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Prediagnostic Circulating Levels of Sex Steroid Hormones and SHBG in Relation to Risk of Ductal Carcinoma In Situ of the Breast among UK Women

By cebp.aacrjournals.org
Published On :: 2020-05-01T00:05:36-07:00

Background:

Sex steroid hormones and sex hormone–binding globulin (SHBG) have been implicated in the etiology of invasive breast cancer, but their associations with risk of the precursor lesion, ductal carcinoma in situ (DCIS) of the breast, remain unclear.

Methods:

We used Cox proportional hazards regression models to estimate the associations of serum levels of estradiol (premenopausal women only), testosterone, and/or SHBG with DCIS risk among 182,935 women. After a median follow-up of 7.1 years, 186 and 531 DCIS cases were ascertained in premenopausal and postmenopausal women, respectively.

 Results:

Total and free estradiol were positively associated with risk of DCIS among premenopausal women. The HRs for the highest versus the lowest tertiles were 1.54 (1.06–2.23) and 1.72 [95% confidence interval (CI), 1.15–2.57], respectively. Among postmenopausal women, elevated levels of free testosterone (FT), and to a lesser extent, total testosterone, were positively associated with DCIS risk. The HRs for the highest versus the lowest quartiles were 1.42 (95% CI, 1.09–1.85) and 1.16 (95% CI, 0.91–1.48), respectively. Serum SHBG levels were inversely associated with risk of DCIS among postmenopausal women (HRq4 vs. q1: 0.75; 95% CI, 0.56–0.99).

 Conclusions:

This study suggests that elevated levels of estradiol are associated with increased risk of DCIS among premenopausal women, and that among postmenopausal women, elevated levels of testosterone, and particularly those of FT, are associated with increased DCIS risk, while elevated levels of SHBG are associated with reduced risk.

 Impact:

These findings may be helpful in developing prevention strategies aimed at reducing breast cancer risk among premenopausal and postmenopausal women.


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Assessing Cancer Treatment Information Using Medicare and Hospital Discharge Data among Women with Non-Hodgkin Lymphoma in a Los Angeles County Case-Control Study

By cebp.aacrjournals.org
Published On :: 2020-05-01T00:05:36-07:00

Background:

We assessed the ability to supplement existing epidemiologic/etiologic studies with data on treatment and clinical outcomes by linking to publicly available cancer registry and administrative databases.

Methods:

Medical records were retrieved and abstracted for cases enrolled in a Los Angeles County case–control study of non-Hodgkin lymphoma (NHL). Cases were linked to the Los Angeles County cancer registry (CSP), the California state hospitalization discharge database (OSHPD), and the SEER-Medicare database. We assessed sensitivity, specificity, and positive predictive value (PPV) of cancer treatment in linked databases, compared with medical record abstraction.

 Results:

We successfully retrieved medical records for 918 of 1,004 participating NHL cases and abstracted treatment for 698. We linked 59% of cases (96% of cases >65 years old) to SEER-Medicare and 96% to OSHPD. Chemotherapy was the most common treatment and best captured, with the highest sensitivity in SEER-Medicare (80%) and CSP (74%); combining all three data sources together increased sensitivity (92%), at reduced specificity (56%). Sensitivity for radiotherapy was moderate: 77% with aggregated data. Sensitivity of BMT was low in the CSP (42%), but high for the administrative databases, especially OSHPD (98%). Sensitivity for surgery reached 83% when considering all three datasets in aggregate, but PPV was 60%. In general, sensitivity and PPV for chronic lymphocytic leukemia/small lymphocytic lymphoma were low.

 Conclusions:

Chemotherapy was accurately captured by all data sources. Hospitalization data yielded the highest performance values for BMTs. Performance measures for radiotherapy and surgery were moderate.

 Impact:

Various administrative databases can supplement epidemiologic studies, depending on treatment type and NHL subtype of interest.


