Owners of the world's largest lithium mine predict production can top 2 million tonnes if expansion projects get the green light.

MIT research scientist, Andrew McAfee, argues we need to rethink our assumptions about capitalism and the environment.   Economic growth, he says, has been gradually decoupling from resource consumption. So, if capitalism survives this current crisis, we may need to adapt our understanding of the way it all works.  We also hear from Annmaree O’Keeffe, from the Lowy Institute’s Pacific Islands Program, about the value of Australia’s international public broadcasting effort now that the Pacific is once again an Australian geopolitical focus.

Cruise ships bring in millions of dollars to Tasmania each year, but tourism operators say if their schedules are not better managed they will continue to be both a "blessing and a curse".

A mistake made more than 40 years ago has created a powerful voting bloc that some experts believe will railroad any Territory Government plan to bring its budget back into the black.

Draper Tools, the hand and power tool distributor, is a family-run company that has been in business for just over a century and has more than 5,000 UK and overseas customers. Historically its customers have been mostly business-to-business (B2B) retailers and distributors but more recently Draper has also begun using its logistics platform to ship to consumers directly on behalf of its customers.

Regional communities are being touted as winners in this year's New South Wales budget, crowned by a Regional Growth Fund of more than $1 billion for projects to promote economic advancement outside of cities.

We can readily understand why investors are attracted to unprofitable companies. For example, Aptose Biosciences...

Cracks the 150,000-employee mark as revenue falls just short of $10bn

Indian services giant HCL Technologies has wound up its 19/20 financial year by reporting 15 percent annual growth but a flat Q4.…

Familial dysautonomia (FD) is the most prevalent form of hereditary sensory and autonomic neuropathy (HSAN). In FD, a germline mutation in the Elp1 gene leads to Elp1 protein decrease that causes sympathetic neuron death and sympathetic nervous system dysfunction (dysautonomia). Elp1 is best known as a scaffolding protein within the nuclear hetero-hexameric transcriptional Elongator protein complex, but how it functions in sympathetic neuron survival is very poorly understood. Here, we identified a cytoplasmic function for Elp1 in sympathetic neurons that was essential for retrograde nerve growth factor (NGF) signaling and neuron target tissue innervation and survival. Elp1 was found to bind to internalized TrkA receptors in an NGF-dependent manner, where it was essential for maintaining TrkA receptor phosphorylation (activation) by regulating PTPN6 (Shp1) phosphatase activity within the signaling complex. In the absence of Elp1, Shp1 was hyperactivated, leading to premature TrkA receptor dephosphorylation, which resulted in retrograde signaling failure and neuron death. Inhibiting Shp1 phosphatase activity in the absence of Elp1 rescued NGF-dependent retrograde signaling, and in an animal model of FD it rescued abnormal sympathetic target tissue innervation. These results suggest that regulation of retrograde NGF signaling in sympathetic neurons by Elp1 may explain sympathetic neuron loss and physiologic dysautonomia in patients with FD.

Nerve growth factor (NGF) regulates many aspects of neuronal biology by retrogradely propagating signals along axons to the targets of those axons. How this occurs when axons contain a plethora of proteins that can silence those signals has long perplexed the neurotrophin field. In this issue of the JCI, Li et al. suggest an answer to this vexing problem, while exploring why the Elp1 gene that is mutated in familial dysautonomia (FD) causes peripheral neuropathy. They describe a distinctive function of Elp1 as a protein that is required to sustain NGF signaling by blocking the activity of its phosphatase that shuts off those signals. This finding helps explain the innervation deficits prominent in FD and reveals a unique role for Elp1 in the regulation of NGF-dependent TrkA activity.

IBM today announced that according to results from International Data Corporation (IDC) Worldwide Quarterly Server Tracker®(June, 2017) IBM has achieved market growth by 3x compared with the total Linux server market which grew at +6 percent. The improved performance are the result of success across IBM Power Systems including IBM’s OpenPOWER LC servers and IBM Power Systems running SAP HANA as well as the OpenPOWER-Ready servers developed through the OpenPOWER Foundation.

Rakon has selected the IBM Storwize V7000 SAN as part of a strategic storage upgrade to meet the needs of its rapidly expanding international quartz crystal manufacturing business.

IBM (NYSE: IBM) today announced that Bendigo and Adelaide Bank has selected IBM XIV Storage System Gen3 as a key infrastructure component for its ongoing development and delivery of customer-focussed business applications.

One hundred IBM (NYSE: IBM) employees from 33 countries – including six from Australia and New Zealand – have been selected to participate in the company's new Corporate Service Corps program. The program is part of the Global Citizen's Portfolio initiative announced by CEO Sam Palmisano to develop leadership skills, while addressing socio-economic challenges in emerging markets.

