pot Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3495-3506DOI: 10.1039/D4MD00275J, Research Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. RussellThe optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3469-3476DOI: 10.1039/D4MD00422A, Research Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hugo Kocek, Dominika Chalupská, Milan Dejmek, Alexandra Dvořáková, Michala Zgarbová, Michal Šála, Karel Chalupský, Petra Krafčíková, Tomáš Otava, Matúš Drexler, Eliška Procházková, Blanka Klepetářová, Milan Štefek, Ján Kozic, Helena Mertlíková-Kaiserová, Evzen Boura, Jan Weber, Radim NenckaSARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot Design, synthesis and mechanistic insights into triclosan derived dimers as potential anti-plasmodials By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00494A, Research Article Shekhar, Shefali Chowdhary, Joel Mosnier, Isabelle Fonta, Bruno Pradines, Vipan KumarIn pursuit of novel anti-plasmodial agents, a library of triclosan-based dimers both with and without a 1H-1,2,3 triazole core were designed, synthesized and evaluated in order to achieve a multitargeted approach.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00562G, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Andreas Simoens, Andreas Dejaegere, Marthe Vandevelde, Christian V. StevensFlow chemistry allows for the rapid and clean synthesis of therapeutically relevant tryptamines in good yields, including the large scale drug rizatriptan.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot Ligand-centred phenotype-driven development of potent kinase inhibitors against oesophageal cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00579A, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Cecilia C. Ayala-Aguilera, Yang Ge, Álvaro Lorente-Macías, Benjamin N. Jones, Catherine Adam, Neil O. Carragher, Asier Unciti-BrocetaA ligand-centred strategy combined with phenotypic screening was used to develop novel antiproliferative inhibitors against oesophageal cancer and identified a lead compound that induces potent anticancer activity and inhibits Aurora kinase A.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot Synthesis and anti-tumor activity of new benzofuran-based chalcone derivatives as potent VEGFR-2 inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00621F, Research ArticleChunfei Zhang, Yixin Liu, Xiao Zhang, Chunping Wan, Zewei MaoA series of novel benzofuran-based chalcone derivatives could be considered as potent VEGFR-2 inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot S-MGBs bearing amidine tail groups are potent, selective antiplasmodial agents By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00619D, Research Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Marina Perieteanu, Tayner Rodriguez Garzon, Leah M. C. McGee, Abedawn I. Khalaf, Colin J. Suckling, Rebecca Beveridge, Vicky M. Avery, Fraser J. Scott25 S-MGBs, including those bearing an amidine tail group, were investigated for their antiplasmodial, in vitro activity against 3D7 and Dd2 strains of P. falciparum. Several potent, and selective, hit compounds were identified.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot Design and synthesis of (E)-3-benzylideneindolin-2-one derivatives as potential allosteric inhibitors of Aurora A kinase By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00373J, Research ArticleYongLai Jiao, Jie Zhong, Jin-Fang Xu, Shaobo Ning, Taigang Liang, Mingzhu Zhao, Jian ZhangThe mitotic kinase Aurora A, a pivotal regulator of cell cycle, is overexpressed in various cancers and has emerged as one of the most promising targets for anticancer drug discovery....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot Investing in companies with ‘indicorn’ potential By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:01:00 +0530 Titan Capital backs seed-stage companies with potential to reach ₹100 crore revenue within five years Full Article Emerging Entrepreneurs
pot Brand expertise and heritage bubbling in a moka pot By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 18:32:59 +0530 Lessons from European brands that have won consumers’ mindspace for long years Full Article Marketing
pot Spotlight on ways to end violence against children By www.thehindubusinessline.com Published On :: Sun, 03 Nov 2024 19:24:25 +0530 Full Article Pulse
pot IIT Delhi’s annual Open House shows AI’s potential use in health care, tech By www.thehindu.com Published On :: Sun, 10 Nov 2024 00:34:59 +0530 Full Article Delhi
pot M.S. Swaminathan, the scientist who sliced potatoes By www.thehindu.com Published On :: Thu, 05 Oct 2023 12:14:12 +0530 Not once did the ‘Rice Man of India’ keep his publisher waiting Full Article Society
