Elite college basketball prospect Donovan Clingan has offers to transfer to better programs, but he wants to stay at Bristol Central to break his mother's records.

Angela Ruch has a full-time ride in the NASCAR Truck Series, a growing family and a docuseries on Facebook. Now, she'd love to get back to racing and get a win.

The Lagos State Police Command has rescued an unidentified woman shortly after she gave birth.   She delivered the baby at a section of the Lekki-Ajah expressway on Friday. Good spirited Nigerians had called operatives of the Rapid Response Squad (RRS) to the scene. The Police said the mother has four other children and are […]

Police rescue homeless mother of 4 who gave birth on Lagos road [Photos]

Remind her that she’s the best: You can stream these shorts right here, from the safety of home. ......

Kali Little was already extra grateful for her mom and grandmother this Mother's Day. Then her 3-year-old was diagnosed with COVID-19. ......

To mark Mother's Day 2020, the hosts and reporters of Fox News Channel and Fox Business Network expressed their appreciation to their mothers and all the moms across America who are helping their families through the coronavirus pandemic. ......

Turkish Labor, Social Services and Family Ministry on May 8 announced visitors will not be allowed to retirement and nursing homes across the country on Mother's Day Sunday, and also during traditional Eid al-Fitr holiday at the end of Muslim holy month of Ramadan.

Epidemic diseases are not random events that afflict societies capriciously and without warning, on the contrary, every society produces its own specific vulnerabilities. To study them is to understand the importance of a society’s structure, its standard of living, and its political priorities. […] Epidemics are a mirror, they show who we really are: Our […]

The post Haunting Forest Spirits – is Mother Nature Striking Back? appeared first on Inter Press Service.

With everyone's attention focused on the coronavirus pandemic, you could be forgiven for forgetting that it's Mother's Day this weekend. Just remember, it's never too ...

We have to find creative yet amazing ways to appreciate our mothers.

Her number was always the first I called whenever I was in a fix.

She got a job as an office assistant but still kept to her passion for rescuing animals.

Kajol opened up about her experience juggling motherhood and acting during the course of her kids childhood

ISLAMABAD: Senate Chairman Muhammad Sadiq Sanjrani Friday condoled the passing away of the mother of Senator Faisal Javed, who is also chairman of the Senate Standing Committee on Information and...

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Beyonce’s mother Tina Lawson said: 'We all got tested. We’ve gotten the results back and everybody is okay'

Samantha Salinas never planned to give birth during a global pandemic, but Mother's Day 2020 may be when her baby finally arrives.

Los Angeles' downtown flower market saw a brisk trade on Thursday morning (May 7) after California Governor Gavin Newsom gave the green light to retail florist stores to begin opening on Friday (May 8), ahead of Mother's Day in the U.S.

Title: Mothers' Stress Could Cause Iron Deficiency in Newborns
Category: Health News
Created: 4/30/2012 10:05:00 AM
Last Editorial Review: 4/30/2012 12:00:00 AM

Title: Low-Income Mothers May Overfeed Their Infants
Category: Health News
Created: 4/28/2012 10:05:00 AM
Last Editorial Review: 4/30/2012 12:00:00 AM

Title: Single Motherhood Doesn't Seem to Hinder Happiness
Category: Health News
Created: 4/26/2014 10:35:00 AM
Last Editorial Review: 4/28/2014 12:00:00 AM

Title: Older Mothers at Higher Risk of Child With Autism, Study Suggests
Category: Health News
Created: 4/29/2014 4:35:00 PM
Last Editorial Review: 4/30/2014 12:00:00 AM

Title: AHA News: Make Mother's Day Last All Year With Wellness and Appreciation
Category: Health News
Created: 4/29/2020 12:00:00 AM
Last Editorial Review: 4/30/2020 12:00:00 AM

