A Polish priest has created a small chapel in the city of Poznan, which besides an altar, lectern, chairs and crucifix, offers an AI-powered program allowing visitors to ask questions about Catholicism and faith. - REUTERS

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Evolutionary molecular biologist Beth Shapiro on the hunt for ancient DNA and her groundbreaking de-extinction and environmental mission  

We may never know what lies beyond the boundaries of the observable universe, but the fabric of the cosmos can tell us whether the universe is infinite or not

Your body is home to trillions of beneficial viruses crucial for a healthy microbiome. We may one day be able to tweak this "virome" to treat obesity and anxiety

When we take a break from exercise, it can feel like we quickly go back to square one. But this isn't the case, and there are various ways to minimise the decline

Evidence suggests that cynicism is bad for your health. Neuroscientist Jamil Zaki describes the three ways to conquer your inner cynic to boost your well-being

Ultra-fast pulses of laser light can be shaped into vortices similar to smoke rings – when chained together, they can carry enough information to transmit a simple image

The destruction of telecommunications cables during the eruption of Hunga Tonga-Hunga Haʻapai volcano in 2022 shows that underwater debris currents can travel at 122 kilometres per hour

Analysis of tree rings shows that two faults near Seattle, Washington ruptured at the same time or soon after each other more than 1000 years ago – a repeat today would cause a major disaster in the region

Photographer Matjaz Krivic has been charting the effects of lithium mining on locals in the world's largest salt flat in Bolivia since 2016

The Kikai-Akahoya eruption of an underwater volcano off the coast of Japan ejected enough material to fill Lake Tahoe twice, three times as much as the eruption of Mount Tambora in 1815

The dynamics of how plants and animals change Earth is central to this last book in a trilogy by Other Minds author and "scuba-diving philosopher" Peter Godfrey-Smith

The earliest evidence of livestock with modified horns has been discovered in ancient Egypt – sheep skulls with horns that point in unnatural directions suggest humans forced them to grow that way

Historians have claimed the people of Easter Island overexploited natural resources, causing a population crash, but new evidence suggests they lived sustainably for centuries

The earliest evidence of livestock with modified horns has been discovered in ancient Egypt – sheep skulls with horns that point in unnatural directions suggest humans forced them to grow that way

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Category: Health and Living
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The human major histocompatibility complex (MHC) is a ~4 Mb genomic segment on Chromosome 6 that plays a pivotal role in the immune response. Despite its importance in various traits and diseases, its complex nature makes it challenging to accurately characterize on a routine basis. We present a novel approach allowing targeted sequencing and de novo haplotypic assembly of the MHC region in heterozygous samples, using long-read sequencing technologies. Our approach is validated using two reference samples, two family trios, and an African-American sample. We achieved excellent coverage (96.6%–99.9% with at least 30x depth) and high accuracy (99.89%–99.99%) for the different haplotypes. This methodology offers a reliable and cost-effective method for sequencing and fully characterizing the MHC without the need for whole-genome sequencing, facilitating broader studies on this important genomic segment and having significant implications in immunology, genetics, and medicine.

Cannabinoid and opioid receptor activities can be modulated by a variety of post-translational mechanisms including the formation of interacting complexes. This study examines the involvement of endogenous and exogenous chaperones in modulating the abundance and activity of cannabinoid CB₁ receptor (CB₁R), opioid receptor (DOR), and CB₁R-DOR interacting complexes. Focusing on endogenous protein chaperones, namely receptor transporter proteins (RTPs), we examined relative mRNA expression in the mouse spinal cord and found RTP4 to be expressed at higher levels compared with other RTPs. Next, we assessed the effect of RTP4 on receptor abundance by manipulating RTP4 expression in cell lines. Overexpression of RTP4 causes an increase and knock-down causes a decrease in the levels of CB₁R, DOR, and CB₁R-DOR interacting complexes; this is accompanied by parallel changes in signaling. The ability of small molecule lipophilic ligands to function as exogenous chaperones was examined using receptor-selective antagonists. Long-term treatment leads to increases in receptor abundance and activity with no changes in mRNA supporting a role as pharmacological chaperones. Finally, the effect of cannabidiol (CBD), a small molecule ligand and a major active component of cannabis, on receptor abundance and activity in mice was examined. We find that CBD administration leads to increases in receptor abundance and activity in mouse spinal cord. Together, these results highlight a role for chaperones (proteins and small molecules) in modulating levels and activity of CB₁R, DOR, and their interacting complexes potentially through mechanisms including receptor maturation and trafficking.

Astronomers have been spotting strange banana-shaped galaxies and the evidence seems to indicate that filaments of dark matter make them take this shape

A new procedure turns an alloy of nickel and titanium into a material as strong as steel but 20 times stretchier – and one application could be building planes with shape-shifting wings

“It might feel like 2064 on the surface, but in its nostalgic, rechargeable heart, the show parties like it’s 1999.”

Popular weight-loss medications including Ozempic and Wegovy contain a drug that seems to decrease cravings for food and drugs – and now there’s evidence that it might make exercise less rewarding, too

Speculation has already run rampant on who Florida Gov. Ron DeSantis will appoint to replace Sen. Marco Rubio if Rubio becomes President-elect Trump's secretary of state.

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We spoke to Reverend Doctor Stephen Cherry, Dean of Chapel at King's College, Cambridge.

President-elect Donald Trump has made many selections to lead his administration as his transition gets underway, ranging from chief of staff to head of the Environmental Protection Agency (EPA). At the same time, a number of crucial positions have yet to be filled just one week removed from the landslide election.

The post Donald Trump’s Administration Takes Shape After 15 Official or Expected Picks appeared first on Breitbart.

Tech companies are force-feeding people AI on search engines and social media platforms and there's no way to opt out. Google search, considered the gateway to the internet, is especially frustrating.

As humans leave space junk behind, there may come a time when human bodies would need to decompose in space. Learn how this happens and why it's a slow process.

‘You deserve something better!’ Ward’s partner Nancy Xu said of result