U19 EURO kicks off in Armenia on Sunday and we pick out a player from each team to keep an eye on.

Even in this extraordinary #MeToo era, ordinary women who've experienced harassment or assault at work are often reluctant to share their stories publicly. Arianna Prothero found that to be just as true as she reported on sexual harassment and assaults in schools and other K-12 workplaces.

The Delaware Department of Justice has filed suit against the developer of The Villages of Noble’s Pond, an 879-lot “55-plus” community in Kent County, for numerous violations of the Consumer Fraud Act, the Deceptive Trade Practices Act, and other Delaware laws protecting consumers against unlawful and predatory behavior. Attorney General Kathy Jennings announced the filing […]

Dover, DE   August 8, 2019 — A Wilmington woman was indicted by the New Castle County Grand Jury for insurance fraud and other felony charges. Theresa T. Milton, 44, of the 900 block of Clayton Street, was indicted on seven felony counts of insurance fraud, one felony count of theft by false pretense, and one […]

THIRTY-FIVE TALENTED STATE EMPLOYEES AND THEIR FAMILY MEMBERS HONORED Delaware Division of the Arts announces award-winning artists in its annual Delaware State Employee Art Exhibition reception & award ceremony Wilmington, Del. (March 19, 2018) – The talented state employees and their family members were recognized for their art work exhibited at the seventh annual Delaware State Employee […]

Division of the Arts announces award-winning artists in its annual Delaware State Employee Art Exhibition reception & award ceremony Dover, Del. (March 18, 2019) – The talented state employees and their family members were recognized for their artwork exhibited at the eight annual Delaware State Employee Art Exhibition sponsored by the National Arts Program® reception […]

DEPARTMENT OF EDUCATION: Professional Standards Board

Division of the Arts announces award-winning artists in its annual Delaware State Employee Art Exhibition Dover, Del. (March 14, 2020) – The talented state employees and their family members were recognized for their artwork exhibited at the ninth annual Delaware State Employee Art Exhibition sponsored by the National Arts Program®. Twenty-nine awards were awarded in […]

Ford has built an all-electric prototype Mustang for the drag strip. With 1,400hp Ford aims to claim a quarter-mile time of 8 seconds at a max speed of 273kmph.

"The first batch of staff were trained at French labs," she said, adding that its equipment is tested every year by internationally recognised third parties.

Owing to the strict interpretations of rules which govern the H-1B work visa program Indian IT companies, as well as their customers, face a shortage of mid-level talent in the US.A major problemThere was a problem of talent at the entry-level in the…

Addressing a gathering at Siddaganga Matha in Tumkur in Karnataka, Modi accused the Opposition of remaining silent on Pakistan’s “atrocities on Hindus, Sikhs, Jains and Christians” and said “jis tarah ki nafrat hum logon se karte hain, vaisa hi swar ab desh ki sansad ke khilaf dikh raha hai.

To Dick Costolo, there’s gold in them thar tweets, and Twitter has just begun to mine it.

By 2020, more than a third of the desired core skill-sets of most occupations will be comprised of skills that are not yet considered crucial.

Jordan’s culture ministry launched the 'My talent from my home' contest in late March, and says it has since attracted more than 67,000 participants and 18 million social network views

Hello, There is a manual in matlab of matching LNA  shown in the link bellow.

In it as shown in the plot bellow they mention input and output circle plots.

Is there such option of input and output circle in cadence virtuoso?

https://www.mathworks.com/help/rf/examples/designing-matching-networks-part-1-networks-with-an-lna-and-lumped-elements.html

Hi Guys,

Anyone know equivalent skill for create detail.

Eugene

તો આજે આપણે જોઇએ કે કઇ રાશિનાં જાતકો માટે આ વૅલેન્ટાઇન કેવો રહેશે. તમને પ્રેમનો રંગ મળશે કે પ્રેમ પર પાણી ફરશે.

