson, Kathleen Hall


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Confessions from correspondent-land : the dangers & delights of life as a foreign correspondent / Nick Bryant

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Bryant, Nick (Nicholas Andrew), author


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Analyzing media messages : using quantitative content analysis in research / Daniel Riffe, Stephen Lacy and Frederick Fico

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Riffe, Daniel


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Digital innovations for mass communications : engaging the user / Paul Martin Lester

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Lester, Paul Martin, author


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Manufacturing consent [videorecording] : Noam Chomsky and the media / directed and produced by Mark Achbar and Peter Wintonick ; produced for NFB Adam Symansky

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Reading YouTube : the critical viewers guide / Anandam Kavoori

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Kavoori, Anandam P


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A dictionary of journalism / Tony Harcup

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Harcup, Tony, author


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The Hoot reader : media practice in twenty-first century India / edited by Sevanti Ninan, Subarno Chattarji

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The Oxford handbook of new audiovisual aesthetics / edited by John Richardson, Claudia Gorbman, Carol Vernallis

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The Oxford handbook of sound and image in digital media / Carol Vernallis, Amy Herzog and John Richardson

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Unruly media : YouTube, music video, and the new digital cinema / Carol Vernallis

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Vernallis, Carol


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Practical activities for ESL students / Anne Vize

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Vize, Anne


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The ethics of journalism : individual, institutional and cultural influences / edited by Wendy N. Wyatt

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