The marble slab appears to be Greek in origin and may have been written in response to the death of a tyrant on the island of Kos

The city's residents sorted waste materials for reuse in future projects, according to new research

Buried in a mass grave in Mexico City, the trio may have been part of the first generation abducted from their homeland and brought to the New World

Central Bank of Chile Working Papers by Andrés Sagner

Have you ever been interested in SOLIDWORKS Simulation but didn’t know where to start? With such a wide variety of design analysis solutions, Simulation can be an intimidating product for someone newer to the SOLIDWORKS suite of products. Well we

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The post Introduction to SOLIDWORKS Simulation – Finite Element Analysis appeared first on SOLIDWORKS Tech Blog.

More than half of the state plans fail to publicly report data on educator equity gaps, the National Council of Teacher Quality found in its analyses.

Many patient and family demographic characteristics are well-known risk factors for nonurgent emergency-department use. No previous study has examined the primary care physician perspective on parental decisions regarding specific nonurgent emergency-department visits by children.

When discussing specific instances when families in their practices sought nonurgent care for children in the emergency department, physicians believed that parents acted appropriately. Neither parents nor primary care physicians saw nonurgent emergency-department visits as a significant enough problem to warrant change. (Read the full article)

Studies of the association between process and outcome measures of the quality of acute asthma care for children have been mixed. These studies are limited by small, single-institution settings or by examining the association at the aggregate level.

This first multicenter analysis of the process-outcome association in acute asthma care for children revealed no association. Because the validity of process measures depends on association with outcomes, further study is needed before implementing existing process measures as performance metrics. (Read the full article)

High-grade vesicoureteral reflux is a risk factor for impaired renal function. Diagnosis by voiding cystourethrography is invasive and highly uncomfortable. As only a minority of children show high-grade vesicoureteral reflux, this exposes the majority to unnecessary distress.

This case-control study proved that high-grade vesicoureteral reflux is identifiable with high sensitivity using urinary proteome analysis, based on capillary electrophoresis coupled to mass spectrometry in a cohort suspected of having vesicoureteral reflux, thus sparing the majority of children from invasive diagnostics. (Read the full article)

Pulmonary hypertension is associated with bronchopulmonary dysplasia in extremely low birth weight infants and contributes to morbidity and mortality.

Pulmonary hypertension affects at least 1 in 6 extremely low birth weight infants and persists to discharge in most survivors. Routine screening of these infants with echocardiography at 4 weeks of age identifies only one-third of those affected. (Read the full article)

Rare diseases in childhood can be debilitating and require lifelong care. Since 1983, the Orphan Drug Act incentives have stimulated the development and significantly improved the availability of treatment products for patients with rare diseases.

We report an increasing pediatric orphan product designations and approvals from 2000 to 2009. The trend indicates that the Orphan Drug Act has continued to address this important unmet need. (Read the full article)

Adherence to guidelines has generally been shown to improve patient care and reduce the cost of care. Current understanding of the varying reasons why clinicians deviate from guidelines is based on surveys and retrospective reviews.

We examined clinician deviations from guidelines in a prospective fashion and attempted to categorize those deviations. Better elucidation of clinician reasoning behind deviations may inform care improvement and help define strategies to eliminate unjustifiable deviations. (Read the full article)

Pediatric osteoarticular infections can be treated with successful microbiologic and clinical outcomes with a transition from parenteral to oral therapy. The best way to determine the timing of this transition is neither well studied nor standardized.

A total of 193 (99.5%) of 194 pediatric patients with acute bacterial osteoarticular infections were successfully transitioned to oral therapy, determined by using a combination of clinical findings and C-reactive protein levels, representing the largest single-center data set analyzed. (Read the full article)

There are limited data regarding the current status of the pediatric clinical trial enterprise.

