French translation of the press release about the Basel Committee publishing a discussion paper on "The regulatory treatment of sovereign exposures" (7 December 2017)

By Dr. Grazie Pozo Christie

When Archbishop Jose Gomez was elected to head the U.S. Conference of Catholic Bishops (USCCB) earlier this month, he tweeted that it was an honor - and not only for him, but for “every Latino Catholic in the country.” He’s right about that. We Latino Catholics feel it a great honor and a point of pride that a fellow Hispanic should take the lead. Not just because he is Latino, but because he’s a man with a sterling character and gentle manner, a man well known both for his sympathetic attitude toward the plight of immigrants and his traditional approach to social issues. This is a powerful and attractive combination to our growing Hispanic Catholic Church.

Gomez, a native of Monterrey, Mexico and a naturalized U.S. citizen, presides over the Los Angeles diocese, the largest and one of the most diverse dioceses in the country. Its parishes encompass more than thirty ethnicities, celebrating masses in languages from Igbo to Hungarian to Tagalog. The catholicity, that is, the universality--of the Catholic Church is a palpable thing in L.A., not simply a doctrinal concept. It’s the result of a constant and varied immigration. 

As leader of the USCCB, Archbishop Gomez will head an American Catholic Church that is about 58% non-Hispanic white and 34% Latino - a church in which most members under 30 are Hispanic. A significant number of the 2.7 million Hispanics that attend mass in Spanish are undocumented, and an even greater number probably know or love someone whose presence here is precarious. Gomez brings a history of heartfelt public support for the undocumented workers that America relies on to farm our crops, tidy our lawns, man our factories, and look after our children. He has been an especially vocal advocate of “dreamers.” “In a special way, I pray for #Dreamers, the day before #Scotus hears oral arguments on the legality of DACA,” he tweeted just after his election.

Archbishop Gomez is the author of the excellent “Immigration and the Next America.” The 2013 book neatly lays out his assessment of our current situation and his vision for a better future. He chronicles the historical background of a nation founded by Puritans searching for freedom but also (and even earlier) colonized by Spanish missionary migrants in a successful quest to evangelize the native population. He assesses a present-day America that lacks moral consensus and is crazed with consumerism, a nation confused about everything from the meaning of sexuality to the value (if any) of human life. He sees a country in which the ties of traditional American values and civic virtues that once bound us to one another are frayed, a country whose uneasy citizenry worries about what the “Next America” will look like. 

Gomez does not downplay the importance of legal norms and the very real toll that the chaos and lawlessness of illegal immigration takes, especially along our southern border. He argues, however, that fear and uncertainty may tempt us to “abandon our commitment to liberty and justice for all, in favor of an insular, racial definition of who can be a true American.” American Catholics, members of an immigrant Church in a country with a long history of anti-Catholic bias have a special responsibility in today’s debates over immigration reform. We bring to the table not only the memory of our ancestor’s experience of discrimination and the Church’s energetic response to the material and spiritual needs of successive waves of migrants, but also its rich tradition of teaching on human dignity and social justice. Catholics are especially suited to envision the face of the “Next America” in a way faithful to the Christian obligation of benevolence to strangers. 

U.S. Hispanics have a lot to be happy about in Archbishop Gomez’s election. He is a man with a tender heart for the vulnerable people in our midst who can also articulate a way forward on immigration that is attractive and optimistic - one based on the highest ideals that are our shared inheritance in this diverse country. He is also a man who bridges the liberal/conservative divide by quietly affirming the traditional mores and values that Hispanics are bent on preserving. But then, I venture to say that his election gives all American Catholics reason to be happy too. 

In “Painting Nationalism Red?”, an engaging new pamphlet published by Democratic Left Scotland, the journalist Neal Ascherson pays tribute to Tom Nairn as Scotland’s “pre-eminent political intellectual”.

Croatia's Zagreb head into the final group game knowing that victory will secure a place in the UEFA Regions' Cup final after they replaced Istanbul at the top of Group A.

The direct effects of prolactin on the nutritional and antimicrobial composition of breast milk have not been examined previously in women.

