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Uttar Pradesh is gearing up to hold the 11th edition of the biennial Defence Expo 2020 in the state capital from February 5 to 9.Prime Minister Narendra Modi will inaugurate the expo in which 1029 companies are expected to participate, Lucknow divisional commissioner Mukesh Meshram said.It would be the biggest such event held in the country, an official release said, adding that 702 companies had participated in the last Defence Expo held in Chennai in 2018.Take a look at what one can expect at the event.

'Sadness is, seeing your favorite player getting old': Twitter re...

CM has assured safe passage for migrant workers, says Sharad Pawar

Arti Singh remembered her first letter to mother on the occasion of Mothers' Day

The coronavirus lockdown has separated many of us from our families, including our mothers. However, Sophie Choudhry is one lucky celeb who is able to spend her quarantine and Mothers' Day with her supermom. In fact, she told us all about her plans for the day.

With the nationwide lockdown in place to fight the spread of COVID-19, the first condolence meeting held on virtual platform. Banerjee had died on March 20 after a prolonged illness while Goswami succumbed to cardiac arrest on April 30.

The structure and function of dioxygenases in histone demethylation and DNA/RNA dimethylation are discussed.

There was an earthquake in Gwynedd yesterday - but you probably didn't feel the earth move  Daily Post

'Rumbling' felt during Ardnamurchan earthquake  BBC News

TatD has been thoroughly investigated as a DNA-repair enzyme and an apoptotic nuclease, and still-unknown TatD-related DNases are considered to play crucial cellular roles. However, studies of TatD from Gram-positive bacteria have been hindered by an absence of atomic detail and the resulting inability to determine function from structure. In this study, an X-ray crystal structure of SAV0491, which is the TatD enzyme from the Gram-positive bacterium Staphylococcus aureus (SaTatD), is reported at a high resolution of 1.85 Å with a detailed atomic description. Although SaTatD has the common TIM-barrel fold shared by most TatD-related homologs, and PDB entry 2gzx shares 100% sequence identity with SAV0491, the crystal structure of SaTatD revealed a unique binding mode of two phosphates interacting with two Ni2+ ions. Through a functional study, it was verified that SaTatD has Mg2+-dependent nuclease activity as a DNase and an RNase. In addition, structural comparison with TatD homologs and the identification of key residues contributing to the binding mode of Ni2+ ions and phosphates allowed mutational studies to be performed that revealed the catalytic mechanism of SaTatD. Among the key residues composing the active site, the acidic residues Glu92 and Glu202 had a critical impact on catalysis by SaTatD. Furthermore, based on the binding mode of the two phosphates and structural insights, a putative DNA-binding mode of SaTatD was proposed using in silico docking. Overall, these findings may serve as a good basis for understanding the relationship between the structure and function of TatD proteins from Gram-positive bacteria and may provide critical insights into the DNA-binding mode of SaTatD.

When songwriter Oscar Hammerstein penned the lyrics “fish gotta swim, birds gotta fly,” he clearly did not have the ratites in mind. Large flightless birds, the ratites include ostriches, emus, rheas and cassowaries, along with kiwis and several extinct species.

The post DNA evidence is rearranging the branches of the avian family tree appeared first on Smithsonian Insider.

The first DNA barcoding survey of crustaceans living on samples of dead coral taken from the Indian, Pacific and Caribbean oceans suggests that the diversity of organisms living on the world’s coral reefs—one of the most endangered habitats on Earth—is seriously underestimated.

The post New DNA study suggests coral reef biodiversity is seriously underestimated appeared first on Smithsonian Insider.

Both investigations were carried out through DNA analysis of fish tissue performed in a laboratory using a U.S. Food and Drug Administration protocol that originated largely at the Smithsonian’s National Museum of Natural History. DNA from the fish in question was identified by matching it against a database of DNA fish barcodes that again, has its origins at the Smithsonian.

The post Smithsonian research with DNA barcoding is making seafood substitution easier to catch appeared first on Smithsonian Insider.

The western long-beaked echidna, one of the world's five egg-laying species of mammal, became extinct in Australia thousands of years ago…or did it?

The post Scientists discover long-beaked echidna may not be a thing of the past in Australia appeared first on Smithsonian Insider.

A new DNA study of ancient corn kernels and cobs from archaeological sites across North America has settled a long debate as to exactly where […]

The post Corn entered Southwest U.S. first along highland route, DNA shows appeared first on Smithsonian Insider.

Giant pandas. Grizzlies. Polar bears. You’ve probably heard a lot about these bear species, but what about Andean bears? To the Quechua and Aymara, the […]

The post 6 Things You Probably Didn’t Know About Andean Bears appeared first on Smithsonian Insider.

DNA analysis is proving to be a valuable tool for scientists trying to gauge the environmental impact that invasive blue catfish (Ictalurus furcatus) and flathead […]

The post DNA solves puzzle of catfish dinners appeared first on Smithsonian Insider.

