Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

Check here each week to keep up with the latest from John MacArthur's pulpit at Grace Community Church.

port louis, mauritius — Mauritius held a parliamentary election Sunday in which Prime Minister Pravind Kumar Jugnauth and his main rivals all promised to tackle a cost-of-living crisis in the Indian Ocean archipelago. Polls closed at 6 p.m. local time (1400 GMT) and results were expected Monday, according to the country's electoral body. The country of about 1.3 million people markets itself as a link between Africa and Asia, deriving most of its revenues from a flourishing offshore financial sector, tourism and textiles. Mauritius also receives aid from China. It has forecast 6.5% economic growth this year compared with 7.0% last year but many voters are not feeling the benefits. Jugnauth's Alliance Lepep coalition has promised to raise minimum wages, increase pensions and reduce value-added tax on some basic goods. It says it will use payments from the U.K. under an October agreement for Britain to cede the Chagos Islands while retaining the U.S.-U.K. Diego Garcia air base. "The alliance led by the prime minister is selling the economic prosperity card, with promises of more money to different segments of the population," said political analyst Subash Gobine. The opposition has also pledged to increase pensions as well as introduce free transport and internet services and reduce fuel prices. It is dominated by the Alliance du Changement coalition led by Navin Ramgoolam and two other parties running in the Linion Reform alliance, whose leaders, Nando Bodha and Roshi Bhadain, plan to alternate as prime minister if they win. Voters were picking lawmakers for the 62 seats in parliament for the next five years, from a list of 68 parties and five political alliances. Music instructor Ivan Mootooveeren, 41, who cast his ballot at a polling center in the capital, Port Louis, told Reuters he was voting for the opposition because the country needed a new direction. Another voter, David Stafford, 36, said young people would make the difference in the election. He did not say who he was voting for but added that people were looking for economic innovation and job opportunities as much as fiscal changes. Arvin Boolell, deputy leader of the Labour Party, a member of the opposition coalition, told Reuters voter turnout had likely exceeded 75%. The electoral body could not be immediately reached to give an official figure for turnout. Whichever party or coalition gets more than half the seats in parliament also wins the prime minister's post. Earlier this month, Jugnauth's government blocked social media platforms until a day after the election, citing national security concerns after conversations between public figures were leaked. It lifted the ban a day later after opposition parties criticized the move.

Panelists See Long Pandemic Recovery in the Pacific, Urge Attention to Community Voices Panelists See Long Pandemic Recovery in the Pacific, Urge Attention to Community Voices

Dispatch teams gave hotline callers life-saving medical treatment advice over the phone on October 7. One such woman told children where to hide from terrorists.

MDA team from Karnei Shomron sped to southern Israel on October 7 to save lives

Former French MP Meyer Habib describes his worries about France's future as antisemitism soars across Europe and violence becomes normalized.

LIVE: Leaders and experts talk aliyah, how to manage finances, real estate in the middle of war.

[allAfrica] World Pneumonia Day is held every year on November 12. This year it focuses on events around partnerships, aiming to lower mortality rates and strengthen pandemic defenses by uniting organizations to expand access to life-saving interventions.

9 reasons to have at least 3 walnuts everyday  The Times of India

[Radio Dalsan] In a move to bolster Somalia's economic recovery and stability, the United States has forgiven $1.14 billion in debt owed by Somalia. The debt cancellation, announced by US Ambassador to Somalia Richard Riley in Mogadishu, is part of a larger $1.2 billion assistance package for Somalia this fiscal year.

JERUSALEM: Aid agencies slammed Israel for continuing to obstruct the delivery of aid to Gaza, despite Tel Aviv’s claims that it had opened an additional crossing into the besieged territory on the eve of a US deadline to boost relief deliveries.

The United States last month warned Israel to improve the humanitarian conditions in Gaza or risk a cut to its military support.

