1. Ameesha Patel sparks dating rumours with Nirvaan Birla after cozy Dubai pic goes viral  TOI Etimes
2. Gadar 2 Actress Ameesha Patel Gets Age Shamed As She Drops A Cosy Photo With Nirvaan Birla  Zee News
3. Ameesha Patel gets trolled over intimate pic with businessman Nirvaan Birla  ap7am
4. Ameesha Patel’s Cozy Photo With 'Darling' Nirvaan Birla Triggers Dating Rumours  News18
5. Did Ameesha Patel Confirm Dating Nirvaan Birla? Gadar 2 Actress Drops Romantic Pic From Dubai Getaway With 'Darling'  Times Now

1. Bhool Bhulaiyaa 3 Box Office Collection Day 12: Kartik Aaryan Delivers 402% More Than His Entire Paycheck For The Horror-Comedy!  Koimoi
2. Bhushan Kumar reveals favouritism behind Bhool Bhulaiyaa 3 and Singham Again Diwali clash: 'I even met Aj  TOI Etimes
3. Hindi video: Bhool Bhulaiyaa 3 Ami Je Tomar 3.0 full video goes viral; who won dance dare, Madhuri Dixit or Vidya Balan?  Mint
4. Bhool Bhulaiyaa 3 vs Singham Again box office collection day 12: Kartik Aaryan-led horror comedy, Ajay Devgn's film in neck-and-neck fight ahead of Kanguva release  Business Today
5. Kartik Aaryan smashes records with Bhool Bhulaiyaa 3, becomes youngest actor to join crore 200 club  Hindustan Times

1. Modi regime sees five-fold jump in ITR filers with income above Rs 50 lakh; middle class tax burden falls  The Economic Times
2. Modi regime sees five-fold jump in ITR filers with income above Rs 50 lakh  Deccan Herald
3. Tax burden shifting to super-rich, but middle class barely growing  The Financial Express
4. Taxpayers with annual income of over ₹1 crore rose 323% to 350,000 in 10 yrs  Hindustan Times
5. More than 8 cr ITRs filed for FY 24, 74 pc in new tax regime  The Economic Times

La Union has been named as the most competitive province in Ilocos region and placed seventh in the nationwide 2024 Cities and Municipalities Competitiveness Index for two consecutive years.

Malta International Airport generated €107.8 million in revenue for the first nine months of 2024, posting a net profit of €39.5 million

Returning to Washington, Trump meets with Biden in the Oval Office

KKL-JNF allocates NIS 4m. to upgrade, create memorial at Re'im Recreation Site in Be'eri Forest, where 384 people were murdered at Nova music festival on October 7.

Numerous security forces surrounded Dayr Qadis and are currently searching the area for the terrorist, the military announced. 

KARACHI: At a time when cities across Punjab are facing the worst air pollution in their history, two members of the ruling coalition on Tuesday made “insensitive” jibes over the issue in their posts on social media.

In his post on X, PPP Chairman Bilawal Bhutto-Zardari shared a chart of the air quality index readings of Pakistan’s major cities on November 10 at 9pm.

The chart showed Peshawar as the most polluted city with an AQI of 591, followed by Multan 573 and Lahore 479. Karachi was 7th with AQI of 78.

“Dear Pakistan, move to Karachi,” wrote Mr Bhutto-Zardari in his post.

Late at night, Defence Minister Khawaja Muhammad Asif said crop burning was unreasonably blamed for the smog when vehicles were the biggest polluters.

He shared a chart showing that total emissions from transport were 127 gigagrams, while that from stubble burning was 5.97gg.

The minister’s post did not mention the chart’s source or when the readings were taken.

He said the chart shows the “real culprits” contributing to the smog, but the people are being misled into believing that stubble burning, which has been going on “since the time of Mohenjo Daro”, was causing the pollution.

In another post, he referred to an order by Lahore High Court Justice Shahid Karim to close markets at 8pm, which was “yet to be implemented”.

According to the minister, the markets in Lahore remained open from 2pm to 2am and blamed the traders for being “intransigent” on this issue.

He also called out political leaders who are not ready to address this issue due to “political expediency”.

Published in Dawn, November 13th, 2024

Residents of India’s capital New Delhi choked in a blanketing toxic smog Wednesday as worsening air pollution surged past 50 times the World Health Organisation’s recommended daily maximum.

Many in the city cannot afford air filters, nor do they have homes they can effectively seal from the misery of foul-smelling air blamed for thousands of premature deaths.