The study demonstrates that recombinant human prolactin increases milk volume, induces changes in milk composition consistent with those during normal lactogenesis, and increases antimicrobially active oligosaccharide concentrations. The data suggest that prolactin is an important mediator of normal lactogenesis. (Read the full article)

The incidence of plagiocephaly varies widely and is based on anecdotal evidence of increase in the number of referrals to specialty clinics. Five studies have produced varying results, indicating that the incidence of plagiocephaly ranges from 3.1% to 61.0%.

This is the first study to estimate the incidence of positional plagiocephaly using 4 community-based data collection sites in infants ranging from 7 to 12 weeks of age. The estimated incidence of positional plagiocephaly was found to be 46.6%. (Read the full article)

There is wide variation in testing and treatment of children hospitalized with pneumonia. Limited data are available on diagnostic testing patterns and the association of test utilization with disposition outcomes for children with pneumonia evaluated in the emergency department (ED).

Significant variation exists in testing for pediatric pneumonia. EDs that use more testing have higher hospitalization rates. However, ED revisit rates were not significantly different between high- and low-utilizing EDs, suggesting an opportunity to reduce testing without negatively affecting outcomes. (Read the full article)

The American Academy of Pediatrics has identified bedding such as pillows, blankets, and quilts as potentially hazardous for the infant sleep environment. Bedding use is a modifiable risk factor for sudden infant death syndrome and unintentional sleep-related suffocation.

Reported bedding use over or under the infant for infant sleep substantially declined from 1993 to 2010. However, about one-half of US infants are still placed to sleep with potentially hazardous bedding despite recommendations against this practice. (Read the full article)

John Boland accepted an offer as an audit associate at the highly competitive firm after just a few months in the Master of Professional Accounting program offered by Penn State Great Valley.

A Fin24 reader under debt consolidation is left with less than R3 000 per month, finding it impossible to make ends meet. A finance expert responds.

Massachusetts Sen. Elizabeth Warren's education plan landed on Monday, and among other consequences, it led to a conversation about her past statements addressing "vouchers."

John Penders
Aug 1, 2006; 118:511-521
ARTICLES

CNA Staff, Apr 24, 2020 / 11:31 am (CNA).- The bishops of Togo called for peace and respect for the rights of citizens after the violent arrest of an opposition leader from his home on Tuesday.

“[E]very citizen has the right and duty to express his/her disapproval in the face of manifest injustice and oppression,” the Catholic bishops of Togo said in a statement, according to English Africa Service.

“The physical violence and other inhuman and degrading treatment inflicted on citizens on this occasion is, therefore, a negation of their rights and freedoms…the Conference of Bishops denounces and condemns them, and calls on authorities to exercise restraint.”

In their statement, the bishops said they were dismayed to learn that opposition leader Agbeyome Kodjo had been arrested at his home this week, “in circumstances of brutality and violence perpetrated by the Defence and Security Forces.”

News reports indicated that police had broken into Kodjo’s home to arrest him for failing to appear before the nation’s intelligence police force. The opposition leader previously served as prime minister of the country, but his diplomatic immunity was removed last month by Parliament.

Kodjo, who heads the Patriotic Movement for Democracy and Development, came in a distant second to incumbent President Faure Gnassingbé Eyadéma in the nation’s February presidential elections.

Kodjo called the results a farce and declared himself the rightful president of the country. He said his calculations showed that he had received some 60% of the nation’s votes, while official tallies put him at about 18%.

Gnassingbé has been president of Togo since 2005 and is entering his fourth term. His father previously ruled the country after a 1967 coup.

Togo has seen political instability and widespread poverty in recent years. Protests in 2017 called for the resignation of Gnassingbé and resulted in harsh crackdowns.

Last month, 90-year-old Archbishop emeritus Philippe Fanoko Kpodzro of Lome was placed under house arrest briefly, after he encouraged protests following the presidential election.