Evaluation of the ClinicalTrials.gov data set allows description of the overall portfolio of clinical trials relevant to US children, which was previously not possible. (Read the full article)

Chromosomal microarray analysis offers a superior diagnostic yield over karyotyping for the evaluation of individuals with developmental disabilities. Many third-party payers, however, do not reimburse for microarray testing, citing a lack of evidence that patients benefit from testing.

This study demonstrates that microarray testing frequently identifies conditions that include features requiring specific medical follow-up and that referring physicians respond to abnormal test results with appropriate clinical actions. Microarray testing, therefore, provides direct benefits to patients. (Read the full article)

Neuropsychiatric conditions comprise a substantial and growing disease burden among children. Pharmacotherapy represents an important treatment option for these conditions, although most drugs are not approved for use in children.

Very few drug trials studying neuropsychiatric conditions focus on children. Furthermore, these trials examine and provide pediatric evidence for only a fraction of all available drugs in the treatment of common neuropsychiatric conditions. (Read the full article)

Infants aged <2 months are at highest risk for pertussis morbidity and mortality but are too young to receive pertussis vaccines. To protect young infants, the Advisory Committee on Immunization Practices recommends mothers receive 1 dose of Tdap during pregnancy.

This article evaluates the effect of Tdap during pregnancy compared with postpartum Tdap and cocooning in preventing infant pertussis cases, hospitalizations, and deaths, as well as their relative cost-effectiveness. (Read the full article)

The intestinal microbiome may play a role in immune system maturation, and it has been postulated that early-life probiotic administration may reduce the risk of allergies and asthma in childhood. To date, however, results from clinical trials have been inconsistent.

In this meta-analysis, administration of probiotics in early life may reduce total immunoglobulin E level and protect against atopic sensitization but do not seem to protect against asthma/wheezing. Future trials should carefully select probiotic strains and include longer follow-up. (Read the full article)

Childhood interstitial lung diseases occur in a variety of clinical contexts and are associated with high morbidity and mortality. Advances in the understanding of disease pathogenesis and use of standardized terminology have facilitated increased case ascertainment.

This study demonstrates that cases of newly described forms of childhood interstitial lung diseases likely occur at all children’s hospitals. With advances in genetic testing and recognition of imaging patterns, a significant portion of cases are identifiable with noninvasive evaluations. (Read the full article)

Individuals with autism spectrum disorders have a higher comorbidity burden than the general pediatric population, including higher rates of seizures, psychiatric illness, and gastrointestinal disorders.

Comorbidities do not occur evenly. Our clustering analysis reveals subgroups characterized by seizure, psychiatric disorders, and complex multisystem disorders including auditory and gastrointestinal disorders. Correlations between seizure, psychiatric disorders, and gastrointestinal disorders are validated on a sample from a second hospital. (Read the full article)

Infant postexposure prophylaxis prevents perinatal hepatitis B (HepB) virus transmission and mortality and morbidity caused by chronic HepB virus infection. The US Perinatal Hepatitis B Prevention Program (PHBPP) identifies and manages infants born to HepB surface antigen–positive women.

It presents the first estimates of the long-term costs and outcomes of postexposure prophylaxis with the PHBPP. It analyzes the effects of the PHBPP, and alternative immunization scenarios, on health and economic outcomes for the 2009 US birth cohort. (Read the full article)

Violence is a leading cause of death. The emergency department (ED) can prevent violence through proven interventions; however, these interventions are not broadly implemented. There is little evidence to inform decision-makers of the costs associated with preventing violence.

We report the costs of a brief violence prevention intervention in the ED. We highlight the economic impact of implementation, showing that brief interventions in the ED are an inexpensive way the health care system can prevent violence in adolescents. (Read the full article)

Numerous studies have demonstrated clinical benefits of medical emergency team (MET) implementation, including reductions in mortality, cardiac arrests, and critical deterioration events. No studies have evaluated the financial costs and benefits of METs.