Smothered in tartar sauce and cheese it’s difficult to know just what species of fish lurks beneath the breaded surface of a fast-food fish sandwich. […]

The post Smithsonian scientist creating DNA database to track Caribbean conch and lobster appeared first on Smithsonian Insider.

It is rare but not entirely uncommon to see a manatee swimming in the Atlantic waters of Maryland and Virginia. This one was dead, however, […]

The post In face of mass extinctions, Smithsonian’s Global Genome Initiative quietly saves world’s DNA appeared first on Smithsonian Insider.

A bite mark on a homicide victim’s skin is not an unusual discovery. A criminal’s teeth marks are also occasionally found on food at a […]

The post Crime bite: DNA on half-eaten food may someday send crooks to jail appeared first on Smithsonian Insider.

A bat specimen collected in France at the end of World War I, since housed in the collections of the Smithsonian’s National Museum of Natural […]

The post DNA on 100-year-old bat from France may help fight deadly fungus in North America appeared first on Smithsonian Insider.

Imke K. Mandemaker, Di Zhou, Serena T. Bruens, Dick H. Dekkers, Pernette J. Verschure, Raghu R. Edupuganti, Eran Meshorer, Jeroen A. Demmers, and Jurgen A. Marteijn

Many chromatin remodeling and modifying proteins are involved in the DNA damage response by stimulating repair or inducing DNA damage signaling. Interestingly, here we identified that down regulation of the H1-interacting protein SET results in increased resistance to a wide variety of DNA damaging agents. We found that this increased resistance is not the result of an inhibitory effect of SET on DNA repair, but rather the consequence of a suppressed apoptotic response to DNA damage. We further provide evidence that the histone chaperone SET is responsible for the eviction of H1 from chromatin. Knock down of H1 in SET-depleted cells resulted in re-sensitization of cells to DNA damage, suggesting that the increased DNA damage resistance in SET-depleted cells is the result of enhanced retention of H1 on chromatin. Finally, clonogenic survival assays show that SET and p53 are epistatic in attenuating DNA damage-induced cell death. Altogether, our data show a role for SET in the DNA damage response as a regulator of cell survival following genotoxic stress.

Isabella Guardamagna, Elisabetta Bassi, Monica Savio, Paola Perucca, Ornella Cazzalini, Ennio Prosperi, and Lucia A. Stivala

Assessing DNA repair is an important endpoint to study the DNA damage response for investigating the biochemical mechanisms of this process and the efficacy of chemotherapy, which often uses DNA damaging compounds. Numerous in vitro methods to biochemically characterize DNA repair mechanisms have been developed so far. However, they show some limitations mainly due to the lack of chromatin organization. Here we describe a functional cell-free system to study DNA repair synthesis in vitro, using G1-phase nuclei isolated from human cells treated with different genotoxic agents. Upon incubation in the correspondent damage-activated cytosolic extracts, containing biotin-16-dUTP, nuclei are able to initiate DNA repair synthesis. The use of specific DNA synthesis inhibitors markedly decreased biotinylated dUTP incorporation, indicating the specificity of the repair response. Exogenously added human recombinant PCNA protein, but not the sensors of UV-DNA damage DDB2 or DDB1, stimulated UVC induced dUTP incorporation. In contrast, a DDB2^PCNA- mutant protein, unable to associate with PCNA, interfered with DNA repair synthesis. Given its responsiveness to different type of DNA lesions, this system offers an additional tool to study DNA repair mechanisms.

The humble salamander may provide evidence to support a controversial claim that North and South America were joined together much earlier than previously thought. The […]

The post Salamander DNA reveals evidence of older land connection between Central and South America appeared first on Smithsonian Insider.

When Smithsonian Conservation Biology Institute conservation biologist Jessica Deichmann joined a project to determine how the construction of a road in Gabon’s Moukalaba-Doudou National Park […]

The post DNA untangles Gabon’s complex web of frog species appeared first on Smithsonian Insider.

Researchers at the Smithsonian's National Zoo's new genetics lab use animal DNA to diagnose new diseases, discover new species help in conservation efforts and solve mysteries.

The post Scientists at a new National Zoo laboratory use DNA to diagnose illnesses and discover new species of animals appeared first on Smithsonian Insider.

Recent analysis using DNA sequencing of ancient Roman pills found aboard a ship that sank in Italy’s Gulf of Baratti between 140 -120 B.C, has revealed that the medicines consist of material from simple garden plants, namely carrot, radish, parsley, celery, wild onion and cabbage.

The post DNA sequencing reveals simple vegetables in ancient Roman medicines appeared first on Smithsonian Insider.