Cooler temperatures and slow-moving winds trap deadly pollutants each winter, stretching from mid-October until at least January.

At dawn on Wednesday, “hazardous” pollutant levels in parts of the sprawling urban area of more than 30 million people topped 806 micrograms per cubic metre, according to monitoring firm IQAir.

That is more than 53 times the WHO-recommended daily maximum of fine particulate matter — dangerous cancer-causing microparticles known as PM2.5 pollutants that enter the bloodstream through the lungs.

By midday, when air usually is at its best, it eased to about 25-35 times above danger levels, depending on different districts.

The city is blanketed in acrid smog each year, primarily blamed on stubble burning by farmers in neighbouring regions to clear their fields for ploughing, as well as factories and traffic fumes.

‘Alarming’

But a report by The New York Times this month, based on air and soil samples it collected over five years, revealed the dangerous fumes also spewing from a power plant incinerating the city’s landfill garbage mountains.

Experts the newspaper spoke to said that the levels of heavy metals found were “alarming”.

Swirling white clouds of smog also delayed several flights across northern India.

The India Meteorological Department said that at least 18 regional airports had a visibility lower than 1,000 metres (1,093 yards) — dropping below 500m in Delhi.

India’s Supreme Court last month ruled that clean air was a fundamental human right, ordering both the central government and state-level authorities to take action.

But critics say arguments between rival politicians heading neighbouring states — as well as between central and state-level authorities — have compounded the problem.

Politicians are accused of not wanting to anger key figures in their constituencies, particularly powerful farming groups.

City authorities have launched several initiatives to tackle pollution, which have done little in practice.

Government trucks are regularly used to spray water to briefly dampen the pollution.

A new scheme unveiled earlier this month to use three small drones to spray water mist was derided by critics as another “band-aid” solution to a public health crisis.

The WHO says that air pollution can trigger strokes, heart disease, lung cancer and other respiratory diseases.

It is particularly punishing for babies, children and the elderly.

A study in The Lancet medical journal attributed 1.67m premature deaths to air pollution in the world’s most populous country in 2019.

1. Longleng District Observes World Pneumonia Day  Eastern Mirror
2. Govt to equip dist hosps to cut child pneumonia deaths  The Times of India
3. World Pneumonia Day: 7 natural ways to keep your lungs healthy  Health shots
4. World Pneumonia Day: 9 foods to fight pneumonia  Firstpost
5. World Pneumonia Day: Three young lives lost daily in Gujarat  Gujarat Samachar

1. Officers Carrying Out Illegal Demolitions Liable To Restore Properties At Personal Cost & Pay Damages:...  Live Law - Indian Legal News
2. How the Supreme Court clamped down on ‘bulldozer’ demolition drives | Explained  The Hindu
3. Akhilsh Yadav`s `Parked In Garage` Jab At Yogi Govt After SC`s Bulldozer Verdict  Zee News
4. SC parked bulldozer in garage forever: Akhilesh Yadav  Hindustan Times
5. What's the message from Supreme Court's order on bulldozer action? Experts debate  India Today

1. Oncologist stabbed at Chennai govt hospital ‘by 26-year-old whose mother is undergoing cancer treatment’  The Indian Express
2. Video: Chennai man calmly walks away after stabbing doctor, wipes knife  India Today
3. Indian Medical Association condemns brutal attack on doctor in Chennai  The New Indian Express
4. Daylight assault on doctor inside Chennai hospital leaves medical fraternity in shock  The Hindu
5. 'No law and order': BJP, AIADMK attack ruling DMK after government doctor stabbed in Chennai  The Times of India

1. Evening brief: BJP asks Delhi govt to close schools amid rising AQI; IMA condemns attack on doctor in Chennai; and more  Hindustan Times
2. Smog Blanket Over North India, Air Quality Drops To "Severe" Level  NDTV
3. BJP targets govt on pollution, AAP says don’t play politics  The Times of India
4. Delhi overtakes Lahore to become world's most polluted city  The Economic Times
5. City In Greyscale: Season’s First Fog, ‘Severe’ Air Day  The Times of India

