CHINA yesterday urged the United States to stop attacking and slandering the country, following the release of a US presidential memorandum that identified China as one of the major drug transit or illicit

The Academic Staff Union of Universities on Tuesday raised an alarm over a plot to sabotage the interest of public universities in the country. ASUU’s National President, Prof Emmanuel Osodeke, at an event marking the 2024 ASUU’s Heroes Day in Abuja, also accused the World Bank and the International Monetary Fund of working relentlessly to

Tel Aviv, Israel — Israeli protesters expressed concern for the hostages in Gaza on Saturday, after Qatar said it was pausing as a key mediator for a cease-fire that would help bring the captives home. Thousands of people rallied in Tel Aviv holding signs reading "400," the number of days since the hostages were taken when Hamas militants attacked southern Israel on October 7, 2023. Efforts to broker a truce in the ensuing war between Hamas and Israel have proven fruitless, and on Saturday Qatar put its mediation on hold until the two sides showed "willingness and seriousness" in talks. Protester Ruti Lior said she was unsure how much sway Qatar had, but was still "very, very worried" by their decision to pull back from negotiations. "This is further proof for me that there really is no seriousness, and these deals are being sabotaged," the 62-year-old psychotherapist told AFP. Saturday's rally featured an installation of masks representing Netanyahu along with signs bearing the word "Guilty." Other placards read "Hostage deal now" and "Drop your weapon, stop the war." "How many more tears must fall and how much more blood must be shed before someone does what needs to be done and brings our children home?" Niva Wenkert, mother of hostage Omer Wenkert, was quoted as saying in a statement released by campaign group Hostage and Missing Families Forum. In the October 7, 2023, attack, Hamas militants killed 1,200 people and captured about 250 hostages, sparking the war in Gaza. Israel says it believes Hamas is still holding 101 hostages, including 35 the military says are dead. Hamas has been designated a terror group by the United States, the U.K. and other Western countries. Israel’s counteroffensive in Gaza has killed more than 43,000 people, according to the territory's health ministry, which does not distinguish between combatants and civilians in its count. Israelis have been protesting weekly to pressure their government to do more to secure the captives' release. Qatar, which has hosted Hamas's political leadership since 2012 with U.S. blessing, has been involved in months of protracted diplomacy aimed at ending the war in Gaza. But the talks, also mediated by Cairo and Washington, have repeatedly hit snags since a one-week truce in November 2023 -- the only one so far -- with both sides trading blame for the impasse. 

boston — A federal judge on Tuesday sentenced a Massachusetts Air National Guard member to 15 years in prison after he pleaded guilty to leaking highly classified military documents about the war in Ukraine.  Jack Teixeira pleaded guilty earlier this year to six counts of willful retention and transmission of national defense information under the Espionage Act following his arrest in the most consequential national security case in years. Brought into court wearing an orange jumpsuit, he showed no visible reaction as he was sentenced by U.S. District Judge Indira Talwani.  Before being sentenced, he apologized for his actions.  "I wanted to say I'm sorry for all the harm that I brought and caused," Texeira said, referencing the "maelstrom" he caused to friends, family, and anyone affected overseas. "I understand all the responsibility and consequences fall upon my shoulders alone and accept whatever that will bring," he said, standing as he addressed the judge.  Afterward, Teixeira hugged one of his attorneys and looked toward his family and smiled before he was led out of court.  The security breach raised alarm over America's ability to protect its most closely guarded secrets and forced the Biden administration to scramble to try to contain the diplomatic and military fallout. The leaks embarrassed the Pentagon, which tightened controls to safeguard classified information and disciplined members found to have intentionally failed to take required action about Teixeira's suspicious behavior.  Earlier in Tuesday's hearing, Assistant U.S. Attorney Jared Dolan argued that 200 months — or a little more than 16 1/2 years — was appropriate given the "historic" damage caused by Teixeira's conduct that aided adversaries of the United States and hurt the country's allies. He also said that the recommendation by prosecutors would send a message to anyone in the military who might consider similar conduct.   "It will be a cautionary tale for the men and women in the U.S. military," Dolan said. "They are going to be told this is what happens if you break your promise, if you betray your country. ... They will know the defendant's name. They will know the sentence the court imposes."  But Teixeira's attorney Michael Bachrach told the judge in court Tuesday that 11 years was sufficient.  "It is a significant, harsh and difficult sentence, one that will not be easy to serve," Bachrach said. "It will serve as an extreme deterrent to anyone, particularly young servicemen. That is enough to keep them deterred from committing serious conduct."  'His intent was to educate' Teixeira, of North Dighton, Massachusetts, had pleaded guilty in March to six counts of the willful retention and transmission of national defense information under the Espionage Act. That came nearly a year after he was arrested in the most consequential national security leak in years.  The 22-year-old admitted that he illegally collected some of the nation's most sensitive secrets and shared them with other users on the social media platform Discord.  When Teixeira pleaded guilty, prosecutors said they would seek a prison term at the high end of the sentencing range. But the defense wrote in their sentencing memorandum earlier that the 11 years is a "serious and adequate to account for deterrence considerations and would be essentially equal to half the life that Jack has lived thus far."  His attorneys described Teixeira as an autistic, isolated individual who spent most of his time online, especially with his Discord community. They said his actions, though criminal, were never meant to "harm the United States." He also had no prior criminal record.  "Instead, his intent was to educate his friends about world events to make certain they were not misled by misinformation," the attorneys wrote. "To Jack, the Ukraine war was his generation's World War II or Iraq, and he needed someone to share the experience with."  Prosecutors, though, had countered that Teixeira does not suffer from an intellectual disability that prevents him from knowing right from wrong. They argued that Teixeira's post-arrest diagnosis as having "mild, high-functioning" autism "is of questionable relevance in these proceedings."  Teixeira, who was part of the 102nd Intelligence Wing at Otis Air National Guard Base in Massachusetts, worked as a cyber transport systems specialist, which is essentially an information technology specialist responsible for military communications networks. He remains in the Air National Guard in an unpaid status, an Air Force official said.  Authorities said he first typed out classified documents he accessed and then began sharing photographs of files that bore SECRET and TOP SECRET markings. Prosecutors also said he tried to cover his tracks before his arrest, and authorities found a smashed tablet, laptop and an Xbox gaming console in a dumpster at his house.  The leak exposed to the world unvarnished secret assessments of Russia's war in Ukraine, including information about troop movements in Ukraine, and the provision of supplies and equipment to Ukrainian troops. Teixeira also admitted posting information about a U.S. adversary's plans to harm U.S. forces serving overseas. 

