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The $50 000 Physical

In this narrative medicine essay, a physician reflects on his father’s experience, at the age of 85 years, of getting a physical examination from a new primary care physician that ended up setting off a cascade of examinations and treatments.




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What Gets Measured Gets (Micro)managed

In this narrative medicine essay, an attending physician reflects on the evolution of the role of the attending physician from a supervisor in the background to a micromanaging supervisor to ensure that the proper steps are followed to meet the quality metrics in place in the current health system.




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A Silent Curriculum

In this narrative medicine essay, a medical student reflects on the ways in which she has seen racism and implicit bias affect clinical practice and emphasizes the importance of examining and challenging these biases to address health inequalities.




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The Quick Physical Exam

In this narrative medicine essay, a teaching physician uses the fictitious characters Holmes and Watson to dispell the belief held by many physicians—that a thorough physical examination is an unnecessary art of the past. His emphasis: taking time to gather data and observe can avoid unneeded tests and guide accurate diagnosis.




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Moral Choices for Today’s Physician

In this essay, Don Berwick considers moral choices physicians face personally, organizationally, and globally and exhorts them to understand that the health of humanity depends on their speaking out against the social injustice of overpricing drugs and services, mass incarceration, and the lack of environmental responsibility.




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Physician-Parents Whose Children Have Rare Diseases

In this essay, a critical care pediatric hospitalist finds herself on the other side of the office table advocating for the specific medical care needed to address her son’s rare skeletal dysplasia and her search for a pediatric specialist with whom to travel on this quest.




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A Medical Student Shares Her Struggle With Depression

In this essay, a young medical student describes her struggle with depression and how the experience of vulnerability has bred a deep compassion for her patients and peers.




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Advice for Starting Medical School

In this narrative medical essay, an internist offers three basic lessons not taught in medical school that he learned about practicing medicine based on his experiences from a patient with whom he has built a trusting relationship over the years.




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Grief After Suicide

In this narrative medicine essay, the author mourns the suicide of young adult of a friend and relives his brother’s suicide 30 years earlier in a stream of consciousness montage of grief and advice to succor for those left behind.




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Full Circle: How Medicine Enabled Avoidance and Acceptance

In this narrative medicine essay, a psychiatrist used her residency to avoid grieving the loss of her brother to suicide but through participation in a grief support group during training she began to thaw enough to remember her brother, watch videos of ephemeral moments like celebrating his fourth birthday, an act that allowed her to see him and her family again.




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An efficient strategy for circulating tumor cell detection: surface-enhanced Raman spectroscopy

J. Mater. Chem. B, 2020, 8,3316-3326
DOI: 10.1039/C9TB02327E, Review Article
Jie Lin, Jianping Zheng, Aiguo Wu
Circulating tumor cells (CTCs) are circulating cancer cells that shed from tumor tissue into blood vessels and circulate in the blood to invade other organs, which results in fatal metastases. Surface-enhanced Raman scattering (SERS) has great potentials in CTCs detection.
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A dual-targeted CeO2–DNA nanosensor for real-time imaging of H2O2 to assess atherosclerotic plaque vulnerability

J. Mater. Chem. B, 2020, 8,3502-3505
DOI: 10.1039/C9TB02459J, Communication
Zhenhua Liu, Yujie Cao, Xiaona Zhang, Huazhen Yang, Yujie Zhao, Wen Gao, Bo Tang
A novel dual-targeted CeO2–DNA nanosensor by modifying with folic acid (FA) and CD36 antibody was designed.
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Highly efficient electrochemiluminescence of ruthenium complex-functionalized CdS quantum dots and their analytical application

J. Mater. Chem. B, 2020, 8,3598-3605
DOI: 10.1039/C9TB02463H, Paper
Xiaofei Wang, Huiwen Liu, Honglan Qi, Qiang Gao, Chengxiao Zhang
Highly efficient electrochemiluminescence of ruthenium complex-functionalized CdS quantum dots via ECL resonance energy transfer (ECL-RET) and their analytical application.
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Electrodeposition of nickel nanostructures using silica nanochannels as confinement for low-fouling enzyme-free glucose detection

J. Mater. Chem. B, 2020, 8,3616-3622
DOI: 10.1039/C9TB02472G, Paper
Jialian Ding, Xinru Li, Lin Zhou, Rongjie Yang, Fei Yan, Bin Su
This work reports an enzyme-free glucose sensor based on nickel nanostructures electrodeposited on a fluorine-doped tin oxide (FTO) electrode modified with a silica nanochannel membrane (SNM).
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Graphene–nucleic acid biointerface-engineered biosensors with tunable dynamic range