14 ફેબ્રુઆરીને વેલેન્ટાઈન ડે તરીકે ઉજવવામાં આવે છે. યુવાન હૈયાઓ આ દિવસની આતુરતાથી રાહ જોતા હોય છે. આ દિવસે યુવક યુવતીઓ પોતાના પ્રીય પાત્રને ગીફ્ટ આપીને પ્રેમનો એકરાર કરતા હોય છે. પરંતુ ગિફ્ટ આપવી અથવા લેવી અલગ અલગ ગ્રહો ઉપર અલગ અલગ અસર કરે છે.

આજના રાશીફળ પ્રમાણે જાણો તમારા ભાગ્ય, સ્વાસ્થ્ય, ધન, પ્રેમ-વિવાહ, નોકરી વગેરેની ભવિષ્યવાણી

Frankfurt (Oder) is building on the strengths of its university to foster the development of successful start-ups through new co-working spaces and the promotion of sustainable practices and products. 

In recognition of the widely acknowledged studies that show that organizations with gender equality perform better financially, this year POWERGEN International, along with partner UL, is launching a new awards program that seeks out women of good character.

In recognition of the widely acknowledged studies that show that organizations with gender equality perform better financially, this year POWERGEN International, along with partner UL, is launching a new awards program that seeks out women of good character.

In recognition of the widely acknowledged studies that show that organizations with gender equality perform better financially, this year POWERGEN International, along with partner UL, is launching a new awards program that seeks out women of good character.

In recognition of the widely acknowledged studies that show that organizations with gender equality perform better financially, this year POWERGEN International, along with partner UL, is launching a new awards program that seeks out women of good character.

A leading overseas talent recruitment platform in China is seeking to partner with Australian universities for its online internship system. Successful partners will work with established companies in China to provide online internship opportunities to graduates.

On 28 May 2009 the Solicitors Regulation Authority announced to the legal profession that 11,000 law firms throughout England and Wales would receive warning cards alerting them to potential fraudulent activity. 130,000 of these warning cards have n...

KATHMANDU: Nepal police on Friday arrested 45 Chinese nationals stranded in the country because of coronavirus restrictions after a protest turned violent, authorities said.Holding placards such as "I want to go home!" they attempted to push towards a prohibited zone near the prime minister's...

LONDON: The UK has fallen silent to mark the 75th anniversary of VE Day as the country was urged to draw on the “same spirit of national endeavour” during the coronavirus crisis.Millions across the country paused at 11am on Friday to remember those who served in the Second World War,...

Retailers usually expect a nearly $20 billion bonanza on a Valentine's Day weekend -- but with an Arctic chill forecast for parts of the United States, will paramours be able to keep alive the retail heat? Mana Rabiee reports.

Desert ants zigzag around the searing sand at high speed but they always manage to find their way home. A new book explains their amazing abilities

Title: Violent Older Siblings Set Bad Example
Category: Health News
Created: 4/30/2014 12:35:00 PM
Last Editorial Review: 5/1/2014 12:00:00 AM

Title: 'Silent' Seizures Tied to Alzheimer's Symptoms
Category: Health News
Created: 5/2/2017 12:00:00 AM
Last Editorial Review: 5/2/2017 12:00:00 AM

ABSTRACT

Obesity is associated with increased disease severity, elevated viral titers in exhaled breath, and significantly prolonged viral shed during influenza A virus infection. Due to the mutable nature of RNA viruses, we questioned whether obesity could also influence influenza virus population diversity. Here, we show that minor variants rapidly emerge in obese mice. The variants exhibit increased viral replication, resulting in enhanced virulence in wild-type mice. The increased diversity of the viral population correlated with decreased type I interferon responses, and treatment of obese mice with recombinant interferon reduced viral diversity, suggesting that the delayed antiviral response exhibited in obesity permits the emergence of a more virulent influenza virus population. This is not unique to obese mice. Obesity-derived normal human bronchial epithelial (NHBE) cells also showed decreased interferon responses and increased viral replication, suggesting that viral diversity also was impacted in this increasing population.