A day before the deadline, the Israeli military said it opened the Kissufim crossing “as part of the effort and commitment to increase the volume and routes of aid” to Gaza.

But the UN agency for Palestinian refugees (UNRWA) and eight humanitarian groups said Israel was still not doing enough to get aid in as the situation in the besieged north becomes especially “catastrophic”.

On eve of US deadline to restore aid supplies to Gaza, Tel Aviv claims to have opened another border crossing

The eight organisations, including Oxfam and Save The Children, said Israel “failed to comply” with US demands — “at enormous human cost for Palestinian civilians in Gaza”.

“The humanitarian situation in Gaza is now at its worst point since the war began in October 2023,” they said in a joint statement.

Asked about whether there were signs the situation had improved ahead of Wednesday’s deadline, Louise Wateridge, an UNRWA emergencies officer, highlighted that “aid entering the Gaza Strip is at its lowest level in months”.

No food was permitted to enter besieged northern Gaza for an entire month, Wateridge said, adding that UN requests to access the area have been repeatedly denied.

Wateridge said that testimonies from the north painted “an endlessly horrific” picture that was becoming “more critical” by the hour.

“Hospitals have been bombed, the doctors inform us that they have run out of blood supplies, they have run out of medicine… there are bodies in the streets.”

Separately, a spokesperson for the Norwegian Refugee Council told Al Jazeera that Israelis were obstructing aid from entering through the crossings.

“Aid is arbitrarily rejected and essential supplies are not allowed in, including timber to help people build shelters as they face winter. Sometimes the requests to access those crossings are denied for over a month,” Shaina Low, NRC’s communications adviser, told Al Jazeera.

Once the aid enters Gaza, aid workers must request safe routes through which they can safely distribute the aid.

“Israel often denies requests to move from place to place in order to reach Palestinian families that are in desperate need,” Low said.

However, the US State Department on Tuesday said that Israel was not violating US law on the level of aid entering Gaza, but called for further progress.

Asked if Israel had met the US demands, State Department spokesman Vedant Patel said of Israel, “We have not made an assessment that they are in violation of US law,” but added: “The overall humanitarian situation in Gaza continues to be unsatisfactory”.

“But in the context of the letter, it’s not about whether we find something satisfactory or not; it’s what are the actions that we’re seeing,” he said, adding that Tel Aviv was taking steps in the right direction.

Attacks on Gaza

Gaza’s civil defence agency said that at least 14 people were killed in Israeli strikes on Tuesday.

On Tuesday, residents said Israeli tanks advanced deeper in Beit Hanoun and besieged four displaced families before ordering them to leave towards Gaza City.

The health ministry in Gaza said on Tuesday that at least 43,665 people have been killed in more than 13 months.

Published in Dawn, November 13th, 2024

What life is and how the mind works fall within the compass of one bold concept. But critics say that by attempting to explain everything, it may end up explaining nothing

Sea-floor nodules raise oxygen levels in the deep ocean, suggesting they may have a valuable role in ecosystems and adding to concerns about the impact of deep-sea mining

Title: Study: Diet Sodas May Raise Risk of Preterm Delivery
Category: Health News
Created: 8/23/2010 10:47:00 AM
Last Editorial Review: 8/23/2010 10:47:52 AM

Title: Obesity May Affect Breast Cancer Recovery
Category: Health News
Created: 8/28/2012 11:01:00 AM
Last Editorial Review: 8/28/2012 12:00:00 AM

Title: Discovery May Improve Diagnosis of Alzheimer's, Parkinson's
Category: Health News
Created: 8/29/2012 6:05:00 PM
Last Editorial Review: 8/30/2012 12:00:00 AM

Title: Should Everyone Over 65 Take a Statin?
Category: Health News
Created: 8/28/2013 4:35:00 PM
Last Editorial Review: 8/29/2013 12:00:00 AM

Title: Concussion Recovery Can Reverse After Return to Activity, Study Shows
Category: Health News
Created: 8/28/2014 9:36:00 AM
Last Editorial Review: 8/28/2014 12:00:00 AM