J. Mater. Chem. B, 2020, 8,3623-3630
DOI: 10.1039/C9TB02388G, Paper
Zhifeng Zhao, Hao Yang, Wenyue Zhao, Sha Deng, Kaixiang Zhang, Ruijie Deng, Qiang He, Hong Gao, Jinghong Li
Programmed biosensors with tunable quantification range and higher specificity have been constructed by engineering graphene–nucleic acid biointerfaces.
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Biomolecular detection, tracking, and manipulation using a magnetic nanoparticle-quantum dot platform

J. Mater. Chem. B, 2020, 8,3534-3541
DOI: 10.1039/C9TB02481F, Paper
Kalpesh D. Mahajan, Gang Ruan, Greg Vieira, Thomas Porter, Jeffrey J. Chalmers, R. Sooryakumar, Jessica O. Winter
Fluorescent and magnetic materials play a significant role in biosensor technology, enabling sensitive quantification and separations with applications in diagnostics, purification, quality control, and therapeutics.
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Ti3C2Tx MXene-derived TiO2/C-QDs as oxidase mimics for the efficient diagnosis of glutathione in human serum

J. Mater. Chem. B, 2020, 8,3513-3518
DOI: 10.1039/C9TB02478F, Communication
Zhaoyong Jin, Gengfang Xu, Yusheng Niu, Xiaoteng Ding, Yaqian Han, Wenhan Kong, Yanfeng Fang, Haitao Niu, Yuanhong Xu
A Ti3C2Tx MXene-derived TiO2/C-QD oxidase mimic was developed and used for the efficient diagnosis of glutathione in human serum.
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Recent advances of tissue-interfaced chemical biosensors

J. Mater. Chem. B, 2020, 8,3371-3381
DOI: 10.1039/C9TB02476J, Review Article
Chuanrui Chen, Yue Guo, Peining Chen, Huisheng Peng
This review discusses recent advances of tissue interfaced chemical biosensors, highlights current challenges and gives an outlook on future possibilities.
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Stretchable gold fiber-based wearable electrochemical sensor toward pH monitoring

J. Mater. Chem. B, 2020, 8,3655-3660
DOI: 10.1039/C9TB02477H, Paper
Ren Wang, Qingfeng Zhai, Yunmeng Zhao, Tiance An, Shu Gong, Zhirui Guo, QianQian Shi, Zijun Yong, Wenlong Cheng
A stretchable gold fiber-based wearable electrochemical pH two-electrodes sensing system for human health monitoring.
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Advances in functional nucleic acid based paper sensors

J. Mater. Chem. B, 2020, 8,3213-3230
DOI: 10.1039/C9TB02584G, Review Article
Rudi Liu, Erin M. McConnell, Jiuxing Li, Yingfu Li
This article provides an extensive review of paper-based sensors that utilize functional nucleic acids, particularly DNA aptamers and DNAzymes, as recognition elements.
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From design to applications of stimuli-responsive hydrogel strain sensors

J. Mater. Chem. B, 2020, 8,3171-3191
DOI: 10.1039/C9TB02692D, Review Article
Dong Zhang, Baiping Ren, Yanxian Zhang, Lijian Xu, Qinyuan Huang, Yi He, Xuefeng Li, Jiang Wu, Jintao Yang, Qiang Chen, Yung Chang, Jie Zheng
Stimuli-responsive hydrogel strain sensors that synergize the advantages of both hydrogel and smart functional materials have attracted increasing interest from material design to emerging applications in health monitors and human–machine interfaces.
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Genetically encoded light-up RNA aptamers and their applications for imaging and biosensing

J. Mater. Chem. B, 2020, 8,3382-3392
DOI: 10.1039/C9TB02668A, Review Article
Puchakayala Swetha, Ze Fan, Fenglin Wang, Jian-Hui Jiang
Light-up RNA aptamers and their applications in bioimaging and biosensing of small ligands and biomacromolecules are described.
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Structurally coloured contact lens sensor for point-of-care ophthalmic health monitoring

J. Mater. Chem. B, 2020, 8,3519-3526
DOI: 10.1039/C9TB02389E, Paper
Yunlong Wang, Qilong Zhao, Xuemin Du
A structurally coloured contact lens sensor has been developed for point-of-care diagnosis of eye diseases.
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Wearable biochemical sensors for human health monitoring: sensing materials and manufacturing technologies

