Considering the players that get the big bucks often get most of the attention when they are signed and drafted, let's take some time to look at the other end of the spectrum. Here are the biggest steals on the Top 100 Prospects list.

Here are the top players in each league who could get the opportunity to show what they can do at the highest level this year, perhaps even contending for Rookie of the Year honors

It's not rare to see former Major League sons in Major League uniforms, but is it unusual to find four in one clubhouse?

Donald Trump did not win the 2020 election, but asserting that he did became a prerequisite for Republicans standing for nomination to Congress or the Senate to win their primaries. An entire party became a vehicle for disinformation.1 Trump did win the 2024 presidential election, and key to that victory was building on the success of that lie. If you control enough of the information ecosystem, truth no longer matters.Another telling example: Haitian migrants in Springfield, Ohio, are not eating cats and dogs. US vice president elect, JD Vance, the source of that claim, admitted as much even as he justified it. “If I have to create stories so that the American media actually pays attention to the suffering of the American people, then that’s what I'm going to do,” he said.2Disinformation in politics is nothing new. History is replete with claims that were fabricated to advance political aims. Although...

A unique population of ventral tegmental area (VTA) neurons co-transmits glutamate and GABA. However, the circuit inputs to VTA VGluT2+VGaT+ neurons are unknown, limiting our understanding of their functional capabilities. By coupling monosynaptic rabies tracing with intersectional genetic targeting in male and female mice, we found that VTA VGluT2+VGaT+ neurons received diverse brainwide inputs. The largest numbers of monosynaptic inputs to VTA VGluT2+VGaT+ neurons were from superior colliculus (SC), lateral hypothalamus (LH), midbrain reticular nucleus, and periaqueductal gray, whereas the densest inputs relative to brain region volume were from the dorsal raphe nucleus, lateral habenula, and VTA. Based on these and prior data, we hypothesized that LH and SC inputs were from glutamatergic neurons. Optical activation of glutamatergic LH neurons activated VTA VGluT2+VGaT+ neurons regardless of stimulation frequency and resulted in flee-like ambulatory behavior. In contrast, optical activation of glutamatergic SC neurons activated VTA VGluT2+VGaT+ neurons for a brief period of time at high frequency and resulted in head rotation and arrested ambulatory behavior (freezing). Stimulation of glutamatergic LH neurons, but not glutamatergic SC neurons, was associated with VTA VGluT2+VGaT+ footshock-induced activity and inhibition of LH glutamatergic neurons disrupted VTA VGluT2+VGaT+ tailshock-induced activity. We interpret these results such that inputs to VTA VGluT2+VGaT+ neurons may integrate diverse signals related to the detection and processing of motivationally salient outcomes.

Endogenous reprogramming of glia into neurogenic progenitors holds great promise for neuron restoration therapies. Using lessons from regenerative species, we have developed strategies to stimulate mammalian Müller glia to regenerate neurons in vivo in the adult retina. We have demonstrated that the transcription factor Ascl1 can stimulate Müller glia neurogenesis. However, Ascl1 is only able to reprogram a subset of Müller glia into neurons. We have reported that neuroinflammation from microglia inhibits neurogenesis from Müller glia. Here we found that the peripheral immune response is a barrier to CNS regeneration. We show that monocytes from the peripheral immune system infiltrate the injured retina and negatively influence neurogenesis from Müller glia. Using CCR2 knock-out mice of both sexes, we found that preventing monocyte infiltration improves the neurogenic and proliferative capacity of Müller glia stimulated by Ascl1. Using scRNA-seq analysis, we identified a signaling axis wherein Osteopontin, a cytokine highly expressed by infiltrating immune cells is sufficient to suppress mammalian neurogenesis. This work implicates the response of the peripheral immune system as a barrier to regenerative strategies of the retina.

The activation of autonomic and hypothalamo-pituitary-adrenal (HPA) systems occurs interdependently with behavioral adjustments under varying environmental demands. Nevertheless, laboratory rodent studies examining the neural bases of stress responses have generally attributed increments in these systems to be monolithic, regardless of whether an active or passive coping strategy is employed. Using the shock probe defensive burying test (SPDB) to measure stress-coping features naturalistically in male and female rats, we identify a neural pathway whereby activity changes may promote distinctive response patterns of hemodynamic and HPA indices typifying active and passive coping phenotypes. Optogenetic excitation of the rostral medial prefrontal cortex (mPFC) input to the ventrolateral periaqueductal gray (vlPAG) decreased passive behavior (immobility), attenuated the glucocorticoid hormone response, but did not prevent arterial pressure and heart rate increases associated with rats’ active behavioral (defensive burying) engagement during the SPDB. In contrast, inhibition of the same pathway increased behavioral immobility and attenuated hemodynamic output but did not affect glucocorticoid increases. Further analyses confirmed that hemodynamic increments occurred preferentially during active behaviors and decrements during immobility epochs, whereas pathway manipulations, regardless of the directionality of effect, weakened these correlational relationships. Finally, neuroanatomical evidence indicated that the influence of the rostral mPFC->vlPAG pathway on coping response patterns is mediated predominantly through GABAergic neurons within vlPAG. These data highlight the importance of this prefrontal->midbrain connection in organizing stress-coping responses and in coordinating bodily systems with behavioral output for adaptation to aversive experiences.