Going for the gut will soon become standard protocol for scientists working to unravel the complex living web of interactions between plants and animals on […]

The post Going for the gut: DNA from beetle stomachs reveals complex network appeared first on Smithsonian Insider.

Why do we love orchids so much? Tom Mirenda, Smithsonian Gardens orchid collection specialist, believes it is partly because orchids seem to look back at […]

The post 5 Crazy Things You Didn’t Know About Orchids appeared first on Smithsonian Insider.

Zebra mussels in the Great Lakes, lionfish in the Atlantic and pythons in the Everglades: Large creatures like these generally draw the spotlight when talking […]

The post DNA is trusty new weapon for detecting slime nets and other invasive marine parasites appeared first on Smithsonian Insider.

A cosplay gathering in the Anaheim Convention Center's Grand Plaza during WonderCon Anaheim 2014.; Credit: Kevin Green/SDCC

For all the sad comic book and pop culture fans who weren't able to get tickets to San Diego Comic-Con, we've got good news for you: They run another convention, and it's closer to Los Angeles. Their little brother WonderCon Anaheim has been growing, with some comparing it to the Comic-Con of old — before it got way too crowded. It's this Friday through Sunday, April 3-5. They're starting to have big stars and lots of great panels, so if you want to get your geek heart sated, here are some of the events you won't want to miss.

Warner Bros. Presentation: San Andreas, Mad Max: Fury Road

San Andreas trailer

The most highly anticipated event at this weekend's convention, Warner Brothers is putting on a special presentation with footage from these two upcoming action films. They haven't announced which stars will be on hand, but these panels often surprise with star power, so you may get a visit from stars like "San Andreas's" Dwayne "The Rock" Johnson or "Mad Max: Fury Road's" Tom Hardy or Charlize Theron. At the Comic-Con panel last year for the "Mad Max" flick, the director talked in detail about the film, so you'll probably at least get his take on the franchise and its resurrection.

DC Comics TV shows: The Flash, Gotham, iZombie

The Flash trailer

While Marvel has been dominant on the big screen, DC has put out a diverse slate of TV shows, with "The Flash" being the biggest hit among them. It's among those getting a spotlight at WonderCon, with creators and stars dishing on the programs that have captured the imaginations of TV fans and comic fans alike. All three shows are also getting special video presentations, likely showing clips of what you can expect the rest of this season. And in case you didn't already know, "iZombie" comes from "Veronica Mars" creator Rob Thomas, so come find out about his latest project.

World Premiere: Batman vs. Robin

Batman vs. Robin trailer

It's become a tradition at both WonderCon and San Diego Comic-Con for DC Comics to debut their latest animated movie, and the new one is based on the critically acclaimed "Court of Owls" storyline by writer Scott Snyder. (Be sure to check out our previous interviews with Snyder — he's even an NPR fan.) The original story is based on how Batman thinks he knows everything there is to know about Gotham City and faces the discovery that there are deep secrets about the city that he had no idea about, and the film also emphasizes him fighting his son Damian.

Sing-alongs: Dr. Horrible & Batman's The Music Meister

Batman: The Brave and the Bold: Drives Us Bats

People go to comic conventions to geek out, and what's geekier than a good old-fashioned singalong? In addition to one for geek god Joss Whedon's much loved Web series "Dr. Horrible's Sing-Along Blog," they're also doing one for the musical episode of animated series "Batman: The Brave and the Bold" — which, just like "Dr. Horrible," features singing by the one and only Neil Patrick Harris. In the Batman cartoon, he plays the Music Meister, a Batman villain who makes both heroes and villains sing, as he drops some tunes of his own.

Superman: The Richard Donner Years Celebrity Super Reunion

Superman: The flying sequence

There's a reunion of stars from the first two of the classic Christopher Reeve Superman movies, including Lois Lane herself, Margot Kidder. You can also see the actors who played characters like Jimmy Olsen, several of the villains and more, as well as two of the producers. Find out what you don't know about the movie that broke ground when it came to depicting flight on-screen and, like the ads promised, made you believe a man could fly.

TV writing panels

Two panels will give you a peek into the world of the writers who write some of the hottest shows on TV: "TV Guide Magazine's Fan Favorites Showrunners" and "Inside The Writers' Room: Earth's Mightiest Writers Re-Assemble Redux." The first of those includes legendary TV showrunners like Dan Harmon of "Community" and the minds behind shows including "Orphan Black," "The Goldbergs" and more. Meanwhile, at the writers room panel, you'll get writers who've worked on shows like "Lost," "Firefly," "Heroes," "The Big Bang Theory," "Agent Carter" and more.

Fan culture programming track

This includes a lot of different panels, but it's a sign of the way fandom is shifting — it's a lifestyle that's far more diverse than it used to be, with a lot more gender parity. This track includes panels on topics like body confidence in cosplay, fashion, fitness, race and more. See what sparks your interest and might invite you into having an identity as a fan being a bigger part of your life while not letting anyone make you feel excluded.