J. Mater. Chem. B, 2020, 8,3423-3436
DOI: 10.1039/C9TB02474C, Review Article
Guanglei Li, Dan Wen
Recent achievements and challenges in materials and manufacturing technologies of sensing electrodes in wearable biosensors have been highlighted.
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Silver nanoprism-based plasmonic ELISA for sensitive detection of fluoroquinolones

J. Mater. Chem. B, 2020, 8,3667-3675
DOI: 10.1039/C9TB02776A, Paper
Meifang Yuan, Qirong Xiong, Ganggang Zhang, Zhijuan Xiong, Daofeng Liu, Hongwei Duan, Weihua Lai
Silver nanoprism-based plasmonic ELISA for qualitative and quantitative detection of fluoroquinolones.
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Novel perylene probe-encapsulated metal–organic framework nanocomposites for ratiometric fluorescence detection of ATP

J. Mater. Chem. B, 2020, 8,3661-3666
DOI: 10.1039/C9TB02319D, Paper
Xiaomeng Zhou, Juanmin Li, Li-Li Tan, Qiang Li, Li Shang
Schematic illustration of PDI@ZIF-8 nanocomposite synthesis and ratiometric fluorescence assay for ATP sensing. 2-MIm: 2-methylimidazole.
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A perylenetetracarboxylic dianhydride and aniline-assembled supramolecular nanomaterial with multi-color electrochemiluminescence for a highly sensitive label-free immunoassay

J. Mater. Chem. B, 2020, 8,3676-3682
DOI: 10.1039/C9TB02368B, Paper
Wei Zhang, Yue Song, Yunyun Wang, Shuijian He, Lei Shang, Rongna Ma, Liping Jia, Huaisheng Wang
A novel multi-color ECL nanomaterial assembled from 3,4,9,10-perylenetetracarboxylic dianhydride (PTCDA) and aniline (An) was used for highly sensitive label-free CEA detection.
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Toehold-regulated competitive assembly to accelerate the kinetics of graphene oxide-based biosensors

J. Mater. Chem. B, 2020, 8,3683-3689
DOI: 10.1039/C9TB02454A, Paper
Huan Du, Junbo Chen, Jie Zhang, Rongxing Zhou, Peng Yang, Xiandeng Hou, Nansheng Cheng
With toehold-regulation, the kinetics of graphene oxide-based biosensors can be accelerated.
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Assessing the range of enzymatic and oxidative tunability for biosensor design

J. Mater. Chem. B, 2020, 8,3460-3487
DOI: 10.1039/C9TB02666E, Review Article
Hattie C. Schunk, Derek S. Hernandez, Mariah J. Austin, Kabir S. Dhada, Adrianne M. Rosales, Laura J. Suggs
This review aims to inspire novel biosensor design by addressing materials chemistries through the lense of enzymatic and oxidative susceptibility in the spectra of inflammatory disease biomarkers.
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Development of CeO2 nanodot encrusted TiO2 nanoparticles with reduced photocatalytic activity and increased biocompatibility towards a human keratinocyte cell line

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00629G, Paper
Alexander Morlando, Marcela Chaki Borrás, Yaser Rehman, Shahnaz Bakand, Philip Barker, Ronald Sluyter, Konstantin Konstantinov
Low photocatalytic CeO2/TiO2 nanocomposite particles with high UV attenuation and reduced ROS generation for application in sunscreen products.
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Recent progress of SERS optical nanosensors for miRNA analysis

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00280A, Review Article
Yudie Sun, lin shi, Lan Mi, Ruiyan Guo, Tao Li
This review focus on emerging applications of surface-enhanced Raman spectroscopy (SERS) optical nanosensors for miRNA analysis, in which the key enhancement factors of SERS signal, i.e. SERS-active substrates, SERS nanoprobes...
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Stable Anchoring of Bacteria-based Protein Nanoparticles for Surface Enhanced Cell Guidance

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00702A, Paper
Open Access
Imma Ratera, Marc Martínez-Miguel, Adriana Kyvik, Lena Montaña, Albert Martínez-Moreno, Olivia Cano-Garrido, Elena Garcia-Fruitos, Esther Vazquez, Nora Ventosa, Judith Guasch, Jaume Veciana, Antonio Villaverde
In tissue engineering, biological, physical, and chemical inputs have to be combined to properly mimic cellular environments and successfully build artificial tissues, which can be designed to fulfil different biomedical...
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Rapidly dissolving microneedle patch for synergistic gene and photothermal therapy of subcutaneous tumor