Title: Every Sudden Infant Death Deserves a Closer Look: Report
Category: Health News
Created: 8/26/2019 12:00:00 AM
Last Editorial Review: 8/27/2019 12:00:00 AM

Title: Flu Shots for Kids Protect Everybody, Study Shows
Category: Health News
Created: 8/21/2020 12:00:00 AM
Last Editorial Review: 8/24/2020 12:00:00 AM

Title: Wildfire Smoke Could Raise Odds for Preterm Delivery
Category: Health News
Created: 8/26/2021 12:00:00 AM
Last Editorial Review: 8/26/2021 12:00:00 AM

Title: AHA News: Newborn Was 'Very Sick Little Boy' Despite Several Normal Prenatal Ultrasounds
Category: Health News
Created: 8/25/2022 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM

Title: Everyday Activities That Can Cut Your Odds for Dementia
Category: Health News
Created: 8/12/2022 12:00:00 AM
Last Editorial Review: 8/15/2022 12:00:00 AM

Two decades into the era of Electronic Health Records (EHRs), the promise of streamlining clinical care, reducing burden, and improving patient outcomes has yet to be realized. A cross-sectional family physician census conducted by the American Board of Family Medicine in 2022 and 2023 included self-reported physician EHR satisfaction. Of the nearly 10,000 responding family physicians, only one-in-four (26.2%) report being very satisfied and one-in-three (33.8%) were not satisfied. These low levels of satisfaction point to the need for greater transparency in the marketplace and pressure to increase user-centric EHR design.

ABSTRACTIntroduction:Emergency contraceptive pills (ECPs) are effective and can be used safely at any age repeatedly within the same cycle. They are often favored by youth yet are underutilized. Private facilities can increase ECP access but present barriers including cost. Identifying effective public-sector ECP distribution models can help ensure equitable access. The Malawi Ministry of Health developed a strategy to improve ECP access in 2020. We documented ECP provision through select public, youth-serving channels recommended by the strategy: general and youth-specific outreach, paid and unpaid community health workers (CHWs), and youth clubs.Methods:We conducted this mixed methods study from November 2022–March 2023 in 2 rural districts (Mchinji and Phalombe) implementing the strategy. We conducted qualitative interviews with 10 national stakeholders, 46 providers, and 24 clients aged 15–24 years about ECP service delivery. Additionally, 25 providers collected quantitative tally data about clients seeking ECPs. We analyzed qualitative data using grounded theory and quantitative data descriptively.Results:Stakeholders and providers reported ECP uptake increased in geographies where the strategy was implemented, especially among youth. Providers documented 3,988 client visits for ECPs over 3 months. Of these visits, 26% were from male clients, 36% were from clients aged younger than 20 years, and 64% received ECPs for the first time. Across channels, youth club leaders and unpaid CHWs reported the most client visits per provider and served the youngest clients. However, no ECPs were dispensed during 29% of visits due to stock-outs. While many providers were supportive of youth accessing ECPs, most held unfavorable attitudes toward repeat use.Conclusion:ECP access should be expanded through provision in the studied channels, especially youth clubs and CHWs. However, to meet demand, the supply chain must be strengthened. We recommend addressing providers’ attitudes about repeat use to ensure informed method choice.