pot After snails, farmers in Idukki battling spotted locust infestation; experts say change in climate pattern could be a cause By www.thehindu.com Published On :: Fri, 18 Oct 2024 20:05:24 +0530 Plantations of over 70 farmers severely affected by the spotted locust infestation at Konnathady and Vathikudy panchayats Full Article Agriculture
pot ‘India is a bright spot in global smartphone scene’ By www.thehindu.com Published On :: Thu, 09 Jun 2016 00:00:00 +0530 Full Article Mumbai Capital
pot The cellular Potts model on disordered lattices By pubs.rsc.org Published On :: Soft Matter, 2024, 20,8337-8352DOI: 10.1039/D4SM00445K, Paper Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hossein Nemati, J. de GraafExtending the cellular Potts model to disordered Voronoi lattices reduces artifacts observed on regular lattices. An order–disorder transition is observed as a function of surface tension on the disordered lattice and the regular lattices.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot Celebspotting: Lakme Fashion Week Winter/Festive 2016 By www.thehindu.com Published On :: Mon, 29 Aug 2016 16:02:46 +0530 Who modelled for whom during this year's edition of Lakme Fashion Week's Winter collection? Full Article Fashion
pot Editorial. Biden’s late withdrawal leaves the Democrats in a spot By www.thehindubusinessline.com Published On :: Wed, 24 Jul 2024 21:29:38 +0530 The Democrats now have to decide afresh a new candidate to replace Biden and, as a result, their overall response to Trump whose worldview is diametrically the opposite to theirs Full Article Editorial
pot ‘Karthika Masa Laksha Deepotsavam’ concludes on a grand note in Nellore By www.thehindu.com Published On :: Sun, 10 Nov 2024 19:15:01 +0530 501 couples participate in the ‘Veera Venkata Satyanarayana Swamy Vratam’ organised on the occasion Full Article Andhra Pradesh
pot Good potential for cosmetic, textile, food processing sectors in Andhra Pradesh: South Korean diplomat By www.thehindu.com Published On :: Tue, 12 Nov 2024 20:30:19 +0530 South Koreans are familiar with Andhra Pradesh and since Kia Motors is here, more Korean companies may wish to come too, says Sangwoo Lim Full Article Andhra Pradesh
pot Spotlighting the work of the Economics Nobel winners By www.thehindu.com Published On :: Thu, 17 Oct 2024 01:51:00 +0530 AJR have emphasised the role of institutions in development but there has been criticism of this approach as privileging western liberal institutions Full Article Comment
pot Karnataka’s untapped tourism potential By www.thehindu.com Published On :: Tue, 29 Oct 2024 01:08:00 +0530 The State has not capitalised on its rich cultural, religious, and natural heritage Full Article Comment
pot Address problems in accident black spots scientifically, Udupi DC tells officials By www.thehindu.com Published On :: Tue, 29 Oct 2024 20:04:27 +0530 Full Article Mangaluru
pot As its industry struggles, Germany services sector offers untapped growth potential By www.thehindu.com Published On :: Mon, 11 Nov 2024 15:50:06 +0530 Full Article Business
pot Veil spotting By www.thehindu.com Published On :: Sat, 27 Aug 2016 16:02:30 +0530 Full Article Cinema
pot ‘Panchathantram’ movie review: This anthology is a potpourri and the women make it watchable By www.thehindu.com Published On :: Fri, 09 Dec 2022 15:12:20 +0530 With Brahmanandam as a storyteller, the Telugu anthology film ‘Panchathantram’ looks at memories through sensory experiences and a couple of stories hit the sweet spot Full Article Movies
pot ‘Anger Tales’ anthology review: Potpourri of hits and misses By www.thehindu.com Published On :: Thu, 09 Mar 2023 17:12:05 +0530 The Telugu anthology ‘Anger Tales’ explores anger that stems from everyday situations through effective performances Full Article Movies
pot Facile one-pot synthesis of novel imidates as multifunctional organic fluorescent materials By pubs.rsc.org Published On :: Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO01628A, Research ArticleFeng-Ting Liu, Shuo Wang, Yong-Shun Chen, Jun-Ying Miao, Bao-Xiang Zhao, Zhao-Min LinA novel one-pot synthesis of multifunctional organic fluorescent imidates from quinolinium salt derivatives, nitrosoarenes and alcohols was presented. This method had a wide substrate scope and excellent isolated yields.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot Synthesis of bambusurils with perfluoroalkylthiobenzyl groups as highly potent halide receptors By pubs.rsc.org Published On :: Org. Chem. Front., 2024, Advance ArticleDOI: 10.1039/D4QO01746C, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Matúš Chvojka, Hennie Valkenier, Vladimír ŠindelářFour new fluorinated bambusuril macrocycles were prepared to show exceptional high binding affinity towards halide anions in acetonitrile.