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The Impact of One-week Dietary Supplementation with Kava on Biomarkers of Tobacco Use and Nitrosamine-based Carcinogenesis Risk among Active Smokers

By cancerpreventionresearch.aacrjournals.org
Published On :: 2020-05-04T05:35:14-07:00

Tobacco smoking is the primary risk factor for lung cancer, driven by the addictive nature of nicotine and the indisputable carcinogenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) as well as other compounds. The integration of lung cancer chemoprevention with smoking cessation is one potential approach to reduce this risk and mitigate lung cancer mortality. Experimental data from our group suggest that kava, commonly consumed in the South Pacific Islands as a beverage to promote relaxation, may reduce lung cancer risk by enhancing NNK detoxification and reducing NNK-derived DNA damage. Building upon these observations, we conducted a pilot clinical trial to evaluate the effects of a 7-day course of kava on NNK metabolism in active smokers. The primary objective was to compare urinary total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL plus its glucuronides, major metabolites of NNK) before and after kava administration as an indicator of NNK detoxification. Secondary objectives included determining kava's safety, its effects on DNA damage, tobacco use, and cortisol (a biomarker of stress). Kava increased urinary excretion of total NNAL and reduced urinary 3-methyladenine in participants, suggestive of its ability to reduce the carcinogenicity of NNK. Kava also reduced urinary total nicotine equivalents, indicative of its potential to facilitate tobacco cessation. Plasma cortisol and urinary total cortisol equivalents were reduced upon kava use, which may contribute to reductions in tobacco use. These results demonstrate the potential of kava intake to reduce lung cancer risk among smokers.


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Radiomics Study of Thyroid Ultrasound for Predicting BRAF Mutation in Papillary Thyroid Carcinoma: Preliminary Results [FUNCTIONAL]

By www.ajnr.org
Published On :: 2020-04-09T06:30:48-07:00

BACKGROUND AND PURPOSE:

It is not known how radiomics using ultrasound images contribute to the detection of BRAF mutation. This study aimed to evaluate whether a radiomics study of gray-scale ultrasound can predict the presence or absence of B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutation in papillary thyroid cancer.

MATERIALS AND METHODS:

The study retrospectively included 96 thyroid nodules that were surgically confirmed papillary thyroid cancers between January 2012 and June 2013. BRAF mutation was positive in 48 nodules and negative in 48 nodules. For analysis, ROIs from the nodules were demarcated manually on both longitudinal and transverse sonographic images. We extracted a total of 86 radiomics features derived from histogram parameters, gray-level co-occurrence matrix, intensity size zone matrix, and shape features. These features were used to build 3 different classifier models, including logistic regression, support vector machine, and random forest using 5-fold cross-validation. The performance including accuracy, sensitivity, specificity, positive predictive value, negative predictive value, and area under the receiver operating characteristic curve, of the different models was evaluated.

 RESULTS:

The incidence of high-suspicion nodules diagnosed on ultrasound was higher in the BRAF mutation–positive group than in the mutation–negative group (P = .004). The radiomics approach demonstrated that all classification models showed moderate performance for predicting the presence of BRAF mutation in papillary thyroid cancers with an area under the curve value of 0.651, accuracy of 64.3%, sensitivity of 66.8%, and specificity of 61.8%, on average, for the 3 models.

 CONCLUSIONS:

Radiomics study using thyroid sonography is limited in predicting the BRAF mutation status of papillary thyroid carcinoma. Further studies will be needed to validate our results using various diagnostic methods.


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Assessment of Apparent Internal Carotid Tandem Occlusion on High-Resolution Vessel Wall Imaging: Comparison with Digital Subtraction Angiography [EXTRACRANIAL VASCULAR]

By www.ajnr.org
Published On :: 2020-04-09T06:30:48-07:00

BACKGROUND AND PURPOSE:

Not all tandem occlusions diagnosed on traditional vascular imaging modalities, such as MRA, represent actual complete ICA occlusion. This study aimed to explore the utility of high-resolution vessel wall imaging in identifying true ICA tandem occlusions and screening patients for their suitability for endovascular recanalization.

MATERIALS AND METHODS:

Patients with no signal in the ICA on MRA were retrospectively reviewed. Two neuroradiologists independently reviewed their high-resolution vessel wall images to assess whether there were true tandem occlusions and categorized all cases into intracranial ICA occlusion, extracranial ICA occlusion, tandem occlusion, or near-occlusion. DSA classified patient images into the same 4 categories, which were used as the comparison with high-resolution vessel wall imaging. The suitability for recanalization of occluded vessels was evaluated on high-resolution vessel wall imaging compared with DSA.

 RESULTS:

Forty-five patients with no ICA signal on MRA who had available high-resolution vessel wall imaging and DSA images were included. Among the 34 patients (34/45, 75.6%) with tandem occlusions on DSA, 18 cases also showed tandem occlusions on high-resolution vessel wall imaging. The remaining 16 patients, intracranial ICA, extracranial ICA occlusions and near-occlusions were found in 2, 6, and 8 patients, respectively, on the basis of high-resolution vessel wall imaging. A total of 20 cases (20/45, 44.4%) were considered suitable for recanalization on the basis of both DSA and high-resolution vessel wall imaging. Among the 25 patients deemed unsuitable for recanalization by DSA, 11 were deemed suitable for recanalization by high-resolution vessel wall imaging.