Expression of the DNA/RNA helicase schlafen family member 11 (SLFN11) has been identified as a sensitizer of tumor cells to DNA-damaging agents including platinum chemotherapy. We assessed the impact of SLFN11 expression on response to platinum chemotherapy and outcomes in patients with metastatic castration-resistant prostate cancer (CRPC). Tumor expression of SLFN11 was assessed in 41 patients with CRPC treated with platinum chemotherapy by RNA sequencing (RNA-seq) of metastatic biopsy tissue (n = 27) and/or immunofluorescence in circulating tumor cells (CTC; n = 20). Cox regression and Kaplan–Meier methods were used to evaluate the association of SLFN11 expression with radiographic progression-free survival (rPFS) and overall survival (OS). Multivariate analysis included tumor histology (i.e., adenocarcinoma or neuroendocrine) and the presence or absence of DNA repair aberrations. Patient-derived organoids with SLFN11 expression and after knockout by CRISPR-Cas9 were treated with platinum and assessed for changes in dose response. Patients were treated with platinum combination (N = 38) or platinum monotherapy (N = 3). Median lines of prior therapy for CRPC was two. Median OS was 8.7 months. Overexpression of SLFN11 in metastatic tumors by RNA-seq was associated with longer rPFS compared with those without overexpression (6.9 vs. 2.8 months, HR = 3.72; 95% confidence interval (CI), 1.56–8.87; P < 0.001); similar results were observed for patients with SLFN11-positive versus SLFN11-negative CTCs (rPFS 6.0 vs. 2.2 months, HR = 4.02; 95% CI, 0.77–20.86; P = 0.002). A prostate-specific antigen (PSA) decline of ≥50% was observed in all patients with SLFN11 overexpression. No association was observed between SLFN11 expression and OS. On multivariable analysis, SLFN11 was an independent factor associated with rPFS on platinum therapy. Platinum response of organoids expressing SLFN11 was reduced after SLFN11 knockout. Our data suggest that SLFN11 expression might identify patients with CRPC with a better response to platinum chemotherapy independent of histology or other genomic alterations. Additional studies, also in the context of PARP inhibitors, are warranted.

BACKGROUND:

Medicaid plays a critical role during the perinatal period, but pregnancy-related Medicaid eligibility only extends for 60 days post partum. In 2014, the Affordable Care Act’s (ACA’s) Medicaid expansions increased adult Medicaid eligibility to 138% of the federal poverty level in participating states, allowing eligible new mothers to remain covered after pregnancy-related coverage expires. We investigate the impact of ACA Medicaid expansions on insurance coverage among new mothers living in poverty.

Treatment of patients with triple-negative breast cancer (TNBC) is limited by a lack of effective molecular therapies targeting this disease. Recent studies have identified metabolic alterations in cancer cells that can be targeted to improve responses to standard-of-care chemotherapy regimens. Using MDA-MB-468 and SUM-159PT TNBC cells, along with LC-MS/MS and HPLC metabolomics profiling, we found here that exposure of TNBC cells to the cytotoxic chemotherapy drugs cisplatin and doxorubicin alter arginine and polyamine metabolites. This alteration was because of a reduction in the levels and activity of a rate-limiting polyamine biosynthetic enzyme, ornithine decarboxylase (ODC). Using gene silencing and inhibitor treatments, we determined that the reduction in ODC was mediated by its negative regulator antizyme, targeting ODC to the proteasome for degradation. Treatment with the ODC inhibitor difluoromethylornithine (DFMO) sensitized TNBC cells to chemotherapy, but this was not observed in receptor-positive breast cancer cells. Moreover, TNBC cell lines had greater sensitivity to single-agent DFMO, and ODC levels were elevated in TNBC patient samples. The alterations in polyamine metabolism in response to chemotherapy, as well as DFMO-induced preferential sensitization of TNBC cells to chemotherapy, reported here suggest that ODC may be a targetable metabolic vulnerability in TNBC.