The sudden appearance of a visual distractor shortly before saccade initiation can capture spatial attention and modulate the saccade trajectory in spite of the ongoing execution of the initial plan to shift gaze straight to the saccade target. To elucidate the neural correlates underlying these curved saccades, we recorded from single neurons in the frontal eye field of two male rhesus monkeys shifting gaze to a target while a distractor with the same eccentricity appeared either left or right of the target at various delays after target presentation. We found that the population level of presaccadic activity of neurons representing the distractor location encoded the direction of the saccade trajectory. Stronger activity occurred when saccades curved toward the distractor, and weaker when saccades curved away. This relationship held whether the distractor was ipsilateral or contralateral to the recorded neurons. Meanwhile, visually responsive neurons showed asymmetrical patterns of excitatory responses that varied with the location of the distractor and the duration of distractor processing relating to attentional capture and distractor inhibition. During earlier distractor processing, neurons encoded curvature toward the distractor. During later distractor processing, neurons encoded curvature away from the distractor. This was observed when saccades curved away from distractors contralateral to the recording site and when saccades curved toward distractors ipsilateral to the recording site. These findings indicate that saccadic motor planning involves dynamic push–pull hemispheric interactions producing attraction or repulsion for potential but unselected saccade targets.

Headlines for November 13, 2024; ACLU Attorney Lee Gelernt on How Rights Groups Are Preparing to Fight Trump’s Mass Deportations; Immigrant Activist to Biden: Close Deportation Cases Now to Take a Weapon Away from Trump; Trump Taps Fossil Fuel Ally Lee Zeldin to Head EPA, Push “Anti-Environmental Agenda”; Head of U.N. Climate Summit in Azerbaijan Caught on Tape Pushing Oil & Gas Deals

Norwegian Bible school students on mission trip to South Africa, shares the Gospel at the garbage dump outside Pretoria

For the past two years OM South Africa SportsLink has attended a prestigious rugby tournament to spread the good news to players, coaches and staff.

OM Philippines brings relief to the earthquake-shattered island of Bohol.

OM Philippines’ relief operations reach a significant milestone with the completion and handover of its first housing project in Northern Cebu.

OM Philippines receives a short-term mission team from Hong Kong.

God is working to transform lives in Mozambique through the efforts of the local OM team.

Limardes Domingo, an OM worker in Mecula, Mozambique, has seen church growth over two years through God's faithful answers to prayer.

OM worker joins a new Arabic-speaking ministry among Syrians in Turkey.

A family in Turkey is impacted by the gospel through contacts with the Bible Correspondence Course.

An OMer sharing the gospel at a police station in Turkey is asked to return and carry on the conversation.

God moves mightily using a teen girl and a team of people to reach a needy area of Southampton, UK.

“I have always wanted to do more than coach specific sport skills,” Joseph said. “This approach touches all areas of fitness: physical, emotional and spiritual–all aspects of a human being.”

Testimony of a Greek woman.

Work of OM Romania among the Roma population

Rose (Scotland) as been developing a growing ministry among residents at a local retirement community. What started with a single conversation has grown into a ministry that impacts many lives through friendship and community outreach.

OM Italy makes increasing use of their excellent facility, Forterocca, as a base for sports and arts ministries.

Incarnate 2014, a course in arts and mission hosted by OM Italy, touches the lives of the students and local community.

OM Italy impacts 150 children during their annual summer camp in Torre Pellice.

As a grandmother with some serious health issues and limited knowledge of Spanish and English, Francine wondered whether God could use her in Spain.

Newlyweds Sam & Lena joined Transform as part of their honeymoon, because they wanted to honour God from the very start of their life together.

Heikki drove the nearly 4,000 km from Finland to Transform in Spain on his motorcycle. A Harley-Davidson and a saxophone were useful instruments in God's hands.

In this second update from the Serbia/Croatia border, OM leader Volker Sachse describes moments of God’s peace that transforms people in a dire situation.

Christina shares about the love between a refugee man and his disabled son, whom she met while volunteering in Šid, Serbia.

Goran’s decision to follow Jesus challenged the cultural values and traditions he grew up with, causing him to live differently in his community.

A group from the Sharing Lives Course visits a mosque in Lausanne, Switzerland, and learns that greater awareness can lead to greater sensitivity.

some testimonies from Aussies who attended the 2010 OCZ and outreaches

Carrie from Hong Kong was challenged and blessed at the same time as a participant in the Out of the Comfort Zone training in Malaysia.

A recent training course in Malaysia unpacks the subject of financial development and reminds participants that it is a ministry based on biblical principles.

Bosnian teenagers attend TeenStreet Europe for the second time—learning more about God and His plan for their lives.

Anna Filion came to El Salvador as a nurse, but learnt that God had bigger plans for her during OM El Salvador’s Samaritan Adventure outreach.

A volunteer from Germany serving with OM El Salvador for 5 months learned that she can do all things through Christ.

In postmodern Finland, an international church in Helsinki preaches God’s Word as it is and challenges its congregation to ‘get into the Bible’ daily.

OM's work in Finland began 50 years ago in 1965. Since then, approximately 3,000 Finns have participated in OM’s work.

After years of dreaming and praying, OM Finland purchases a new vehicle to replace the old Bus4Life, opening more opportunities to reach Eastern Europe.

Nathan Schmutz, an OMer working in Latin America, shares how a five year-old girl embodies OM's new mission statement.

A woman has been arrested after leaving her son unattended along a road, allowing him to run off in the night following a tantrum and falsely reporting a kidnapping.

President-elect Donald Trump was welcomed at the White House on Wednesday after declining to do the same for President Joe Biden after the 2020 election.

Barranquilla, Colombia :: Logos Hope's focus for her time in Latin America is to encourage Latinos to serve God around the world.

India will open their campaign against Pakistan at Dubai on November 30

With Sales Accelerator, Del Monte can 'tweak the levers' during a campaign to boost reach and revenu