 CONCLUSIONS:

High-resolution vessel wall imaging could allow identification of true ICA tandem occlusion in patients with an absence of signal on MRA. Findings on high-resolution vessel wall imaging can be used to screen more suitable candidates for recanalization therapy.


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Check these 7 things carefully before you buy a new home

By batdongsan.com.vn
Published On :: 18:49 21/02/2019

Buying a new house is a very big deal, and you want to make sure that your dream home doesn’t turn into a nightmare. It’s wise to check things out before you put in an offer.


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More than 900 COVID-19 cases at Cargill plant, but governments allow it to reopen

By feedproxy.google.com
Published On :: Thu, 07 May 2020 18:05:13 +0000

Karl Nerenberg

Cargill Incorporated is the largest privately held company in the United States, and that means it is essentially a family business. 

You cannot buy Cargill shares on the Toronto, New York or any other stock exchange. The descendants of William Cargill, who founded the company in 1865 as a grain storage operation, own 90 per cent of the company.

But if it is a family business, Cargill is no mom-and-pop operation. 

The company has grown over the past century and a half into a multi-tentacled corporate behemoth, involved in everything from grain to livestock to potash to steel to transport to financial services. In 2018, Cargill and its various subsidiaries reported revenues of over $110 billion. 

Cargill has operations on five continents, in more than 70 countries, including Canada, and the company's meat-packing plant in High River, Alberta is a tiny piece of that worldwide empire. 

In this country, however, the High River plant has an extremely high profile. It is one of the epicentres of COVID-19 in Canada -- in all of North America, in fact -- with over 900 reported cases out of 2,000 employees. That's almost half the workforce.  

Two people have died in connection with the Cargill outbreak -- one, a plant worker originally from Vietnam; the other, an infected plant worker's father, who had been visiting from the Philippines.

Cargill initially resisted pleas from workers and their union to close the plant, but finally relented, in late April. After only two weeks, it hastily reopened, on Monday, May 4, giving the largely immigrant workforce the Hobson's choice of either going back to a potentially fatal workplace or losing their jobs. 

Neither the workers, nor their union think the plant has become safe. 

The union, the United Food and Commercial Workers (UFCW), has gone to court to force a shutdown, until Cargill can absolutely guarantee safe and healthy conditions for all employees. 

The UFCW does not think the notoriously low-paid plant workers should have to risk their lives to fatten the balance sheet of a U.S.-based transnational corporation that ranks number 15 on the Fortune 500. 

Kenney and Trump on the same wavelength

Alberta Premier Jason Kenney has a different view from that of the union and the workers it represents. 

The premier, and former Harper Conservative government cabinet minister, appropriates a concept meant to describe access to necessary basic foodstuffs we all need for sustenance – food security – and applies it to the much different situation of the High River plant. The Cargill workers have to do their part, the Alberta premier argues, to ensure food security for Canadians. 

The truth is that Canada's food security does not depend on meat from Cargill or any other commercial operation. 

If our local butcher runs out of hamburger for the barbecue, we all have other nutritious options. There are, for instance, the protein-packed pulses -- chickpeas, lentils and the like -- that farmers in Saskatchewan grow in great quantity. 

In the U.S., as in Canada, COVID-19 has been particularly hard on the meat-packing industry, forcing more than 20 plant closures, and causing meat shortages on grocery shelves. Some fast food chains have even had to take hamburgers off the menu. 

Corporate executives in the meat industry told U.S. President Trump that they were reluctant to reopen their U.S.-based plants for fear of lawsuits. The U.S. is a far more litigious country than Canada. 

The president's response was to give the corporations cover, by invoking the U.S. Defense Protection Act (DPA). In effect, the president is forcing the corporations to reopen their plants. 

The purpose of the DPA is to allow a president to harness the resources of private industry to serve public needs in time of war or national emergency. Many have urged Trump to invoke the act to assure production of personal protective equipment for front-line workers during the pandemic, but he has refused. 

Now, Trump is using the extraordinary powers of the DPA to force workers back to dangerous plants, while shielding their bosses from responsibility.