IMPORTANCE Currently, 50% of the adult population worldwide is overweight or obese. In these studies, we demonstrate that obesity not only enhances the severity of influenza infection but also impacts viral diversity. The altered microenvironment associated with obesity supports a more diverse viral quasispecies and affords the emergence of potentially pathogenic variants capable of inducing greater disease severity in lean hosts. This is likely due to the impaired interferon response, which is seen in both obese mice and obesity-derived human bronchial epithelial cells, suggesting that obesity, aside from its impact on influenza virus pathogenesis, permits the stochastic accumulation of potentially pathogenic viral variants, raising concerns about its public health impact as the prevalence of obesity continues to rise.

ABSTRACT

All enterococci produce a complex polysaccharide called the enterococcal polysaccharide antigen (EPA). This polymer is required for normal cell growth and division and for resistance to cephalosporins and plays a critical role in host-pathogen interaction. The EPA contributes to host colonization and is essential for virulence, conferring resistance to phagocytosis during the infection. Recent studies revealed that the "decorations" of the EPA polymer, encoded by genetic loci that are variable between isolates, underpin the biological activity of this surface polysaccharide. In this work, we investigated the structure of the EPA polymer produced by the high-risk enterococcal clonal complex Enterococcus faecalis V583. We analyzed purified EPA from the wild-type strain and a mutant lacking decorations and elucidated the structure of the EPA backbone and decorations. We showed that the rhamnan backbone of EPA is composed of a hexasaccharide repeat unit of C2- and C3-linked rhamnan chains, partially substituted in the C3 position by α-glucose (α-Glc) and in the C2 position by β-N-acetylglucosamine (β-GlcNAc). The so-called "EPA decorations" consist of phosphopolysaccharide chains corresponding to teichoic acids covalently bound to the rhamnan backbone. The elucidation of the complete EPA structure allowed us to propose a biosynthetic pathway, a first essential step toward the design of antimicrobials targeting the synthesis of this virulence factor.

IMPORTANCE Enterococci are opportunistic pathogens responsible for hospital- and community-acquired infections. All enterococci produce a surface polysaccharide called EPA (enterococcal polysaccharide antigen) required for biofilm formation, antibiotic resistance, and pathogenesis. Despite the critical role of EPA in cell growth and division and as a major virulence factor, no information is available on its structure. Here, we report the complete structure of the EPA polymer produced by the model strain E. faecalis V583. We describe the structure of the EPA backbone, made of a rhamnan hexasaccharide substituted by Glc and GlcNAc residues, and show that teichoic acids are covalently bound to this rhamnan chain, forming the so-called "EPA decorations" essential for host colonization and pathogenesis. This report represents a key step in efforts to identify the structural properties of EPA that are essential for its biological activity and to identify novel targets to develop preventive and therapeutic approaches against enterococci.

Finding common ground and building trust between local stakeholders could help prevent violent encounters between police and young black men, new research finds.

Key Points

Mycoplasma gallisepticum is the primary etiological agent of chronic respiratory disease in chickens. Live attenuated vaccines are most commonly used in the field to control the disease, but current vaccines have some limitations. Vaxsafe MG (strain ts-304) is a new vaccine candidate that is efficacious at a lower dose than the current commercial vaccine strain ts-11, from which it is derived. In this study, the transcriptional profiles of the trachea of unvaccinated chickens and chickens vaccinated with strain ts-304 were compared 2 weeks after challenge with M. gallisepticum strain Ap3AS during the chronic stage of infection. After challenge, genes, gene ontologies, pathways, and protein classes involved in inflammation, cytokine production and signaling, and cell proliferation were upregulated, while those involved in formation and motor movement of cilia, formation of intercellular junctional complexes, and formation of the cytoskeleton were downregulated in the unvaccinated birds compared to the vaccinated birds, reflecting immune dysregulation and the pathological changes induced in the trachea by infection with M. gallisepticum. Vaccination appears to protect the structural and functional integrity of the tracheal mucosa 2 weeks after infection with M. gallisepticum.