ABSTRACTIntroduction:Postpartum hemorrhage (PPH) remains the leading cause of maternal mortality. A new clinical intervention (E-MOTIVE) holds the potential to improve early PPH detection and management. We aimed to develop and pilot implementation strategies to support uptake of this intervention in Kenya, Nigeria, South Africa, and Tanzania.Methods:Implementation strategy development: We triangulated findings from qualitative interviews, surveys and a qualitative evidence synthesis to identify current PPH care practices and influences on future intervention implementation. We mapped influences using implementation science frameworks to identify candidate implementation strategies before presenting these at stakeholder consultation and design workshops to discuss feasibility, acceptability, and local adaptations. Piloting: The intervention and implementation strategies were piloted in 12 health facilities (3 per country) over 3 months. Interviews (n=58), case report forms (n=1,269), and direct observations (18 vaginal births, 7 PPHs) were used to assess feasibility, acceptability, and fidelity.Results:Implementation strategy development: Key influences included shortages of drugs, supplies, and staff, limited in-service training, and perceived benefits of the intervention (e.g., more accurate PPH detection and reduced PPH mortality). Proposed implementation strategies included a PPH trolley, on-site simulation-based training, champions, and audit and feedback. Country-specific adaptations included merging the E-MOTIVE intervention with national maternal health trainings, adapting local PPH protocols, and PPH trollies depending on staff needs. Piloting: Intervention and implementation strategy fidelity differed within and across countries. Calibrated drapes resulted in earlier and more accurate PPH detection but were not consistently used at the start. Implementation strategies were feasible to deliver; however, some instances of limited use were observed (e.g., PPH trolley and skills practice after training).Conclusion:Systematic intervention development, piloting, and process evaluation helped identify initial challenges related to intervention fidelity, which were addressed ahead of a larger-scale effectiveness evaluation. This has helped maximize the internal validity of the trial.

The development of transforming growth factor βreceptor inhibitors (TGFβRi) as new medicines has been affected by cardiac valvulopathy and arteriopathy toxicity findings in nonclinical toxicology studies. PF-06952229 (MDV6058) selected using rational drug design is a potent and selective TGFβRI inhibitor with a relatively clean off-target selectivity profile and good pharmacokinetic properties across species. PF-06952229 inhibited clinically translatable phospho-SMAD2 biomarker (≥60%) in human and cynomolgus monkey peripheral blood mononuclear cells, as well as in mouse and rat splenocytes. Using an optimized, intermittent dosing schedule (7-day on/7-day off/cycle; 5 cycles), PF-06952229 demonstrated efficacy in a 63-day syngeneic MC38 colon carcinoma mouse model. In the pivotal repeat-dose toxicity studies (rat and cynomolgus monkey), PF-06952229 on an intermittent dosing schedule (5-day on/5-day off cycle; 5 cycles, 28 doses) showed no cardiac-related adverse findings. However, new toxicity findings related to PF-06952229 included reversible hepatocellular (hepatocyte necrosis with corresponding clinically monitorable transaminase increases) and lung (hemorrhage with mixed cell inflammation) findings at ≥ targeted projected clinical efficacious exposures. Furthermore, partially reversible cartilage hypertrophy (trachea and femur in rat; femur in monkey) and partially to fully reversible, clinically monitorable decreases in serum phosphorus and urinary phosphate at ≥ projected clinically efficacious exposures were observed. Given the integral role of TGFβ in endochondral bone formation, cartilage findings in toxicity studies have been observed with other TGFβRi classes of compounds. The favorable cumulative profile of PF-06952229 in biochemical, pharmacodynamic, pharmacokinetic, and nonclinical studies allowed for its evaluation in cancer patients using the intermittent dosing schedule (7-day on/7-day off) and careful protocol-defined monitoring.