As for the High River Cargill plant workers, they fall under provincial labour jurisdiction. And the Alberta premier has already indicated he will not lift a finger to protect them. But there might be a way that federal authorities could step in.

Jagmeet Singh urges Trudeau government to act

In Canada, it is the federal government that has authority over food safety, and NDP Leader Jagmeet Singh believes the Trudeau team should assertively use that power to protect the Cargill workers.

Singh put the question to Deputy Prime Minister Chrystia Freeland during the House of Commons' weekly face-to-face session on Wednesday, May 6.

"Food safety and worker safety cannot be divorced," Singh told the House. "Will the government ensure that the Cargill workers are in safe work conditions?"

Freeland, in a manner all-too-typical of Liberal politicians, dissimulated, offering sympathy but no action.

"The member opposite is quite right that where the federal government has particular authority in food processing is to guarantee the safety of the foods processed there for Canadians to eat," she said, and then expressed some vague sentiments of concern. "When it comes to Cargill and food processing, I agree with the member opposite that it's something we all need to be particularly concerned about, and we have been."

The NDP leader was not satisfied. 

"Will the government commit to using the authority that it has under food safety to ensure that workers are also safe, because there's no way that food can truly be safe if workers are in dangerous conditions and if workers are contracting COVID-19?" Singh asked, adding: "If workers are dying, the food can't be safe."

Freeland would not budge. The Trudeau government wants to get credit for caring, without pushing the envelope in dealing with the most prickly and confrontational provincial government in the country, Alberta's. 

"I think we all understand there is a very clear difference between the duty to inspect food which is produced and to ensure that that food is safe for Canadians, and even more sacred duty to ensure that workers are working in safe conditions," Freeland answered. "We take both of those extremely seriously and we are aware what falls specifically in our jurisdictions. Having said that, we care very much about all Canadian workers." 

Freeland's assertion that responsibility for the safety of a product that consumers eat does not include making sure a processing plant is not an active breeder of a deadly virus reflects a narrow and limited understanding of the federal role. 

There is no evidence of food borne transmission of COVID-19, or of food packaging carrying the virus, according to authorities in both the U.S. and Canada.

But experts have not always got it right about COVID-19 since the outbreak at the beginning of this year. At this stage, all we know for sure is that there remain many unanswered questions about it.

'The worst company in the world'

What is not in doubt is the kind of company we're dealing with. 

Not too long ago the U.S. environmental organization Mighty Earth undertook a study of the social and environmental impact of Cargill's operations and issued a report they called "The Worst Company in the World."

The report opens by stating "when it comes to addressing the most important problems facing our world, including the destruction of the natural environment, the pollution of our air and water, the warming of the globe, the displacement of Indigenous peoples, child labor, and global poverty, Cargill is not only consistently in last place, but is driving these problems at a scale that dwarfs their closest competitors."

The report details how Cargill has become more powerful than governments and has betrayed repeated promises to adhere to high environmental standards. 

"Nowhere is Cargill's pattern of deception and destruction more apparent than in its participation in the destruction of the lungs of the planet, the world's forests. Despite repeated and highly publicized promises to the contrary, Cargill has continued to bulldoze ancient ecosystems, sometimes within the bounds of lax laws -- and, too often, outside those bounds as well."

With the advent to power of virulently anti-environmental Trump in the U.S. and Jair Bolsonaro in Brazil, there is now virtually no limit, Mighty Earth says, to Cargill's capacity to ravage rainforests, savannahs and other vital habitats. 

Mighty Earth cites many examples. 

One of those is that of "the Gran Chaco, a 110-million-hectare ecosystem spanning Argentina, Bolivia, and Paraguay." 

This ecosystem "is one of the largest remaining continuous tracts of native vegetation in South America, second in size only to the Amazon rainforest. These forests are home to vibrant communities of Indigenous Peoples … who have depended on and coexisted with the Chaco forest for millennia."

Cargill, the report tells us, is now actively endangering both the people and other inhabitants of the Gran Chaco to produce a cash crop -- soy -- that feeds the animals which become Big Macs and Whoppers.

"Once the impenetrable stronghold of creatures like the screaming hairy armadillo, the jaguar, and the giant anteater, Cargill has infiltrated the Gran Chaco, bulldozing and burning to make way for vast fields of genetically modified soy."

Mighty Earth also documents Cargill's use of violence to subdue Indigenous peoples, its exploitative labour practices, including child labour, and its predatory practices that have driven competitors out of certain businesses. 

This is the company that Jason Kenney says must be allowed to operate, uninhibited by health concerns, to assure our food security. 