Air pollution is one of the leading causes of early deaths worldwide, with particulate matter (PM) as an emerging factor contributing to this trend. PM is classified based on its physical size, which ranges from PM₁₀ (diameter ≤10 μm) to PM_2.5 (≤2.5 μm) and PM_0.5 (≤0.5 μm). Smaller-sized PM can move freely through the air and readily infiltrate deep into the lungs, intensifying existing health issues and exacerbating complications. Lung complications are the most common issues arising from PM exposure due to the primary site of deposition in the respiratory system. Conditions such as asthma, COPD, idiopathic pulmonary fibrosis, lung cancer and various lung infections are all susceptible to worsening due to PM exposure. PM can epigenetically modify specific target sites, further complicating its impact on these conditions. Understanding these epigenetic mechanisms holds promise for addressing these complications in cases of PM exposure. This involves studying the effect of PM on different gene expressions and regulation through epigenetic modifications, including DNA methylation, histone modifications and microRNAs. Targeting and manipulating these epigenetic modifications and their mechanisms could be promising strategies for future treatments of lung complications. This review mainly focuses on different epigenetic modifications due to PM_2.5 exposure in the various lung complications mentioned above.

Background

Lung cancer ranks as the leading cause of cancer-related deaths worldwide. There is evidence that second-hand smoke (SHS) exposure is a risk factor for the development of lung cancer in never-smokers. This systematic review and meta-analysis aims to provide the most accurate quantification of the association between SHS exposure and lung cancer risk in never-smokers.

Extracellular vesicles (EVs) released by various cells play crucial roles in intercellular communication within the respiratory system. This review explores the historical context and significance of research into extracellular vesicles. Categorised into exosomes (sized 30–150 nm), microvesicles (sized 50–1000 nm) and apoptotic bodies (sized 500–2000nm), based on their generation mechanisms, extracellular vesicles carry diverse cargoes of biomolecules, including proteins, lipids and nucleic acids. Respiratory ailments are the primary contributors to both mortality and morbidity across various populations globally, significantly impacting public health. Recent studies have underscored the pivotal role of extracellular vesicles, particularly their cargo content, in mediating intercellular communication between lung cells in respiratory diseases. This comprehensive review provides insights into extracellular vesicle mechanisms and emphasises their significance in major respiratory conditions, including acute lung injury, COPD, pulmonary hypertension, pulmonary fibrosis, asthma and lung cancer.

Publisher Chucklefish and developer Robust Games announced the point-and-click puzzle game, Loco Motive, will launch for the Nintendo Switch and PC via Steam and GOG n November 21 for $17.99 / £14.99 / €17.99.

"Were thrilled to get Loco Motive into the hands of players!” said Robust Games creative director and co-founder Adam Riches. "From the humble origins of a simple game jam to a fully fledged adventure in its own right, the last few years have been a whirlwind."

Robust Games technical director and co-founder Joseph Riches added, "My brother and I always wanted to create something together, and we’re very grateful to have had that opportunity. There was an unrelenting drive to make Loco Motive happen, and it’s our hope that players will see our passion and love for the genre reflected in this game."

View the release date trailer below:

Read details on the game below:

Welcome aboard the Reuss Express, a journey of a life-time derailed by an unexpected assassination.

On the eve of a landmark speech by the wealthy heiress Lady Unterwald, a straight-laced lawyer, a crime novelist-turned rookie detective, and an undercover spy find themselves embroiled in a murder, a mystery, and worst of all… an adventure! Now stuck onboard a luxurious steam train, within stabbing distance of a cold-blooded killer, the race is on to prove their innocence once and for all!

Play as Diana, Arthur and Herman to unwrap the mystery and put your point and click puzzle-solving skills to the test...

Features:

• A comedy adventure that hits like smooth jazz, set onboard a 1930s express train
• Take control of three playable characters, in an interlinking comedic adventure
• Uncover a deadly mystery, full of twists, turns and slapstick humour
• Meet a train-full of quirky and somewhat suspicious fellow passengers
• Stop at nothing to solve item-based puzzles, that won’t leave you head-scratching for hours
• Choose how you play - take direct interactive character control, or opt for a classic point and click experience
• Beautifully detailed pixel art animations
• Need a little nudge in the right direction? Telephone for assistance with an in-game hint call-line!
• With the slinky sounds of composer Paul Zimmermann (Wildfrost, Space Haven)
• Voice Acting!

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463050/loco-motive-releases-november-21-for-switch-and-pc/

Capcom and TiMi Studio Group have announced free-to-play open-world survival game, Monster Hunter Outlanders, for iOS and Android.