Blade Urban Air Mobility Program in India: The air-taxi has begun operations in Mumbai, Pune, and Shirdi, today

<b>New Delhi:</b> NCP chief Sharad Pawar on Monday today met Congress president Sonia Gandhi at her residence here amidst an impasse between the BJP and its ally the Shiv Sena on the government formation in Maharashtra. Speaking to reporters after the meeting, Pawar reiterated that the "mandate to NCP given

One out of three reputed firms is having a non-Dane at the steerage as organizations in Denmark are viewing the whole globe as their pool for notable talents. The point when Denmark's biggest organizations require a CEO, they are progressively set outside…

Denmark has reclaimed its position as the world’s happiest nation. This was mentioned as per the reports from fourth World Happiness that was revealed.Denmark tops the list in the initial report in the year 2012 and 2013. But last year it was replaced…

The deaths of 16 migrant workers from Madhya Pradesh, who were crushed by a train in Maharashtra's Aurangabad on Friday, has raised serious questions about the coordination between the governments of...

Quarterbacks at the top. Elite wide receiver talent. And a top tier of offensive linemen. The Class of 2021 could be special.

A number of recent announcements highlight just how quickly and aggressively the U.S. offshore wind industry is growing in the Northeast. States are enacting offshore wind target capacity laws and initiatives and companies are setting up offices in the region and making strategic hires so they can participate in what will soon be a booming industry.

On 18 July 2017, the Court of Appeal handed down judgment in Catesby Estates and SSCLG v Steer and Historic England in considering whether an inspector erred in law in his understanding of the concept of the “setting” of a Grade I listed...

Cornerstone Telecommunications Infrastructure Limited v Compton Beauchamp Estates Limited [2019] EWCA Civ 1755 The Court of Appeal’s judgement is the latest decision concerning the Code and the first appeal heard concerning the Electr...

Alger -Le nombre de fonctionnaires...

Pressure from progressives for more expansive government assistance programs, especially now during the COVID pandemic, along with concerns over a recent sexual assault allegation and a challenge from a third-party candidate, threaten to fracture that unified support

Part 4 of 4 Compared to the rest of the world, OTT regulation is fairly advanced in Europe and subject to a completely different approach in Africa and Middle East. It seems that in this part of the world, OTT services are commonly banned to protect...

On 3 June 2016, the Supreme Court ruled that a valid right of pledge can be established on goods that are delivered subject to retention of title (of ownership). If the buyer is declared bankrupt, the conditional ownership can become an uncondition...

On 28 July 2017 the Legislative Decree transposing Directive 2014/65/EU on markets in financial instruments (MiFID II) and Regulation (EU) 600/2014 (MiFIR) in Italy (the “Decree”) has been finally approved.The Decree amends and integrate...

Opposition to President Donald Trump has consolidated Democratic party...

[Nyasa Times] Malawi opposition supporters erupted into wild scenes of celebrations on Friday after the Supreme Court on Friday in a unanimous decision upheld an earlier constitutional court ruling that declared President Peter Mutharika was "not duly elected" in a disputed 2019 vote.

Someone has said that God plus one equals a majority. The truth is that God alone makes a majority. If every creature in the material and immaterial universe combined to oppose God together, still He would not be defeated. He is infinitely greater, and holier, and wiser, and more powerful than the aggregate of all His creation.

A series of deadly unrests in the last two weeks that have claimed nearly two dozen lives.

A meeting in Hong Kong’s legislature descended into shouting matches and scuffles as 11 opposition lawmakers were thrown out by a pro-establishment leader who took control of a key committee to begin clearing a backlog of bills for review.The pan-democrats walked out of talks on Friday after losing their hold over the House Committee, threatening court action against Legislative Council staff, including legal advisers and security guards, whom they accused of abandoning political neutrality and…

LONDON: Fifty Labour Party parliamentarians have told the new Labour leader Keir Starmer that his recent statement on Indian Occupied Kashmir after a meeting with Labour Friends of India is...

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LONDON: Fifty Labour Party parliamentarians have told the new Labour leader Keir Starmer that his recent statement on Indian Occupied Kashmir after a meeting with Labour Friends of India is...