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00105H, Paper
Qinan Xu, Xinfang Li, Peng Zhang, Youxiang Wang
Synergistic gene and photothermal therapy conducted by p53 DNA/IR820 MN patch may be a promising strategy for subcutaneous tumor treatments.
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Encapsulated DNase Improving the Killing Efficiency of Antibiotics in Staphylococcal Biofilms

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00441C, Communication
Chenhui Liu, Yu Zhao, Wanqi Su, Jingshan Chai, Lina Xu, Jingjing Cao, Yang Liu
We developed a polymer-encapsulated DNase, n(DNase), which can efficiently accumulate in biofilm and expose the DNase to cleave the eDNA of biofilm. CLSM and crystal violet results demonstrated an effective...
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Mechanically robust enzymatic degradable shape memory polyurethane urea with rapid recovery response induced by NIR

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00798F, Paper
Xin Li, Wenkai Liu, Yaomin Li, Wanling Lan, Daiguo Zhao, Hecheng Wu, Yuan Feng, Xueling He, Zhen Li, Jiehua Li, Feng Luo, Hong Tan
Biodegradable shape memory polymers have great potential using in minimally invasive surgical procedures. Herein, a series of shape memory polyurethanes (SMPUs) containing chymotrypsin-inspired chain extenders with adjustable mechanical properties and...
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Development of mucoadhesive cationic polypeptide micelles for sustained cabozantinib release and inhibition of corneal neovascularization

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00874E, Paper
Haijie Han, Qichuan Yin, Xiajing Tang, Xiaoning Yu, Qiang Gao, Yelei Tang, Andrzej Grzybowski, Ke Yao, Jian Ji, Xingchao Shentu
Corneal neovascularization (CNV) is one of the leading risk factors for vision loss. Anti-angiogenic drugs can theoretically be extended to the treatment of CNV. However, the application of these drugs...
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Multi-Stimuli Responsive Polymeric Prodrug Micelles for Combined Chemotherapy and Photodynamic Therapy

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00539H, Paper
Cheng Hu, Weihua Zhuang, Tao Yu, Liang Chen, Zhen Liang, Gaocan Li, Yunbing Wang
Nowadays, cancer therapy faces severe challenges on boosting therapeutic efficiency and reducing the side effects of drugs. To overcome these challenges, herein multifunctional polymeric prodrug micelles with combining chemotherapy and...
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Biomimetic Immunomagnetic Gold Hybrid Nanoparticles Coupled with Inductively Coupled Plasma Mass Spectrometry for the Detection of Circulating Tumor Cells

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00403K, Paper
Zhimin Chang, Hang Zhou, Chao Yang, Rui Zhang, Qiannan You, Ruhong Yan, Li Li, Mingfeng Ge, Yuguo Tang, Wen-fei Dong, Zheng Wang
Immunomagnetic beads are important tools for the isolation and detection of circulating tumor cells (CTCs). However, the current immunomagnetic bead technique provides poor CTC separation purity due to nonspecific binding...
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Fluorinated porphyrin-based theranostics for dual imaging and chemo-photodynamic therapy

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00083C, Paper
Huaibin Zhang, Shaowei Bo, Kai Zeng, Jie Wang, Yu Li, Zhigang Yang, Xin Zhou, Shizhen Chen, Zhong-Xing Jiang
A modular strategy facilitates the convenient and standardized preparation of multifunctional theranostics for cancer therapy.
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Bioinspired polydopamine nanoparticles: synthesis, nanomechanical properties, and efficient PEGylation strategy

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/C9TB02769F, Paper
Islam Zmerli, Jean-Philippe Michel, Ali Makky
We established tightly controlled experimental conditions to synthesize polydopamine nanoparticles with well-defined and reproducible physicochemical properties such as size, yield and nanomechanics.
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Aqueous surface gels as low friction interfaces to mitigate implant-associated inflammation

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00582G, Perspective
Allison L. Chau, Jonah Rosas, George D. Degen, Lisa K. Månsson, Jonathan Chen, Eric Valois, Angela A. Pitenis
Soft implant surfaces should be designed with an eye toward natural, healthy biointerfaces, which use high water content aqueous gel gradients to reduce contact pressures and frictional shear stresses and thus reduce inflammation and discomfort.
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Phosphates-responsive 2D-Metal─Organic-Framework-Nanozymes for Colorimetric Detection of Alkaline Phosphatase