: IBM (NYSE: IBM) today announced it has signed a five-year multimillion dollar agreement with Veda (ASX: VED), a leading provider of credit information and analysis in Australia and New Zealand. The agreement extends Veda's existing strategic outsourcing relationship with IBM, which continues to provide Veda with a highly reliable and resilient infrastructure, and now includes cloud services.

We show a causal impact of immigration on innovation and dynamism in US counties. To identify the causal impact of immigration, we use 130 years of detailed data on migrations from foreign countries to US counties to isolate quasi-random variation in the ancestry composition of US counties that results purely from the interaction of two historical forces: (i) changes over time in the relative attractiveness of different destinations within the US to the average migrant arriving at the time and (ii) the staggered timing of the arrival of migrants from different origin countries. We then use this plausibly exogenous variation in ancestry composition to predict the total number of migrants flowing into each US county in recent decades. We show four main results. First, immigration has a positive impact on innovation, measured by the patenting of local firms. Second, immigration has a positive impact on measures of local economic dynamism. Third, the positive impact of immigration on innovation percolates over space, but spatial spillovers quickly die out with distance. Fourth, the impact of immigration on innovation is stronger for more educated migrants.

Panasonic is freezing plans to expand its role as Tesla's electric car battery supplier, a move that raises new questions about demand for Tesla's Model 3 — and the company's future.

With auto sales slammed by COVID-19, Musk sticks to his vision of a beautiful future for Tesla. But what about cash?

The rural Johnson County town hopes to take advantage of growth while retaining its small-town charm.

Grim new evidence that temporary closures and pandemic-related layoffs are hammering the local job market.

The Digital Development Group foresees dynamic growth in its industry. “On Nov. 21st we launched our first channel. We are excited to announce 5 more channels coming before year-end. On the heels of those developments we believe it is important to continue to define our mission.”

DigiDev is targeting the revolutionary “OTT” technology arena. “OTT” or Over The Top devices piggyback on existing network services in consumers’ homes or offices; pull content from the Internet and deliver it to their TV or Internet enabled device. DigiDev uses OTT technology to deliver programming to billions of desktops, mobile and smart/Internet enabled TV devices around the world.

“The market for digital distribution to 'smart' (Internet enabled) devices (smart-TV, tablet, smart-phones) continues to grow at an astonishing rate,” states Martin W. Greenwald, Chairman and CEO of DigiDev. “AppleTV, GoogleTV, and Roku sales this Holiday season are running considerably ahead of last year’s tally.”

Kicking people off food stamps this late in the business cycle makes no sense.

Marketing tactics change constantly. Each year new tactics become more impactful, and old ones fade into obscurity. Sticking to the same tactics is stale for your current customers and potential customers, too. Instead of just running the same growth tactics for years on end, it’s time to make a switch in 2020. Here are four unique growth tactics […]

The post 4 Unique Growth Tactics for 2020 appeared first on ReadWrite.

Growth is top of mind for most companies, but it can be tricky to get started with developing a growth framework. For one thing, most companies aren’t organized around growth, so thinking about growth requires a lot of collaboration between teams. Additionally, companies often don’t have easy access to all of the data they need to understand growth.

Corporate Members Event

Event participants

Dr Christopher Smart, Whitehead Senior Fellow, Chatham House; Senior Fellow, Mossavar-Rahmani Center for Business and Government, Harvard Kennedy School; Special Assistant to President Obama, International Economics, Trade and Investment (2013-15)

Chair: Kenneth Cukier, Senior Editor of Digital Products, The Economist

28 June 2017

This paper examines how governments on both sides of the Atlantic are establishing frameworks that attempt to govern the commercial uses of data. It covers areas such as data analytics driving productivity and growth, the 'industrial internet of things', and the policy context and political forces shaping data rules in the US and Europe.

Invitation Only Research Event

Event participants

Diane Coyle, Professor, University of Manchester; Founder and Managing Director, Enlightenment Economics

Yi Zhang
Sep 1, 2005; 4:1240-1250
Research

MS Brown
Jul 1, 1980; 21:505-517
Reviews

Invitation Only Research Event

Event participants

Rodrigo Malmierca, Minister for Foreign Trade and Investment, Cuba
Chair: Dr Christopher Sabatini, Senior Research Fellow for Latin America, Chatham House; Lecturer, Columbia University, School of International and Public Affairs

Growth at any cost is, well, costing us — and we can’t rely on the marketplace to solve the earth’s problems.