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ABSTRACT

Much of the diversity of prokaryotic genomes is contributed by the tightly controlled recombination activity of transposons (Tns). The Tn3 family is arguably one of the most widespread transposon families. Members carry a large range of passenger genes incorporated into their structures. Family members undergo replicative transposition using a DDE transposase to generate a cointegrate structure which is then resolved by site-specific recombination between specific DNA sequences (res) on each of the two Tn copies in the cointegrate. These sites also carry promoters controlling expression of the recombinase and transposase. We report here that a number of Tn3 members encode a type II toxin-antitoxin (TA) system, typically composed of a stable toxin and a labile antitoxin that binds the toxin and inhibits its lethal activity. This system serves to improve plasmid maintenance in a bacterial population and, until recently, was believed to be associated with bacterial persistence. At least six different TA gene pairs are associated with various Tn3 members. Our data suggest that several independent acquisition events have occurred. In contrast to most Tn3 family passenger genes, which are generally located away from the transposition module, the TA gene pairs abut the res site upstream of the resolvase genes. Although their role when part of Tn3 family transposons is unclear, this finding suggests a potential role for the embedded TA in stabilizing the associated transposon with the possibility that TA expression is coupled to expression of transposase and resolvase during the transposition process itself.

IMPORTANCE Transposable elements (TEs) are important in genetic diversification due to their recombination properties and their ability to promote horizontal gene transfer. Over the last decades, much effort has been made to understand TE transposition mechanisms and their impact on prokaryotic genomes. For example, the Tn3 family is ubiquitous in bacteria, molding their host genomes by the paste-and-copy mechanism. In addition to the transposition module, Tn3 members often carry additional passenger genes (e.g., conferring antibiotic or heavy metal resistance and virulence), and three were previously known to carry a toxin-antitoxin (TA) system often associated with plasmid maintenance; however, the role of TA systems within the Tn3 family is unknown. The genetic context of TA systems in Tn3 members suggests that they may play a regulatory role in ensuring stable invasion of these Tns during transposition.

ABSTRACT

Aquifers, which are essential underground freshwater reservoirs worldwide, are understudied ecosystems that harbor diverse forms of microbial life. This study investigated the abundance and composition of prokaryotic and viral communities in the outflow of five springs across northern Florida, USA, as a proxy of microbial communities found in one of the most productive aquifers in the world, the Floridan aquifer. The average abundances of virus-like particles and prokaryotic cells were slightly lower than those reported from other groundwater systems, ranging from 9.6 x 10³ ml^–1 to 1.1 x 10⁵ ml^–1 and 2.2 x 10³ ml^–1 to 3.4 x 10⁴ ml^–1, respectively. Despite all of the springs being fed by the Floridan aquifer, sequencing of 16S rRNA genes and viral metagenomes (viromes) revealed unique communities in each spring, suggesting that groundwater microbial communities are influenced by land usage in recharge zones. The prokaryotic communities were dominated by Bacteria, and though the most abundant phyla (Proteobacteria, Cyanobacteria, and Bacteroidetes) were found in relatively high abundance across springs, variation was seen at finer taxonomic resolution. The viral sequences were most similar to those described from other aquatic environments. Sequencing resulted in the completion of 58 novel viral genomes representing members of the order Caudovirales as well as prokaryotic and eukaryotic single-stranded DNA (ssDNA) viruses. Sequences similar to those of ssDNA viruses were detected at all spring sites and dominated the identifiable sequences at one spring site, showing that these small viruses merit further investigation in groundwater systems.

IMPORTANCE Aquifer systems may hold up to 40% of the total microbial biomass on Earth. However, little is known about the composition of microbial communities within these critical freshwater ecosystems. Here, we took advantage of Florida’s first-magnitude springs (the highest spring classification based on water discharge), each discharging at least 246 million liters of water each day from the Floridan aquifer system (FAS), to investigate prokaryotic and viral communities from the aquifer. The FAS serves as a major source of potable water in the Southeastern United States, providing water for large cities and citizens in three states. Unfortunately, the health of the FAS and its associated springs has declined in the past few decades due to nutrient loading, increased urbanization and agricultural activity in aquifer recharge zones, and saltwater intrusion. This is the first study to describe the prokaryotic and viral communities in Florida’s first-magnitude springs, providing a baseline against which to compare future ecosystem change.