"It’s time for mobile players to fully enjoy what makes Monster Hunter one of the most beloved franchises in gaming," said TiMi Studio Group producer Dong Huang. "Monster Hunter Outlanders not only offers players an authentic hunting experience, but it does it in a massive open world featuring the community and social systems players are looking for today."

View the announcement trailer below:

Read details on the game below:

Vast Open World and Crafting

Explore seamlessly connected fields—including forests, swamps, and deserts—and enjoy hunting anytime and anywhere on your smartphone.

Not only can you utilize the environment’s creatures and field mechanics to gain the upper hand, elements useful for exploring the game’s vast open-world like crafting individualized gear and tools are also being prepared.

Traditional Monster Hunter Weapons

While maintaining the core gameplay experience of the Monster Hunter series, Monster Hunter Outlanders has optimized its battle system to maximize enjoyment. Face off against monsters while wielding the series’ traditional weapons.

Switchable Characters

As you progress through the story, you will encounter various unique characters. Not only can they become your allies, but you will also be able to control them yourself.

Reliable Companions

In addition to the Monster Hunter series’ familiar Felyne companions, Monster Hunter Outlanders will introduce other companions who will join you on quests and assist with item gathering and monster hunting.

Solo or Multiplayer

Partake in the traditional hunting experience where you can play solo, or join a hunting party of up to four.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463053/monster-hunter-outlanders-announced-for-ios-and-android/

Microsoft Gaming CEO Phil Spencer speaking with Bloomberg revealed Xbox is still open to acquiring more publishers and developers.

"We definitely want to be in the market, and when we can find teams and technology and capability that add to what we're trying to do in gaming at Microsoft, absolutely we will keep our heads up," said Spencer.

Spencer added no deals were "imminent" and any that might happen won't be on the scale of Activision Blizzard.

China is a potential area for acquisitions, according to Spencer. 

"It’s been a good area for us to learn from creative teams that have real unique capability," he said. "The real opportunity is to partner with creative teams in China for global."

Xbox in recent years has acquired Activision Blizzard, Bethesda parent company ZeniMax, and over a dozen other studios.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463054/xbox-is-still-open-to-acquiring-more-publishers-and-developers/

The fluffy chick’s chunky form is slimming down as he starts to fledge

Top 10 Animals with the Strongest Senses  Moneycontrol

1. Sunita Williams breaks silence on weight loss rumours, says THIS has 'definitely changed' her body | Mint  Mint
2. "My Body Has Changed, But....": Sunita Williams On Health Aboard Space Station  NDTV
3. After Sunita Williams, NASA now worried about her stranded mission partner's losing body mass  Hindustan Times
4. Stranded Sunita Williams dismisses severe weight loss rumours, says she feels ‘healthier than ever’  The Times of India
5. Exclusive | NASA races to stabilize astronaut Sunita Williams' weight  New York Post

1. 'We've got a bit of history': Ricky Ponting responds to Gautam Gambhir's remarks, calls him 'prickly...  Moneycontrol
2. Ricky Ponting hits back at Gautam Gambhir, calls him 'prickly character'  The Times of India
3. 'That's a bad move, Ricky. What are you doing?': Ponting's Virat Kohli jibe questioned amid 'spicy' ball-tampering claim  Hindustan Times
4. "What Are You Doing?" Lee Warns Ricky Ricky Ponting Over 'Virat Kohli Remark'  NDTV Sports
5. ‘What Are You Doing?’: Former Australian Cricketer Hits Back At Ricky Ponting Over Remark On Virat Kohli’s Test Form  News24

1. Kanguva Box Office Day 1 Advance Booking: Suriya Starrer Jumps By 353%, Already Enters Biggest Tamil Openers Of 2024!  Koimoi
2. 5 Reasons To Watch Suriya and Bobby Deol Starrer 'Kanguva' In Theatres  Zee News
3. Waiting for Suriya's 'Kanguva', watch these blockbuster films by National Award-winning actor for free  India TV News
4. Kanguva budget and actor salaries: Suriya took Rs 39 crore, Bobby Deol earned Rs 5 crore for his role – How much money others charged for the film  The Financial Express
5. Kanguva Movie Release, Review Live Updates: Suriya-starrer has already earned over Rs 7.3 crore before opening day  The Indian Express