There's so much more, like Will Forte doing a panel promoting his new show "The Last Man On Earth," the annual cosplay masquerade and so much more. Tickets are sold out for Saturday, but at press time, tickets were still available for both Friday and Sunday at WonderCon.

This content is from Southern California Public Radio. View the original story at SCPR.org.

Full Text:

A National Science Foundation-funded study found that Charles Darwin's famous finches defy what has long been considered a key to evolutionary success: genetic diversity. The research on finches of the Galapagos Islands could change the way conservation biologists think about a species' potential for extinction in naturally fragmented populations. Researchers examined 212 tissue samples from museum specimens and living birds. Some of the museum specimens in the study were collected by Darwin himself in 1835. Only one of the extinct populations, a species called the vegetarian finch, had lower genetic diversity compared to modern survivors. Specifically, researchers believe a biological phenomenon called sink-source dynamics is at play in which larger populations of birds from other islands act as a "source" of immigrants to the island population that is naturally shrinking, the "sink." Without these immigrant individuals, the natural population on the island likely would continue to dwindle to local extinction. The immigrants have diverse genetics because they are coming from a variety of healthier islands, giving this struggling "sink" population inflated genetic diversity.

Image credit: Jose Barreiro

While confirming that the science behind DNA forensics is valid, a new report from a committee of the National Research Council recommends new ways of interpreting DNA evidence to help answer a key question for jurors -- how likely it is that two matching samples came from different people.

The Gulf Research Program (GRP) of the National Academies of Sciences, Engineering, and Medicine is collaborating with the Sea Grant Oil Spill Science Outreach Program to convene a series of workshops aimed at improving community preparedness for future oil spills.

When Sara Altschule took a 23andMe ancestry test, the results confirmed what she already suspected - She is 77 percent Ashkenazi Jewish.

Patt Morrison's outfit from her June 5, 2013 Patt's Hats entry. ; Credit: Michelle Lanz/KPCC

There are so many things  I like about this dress – the sleeve length, the boat neck, the fact that it’s navy and not black, and the fact that it wasn’t made in Bangladesh – but mostly it’s the gaily asymmetrical floral design that caught my eye.

The pattern is front and back, and I’m a stickler about those things. It looks like I have been loaded down with festive leis, but also loaded with one too many Mai Tais, so the flower garlands are askew as if I were listing a little bit.

There’s more of my current yellow shoe madness with these very Michelle Obama kitten-heel slingbacks in two different tones of yellow, one a more acid shade and the other more canary, or perhaps chrome yellow. That’s not to be confused with “Crome Yellow,” a very sardonic Aldous Huxley novel parodying the artsy intelligentsia set of 1920s England.

I hope you can see this bracelet. It’s a piece of Victorian mourning jewelry. The Victorians went way, way over the top on this stuff; some of it borders on the ghoulish, with lockets containing elaborately braided locks or even portraits or scenes made entirely from the hair of the deceased. I can admire the artistry but the sentiment can seem excessive. This piece, though, has a black and white enamel border around a tiny fly. Why a fly, I wondered. Then I read the inscription inside:

“From JR to AHR [clearly a husband to a wife] in loving memory of our darling little May Queen, died 7th August 1880, age 14 Mos.”

That inscription made the fly make sense. It’s a mayfly, a creature that lives a few days, or even just a few minutes, and here was this little girl, born in May – hence the May Queen reference to the mythical springtime queen of antiquity -- and died barely a year thereafter. So sweet, so sad, so human, all from an inscription on a bracelet. The girl’s parents are long dead, and so too are any siblings she may have had, but it can touch us more than 130 years later.

This content is from Southern California Public Radio. View the original story at SCPR.org.

4 awesome discoveries you probably didn't hear about this week -- Episode 31

4 awesome discoveries you probably didn't hear about this week -- Episode 32

Full Text:

A National Science Foundation-funded study found that Charles Darwin's famous finches defy what has long been considered a key to evolutionary success: genetic diversity. The research on finches of the Galapagos Islands could change the way conservation biologists think about a species' potential for extinction in naturally fragmented populations. Researchers examined 212 tissue samples from museum specimens and living birds. Some of the museum specimens in the study were collected by Darwin himself in 1835. Only one of the extinct populations, a species called the vegetarian finch, had lower genetic diversity compared to modern survivors. Specifically, researchers believe a biological phenomenon called sink-source dynamics is at play in which larger populations of birds from other islands act as a "source" of immigrants to the island population that is naturally shrinking, the "sink." Without these immigrant individuals, the natural population on the island likely would continue to dwindle to local extinction. The immigrants have diverse genetics because they are coming from a variety of healthier islands, giving this struggling "sink" population inflated genetic diversity.

Image credit: Jose Barreiro