ABSTRACT

Bacteria that encounter antibiotics can efficiently change their physiology to develop resistance. This intrinsic antibiotic resistance is mediated by multiple pathways, including a regulatory system(s) that activates specific genes. In some Streptomyces and Mycobacterium spp., the WblC/WhiB7 transcription factor is required for intrinsic resistance to translation-targeting antibiotics. Wide conservation of WblC/WhiB7 within Actinobacteria indicates a critical role of WblC/WhiB7 in developing resistance to such antibiotics. Here, we identified 312 WblC target genes in Streptomyces coelicolor, a model antibiotic-producing bacterium, using a combined analysis of RNA sequencing and chromatin immunoprecipitation sequencing. Interestingly, WblC controls many genes involved in translation, in addition to previously identified antibiotic resistance genes. Moreover, WblC promotes translation rate during antibiotic stress by altering the ribosome-associated protein composition. Our genome-wide analyses highlight a previously unappreciated antibiotic resistance mechanism that modifies ribosome composition and maintains the translation rate in the presence of sub-MIC levels of antibiotics.

IMPORTANCE The emergence of antibiotic-resistant bacteria is one of the top threats in human health. Therefore, we need to understand how bacteria acquire resistance to antibiotics and continue growth even in the presence of antibiotics. Streptomyces coelicolor, an antibiotic-producing soil bacterium, intrinsically develops resistance to translation-targeting antibiotics. Intrinsic resistance is controlled by the WblC/WhiB7 transcription factor that is highly conserved within Actinobacteria, including Mycobacterium tuberculosis. Here, identification of the WblC/WhiB7 regulon revealed that WblC/WhiB7 controls ribosome maintenance genes and promotes translation in the presence of antibiotics by altering the composition of ribosome-associated proteins. Also, the WblC-mediated ribosomal alteration is indeed required for resistance to translation-targeting antibiotics. This suggests that inactivation of the WblC/WhiB7 regulon could be a potential target to treat antibiotic-resistant mycobacteria.

Human activities and population growth have increased the natural burden of reactive nitrogen (N) in the environment. Excessive N deposition on Earth’s surface leads to adverse feedbacks on ecosystems and humans. Similar to that of air pollution, emission control is recognized as an efficient means to control acid deposition. Control...

Background

Arteriovenous fistulas placed surgically for dialysis vascular access have a high primary failure rate resulting from excessive inward remodeling, medial fibrosis, and thrombosis. No clinically established pharmacologic or perisurgical therapies currently address this unmet need. Statins’ induction of multiple anti-inflammatory and antithrombotic effects suggests that these drugs might reduce arteriovenous fistula failure. Yet, the in vivo physiologic and molecular effects of statins on fistula patency and maturation remain poorly understood.

Discovery of the Breagh gas field in the Southern North Sea (SNS) has demonstrated the potential that the Lower Carboniferous (Visean, 346.7–330.9 Ma) Farne Group reservoirs have to contribute to the UK's future energy mix. New biostratigraphic correlations provide a basis to compare Asbian and Brigantian sedimentary cores from the Breagh Field and age-equivalent sediments exposed on the Northumberland Coast, which has proved critical in gaining an understanding of exploration and development opportunities. Thirteen facies associations characterize the mixed carbonate–siliciclastic system, grouped into: marine, delta front, delta shoreface, lower delta plain and upper delta plain gross depositional environments. The facies associations are interpreted as depositing in a mixed carbonate and siliciclastic fluvio-deltaic environment, and are arranged into coarsening- and cleaning-upward cycles (parasequences) bounded by flooding surfaces. Most cycles are characterized by mouth bars, distributary channels, interdistributary bays and common braided rivers, interpreted as river-dominated deltaic deposits. Some cycles include rare shoreface and tidally-influenced deposits, interpreted as river-dominated and wave- or tide-influenced deltaic deposits. The depositional processes that formed each cycle have important implications for the reservoir net/gross ratio (where this ratio indicates the proportion of sandstone beds in a cycle), thickness and lateral extent. The deltaic deposits were controlled by a combination of tectonic and eustatic (allocyclic) events and delta avulsion (autocyclic) processes, and are likely to reflect a changing tectonic regime, from extension within elongate fault-bounded basins (synrift) to passive regional thermal subsidence (post-rift). Deep incision by the Base Permian Unconformity across the Breagh Field has removed the Westphalian, Namurian and upper Visean, to leave the more prospective thicker clastic reservoirs within closure.