1. Nitish Kumar tries to touch PM Modi's feet on stage | Watch  Hindustan Times
2. Video: Nitish Kumar Bends To Touch PM's Feet At Event, He Does This  NDTV
3. PM Modi states ‘1 lakh medical seats in India’, vows to add ‘75,000 more’, lays foundation stone of AIIMS in Bihar  Mint
4. Watch: PM Modi's unexpected gesture as Nitish Kumar bows down to touch his feet  The Times of India
5. PM Modi lays foundation stone for AIIMS Darbhanga in Bihar, says NDA Govt committed to welfare of people  The Hindu

1. How Yogi Adityanath government reacted to Supreme Court's 'bulldozer justice' ruling  Moneycontrol
2. How the Supreme Court clamped down on ‘bulldozer’ demolition drives | Explained  The Hindu
3. Officers Carrying Out Illegal Demolitions Liable To Restore Properties At Personal Cost & Pay Damages:...  Live Law - Indian Legal News
4. Supreme Court's Demolition Verdict Will Help Curb Organised Crime: UP  NDTV
5. SC parked bulldozer in garage forever: Akhilesh Yadav  Hindustan Times

1. Chennai hospital stabbing: IMA demands ‘overhaul of security atmosphere’  Hindustan Times
2. Video: Chennai man calmly walks away after stabbing doctor, wipes knife  India Today
3. Chennai doctor stabbed, raises safety concerns among health workers, Tamil Nadu govt takes action: What happened so far  Mint
4. 'No law and order': BJP, AIADMK attack ruling DMK after government doctor stabbed in Chennai  The Times of India
5. Indian Medical Association condemns brutal attack on doctor in Chennai  The New Indian Express

1. Donald Trump meets Joe Biden in White House; both pledge smooth transition  The Hindu
2. Power Transition Will Be "As Smooth As You Can Get", Says Trump  NDTV
3. US President Biden meets President-elect Donald Trump at White House, leaders vow smooth transition of power  The Financial Express
4. Joe and Donald warm up by the White House fireplace  The Times of India
5. Biden greets Trump with handshake, both pledge smooth transition  Moneycontrol

The new trailer teases thrilling visuals and choreography that bring Yuto Suzuki’s manga to life, with Sakamoto’s seemingly unstoppable strength tearing through anything in his path

The upcoming season, created by Sam Levinson, will consist of eight episodes and is expected to include a time jump that catches up with the characters in new stages of their turbulent lives

In ‘Hoemonal,’ Sumukhi Suresh brings to the stage, candid comedy on health, singlehood, and resilience, and tackling taboos with humor that resonates beyond laughs

The feverish Cannes-winning spectacle dazzles with audacity but stumbles under the weight of its own ambition

Alison Hammond's fall not even halfway into the Great British Bake Off's week eight caused chaos in the tent.

Noel Fielding called the moment ‘the best thing I’ve ever seen’

Actor said he won’t be ‘rushing’ to watch it after hearing about scene

West was a star of the stage and the screen and died in his sleep, his children have announced

Wedding bells rang at Trinity Methodist Church yesterday afternoon (Nov 12) as couples renewed their vows — but it was all for a scene in local director Jack Neo's upcoming movie, I Want To Be Boss. Among them, however, was an actual couple who have been married for more than six decades — Jack's very own parents. "I want to leave a beautiful memory of them in the movie," the 64-year-old actor-director told local media on the set. His mum, 86, was dressed in a white wedding gown with tulle sleeves, while Jack's father, 91, looked sharp in a black suit with a matching bowtie. Jack added: "I especially requested that my mum put on a wedding dress today for this scene, because the first time they wore their wedding outfits, I only got to see them in photos. I can see them now."

Indian-American Democrat Raja Krishnamoorthi today won the Congressional election from Illinois, defeating Republican former Elmhurst Mayor Peter DiCianni.

Two-term Louisiana Governor Bobby Jindal, the first ever Indian-American to be elected as a state Governor, is among the shortlisted candidates for Trump's Cabinet, according to a media report.

Fashion trends come and go, but high heels are forever - they have been a fashion statement since sixteenth-century France and entered the average western woman's wardrobe in the nineteenth century. But why? They are often painful,...

Facebook has acquired emotion detection start-up FacioMetrics to push its artificial intelligence (AI) research into building facial gesture controls.

It really is recognized that we are entering an era in which items relating to extremely innovative technology dazzle our senses each of the time. As a consequence people must be confronted with significant problems to search for goods...

Shopping coupons are now widely in use and we often wonder about the reason behind the popularity of these coupons. We often found that there are lots of dedicated websites dealing only with coupons and they are enjoying huge traffic....

Crown Equity Holdings Inc....