If you believe that, you might also believe that injecting bleach into your veins can cure COVID-19, or that, as many opinion leaders in the U.S. say, it is necessary to accept that thousands must die in the interests of what they call the economy. 

The owners of Cargill are not personally offering to sacrifice their lives. They are offering their employees' lives instead.

Karl Nerenberg has been a journalist and filmmaker for more than 25 years. He is rabble's politics reporter.

Image: Alberta Newsroom/Flickr

 


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Bandai Namco announces RPG Scarlet Nexus for Xbox Series X and Xbox One

By feedproxy.google.com
Published On :: Thu, 07 May 2020 17:20:11 GMT

Bandai Namco has announced a new RPG, Scarlet Nexus, for the Xbox Series X and Xbox One. It will feature Smart Delivery. A release date was not announced. 

"The next generation of video game home consoles lets the development team realize the full potential of Scarlet Nexus," said producer Keita Iizuka. "Players can expect visuals and psychic battles with high resolution and frame rate along with fully interactive real-time battles with dynamic animation. Utilizing Smart Delivery on Xbox Series X also means players can enjoy the best version of Scarlet Nexus regardless of whether they are playing on the next generation with Xbox Series X or Xbox One."

Bandai Namco America senior brand manager Stephen Akana added, "Scarlet Nexus aims to change the way gamers view Japanese RPGs with a powerful futuristic aesthetic as well as a streamlined combat system that balances fast-paced action with strategic planning. Lead by an extremely talented team at Bandai Namco Studios, including members from fan-favorite title Tales of Vesperia, Scarlet Nexus combines years of game development experience with the excitement and creative freedom of the power behind the next generation of home console systems."

View the announcement trailer below:

Here is an overview of the game:

Scarlet Nexus takes place in the far distant future, where a psionic hormone was discovered in the human brain, granting people extra-sensory powers and changed the world as we knew it. As humanity entered this new era, deranged mutants known as Others began to descend from the sky with a hunger for human brains. Impervious to conventional weapons, those with acute extra-sensory abilities, known as psionics, were our only chance to fight the onslaught from above and preserve humanity. Since then, psionics have been scouted for their talents and recruited to the Other Suppression Force, humanity’s last line of defense.

In Scarlet Nexus, players will take on the role of Yuito Sumeragi, armed with a talent in psycho-kinesis, and explore the futuristic city of New Himuka and uncover the mysteries of a Brain Punk future caught between technology and physic abilities. With these psycho-kinetic powers, the world becomes an important ally. Lift, break, and hurl pieces of the environment to build attack combos and lay waste to enemies.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/443425/bandai-namco-announces-rpg-scarlet-nexus-for-xbox-series-x-and-xbox-one/


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Monster-fighting action game Scarlet Nexus is coming to PC

By feedproxy.google.com
Published On :: Fri, 08 May 2020 20:48:08 +0000

This anime-style action game about fighting off the creatively-named “others” was one of the many trailers we peeped during Xbox’s big reveal real yesterday. Bandai Namco have announced that Scarlet Nexus is actually coming to PC as well, so we’ll get to do a bit of monster butt-kickin’ too. Is that an evil bouquet of […]


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  • PC Game News
  • Bandai Namco
  • Bandai Namco Entertainment
  • Bandai Namco Studios
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Captured carbon dioxide could be used to help recycle batteries

By www.newscientist.com
Published On :: Mon, 13 Jan 2020 16:00:43 +0000

We have to capture carbon dioxide to slow climate change, but instead of simply burying it we could first use it to extract useful metals from old electrical equipment


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Can we quit cobalt batteries fast enough to make electric cars viable?

By www.newscientist.com
Published On :: Wed, 19 Feb 2020 14:13:19 +0000

Electric cars depend on cobalt as a key ingredient in their batteries, but a new analysis reveals we may run out by 2030, while car firm Tesla is moving to other types of battery in China


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AI could help make fast-charging, long-lasting electric car batteries

By www.newscientist.com
Published On :: Wed, 19 Feb 2020 16:00:57 +0000

Artificial intelligence is helping optimise the recharging batteries in electric vehicles, balancing speed while maximising lifespan


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Flying cars remain science fiction as 24 teams fail to claim $1m prize

By www.newscientist.com
Published On :: Mon, 02 Mar 2020 16:56:26 +0000

Flying car hopefuls were meant to take off at a competition on a NASA airbase, but no team claimed the prize after a string of crashes and no-shows


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Samsung Hops on the Finance Train, Announces New Debit Card

By feedproxy.google.com
Published On :: Fri, 08 May 2020 16:00:00 +0000

Big Tech is coming for your transaction data.


