Toni Tripp-Reimer
Jan 1, 2001; 14:
Articles

Here is some insight into the first ever blockchain advert

The SAS Universal Viewer displays null values appropriately as blanks for XPT files. However, when you select Table ? Save As and save an XPT file as either an XML or CSV file, the SAS Universal Viewer con

(University of Southern Denmark) Investing in the future: Researchers show how cannibalism among the invasive comb jelly enables adults to survive severe conditions at the edge of their ecological range with implications for the use and evolutionary origins of cannibalism.

Toni Tripp-Reimer
Jan 1, 2001; 14:
Articles

No abstract

Insulin is first produced in pancreatic β-cells as the precursor prohormone proinsulin. Defective proinsulin processing has been implicated in the pathogenesis of both type 1 and type 2 diabetes. Though there is substantial evidence that mouse β-cells process proinsulin using prohormone convertase 1/3 (PC1/3) then prohormone convertase 2 (PC2), this finding has not been verified in human β-cells. Immunofluorescence with validated antibodies reveals that there was no detectable PC2 immunoreactivity in human β-cells and little PCSK2 mRNA by in situ hybridization. Similarly, rat β-cells were not immunoreactive for PC2. In all histological experiments, PC2 immunoreactivity in neighbouring α-cells acts as a positive control. In donors with type 2 diabetes, β-cells had elevated PC2 immunoreactivity, suggesting that aberrant PC2 expression may contribute to impaired proinsulin processing in β-cells of patients with diabetes. To support histological findings using a biochemical approach, human islets were used for pulse-chase experiments. Despite inhibition of PC2 function by temperature blockade, brefeldin-A, chloroquine, and multiple inhibitors that blocked production of mature glucagon from proglucagon, β-cells retained the ability to produce mature insulin. Conversely, suppression of PC1/3 blocked processing of proinsulin but not proglucagon. By demonstrating that healthy human β-cells process proinsulin by PC1/3 but not PC2 we suggest that there is a need to revise the longstanding theory of proinsulin processing.

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

James A. Levine
Nov 1, 2011; 60:2667-2668
Editorials

In the UK, junk food advertising is banned on children’s TV - but manufactures are still able to target children in other ways.  A recent report from the WHO  "Tackling food marketing to children in a digital world", takes a look at the issue. In this podcast we're joined by João Breda, programme manager for nutrition physical activity and...

Presentación del reporte que refleja el contenido de encuentros del grupo de estudio sobre la migración México-Estados Unidos convocado por El Colegio de México y el Migration Policy Institute (MPI).

Poverty and poor or non-existent health insurance coverage might worsen the effects of heart failure, the American Heart Association said Thursday.

New York City has been the epicenter of the COVID-19 outbreak in the United States, with immigrant populations in areas such as the Bronx "disproportionately" affected, a commentary in JAMA Internal Medicine says.

Americans across a large portion of the Northeast are in the midst of an unusually late-season blast of Arctic air courtesy of the polar vortex.

For loners, recluses, and other solitary types such as myself, sheltering-in-place feels natural and normal. However scary other aspects of this pandemic might be, for us, this aspect isn’t. Working...

More than 1 million Tajiks migrate to Russia every year—a sizeable outflow for a country of about 9 million people. These high levels of emigration have had major effects for Tajikistan, especially in the generation of remittances that help lift everyday Tajiks out of poverty but have also made the country increasingly dependent on Russia. This article explores challenges faced by Tajik migrants in Russia and the effects of emigration on Tajikistan’s economy and society.

La migración entre México y Estados Unidos ha cambiado dramáticamente en los últimos años, pero las políticas y la retórica política en ambos países no se han actualizado a este contexto a la misma velocidad. Este reporte explora esta nueva realidad migratoria y cómo los dos gobiernos podrían trabajar juntos para abordar los desafíos de políticas públicas que tienen en común.

So, you wanted to follow this nice website for new content, but it doesn’t have an RSS feed yet? Don’t…

Advertising -- Psychological aspects.

Poverty.

Over 3,300 advertising items and publications dating from 1850 to 1920, illustrating the rise of consumer culture and the birth of a professionalized advertising industry in the United States.

London : Macmillan, 1897.

London : Macmillan, 1886.

[London] : [publisher not identified], [2019]

In the varied and vital roles they play – as farmers, farm workers, entrepreneurs, caregivers and community leaders – rural women form the backbone of rural societies. Almost everywhere, they make crucial contributions to food production, food processing and marketing. Indeed, because women produce, process and prepare much of the food available, they are critical to the food security of [...]

In a written decision released Thursday, a panel of three appeal court judges said the judge who granted the award to McCaw North Drilling and Blasting Ltd. misinterpreted a clause in the contract for the cleanup.

Para Roberto Ramírez de Costa Rica, servir a Dios en misiones ha sido un paso de fe tras otro. Perdió su trabajo, su estabilidad financiera e incluso a su prometida, pero ganó mucho más.

Google soon will require all advertisers to prove their legitimacy, regardless of the advertising content. All advertisers will have to verify their identity, submit personal IDs and business verification documents, said John Canfield, Google's director of product management for ads integrity. Google began requiring political advertisers to verify their identity in the runup to the 2018 elections.

Ralph Goodale says building water diversion conduits in Lake Diefenbaker could help grow Saskatchewan's economy and environment but it comes with a $3 billion price tag.

CNA Staff, Apr 23, 2020 / 01:30 pm (CNA).- Iran has sentenced a 21 year-old Christian woman to prison and lashing for “disturbing public order,” after she protested the destruction of a passenger jet by the military.

Mary (Fatemeh) Mohammadi, a 21 year-old Iranian convert to Christianity, was arrested on Jan. 12 after taking part in anti-government protests that followed the shooting down of a passenger jet, Ukrainian Air Flight 752, by the Iranian Revolutionary Guard (IRG).  Iran announced several days after the incident that the IRG mistakenly shot the plane down, resulting in the deaths of all 176 people on board the flight.

In an Instagram post on Wednesday, Mohammadi said her sentence of three months and one day in prison is suspended for one year. She was also sentenced to 10 lashes.

Mohammadi said she has been tortured in prison and suffered “terrible conditions” for “protesting against the slaughter of human beings.” She said she did not appeal her sentence “because the appeal courts have turned into affirmative tribunals.” 

The U.S. Commission on International Religious Freedom (USCIRF) tweeted a condemnation of Mohammadi’s sentencing on Wednesday, saying that “No peaceful activist should be targeted on the basis of their religious beliefs.”

President Trump highlighted her case in his remarks at the National Prayer Breakfast on Feb. 6, saying that she “was seized and imprisoned in Iran because she converted to Christianity and shared the Gospel with others.

U.S. Secretary of State Mike Pompeo also discussed Mohammadi’s case in a Feb. 12 interview with Tony Perkins on Washington Watch. Perkins is also the chair of USCIRF.

Pompeo said the U.S. was “deeply concerned” of reports of Mohammadi’s arrest, and said she was “targeted by the regime because she made the choice to convert to Christianity.”

According to the All Party Parliamentary Group for International Freedom of Religion or Belief, Mohammadi was “physically and emotionally abused during her arrest and transfer to Qarchak prison,” and was questioned about her faith at her hearing.

Correction: This article originally stated that Mohammadi was one of a group of survivors of religious persecution who met with President Trump last July at the White House, as reported in the Christian Post. It was a different Iranian Christian, Dabrina Bet Tamraz, who met with Trump, not Mohammadi.