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot DABSO-Mediated Pummerer Reaction Enables One-Pot Synthesis of Pyrroloquinolines for Accessing Marinoquinolines: Mechanistic, Photophysical and Pharmacological Investigations By pubs.rsc.org Published On :: Org. Chem. Front., 2024, Accepted ManuscriptDOI: 10.1039/D4QO01512F, Research ArticleRahimuddin Khan, Dipun Kumar Penthi, Aditi Chatterjee, Chandrakanta Sahoo, Shanti Gopal Patra, Viswanathan Arun Nagaraj, Tabrez KhanA new one-pot acid- and exogenous oxidant-free synthesis of pyrrolo[2,3-c]quinolines has been developed. The strategy involves chemoselective reduction of the 3-(2-nitrophenyl)-1H-pyrroles (pyrrolnitrin derivatives) and subsequent DABSO-facilitated Pummerer reaction in the...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot World Test Championship standing: India loses top spot to Australia, slips to second By www.thehindu.com Published On :: Sun, 03 Nov 2024 17:24:51 +0530 India lost to New Zealand by 25 runs in the third and final Test in Mumbai resutling in a 0-3 whitewash, their first in a home Test series since South Africa's 2-0 win in 1999-2000 Full Article Cricket
pot Carbonate weakens the interactions between potassium and calcareous soil By pubs.rsc.org Published On :: RSC Adv., 2024, 14,35275-35285DOI: 10.1039/D4RA05988C, Paper Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Wei Du, Shifeng Wang, Yizhe Yang, Chenyang Xu, Feinan Hu, Wuquan Ding, Jialong LvAdsorption energies of K+ in carbonate-removed (CREM) and carbonate-reserved (CRES) calcareous soil.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot Synthesis and antibiotic potential of myxocoumarin-inspired chromene dione analogs By pubs.rsc.org Published On :: RSC Adv., 2024, 14,35215-35219DOI: 10.1039/D4RA05941G, Paper Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Antonia Behnsen, Gesa Hertrampf, Sandra Vojnović, Jasmina Nikodinović-Runić, Tobias A. M. GulderThe myxocoumarins are natural products with strong antibiotic activity. We herein explored structural simplification of the myxocoumarins while aiming to retain their antibacterial properties. This led to the discovery of potent myxochromene diones.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot Design, synthesis, and evaluation of novel thiadiazole derivatives as potent VEGFR-2 inhibitors: a comprehensive in vitro and in silico study By pubs.rsc.org Published On :: RSC Adv., 2024, 14,35505-35519DOI: 10.1039/D4RA04158E, Paper Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Ibrahim H. Eissa, Walid E. Elgammal, Hazem A. Mahdy, Susi Zara, Simone Carradori, Dalal Z. Husein, Maymounah N. Alharthi, Ibrahim M. Ibrahim, Eslam B. Elkaeed, Hazem Elkady, Ahmed M. MetwalyThis study aims to investigate the potential of designed 2,3-dihydro-1,3,4-thiadiazole derivatives as anti-proliferative agents targeting VEGFR-2, utilizing a multidimensional approach combining in vitro and in silico analyses.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot Avinash Sable overwrites own meet record, Kushare consolidates Paris spot By www.thehindu.com Published On :: Sat, 29 Jun 2024 22:29:44 +0530 The national record holder Avinash Sable, who has already attained the Paris Olympic qualifying standard, clocked 8:31.75 to overwrite his own previous meet record of 8:33.19, set five years ago in Lucknow. Full Article Athletics
pot Silver futures rise on spot demand By www.thehindubusinessline.com Published On :: Wed, 12 Jun 2024 13:55:41 +0530 Silver prices mainly rise due to fresh positions built up by participants on a positive domestic trend, say analysts Full Article Gold & Silver
pot Unravelling the potential of low-valent tunable vanadium complexes in the nitrogen reduction reaction (NRR) By pubs.rsc.org Published On :: Dalton Trans., 2024, Advance ArticleDOI: 10.1039/D4DT02217C, PaperBijoy Ghosh, Sahtaz Ahmed, Ashwini K. PhukanComprehensive computational investigations predict the potential of several hitherto unknown tripodal vanadium complexes in the nitrogen reduction reaction (NRR) without the probability of generation of hydrazine as a side product.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot One-pot facile synthesis of rod-like Bi2S3 particles in deep eutectic solvent and their ppb-level selective H2S gas detection By pubs.rsc.org Published On :: Dalton Trans., 2024, Advance ArticleDOI: 10.1039/D4DT03006K, CommunicationReiko Furukawa, Takuya Hasegawa, Ayahisa Okawa, Shu YinRod-like Bi2S3 particles were synthesized by one-pot reactions with choline chloride-based DESs, and showed sub-ppm level selective H2S gas detection. Acetamide-based DES yielded uniform particles with excellent gas sensitivity.