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UFC 249: UFC issue statement on Jacare Souza's positive coronavirus test, axe Hall bout

By feedproxy.google.com
Published On :: Sat, 09 May 2020 07:33:00 +0100



The UFC is set to return to return to action this weekend.


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Premier League clubs scared 50 players could revolt and put stop to Project Restart plans

By feedproxy.google.com
Published On :: Sat, 09 May 2020 00:00:00 +0100



Premier League clubs are fearful that a significant number of first-team stars may refuse to return to action if the league's Project Restart plan gets the green light.


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Driverless cars and the other biggest sci and tech fails of the decade

By www.newscientist.com
Published On :: Wed, 18 Dec 2019 18:00:00 +0000

Whether it was driverless cars, lab-grown meat or faster-than-light neutrinos, some things just didn't live up to the hype in the 2010s


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Earth has acquired a brand new moon that's about the size of a car

By www.newscientist.com
Published On :: Wed, 26 Feb 2020 16:24:44 +0000

Astronomers have spotted an asteroid that has been captured by Earth's gravity, making it a temporary mini-moon. It will probably fly away again in April


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The moon is emitting carbon, raising questions about how it was formed

By www.newscientist.com
Published On :: Wed, 06 May 2020 19:00:48 +0000

The leading hypothesis for how the moon formed involves a collision between a Mars-sized object and Earth that would have boiled away elements like carbon, making its discovery on the moon a mystery


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Video Friday: Kuka's Robutt Is a Robot Designed to Assess New Car Seats

By feedproxy.google.com
Published On :: Fri, 25 Oct 2019 18:10:00 GMT

Your weekly selection of awesome robot videos


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Ocarina Of Time's 'Saria's Song' Performed On 24 Partially Empty Wine Bottles

By feedproxy.google.com
Published On :: Fri, 08 May 2020 11:00:11 -0500

This is a video of musician and Instagrammer nathanleighsays performing Saria's Song (the Lost Woods theme) from The Legend Of Zelda: Ocarina Of Time on 24 partially empty wine bottles. How about that! Of course this would never work at my aunt's house on account of the bottles all playing the same note because they're empty. And the cats! Soooooo many cats. Keep going for the performance as well as a clip of Link learning Saria's song from the actual game.


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FIFA 20 TOTS La Liga Confirmed with New Team of the Season Ultimate Team Cards

By www.dailystar.co.uk
Published On :: Fri, 8 May 2020 23:50:00 +0000



FIFA 20 Team of the Season So Far Premier League Squad is now live and features Lionel Messi, Luis Suarez and Antoine Griezmann.


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RPGCast – Episode 316: “rgpCARST”

By feedproxy.google.com
Published On :: Sat, 09 Aug 2014 18:46:01 +0000

This week Anna is Style Savvy. Chris is Monster Hunting. Quin gets Elite and dangerous (complete with flightstick). Square Enix gets sued. And Europe gets...


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RPGCast – Episode 425: “Licking His Cartridge”

By feedproxy.google.com
Published On :: Sat, 13 May 2017 19:04:08 +0000

Kelley gets a Switch. Chris gets a GM mode. Anna Marie gets a new world of secrets. And Alice gets more football to manage? What?


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RPGCast – Episode 469: “DoesHeHaveaScarf.com”

By feedproxy.google.com
Published On :: Sat, 14 Jul 2018 21:10:34 +0000

This show marked the beginning of the Donut Wars. Why they began, historians disagree. All that is known is that the destruction left in their...


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RPGCast – Episode 473: “There’s A Car In Our Garden”

By feedproxy.google.com
Published On :: Sat, 18 Aug 2018 20:07:47 +0000

While Anna Marie, Chris, and Kelley play the new WoW expansion, Josh dabbles in film criticism. Then Nintendo has a Blizzard come in. Finally, some people decide to start dating inanimate objects.


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Coronavirus in Scotland: Testing strategy to be reviewed amid care worker reports

By feedproxy.google.com
Published On :: Fri, 08 May 2020 10:41:30 +0100

THE SCOTTISH Government is reviewing its Covid-19 testing strategy after the Deputy First Minster has been left “frustrated” by reports home care workers have been told to travel to the other side of Scotland for tests.