More than a decade’s worth of stagnant health packages lead to the build-up of PhilHealth’s idle funds, according to the government corporation’s chief. 

Francis Ndege isn’t sure if his customers in Africa’s largest slum can afford to keep buying rice from him. Prices for rice grown in Kenya soared a while ago because of higher fertilizer prices and a yearslong drought in the Horn of Africa that has reduced production. Cheap rice imported from India had filled the gap, feeding many of the hundreds of thousands of residents in Nairobi's Kibera slum who survive on less than $2 a day. But that is changing. The price of a 25-kilogram (55-pound) bag of rice has risen by a fifth since June. Wholesalers are yet to receive new stocks since India, the world's largest exporter of rice by far, said last month that it would ban some rice shipments. It's an effort by the world’s most populous nation to control domestic prices ahead of a key election year — but it’s left a yawning gap of around 9.5 million metric tons (10.4 tons) of rice that people around the world need, roughly a fifth of global exports. “I’m really hoping the imports keep coming,” said Ndege, 51, who's sold rice for 30 years. He isn’t the only one. Global food security is already under threat since Russia halted an agreement allowing Ukraine to export wheat and the El Nino weather phenomenon hampers rice production. Now, rice prices are soaring — Vietnam’s rice export prices, for instance, have reached a 15-year high — putting the most vulnerable people in some of the poorest nations at risk. The world is at an “inflection point," said Beau Damen, a natural resources officer with the U.N. Food and Agriculture Organization based in Bangkok. Even before India’s restrictions, countries already were frantically buying rice in anticipation of scarcity later when the El Nino hit, creating a supply crunch and spiking prices. What could make the situation worse is if India’s ban on non-basmati rice creates a domino effect, with other countries following suit. Already, the United Arab Emirates has suspended rice exports to maintain its domestic stocks. Another threat is if extreme weather damages rice crops in other countries. An El Nino is a natural, temporary and occasional warming of part of the Pacific Ocean that shifts global weather patterns, and climate change is making them stronger. Scientists expect the one underway to expand to supersized levels, and, in the past, they have resulted in extreme weather ranging from drought to flooding. The impact would be felt worldwide. Rice consumption in Africa has been growing steadily, and most countries are heavily dependent on imports. While nations with growing populations like Senegal have been trying to grow more of their own rice — many are struggling. Amadou Khan, a 52-year-old unemployed father of five in Dakar, says his children eat rice with every meal except breakfast, which they often have to skip when he's out of work. “I am just getting by — sometimes, I’ve trouble taking care of my kids,” he said. Imported rice — 70% of which comes from India — has become prohibitively expensive in Senegal, so he's eating homegrown rice that costs two-thirds as much. Senegal will turn to other trading partners like Thailand or Cambodia for imports, though the West African country is not “far from being self-sufficient" on rice, with over half of its demand grown locally, Agriculture Ministry spokesperson Mamadou Aïcha Ndiaye said. Asian countries, where 90% of the world’s rice is grown and eaten, are struggling with production. The Philippines was carefully managing water in anticipation of less rain amid the El Nino when Typhoon Doksuri battered its northern rice-producing region, damaging $32 million worth of rice crops — an estimated 22% of its annual production. The archipelago nation is the second-largest importer of rice after China, and President Ferdinand Marcos Jr. has underscored the need to ensure adequate buffers. India’s rice restrictions also were motivated by erratic weather: An uneven monsoon along with a looming El Nino meant that the partial ban was needed to stop food prices from rising, Indian food policy expert Devinder Sharma said. The restrictions will take offline nearly half the country's usual rice exports this year, said Ashok Gulati of the Indian Council for Research on International Economic Relation. Repeated restrictions make India an unreliable exporter, he added. “That’s not good for the export business because it takes years to develop these markets,” Gulati said. Vietnam, another major rice exporter, is hoping to capitalize. With rice export prices at a 15-year high and expectations that annual production to be marginally higher than last year, the Southeast Asian nation is trying to keep domestic prices stable while boosting exports. The Agriculture Ministry says it's working to increase how much land in the Mekong Delta is dedicated to growing rice by around 500 square kilometers — an area larger than 90,000 football fields. Already the Philippines is in talks with Vietnam to try to get the grain at lower prices, while Vietnam also looks to target the United Kingdom, which receives much of its rice from India. But exporters like Charoen Laothamatas in neighboring Thailand are wary. The Thai government expects to ship more rice than it did last year, with its exports in the first six months of the year 15% higher than the same period of 2022. But the lack of clarity about what India will do next and concerns about the El Nino means Thai exporters are reluctant to take orders, mill operators are unwilling to sell and farmers have increased the prices of unmilled rice, said Laothamatas, president of the Thai Rice Exporters Association. With prices fluctuating, exporters don't know what prices to quote — because prices may spike again the next day. “And no one wants to take the risk,” Laothamatas said.