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot Improved microbial water quality and ozone performance following coagulation: implications for carbon based advanced treatment for potable reuse By pubs.rsc.org Published On :: Environ. Sci.: Water Res. Technol., 2024, Advance ArticleDOI: 10.1039/D4EW00638K, Paper Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Christina M. Morrison, Ariel J. Atkinson, Daniel Gerrity, Eric C. WertCoagulation/flocculation of secondary effluent with FeCl3 (1) removed MS2 bacteriophage and bacterial endospores up to 2–3 LRVs, (2) removed rapid surrogates at levels correlative with microbial removal, and (3) improved downstream O3 performance.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot Is sugar in a sweet spot? By www.thehindubusinessline.com Published On :: Sun, 29 Oct 2017 20:35:09 +0530 Prices will remain in the same range, between ₹3,600 and ₹3,700 per tonne, says Vijay S Banka Full Article People
pot IIMA proves it is gold standard for management studies, bags top spot in NIRF list for 5th consecutive time By www.thehindubusinessline.com Published On :: Mon, 12 Aug 2024 18:07:46 +0530 Institute has been topping NIRF’s list of best management colleges since 2020 Full Article Education
pot An electric double layer regulator empowers robust solid-electrolyte interphase for potassium metal batteries By pubs.rsc.org Published On :: Energy Environ. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4EE03978E, PaperXueyu Lian, Liang Xu, Zhijing Ju, Ziang Chen, Xiaopeng Chen, Yuyang Yi, Zhengnan Tian, Tao Cheng, Shi Xue Dou, Xinyong Tao, Jingyu SunThe electric double layer (EDL) plays a key role in constructing solid electrolyte interphase (SEI) for high-energy metal anodes. Nevertheless, the significance of EDL and its associated influence remain elusive...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot Stray dog menace puts Railways, Kozhikode Corporation in a spot By www.thehindu.com Published On :: Tue, 12 Nov 2024 21:21:41 +0530 A tourist from Germany was bitten by a stray dog at the Kozhikode railway station recently Full Article Kozhikode
pot Surface treatment of magnetite nanoparticle thin films with potassium phosphate for calcium phosphate precipitation By pubs.rsc.org Published On :: React. Chem. Eng., 2024, 9,782-786DOI: 10.1039/D4RE00048J, CommunicationReo Kimura, Kazuto Sugimoto, Iori Yamada, Motohiro TagayaThe treatment of magnetite nanoparticle thin films with potassium phosphate and their surface reaction with simulated body fluid were in situ monitored by the QCM-D technique, which is suitable for the precipitation of calcium phosphate.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot Spotted! Preity's husband at Wankhede By www.rediff.com Published On :: Sun, 07 May 2022 14:19:18 +0530 Bollywood actor Preity Zinta was spotted at the Wankhede stadium on Saturday afternoon with her husband Gene Goodenough. Full Article
pot Spotted! Rishabh Pant's Lady Love By www.rediff.com Published On :: Mon, 09 May 2022 12:20:29 +0530 Isha will be hoping that Rishabh's luck changes for the better and DC makes the playoffs on the back of his batting and captaincy. Full Article
pot Birthday Boy Dhoni Spotted At Wimbledon By www.rediff.com Published On :: Thu, 06 Jul 2022 11:23:34 +0530 Dhoni will be 41 on July 7. Full Article
pot Pant Spotted At Dhoni's Birthday Party By www.rediff.com Published On :: Thu, 07 Jul 2022 13:05:36 +0530 On Wednesday night, Sakshi Singh Dhoni posted a video on Instagram of her husband bringing in his 41st birthday in London. Full Article
pot Unravelling the potential of yolkin for nutraceutical use: the origin, structure, and functional insights of a hen egg yolk polypeptide complex By pubs.rsc.org Published On :: Food Funct., 2024, 15,10746-10760DOI: 10.1039/D4FO03023K, Paper Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Aleksandra Zambrowicz, Katarzyna Kapczyńska, Paweł Kania, Jakub Stanisław Nowak, Marta Kaszowska, Katarzyna Szymczak-Kulus, Wioletta Kazana-Płuszka, Marta Piksa, Sabina Górska, Dominika Jakubczyk, Józefa Macała, Agnieszka ZabłockaThe nutraceutical potential of yolkin health benefits from hen egg yolk.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
pot Antigenotoxic and cosmetic potential of elderberry (Sambucus nigra) extract: protection against oxidative DNA damage By pubs.rsc.org Published On :: Food Funct., 2024, 15,10795-10810DOI: 10.1039/D4FO03217A, PaperSara Gonçalves, Francisco Peixoto, Tayse F. F. da Silveria, Lillian Barros, Isabel GaivãoThe integrity of the genome is under constant threat from both endogenous and exogenous factors that induce oxidative stress and accelerate ageing.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