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/C9TB02542A, Paper
Xiaoyu Wang, Xiaoqian Jiang, Hui Wei
In this study, a simple colorimetric method with tunable dynamic range for alkaline phosphatase (ALP) activity assay was developed by using peroxidase-mimicking two-dimensional-metal─organic-framework (2D-MOF). Phosphates including pyrophosphate (PPi), ATP, and...
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Seedless Synthetic Branched Gold Nanoshell for Chemo-thermal Antitumor Therapy

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00891E, Paper
Lei Li, Yihan Fu, Zichuang Xu, Xuwu Zhang, Zining Hao, Yaqian He, Wenbin Gao, Dawei Gao
Gold nanomaterials (GNMs) were used in photothermal therapy due to their superior optical properties and excellent biocompatibility. However, the complex preparation process of seed-mediated growth limits further clinical applications of...
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Controllable hydrogen bonded self-association for the formation of multifunctional antimicrobial materials

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00875C, Paper
Lisa White, Jessica E. Boles, Nyasha Allen, Luke Alesbrook, J. Mark Sutton, Charlotte Hind, Kira Hilton, Laura R. Blackholly, Rebecca Ellaby, George Williams, Daniel P Mulvihill, Jennifer Ruth Hiscock
SSAs are a class of Supramolecular Self-associating Amphiphilic salt, the anionic component of which contains a covalently bound hydrogen bond donor-acceptor motif. This results in a monomeric unit which can...
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Unique Sequence-Dependent Properties of Trinucleotide Repeat Monolayers: Electrochemical, Electrical, and Topographic Characterization

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00507J, Paper
Narges Asefifeyzabadi, Motahareh Taki, Madison Funneman, Tingjie Song, Mohtashim Hassan Shamsi
Trinucleotide repeat (TNR) sequences widely exist in nature and their overgrowth is associated with two dozen neurodegenerative diseases in humans. These sequences have unique helical flexibility which affects their biophysical...
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In vivo immunological response of exposure to PEGylated graphene oxide via intraperitoneal injection

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00499E, Paper
Zhaowen Ding, Nana Luo, Hua Yue, Yongjun Gao, Guanghui Ma, Wei Wei
2D PEGylated graphene oxide showed stealth-but-immune-activating capacity on macrophages, along with specific intraperitoneal immunological response in vivo.
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A waterborne polyurethane 3D scaffold containing PLGA with a controllable degradation rate and an anti-inflammatory effect for potential applications in neural tissue repair

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00656D, Paper
Bohong Du, Hang Yin, Yue Chen, Weiwei Lin, Yanchao Wang, Daiguo Zhao, Gang Wang, Xueling He, Jiehua Li, Zhen Li, Feng Luo, Hong Tan, Qiang Fu
3D connected porous LGPU scaffolds with adjustable degradation and a strong anti-inflammatory effect were prepared for neural tissue repair.
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Glutathione- and light-controlled generation of singlet oxygen for triggering drug release in mesoporous silica nanoparticles

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00636J, Paper
Roy C. H. Wong, Dennis K. P. Ng, Wing-Ping Fong, Pui-Chi Lo
An activatable phthalocyanine-based photosensitiser and a singlet-oxygen-triggered doxorubicin releasing system have been incorporated into mesoporous silica nanoparticles, which can release the encapsulated doxorubicin in a controllable manner.
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Multivalent cationic dendrofullerenes for gene transfer: synthesis and DNA complexation

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00113A, Paper
Beatriz M. Illescas, Alfonso Pérez-Sánchez, Araceli Mallo, Ángel Martín-Domenech, Ignacio Rodríguez-Crespo, Nazario Martín
Non-viral nucleic acid vectors able to display high transfection efficiencies with low toxicity and overcoming the multiple biological barriers are needed to further develop the clinical applications of gene therapy.
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Progress in biomimetic leverages for marine antifouling using nanocomposite coatings

J. Mater. Chem. B, 2020, 8,3701-3732
DOI: 10.1039/C9TB02119A, Review Article
Mohamed S. Selim, Sherif A. El-Safty, Mohamed A. Shenashen, Shimaa A. Higazy, Ahmed Elmarakbi
Because of the environmental and economic casualties of biofouling on maritime navigation, modern studies have been devoted toward formulating advanced nanoscale composites in the controlled development of effective marine antifouling self-cleaning surfaces.
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