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Stella McCartney goes wild to drive home animal-free message

By www.theguardian.com
Published On :: 2020-03-02T13:20:09Z

Paris show features wildlife costumes to emphasise the label’s planet-friendly ethos

The singer Janelle Monáe and actor Shailene Woodley were in the front row, but two rabbits, a fox, a horse, two cows and a crocodile stole the show. People in lifesize animal costumes, of the kind more usually seen at theme park parades than at Paris fashion week, joined models for the finale of Stella McCartney’s show, swinging their new-season handbags and posing for the cameras.

The optics were fun, but the message was serious – that there are animals on almost every catwalk, it’s just that they are usually dead. The half-moon shoulder bag carried jauntily by a brown cow here was made from a vegan alternative to leather, while other bags were created from second-life plastic.

Continue reading...


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Bat 'super immunity' may explain how bats carry coronaviruses, study finds

By www.sciencedaily.com
Published On :: Wed, 06 May 2020 13:36:14 EDT

Researchers have uncovered how bats can carry the Middle East respiratory syndrome (MERS) coronavirus without getting sick -- research that could shed light on how coronaviruses make the jump to humans and other animals.


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Position statement addresses difficult issue: allocating scare resources in COVID-19 era

By www.sciencedaily.com
Published On :: Wed, 06 May 2020 16:22:01 EDT

The COVID-19 pandemic has placed unprecedented pressure on societies worldwide, given the pandemic's rapid, often deadly spread. In health care, the pandemic has raised the pressing question of how society should allocate scarce resources during a crisis.


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Skin-to-skin 'kangaroo care' shows important benefits for premature babies

By www.sciencedaily.com
Published On :: Thu, 07 May 2020 10:24:34 EDT

A world-first study has demonstrated significant benefits to a premature baby's heart and brain function when held by the parent in skin-to-skin contact. Parent-infant skin-to-skin care (SSC) or kangaroo care, started in the late 1970s in Columbia when incubators to keep babies warm were not available. It is now widely recognized as a beneficial component of holistic care provided for pre-term infants.


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Tracee Ellis Ross: 'As a kid, singing was too scary a dream'

By www.theguardian.com
Published On :: 2020-05-02T08:00:18Z

She’s acted, modelled, worked with Kanye West and Drake. But the Black-ish star didn’t dare follow her mother, Diana Ross – until now

There is a strange noise coming from Tracee Ellis Ross’s Los Angeles garden. Hang on, she says, looking away from her computer screen to the window with an alarmed expression. “I’m just going to go check that out. Stand by!”

If this were a horror movie, then the stylish woman disappearing into the distance would never come back. But it isn’t a horror movie, it’s a Zoom interview, and Ross, a Golden Globe-winning actor best known for her role in the US sitcom Black-ish, is talking to me from the sunny living room of her home. Or at least she was; right now, I’m staring at a fiddle-leaf fig tree and a comfortable-looking couch.

Continue reading...


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Oscars on demand: will the Academy be able to put the streaming genie back in the bottle?

By www.theguardian.com
Published On :: 2020-04-29T15:25:40Z

With cinemas closed and major titles delaying their release, the Academy has changed its rules to welcome some streaming titles. Will they regret it?

‘What about the Oscars?” might not be the question at the top of your mind as you consider the manifold uncertainties raised by the coronavirus pandemic. A Hollywood awards ceremony scheduled for the end of February 2021, one might think, has fewer immediate concerns than most cultural institutions do right now. Yet panic has been rising within the Academy: the show itself may go on, but with cinemas closed for the foreseeable future and dozens of major titles either rescheduling or indefinitely delaying their release dates, will it have have enough standout films to celebrate?

For some weeks now, the joke around the industry has been that Leigh Whannell’s hit psychothriller The Invisible Man – one of the few popular and critical successes to be released in the year’s early months – may as well collect its gongs now. But a crucial rule change announced on Tuesday by Academy CEO Dawn Hudson and president David Rubin has ensured that it will face some competition after all, even if its rivals never see the inside of a cinema.

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Why are the Oscars still so white? – podcast

By www.theguardian.com
Published On :: 2020-02-07T03:00:00Z

Following a strikingly white and male list of Bafta nominees, this year’s Academy Awards shortlists are barely more diverse. It’s a chronic problem in an industry running out of excuses for its slow pace of change. Lanre Bakare examines why the Oscars are still so white. Plus: Joan E Greve on a hectic week of US politics

When the lists of nominees for the major film awards in 2020 were announced, there was, once again, a glaring anomaly. Not a single person of colour was nominated in the Bafta acting categories, while the Oscars managed only Cynthia Erivo for her part in Harriet.

