Crypto investors see an end to increased scrutiny under U.S. Securities and Exchange Commission Chair Gary Gensler whom Trump has said he will replace

San Jose State’s Claire Komives is testing an antivenom inspired by opossum biochemistry against various snake species to prevent deaths in the developing world

The company claims its technology will allow it to access previously undruggable targets

The partners expect to begin clinical studies of the compound later this year

The company claims its technology will allow it to access previously undruggable targets

The Meridian feels comfortable and upright with the quality of gadgetry, interiors and plastics expected from an international brand car.However, it lacks the overall premium-ness that may come with a top-end Japanese car or even a mid-range German car, says Pavan Lall.

Fitbit also plans on giving out six months of free premium subscription service to those who purchase the new devices

The proposed changes to SEBI's definition of UPSI are aimed at increasing regulatory clarity and consistency

India has reduced the time period for foreign investors to seek international arbitration from five years to three years as part of the recently signed investment pact with the United Arab Emirates (UAE), a departure from its model Bilateral Investment Treaty (BIT).

Since 2010, Thai firms have led or taken part in $83 billion of overseas M&A, including 18 deals of $1 billion or more.

The post Bangkok Bank’s bid for Permata reflects Thailand’s overseas M&A ambition appeared first on DealStreetAsia.

As schools and businesses get set to reopen some citizens urge caution, wary of a spike in infections

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France is set to end eight weeks of strict lockdown as the government urged people to behave responsibly to avoid a sudden spike in coronavirus cases.

Hours before the national déconfinement there were reports of two new Covid-19 clusters in départments designated green – areas where the virus has largely stopped circulating and where most restrictions are being lifted.

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Prime force of rock’n’roll who made an explosive impact with songs such as Tutti Frutti, Good Golly, Miss Molly, Lucille and Long Tall Sally

Little Richard, who has died aged 87, was the self-proclaimed king of rock’n’roll. Such was his explosive impact that many of the baby boom generation will vividly recall the moment when they first encountered his assault on melody.

Awopbopaloobop alopbamboom! That first hit, Tutti Frutti, released in October 1955, was wild, delicious gibberish from a human voice as no other, roaring and blathering above a band like a fire-engine run amok in the night. We glimpsed a new universe. The Sinatra-sophisticats were slain with a shout. Enter glorious barbarity, chaos and sex. With a few others – Fats Domino, Bill Haley, Elvis Presley, Chuck Berry, Jerry Lee Lewis and Buddy Holly – Little Richard laid down what rock’n’roll was to be like, and he was the loudest, hottest and most exhibitionist of them all.

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Radio and TV producer who revitalised The Archers during his tenure as editor

Despite being a soft-spoken Lancastrian of mild-mannered appearance, the writer and producer William Smethurst, who has died aged 71, was known to his detractors in radio and television as “Butcher Bill”. But the ruthless skills combined with mischievous flair that he displayed as editor of The Archers for eight years from 1978 were widely credited with saving Radio 4’s flagging rural soap opera and making it the cult show it later became. Smethurst was the man who licensed writers to scandalise sleepy Ambridge and once persuaded Princess Margaret to make a guest appearance.

He was less successful when Central TV lured him from BBC Pebble Mill in Birmingham to pull off the same trick with Crossroads, its Midlands motel saga, which had run out of steam. Smethurst ditched Tony Hatch’s theme tune, killed off characters (much as he had Dan and Doris Archer), and made the plots (and scenery) more credible and the cast much more glamorous, with the help of the motel swimming pool he installed. Some critics preferred its previous awfulness and the show folded in 1988.

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Howard Green, who has died aged 91, was my first editor, a journalist of the old school who worked his way up from junior reporter at 15 to the board of Thomson Regional Newspapers (TRN) when it was a force in the British regional press.

In the mid-1960s he was a key player in the plans of his Canadian proprietor, Lord (Roy) Thomson of Fleet, to ring London with new evening papers, located on the emerging motorway network and printed on state-of-the-art web offset presses. With well-run local papers still profitable, the big idea was eventually to print and distribute Fleet Street newspapers away from the clutches of its famously disruptive unions.

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John Goodwin, who has died aged 97, was a theatre public relations man whose skills earned him an influence far beyond the Royal Shakespeare Company and the National Theatre, with which he was associated for most of his working life.

He was born in London, where his father, Albert Goodwin, worked for the Inland Revenue; his mother was the musical comedy actor Jessie Lonnen, whose father, EJ Lonnen, had also been a star in burlesque, and Johnny was drawn to the theatre from childhood. After second world war service in the Royal Navy, during which he saw action on a destroyer in the North Atlantic, he first joined what was then still the Shakespeare Memorial theatre in Stratford in 1948.