The costs of operating an MET can plausibly be recouped with a modest reduction in critical deterioration events. Hospitals reimbursed with bundled payments could see real financial savings by reducing critical deterioration events with a MET. (Read the full article)

An increasing number of children are unvaccinated at entry into public schools, potentially endangering children who cannot be vaccinated for medical reasons and threatening herd immunity. Voluntary exemptions from immunizations vary geographically and by parental characteristics.

We find that exemption behavior is highest in peripheral areas of cities and that specific types of student populations are associated with high exemption rates. Additionally, there is spatial overlap between clusters of high personal exemption and medical exemption populations. (Read the full article)

Biotinidase deficiency (BD) might cause severe and permanent consequences. Cases detected through newborn screening and under treatment are shown to remain asymptomatic. However, some countries, including Spain, do not provide universal BD screening within their national newborn screening programs.

It provides a first estimate of the lifetime costs and health outcomes of a Spanish birth cohort with and without neonatal screening for BD. It shows that newborn screening for BD is likely to be a cost-effective use of resources. (Read the full article)

The new analysis significantly increases the annual estimate of undocumented high school students earning diplomas that has long been used in debates about immigration and special protections for immigrant youth who were illegally brought to the U.S. as children.

Dihydroartemisinin-piperaquine has shown excellent efficacy and tolerability in malaria treatment. However, concerns have been raised of potentially harmful cardiotoxic effects associated with piperaquine. The population pharmacokinetics and cardiac effects of piperaquine were evaluated in 1,000 patients, mostly children enrolled in a multicentre trial from 10 sites in Africa. A linear relationship described the QTc-prolonging effect of piperaquine, estimating a 5.90ms mean QTc-prolongation per 100ng/mL increase in piperaquine concentration. The effect of piperaquine on absolute QTc-interval estimated a mean maximum QTc-interval of 456ms (EC₅₀=209ng/mL). Simulations from the pharmacokinetic-pharmacodynamic models predicted 1.98-2.46% risk of having QTc-prolongation > 60ms in all treatment settings. Although piperaquine administration resulted in QTc-prolongation, no cardiovascular adverse events were found in these patients. Thus, the use of dihydroartemisinin-piperaquine should not be limited by this concern.

The off-label use of third generation cephalosporin (3GC) during in ovo vaccination or vaccination of newly hatched chicks, was a common practice worldwide. CMY-2-producing Escherichia coli have been disseminated among broiler production. The objectives of this study were to determine the epidemiological linkage of bla_CMY-2-positive plasmids among broilers both within and outside Japan because grandparent stock and parent stock were imported in Japan. We examined the whole genome sequences of 132 3GC-resistant E. coli isolates collected from healthy broilers during 2002-2014. The predominant 3GC-resistance gene was bla_CMY-2, which was detected in the plasmids of 87 (65.9%) isolates. The main plasmid replicon types were IncI1-I (n=21; 24.1%), IncI (n=12; 13.8%), IncB/O/K/Z (n=28; 32.2%), and IncC (n=22; 25.3%). Those plasmids were subjected to gene clustering and network analyses and plasmid multi-locus sequence typing (pMLST). The chromosomal DNA of isolates was subjected to MLST and single nucleotide variant (SNV)-based phylogenetic analysis.

MLST and SNV-based phylogenetic analysis revealed high diversity of E. coli isolates. ST429 harboring bla_CMY-2-positive IncB/O/K/Z was closely related to isolates from broiler in Germany harboring bla_CMY-2-positive IncB/O/K/Z. pST55-IncI and pST12-IncI1-I and pST3-IncC were prevalent in western Japan. pST12-IncI1-I and pST3-IncC were closely related to those detected in E. coli isolates from chicken in American continent, whereas 26 IncB/O/K/Z were related to those in Europe. These data will be useful to reveal the whole picture of transmission of CMY-2-producing bacteria in and out of Japan.