It is an issue that the industry is well aware of: in 2015, the ceremony saw #OscarsSoWhite trending on Twitter, while actors such as Eddie Murphy were rebuking the academy from the stage back in the 1990s. So what explains the glacial pace of change? Guardian arts and culture correspondent Lanre Bakare tells Anushka Asthana that there have been plenty of false dawns over the years in the quest for greater diversity.

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Trump mocks Oscar win for Parasite: 'What the hell was that about?' – video

By www.theguardian.com
Published On :: 2020-02-21T09:27:18Z

Donald Trump takes a jab at the South Korean film Parasite, best picture at this year's Oscars, telling supporters in Colorado that the US has 'enough problems with South Korea', and: ‘Can we get Gone With the Wind back?’ He also dismisses Brad Pitt, who – during his Oscars speech said his 45-second slot was more than John Bolton received at the US president's Senate impeachment trial. Trump calls the actor a 'little wise guy'

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Bill Maher Says Republicans 'Don't Care' About Tara Reade's Biden Allegations, Challenges Timing of Sexual Assault Claims

By www.newsweek.com
Published On :: Sat, 09 May 2020 09:34:34 -0400

Bill Maher said Republicans "don't care" about Tara Reade's sexual assault allegations, saying such claims are simply used as a "unilateral weapon" against Democrats.


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Vande Bharat Mission: Air India flight carrying Indian nationals from Dhaka arrives in Delhi

By in.news.yahoo.com
Published On :: Sat, 09 May 2020 08:11:44 -0500

New Delhi, May 09 (ANI): An Air India flight carrying 129 passengers from Dhaka, Bangladesh has landed at Delhi airport. The stranded Indian nationals are being brought back to the country through government’s initiative, ‘Vande Bharat Mission’.



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UK has enough intensive care units for coronavirus, expert predicts

By www.newscientist.com
Published On :: Wed, 25 Mar 2020 13:43:16 +0000

Neil Ferguson, whose modelling has informed the UK's coronavirus strategy, says that the need for intensive care beds will come close to, but not exceed, national capacity


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Wuhan’s covid-19 crisis: Intensive care doctors share their stories

By www.newscientist.com
Published On :: Wed, 15 Apr 2020 18:00:00 +0000

Three doctors reveal what it was like at the heart of Hubei province’s coronavirus crisis, as the epidemic peaked in Wuhan and spread elsewhere


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The secret lives of parasites – from killers to healthcare heroes

By www.newscientist.com
Published On :: Fri, 17 Apr 2020 16:21:40 +0000

Parasites are a huge global treat to human life, but some of them could actually help us treat disease. Parasitologist Charlotte Evans explores the secret lives of these frightening organisms.


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Andrew Garfield, Michael Shannon and Other 2017 Oscar Nominees Respond to Academy Nod

By blogs.wsj.com
Published On :: Tue, 24 Jan 2017 18:28:06 +0000

Some of this year's Oscar nominees, including Andrew Garfield and Michael Shannon, react to news of their nomination.


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Iranian Oscar-Winning Director Says He’ll Skip Awards in Protest

By blogs.wsj.com
Published On :: Mon, 30 Jan 2017 05:12:03 +0000

Oscar-winning Iranian director Asghar Farhadi said Sunday he will not attend the Academy Awards on Feb. 26, “even if exceptions were to be made for my trip,” as protests over President Donald Trump's immigration ban spread to Hollywood's biggest global stage.


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Ranked! Top 10 F1 cars that never won a Grand Prix

By in.news.yahoo.com
Published On :: Sat, 09 May 2020 08:25:38 -0500


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The 25 Scariest Games of This Generation

By www.ign.com
Published On :: Sat, 9 May 2020 03:01:15 +0000

This generation saw a boom in quality horror games and we're counting down the 25 scariest.


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Invasive 'comb' jellyfish cannibalize their young when food is scarce, study reveals

By www.foxnews.com
Published On :: Fri, 08 May 2020 22:16:52 GMT

An strange, invasive species of jellyfish in Europe eats its own young when food is low, a new study claims.


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Lil Wayne's music was always being leaked through CDs he left in his car

By www.music-news.com
Published On :: Sat, 09 May 2020 11:16:00 +0100

The rapper detected the source of where his music was being released from - and tracked it down to when he would leave CDs in his car at the car wash.


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