The emergence of drug resistance is a major obstacle for the success of targeted therapy in melanoma. Additionally, conventional chemotherapy has not been effective as drug-resistant cells escape lethal DNA damage effects by inducing growth arrest commonly referred to as cellular dormancy. We present a therapeutic strategy termed "targeted chemotherapy" by depleting protein phosphatase 2A (PP2A) or its inhibition using a small molecule inhibitor (1,10-phenanthroline-5,6-dione [phendione]) in drug-resistant melanoma. Targeted chemotherapy induces the DNA damage response without causing DNA breaks or allowing cellular dormancy. Phendione treatment reduces tumor growth of BRAF^V600E-driven melanoma patient-derived xenografts (PDX) and diminishes growth of NRAS^Q61R-driven melanoma, a cancer with no effective therapy. Remarkably, phendione treatment inhibits the acquisition of resistance to BRAF inhibition in BRAF^V600E PDX highlighting its effectiveness in combating the advent of drug resistance.

Patients with HPV16⁺ cervical cancer and high T-cell responses to an HPV16 vaccine survived longer.

A chemotherapy-induced shift to ICOSL⁺ B cells in breast tumors correlated with better survival.

पूरी दुनिया में मई महीने के दूसरे रविवार को मदर्स डे मनाया जाता है। इस बार 10 मई को मदर्स डे मनाया जाएगा। यूं तो मां के साथ हर दिन विशेष होता है लेकिन मदर्स डे का भी अपना खास महत्व हो जाता है।

We might pride ourselves on our top-notch LMS and training content, and how it can help learners develop as professionals and as people. But let […]

The post Learning from Our Mothers: 8 Lessons from the World's Greatest Trainers appeared first on e-Learning Feeds.

मां के लिए कोई एक दिन नहीं होता वो अलग बात है कि एक खास दिन मां के नाम निश्चित कर दिया गया है। मई महीने में दूसरे हफ्ते के रविवार को मदर्स डे मनाया जाता है।

मदर्स डे के मौके पर मां को स्पेशल फील करवाने का बेहतरीन विकल्प है तोहफा। आप अपनी मां को सरप्राइज गिफ्ट दे सकते हैं। जिन्हें देखकर मां जरुर खुश हो जाएंगी।

मई महीने में दूसरे हफ्ते के रविवार को मदर्स डे को तौर पर मनाया जाता है। मां के लिए कोई एक दिन नहीं होता है, वो अलग बात है कि एक खास दिन को मां के नाम निश्चित कर दिया गया है।

Mother's Day 2020 Best Mobile Under rs 10000: इस मदर्स डे आप भी अपनी मां को उपहार में स्मार्टफोन देकर विश कर सकते हैं। इन स्मार्टफोन की कीमत 10,000 रुपये से कम है। साथ ही इनमें आपको दमदार फीचर्स मिलेंगे।

Sustainable fashion collaboration featuring only biodegradable fabrics will be sold online

John Lewis and the fashion brand Mother of Pearl have chosen Earth Day for the launch of their sustainable fashion collaboration, specifically for its geopolitical symbolism.

Earth Day, which celebrates its 50th anniversary on 22 April, seemed an appropriate day to launch a collection bringing rigorous standards of ethical design to mass market fashion. A launch date that pays homage to the planet rather than the artificial seasons of fashion, and dovetails with the concept of timeless, seasonless clothes designed for wardrobe longevity.

Marisa Bardach Ramel is co-author of “The Goodbye Diaries: A Mother-Daughter Memoir,” written with her mother Sally Bardach. As Mother’s Day approaches, I long to sit beside you, pour you some tea and talk about all the things.

The presence of bacteria that break down fibre in a mother’s gut is linked to a reduced risk of food allergies in her child’s first year of life

On a Mother's Day unlike previous ones, here are a few ideas to help you celebrate, whether your mom is near, far, or socially isolating.

Expensive but powerful

This will be my 23rd Mother’s Day without my mother and while it gets easier, it is never easy.

The following is a brief roundup of the latest scientific studies on the novel coronavirus and efforts to find treatments and vaccines for COVID-19, the illness caused by the virus.