Thematic collection: This article is part of the Under-explored plays and frontier basins of the UK continental shelf collection available at: https://www.lyellcollection.org/cc/under-explored-plays-and-frontier-basins-of-the-uk-continental-shelf

The progressive development of microfabrics from initial deposition to slump deformation and then a submarine slide was investigated in an active subduction zone using cores recovered during the Integrated Ocean Drilling Program Expedition 333. A Pleistocene–Holocene sequence was recovered at Site C0018A, which was located on a slope basin on the footwall of the megasplay fault in the Nankai Trough, SW Japan. Six mass-transport deposit units intercalated with coherent intervals were recovered from the upper 190 m of the drilled succession. The initial microfabrics in the undeformed hemipelagic sediments were characterized by random and porous fabrics composed predominantly of clay aggregations and connectors. The initial fabrics were cardhouse fabrics, which consist of clay flakes with edge-to-edge (E–E) and/or edge-to-face (E–F) contacts. These initial microfabrics developed into compacted microfabrics, which are random and consolidated fabrics (bookhouse fabrics) that consist of clay flakes with E–F and/or face-to-face (F–F) contacts and develop during burial as a pure shear deformation. During slumping, these fabrics were then deformed under simple shear to become predominantly F–F contacts and form clay chains. Thus, the microfabrics in these submarine slides are a sedimentary mélange that developed locally into a preferred clay orientation with F–F contacts.

Supplementary material: A schematic illustration showing sedimentation processes and fabrics is available at https://doi.org/10.6084/m9.figshare.c.4483385

Thematic collection: This article is part of the Polygenetic mélanges collection available at: https://www.lyellcollection.org/cc/polygenetic-melanges

We previously produced a heavy-chain-only antibody (Ab) VH domain (V_HH)-displayed phage library from two alpacas that had been immunized with ricin toxoid and nontoxic mixtures of the enzymatic ricin toxin A subunit (RTA) and binding ricin toxin B subunit (RTB) (D. J. Vance, J. M. Tremblay, N. J. Mantis, and C. B. Shoemaker, J Biol Chem 288:36538–36547, 2013, https://doi.org/10.1074/jbc.M113.519207). Initial and subsequent screens of that library by direct enzyme-linked immunosorbent assay (ELISA) yielded more than two dozen unique RTA- and RTB-specific V_HHs, including 10 whose structures were subsequently solved in complex with RTA. To generate a more complete antigenic map of ricin toxin and to define the epitopes associated with toxin-neutralizing activity, we subjected the V_HH-displayed phage library to additional "pannings" on both receptor-bound ricin and antibody-captured ricin. We now report the full-length DNA sequences, binding affinities, and neutralizing activities of 68 unique V_HHs: 31 against RTA, 33 against RTB, and 4 against ricin holotoxin. Epitope positioning was achieved through cross-competition ELISAs performed with a panel of monoclonal antibodies (MAbs) and verified, in some instances, with hydrogen-deuterium exchange mass spectrometry. The 68 V_HHs grouped into more than 20 different competition bins. The RTA-specific V_HHs with strong toxin-neutralizing activities were confined to bins that overlapped two previously identified neutralizing hot spots, termed clusters I and II. The four RTB-specific V_HHs with potent toxin-neutralizing activity grouped within three adjacent bins situated at the RTA-RTB interface near cluster II. These results provide important insights into epitope interrelationships on the surface of ricin and delineate regions of vulnerability that can be exploited for the purpose of vaccine and therapeutic development.

Loess, a wind-blown silty soil, can be deposited under a variety of moisture conditions, including dry deposition, wet deposition and gravitational settling of aggregations formed in moist air by capillary forces at grain contacts. This experimental study uses single and double oedometer tests to assess the effect of depositional water content on the collapse potential of reconstituted samples of the Langley Silt Member, known as Brickearth, a natural loessic soil. A freefall sample preparation technique was used to mimic loess formation and environmental scanning electron microscopy was used to relate the observed behaviour to sample fabric. The results show that loess deposited at higher water contents has a greater collapse potential, which is shown to be related to its looser, more granular fabric.