A. Seesanea and I. E. Verbitsky
St. Petersburg Math. J. 31 (2020), 557-572.
Abstract, references and article information

Insulin-like growth factors (IGFs), specifically IGF1 and IGF2, promote glucose metabolism, with their availability regulated by IGF-binding proteins (IGFBPs). We hypothesized that IGF1 and IGF2 levels, or their bioavailability, are reduced during type 1 diabetes development. Total serum IGF1, IGF2, and IGFBP1–7 levels were measured in an age-matched, cross-sectional cohort at varying stages of progression to type 1 diabetes. IGF1 and IGF2 levels were significantly lower in autoantibody (AAb)⁺ compared with AAb^– relatives of subjects with type 1 diabetes. Most high-affinity IGFBPs were unchanged in individuals with pre–type 1 diabetes, suggesting that total IGF levels may reflect bioactivity. We also measured serum IGFs from a cohort of fasted subjects with type 1 diabetes. IGF1 levels significantly decreased with disease duration, in parallel with declining β-cell function. Additionally, plasma IGF levels were assessed in an AAb⁺ cohort monthly for a year. IGF1 and IGF2 showed longitudinal stability in single AAb⁺ subjects, but IGF1 levels decreased over time in subjects with multiple AAb and those who progressed to type 1 diabetes, particularly postdiagnosis. In sum, IGFs are dysregulated both before and after the clinical diagnosis of type 1 diabetes and may serve as novel biomarkers to improve disease prediction.

Methods that provide rapid access to radiolabeled antibodies are vital in the development of diagnostic and radiotherapeutic agents for positron emission tomography (PET) or radioimmunotherapy. The human hepatocyte growth factor receptor (c-MET) signaling pathway is dysregulated in a number of malignancies including gastric cancer, and is an important biomarker in drug discovery. Here, we used a photoradiochemical approach to produce ⁸⁹Zr-radiolabeled onartuzumab (a monovalent, anti-human c-MET antibody), starting directly from the fully formulated drug (MetMAb). Methods: Simultaneous ⁸⁹Zr-radiolabeling and protein conjugation was performed in one-pot reactions containing ⁸⁹Zr-oxalate, the photoactive chelate DFO-aryl azide (DFO-ArN3) and MetMAb to give ⁸⁹ZrDFO-azepin-onartuzumab. As a control, ⁸⁹ZrDFO-Bn-NCS-onartuzumab was prepared via a conventional two-step process using pre-purified onartuzumab and DFO-Bn-NCS. Radiotracers were purified by using size-exclusion methods and evaluated by radiochromatography. Radiochemical stability was studied in human serum and immunoreactivity was determined by cellular binding assays using MKN-45 gastric carcinoma cells. PET imaging at multiple time points (0–72 h) was performed in female athymic nude mice bearing subcutaneous MKN-45 xenografts. Biodistribution experiments were performed after the final image. Tumor specificity of ⁸⁹ZrDFO-azepin-onartuzumab was assessed by competitive inhibition (blocking) studies. Results: Initial photoradiosynthesis experiments produced ⁸⁹ZrDFO-azepin-onartuzumab in <15 min. with an isolated decay-corrected radiochemical yield (RCY) of 24.8%, a radiochemical purity (RCP) ~90% and a molar activity (Am) of ~1.5 MBq nmol^-1. Reaction optimization improved the radiochemical conversion (RCC) of ⁸⁹ZrDFO-azepin-onartuzumab to 56.9±4.1% (n = 3), with isolated RCYs of 41.2±10.6% (n = 3), and RCPs >90%. Conventional methods produced ⁸⁹ZrDFO-Bn-NCS-onartuzumab with isolated RCY >97%, RCP >97% and Am ~14.0 MBq nmol^-1. Both radiotracers were immunoreactive and stable in human serum. PET imaging and biodistribution studies showed high tumor uptake for both radiotracers. By 72 h, tumor and liver uptake reached 15.37±5.21 %ID g^-1, 6.56±4.03 %ID g^-1, respectively for ⁸⁹ZrDFO-azepin-onartuzumab (n = 4), and 21.38±11.57 %ID g^-1 and 18.84±6.03 %ID g^-1 for ⁸⁹ZrDFO-Bn-NCS-onartuzumab (n = 4). Blocking experiments gave a statistically significant reduction in tumor uptake (6.34±0.47 %ID g^-1) of ⁸⁹ZrDFO-azepin-onartuzumab (n = 4). Conclusion: Experiments demonstrate that photoradiosynthesis is a viable alternative approach for producing ⁸⁹Zr-radiolabeled antibodies direct in protein formulation buffer which reduces protein aggregation and liver uptake.

Invitation Only Research Event

Event participants

Abebe Aemro Selassie, Director, African Department, International Monetary Fund
Chair: Elizabeth Donnelly, Deputy Head and Research Fellow, Africa Programme, Chatham House

3 October 2019

The Chatham House Africa Programme designed the Sudan Stakeholder Dialogues series to help identify the factors that have led to the current economic crisis, the immediate steps that need to be taken to avert collapse and stabilize the economy, and the longer-term structural reforms required to set Sudan on the path to recovery. The project is funded by Humanity United.

10 October 2019

This briefing note is the result of a collaborative research process with the Zimbabwean private sector, government representatives, industry organizations and experts, drawing on best practice and senior-level insights to identify policy options for long-term economic revival and expansion in Zimbabwe, and pathways for inclusive development.