CONTEXT:

Several antiemetics have been used in children with acute gastroenteritis. However, there is still controversy over their use.

In a sprawling but nuanced examination, comedian John Oliver explained why the U.S. standardized testing system exists and the harms it creates.

Watch our live studio analysis as Fin24's Moeshfieka Botha unpacks the 2018 Budget Speech with a number of prominent political commentators and analysts.

Agency: NAT Closing Date: 5/20/2020

lawyers who has experience in Civil Practice 5-6yrs.We are looking for lawyers who has experience in Civil Practice 5-6yrs. Please share your detailed profile at email id - sk.h.analysis@gmail.com.

lawyers who has experience in Civil Practice 5-6yrs.We are looking for lawyers who has experience in Civil Practice 5-6yrs. Please share your detailed profile at email id - sk.h.analysis@gmail.com

There is a decreasing trend among the Indian students reaching the US to seek education over the years, as per a report. As per the Open Doors Report focusing on International Educational Exchange, the yearly growth of students from India, to the US…

An analysis of Covid-19 death cases by the health ministry also shows that 30% of the dead were in the 40-60 years age group, and just 7% were under 40 years.

ICMR, at present, is only using Watson for backend reporting, but it also needs to deploy it for data analysis and forecasting trends.

CSR In India 2019 is contributed by SUBAH, an enabler of CSR in India

Hi,

I was wondering if it is possible to save the coordinates of each stripe and row of the power grid 

and if it is possible to find out the effective resistance between two given points using Voltus

My goal is to built a resistance model of the power grid

Thanks

I have been using Voltus to do IR drop analysis but I got caught on one signal. It is negative. When I use:

set_pg_nets -net negsupply -voltage -5 -threshold -4.5 -package_net_name NEGSUP -force

Voltus dies with a backtrace. Looking at the beginning of the trace you see it suggests that the problem is it set maximum to -5 and minimum to 0. Is there another way to express a negative voltage supply for IR drop analysis?

The Triple Beat analysis is similar to Rapid IP2/IP3 analysis except that it uses three tones instead of two. It is used in cases where two closely-spaced small-signal inputs from a transmitter leak in to the receiver along with an intended small-signal RF input signal. (read more)

Have you ever manufactured a printed circuit board (PCB) without analyzing all the routed signal traces? Most designers will say “yes, all the time.” Trace widths and spacing are set by constraints,...

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All PCB designers know the importance of proper power delivery for successful board design. Integrated circuits need the power to turn on, and ICs with marginal power delivery will not operate reliably. Since power planes can...(read more)

Have you ever manufactured a printed circuit board (PCB) without analyzing all the routed signal traces? Most designers will say “yes, all the time.” Trace widths and spacing are set by constraints, and many designers simply don’t h...(read more)

Here is another blog in the multi-part series that aims at providing in-depth details of electromagnetic analysis in the Virtuoso RF solution. Read to learn about the nuances of port setup for electromagnetic analysis.(read more)

Malware Analysis Part I - This guide is the first part of a series of three where we begin with setting up the very foundation of a analysis environment; the analysis station. It will give the reader a quick recap in the different phases of malware analysis along with a few examples. It will then guide the reader in how to build an analysis station optimized for these phases. Along with this, the guide also introduces a workflow that will give the reader a good kick-start in performing malware analysis on a professional basis, not only on a technical level.

This article explains the technical procedure and challenges involved in extracting data and artifacts from iPhone backups.

Htcap is a web application analysis tool for detecting communications between javascript and the server. It crawls the target application and maps ajax calls, dynamically inserted scripts, websockets calls, dynamically loaded resources and some interesting elements. The generated report is meant to be a good starting point for a manual web application security audit. Htcap is written in python and uses phantomjs to load pages injecting a probe that analyzes javascript behaviour. Once injected, the probe, overrides native javascript methods in order to intercept communications and DOM changes. It also simulates user interaction by firing all attached events and by filling html inputs.