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For more than 20 years Robin Callard, who has died of motor neurone disease aged 73, was professor of immunobiology at University College London, attached to the Institute of Child Health (ICH), clinical partner of Great Ormond Street hospital.

Born and raised in Hamilton, New Zealand, Robin was the eldest child of Eddie Callard, an entrepreneurial Australian photographer, and Vivienne (nee Wilson), who ran a fashion shop. A fourth generation Kiwi, Vivienne was also a descendant of Joseph Priestley, the eighteenth-century radical polymath and scientist widely credited with the discovery of oxygen.

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Hillary Clinton and Donald Trump today scrambled to make their final pitch to voters in the closely-contested U.S. presidential race dogged by controversies like the Democratic nominee's email scandal.

The cryptocurrency has attracted people who mistrust institutions — and those looking for a way to get rich quick

Guiluli is a Red Mighty, a mutation of humans born from the Corporate World War. After 54 years of existence, Pre-ev (non mutated) humans still don't much like the Red Mighties and as a result, the Red Mighties have created their own Nationland.

Despite all of the world's natural resources being either consumed or poisoned by the war, the Nationland has cleaned up its land, so they have pure water and soil free of contaminants in which to grow food. Yet another reason for those off the Nationland to dislike the Red Mighties.

I like the idea of the evolved/mutated species emerging from a human race destroyed by its own vices and desires. It seems that hominids may be ripe for another evolutionary step, after all we have been homo sapiens for a while now. Maybe this is the next step.

This is an interesting twist on a typical dystopian novel in that I feel there is way more hope of a future that isn't just trying to exist day to day but actually thrive as a civilization. The possibility of cleaning up what we have destroyed. Backbiters is a great read for those that enjoyed the Hunger Games, Divergent, Not a Drop to Drink.

AMBITION Shoot for the moon. Even if you miss, you'll land among the stars. Or the unimaginable hideous gapin void of space. One of the two.

Name: Hot Tamales Licorice Bites Brand: Just Born Place Purchased: Target (Glendale) Price: $1.89 Size: 8 ounces Calories per ounce: 113 Type: Licorice/Cinnamon Rating: 8 out of 10

Scientists know that two-star systems can support planets, but the question has remained whether an Earth-size terrestrial planet were orbiting two suns could it support life. A study in the journal Nature Communications has now found that an Earth-like planet orbiting two stars could be habitable if it were within a certain range from its two stars.

Trying Instagram on Android.. feels a bit slow maybe because my phone doesn’t have ICS (Taken with Instagram at St Peter’s College)

We reassessed our hierarchy of needs, and survival always outweighs the rest. To be blunt, we would rather have load shedding than risk dying, writes Adriaan Basson.

Lebogang Manyama is the most important player for Kaizer Chiefs in their quest to win the Absa Premiership title, according to Stellenbosch midfielder Mpho Matsi.

Invitation Only Research Event

Event participants

Professor Philippe Sands QC, Barrister, Matrix Chambers
Chris Whomersley, Deputy Legal Adviser, Foreign and Commonwealth Office (2002-14)
Professor Julia Xue, Academy Senior Fellow, International Law Programme, Chatham House
Chair: Elizabeth Wilmshurst, Distinguished Fellow, International Law Programme, Chatham House

Hidden in the flash. posted a photo:

With a lockdown in place it is against the rules for me to go to places I like to shoot, so I though I would try to create a series called Isolated creativity. The series is not intended to be a diary but a way of documenting thoughts and emotions via photography.

I've felt a bit like Pink Rabbit over the passed few day. I'm not fed up and depressed by the lockdown but by the people who think that it's okay to break the rules. By the tabloid media that run stories that convince people it's okay to go out and about, when it Isn't. By the political points scoring that has started to appear in all forms of media.Lastly I fed up with second home owners that have turned up during lockdown and appear to be going out and about most days.

Just like Pink Rabbit I have the blues.

Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues. However, it is up-regulated in a diverse set of hematologic and solid malignancies, thus ROR2 represents a candidate antigen for antibody-based cancer therapy. Here we describe the affinity maturation and humanization of a rabbit mAb that binds human and mouse ROR2 but not human ROR1 or other human cell-surface antigens. Co-crystallization of the parental rabbit mAb in complex with the human ROR2 kringle domain (hROR2-Kr) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mutagenesis and selection. The affinity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and framework fine tuning and again co-crystallized with hROR2-Kr. We show that the affinity-matured and humanized mAb retains strong affinity and specificity to ROR2 and, following conversion to a T cell–engaging bispecific antibody, has potent cytotoxicity toward ROR2-expressing cells. We anticipate that this humanized affinity-matured mAb will find application for antibody-based cancer therapy of ROR2-expressing neoplasms.