ABSTRACT

The chemical structures of soluble fiber carbohydrates vary from source to source due to numerous possible linkage configurations among monomers. However, it has not been elucidated whether subtle structural variations might impact soluble fiber fermentation by colonic microbiota. In this study, we tested the hypothesis that subtle structural variations in a soluble polysaccharide govern the community structure and metabolic output of fermenting microbiota. We performed in vitro fecal fermentation studies using arabinoxylans (AXs) from different classes of wheat (hard red spring [AX_HRS], hard red winter [AX_HRW], and spring red winter [AX_SRW]) with identical initial microbiota. Carbohydrate analyses revealed that AX_SRW was characterized by a significantly shorter backbone and increased branching compared with those of the hard varieties. Amplicon sequencing demonstrated that fermentation of AX_SRW resulted in a distinct community structure of significantly higher richness and evenness than those of hard-AX-fermenting cultures. AX_SRW favored OTUs within Bacteroides, whereas AX_HRW and AX_HRS favored Prevotella. Accordingly, metabolic output varied between hard and soft varieties; higher propionate production was observed with AX_SRW and higher butyrate and acetate with AX_HRW and AX_HRS. This study showed that subtle changes in the structure of a dietary fiber may strongly influence the composition and function of colonic microbiota, further suggesting that physiological functions of dietary fibers are highly structure dependent. Thus, studies focusing on interactions among dietary fiber, gut microbiota, and health outcomes should better characterize the structures of the carbohydrates employed.

IMPORTANCE Diet, especially with respect to consumption of dietary fibers, is well recognized as one of the most important factors shaping the colonic microbiota composition. Accordingly, many studies have been conducted to explore dietary fiber types that could predictably manipulate the colonic microbiota for improved health. However, the majority of these studies underappreciate the vastness of fiber structures in terms of their microbial utilization and omit detailed carbohydrate structural analysis. In some cases, this causes conflicting results to arise between studies using (theoretically) the same fibers. In this investigation, by performing in vitro fecal fermentation studies using bran arabinoxylans obtained from different classes of wheat, we showed that even subtle changes in the structure of a dietary fiber result in divergent microbial communities and metabolic outputs. This underscores the need for much higher structural resolution in studies investigating interactions of dietary fibers with gut microbiota, both in vitro and in vivo.

Glass is the favorite material for parenteral packaging because of its physico-chemical properties. Type I borosilicate glass is worldwide use at this scope, but it may have some issues related to breakage, corrosion and delamination that might compromise the drug quality, safety and efficacy. These issues can be mitigated and avoided starting from the appropriate selection of the most suitable raw material at the early stage of the glass container design. In this study, Type I borosilicate glass vials manufactured using two glass tubes having different chemical compositions, were studied and compared in terms of their resistance to corrosion. Testing design was applied with the aim to select the best practice approach comparing different storage simulation conditions: ageing treatment through autoclaving and stability testing (real-time and accelerated). Clear differences were found between the different glass types in terms of hydrolytic and corrosion resistance that highlighted the relation between chemical composition and glass chemical durability. Non-negligible differences were also observed using different storage conditions.

Accumulation of lipid in skeletal muscle is thought to be related to the development of insulin resistance and type 2 diabetes. Initial work in this area focused on accumulation of intramuscular triglyceride; however, bioactive lipids such as diacylglycerols and sphingolipids are now thought to play an important role. Specific species of these lipids appear to be more negative toward insulin sensitivity than others. Adding another layer of complexity, localization of lipids within the cell appears to influence the relationship between these lipids and insulin sensitivity. This article summarizes how accumulation of total lipids, specific lipid species, and localization of lipids influence insulin sensitivity in humans. We then focus on how these aspects of muscle lipids are impacted by acute and chronic aerobic and resistance exercise training. By understanding how exercise alters specific species and localization of lipids, it may be possible to uncover specific lipids that most heavily impact insulin sensitivity.