Historically, the intestinal lymphatics were considered passive conduits for fluids, immune cells, dietary lipids, lipid soluble vitamins, and lipophilic drugs. Studies of intestinal lymphatic drug delivery in the late 20th century focused primarily on the drugs’ physicochemical properties, especially high lipophilicity, that resulted in intestinal lymphatic transport. More recent discoveries have changed our traditional view by demonstrating that the lymphatics are active, plastic, and tissue-specific players in a range of biological and pathological processes, including within the intestine. These findings have, in turn, inspired exploration of lymph-specific therapies for a range of diseases, as well as the development of more sophisticated strategies to actively deliver drugs or vaccines to the intestinal lymph, including a range of nanotechnologies, lipid prodrugs, and lipid-conjugated materials that "hitchhike" onto lymphatic transport pathways. With the increasing development of novel therapeutics such as biologics, there has been interest in whether these therapeutics are absorbed and transported through intestinal lymph after oral administration. Here we review the current state of understanding of the anatomy and physiology of the gastrointestinal lymphatic system in health and disease, with a focus on aspects relevant to drug delivery. We summarize the current state-of-the-art approaches to deliver drugs and quantify their uptake into the intestinal lymphatic system. Finally, and excitingly, we discuss recent examples of significant pharmacokinetic and therapeutic benefits achieved via intestinal lymphatic drug delivery. We also propose approaches to advance the development and clinical application of intestinal lymphatic delivery strategies in the future.

PURPOSE

Currently, 40% of counties in the United States do not have an obstetrician or midwife, and in rural areas the likelihood of childbirth being attended to by a family medicine (FM) physician is increasing. We sought to characterize the effect of the FM presence on unit culture and a key perinatal quality metric in Iowa hospital intrapartum units.

The respiratory literature, both written and in online formats, is growing exponentially. Capturing quality content, to meet the learning needs of those working in all fields of respiratory medicine and delivering it in a palatable, accessible format is challenging but paramount. In this article we discuss ways to determine the information content and review different methods of delivering this content to those who need it.

Kelley gets bored and cleans her bathroom. Memories of the Virtual Boy make Josh's eyes hurt. Robert can't stop singing about Albuquerque. Chris, meanwhile, decides to make his own farming sim with coffee shops and old people.

The post RPG Cast – Episode 719: “Good morning, everybody. Hairball!” appeared first on RPGamer.

Ryan slip 'n slides his health away. Robert lives on the side of danger and poor choices in video games. Meanwhile, Chris makes his own bathtub Geralt.

The post RPG Cast – Episode 725: “Not Every Idea in the Factory Is a Good One” appeared first on RPGamer.

Today in "person you already like says something you already agree with, but it’s still good to hear them say it" news, Arkane founder and im-simmy RPG studio WolfEye head Raphael Colantonio has spoken on Microsoft’s decision to shutter Prey (2017) studio Arkane Austin - alongside a handful of others - back in May.

Colantonio, who founded Arkane in 1999 and departed in 2017 to form Weird West studio WolfEye, recently chatted to Jeremy Peel for PC Gamer about Arkane’s closure, saying:

I think if you look a little bit, it's obvious that Arkane Austin was a very special group of people that have made some cool things and that could pull it off again. I think it was a decision that just came down to, 'We need to cut something.' Was it to please the investors, the stock market? They're playing a different game.

Read more

News of the asteroid 2024 RW1 impacting near the Philippines may have come as a shock this week, but space agencies and astronomers around the world are keeping an eye out to protect us

The second-closest planet to the sun is more geologically active than we thought and could have more than 17,000 venusquakes a year

The Biden administration passed $3 trillion of legislation aimed at revitalizing the American economy and fostering green, equitable, "middle-out" growth.

My home state, the Garden State, is angry mercurial, and Trump came frighteningly close to winning there a week ago.

From Goats to airplanes, Xbox Game Pass has another bumper month in store for subscribers. Here's everything you need to know about what is heading to PC and console this November 2024

Black Ops 6 is here, and fans have been itching to know what's included in Season 1 - and now we have an answer. Here's what's included, and when you can play

PS5 owners can play some great games this month, including a Bethesda hit and more. Here's what's free for PS Plus subscribers for November, with more to be announced.

Cement is ubiquitous, but the process of making it emits carbon into the atmosphere. The industry says there's no easy way to avoid that, which is why it's turning to carbon capture and storage technology as a way to decarbonize.

Tech expert Kurt “CyberGuy" Knutsson helps you honor our heroes with these powerful podcasts, audiobooks and documentaries this Veterans Day.