Proceeding to the discovery phase means both parties must collect and exchange evidence.

Former Meta COO Sheryl Sandberg delivers an emotional address on her post-October 7 transformation, urging Jewish leaders to combat rising antisemitism and campus bias.

Sullivan laid the blame squarely on Hamas, clarifying that the issue was that the group simply didn’t want to make a deal under any terms.

Houthi spokesperson Yahya Sarea had earlier said the first operation targeted a US aircraft carrier in the Arabian sea with a number of missiles and drones.

International Day for the Eradication of Poverty

Linet Makwera (28) has a baby strapped on her back as she totters barefoot, picking tiny pieces of wood on both sides of a dusty and narrow road, peering fearfully at people passing by along the road in Chimanimani’s Mutambara area in Gonzoma village located in Zimbabwe’s Manicaland Province, east of the country. Her fears, […]

  More durable than bronze, higher than Pharaoh’s pyramids is the monument I have made, a shape that angry wind or hungry rain cannot demolish, nor the innumerable ranks of the years that march in centuries. I shall not wholly die: some part of me will cheat the goddess of death. Thus wrote, not without […]

It’s no coincidence that extreme heat is engulfing huge swaths of Asia, Europe and North America all at the same time.

KARACHI: The Federal Board of Revenue’s (FBR) decision to fix the minimum retail price (MRP) of tea at Rs1,200 per kg for levying sales tax would make the commodity more expensive, warned traders on Tuesday.

Pakistan Tea Association (PTA) Chairman Mohammad Altaf said the MRP at the import stage would have an adverse impact of Rs150-300 per kg on imported tea prices.

The flat MRP also ignores global tea prices hovering between 0.50 cents to over $3 per kg. Tea is imported in different packaging, with bulk shipments typically weighing more than 5kgs and around/approximately 80kgs. An 18 per cent general sales tax is already charged based on the imported tea.

He said before fixing the MRP for sales tax purposes, it is crucial to consider that the definition of “manufacturer” in Section 2(16) of the Sales Tax Act 1990, includes activities such as blending, mixing, processing, and packaging, as clarified in Circular No. 3(11) ST-L&P/2013-94433-R dated July 17, 2019. Based on this, tea imported for these processes qualifies as “raw material”.

Tea sellers warn FBR move will incentivise arrival of low-quality product via illegal channels

“According to judicial interpretations (e.g., CTO v. Rajasthan Taxchem Ltd., 2007) and definitions in Advanced Law Lexicon, “raw material” includes ingredients necessary for manufacturing. Tea used in blending and packaging clearly falls under this category, he added.

Accordingly, sales tax should be based on the import value, as per Subsection 46(f) of Section 2 of the Sales Tax Act, 1990, rather than the minimum retail price, Altaf said.

Tea retail prices vary significantly due to numerous factors, including the company, method of sale (open or packaged), product quality, and regional differences. The PTA chief said that the flat MRP rate per kg also does not reflect the prices charged by most traders, manufacturers, and sellers.

The imposition of a flat rate per kg would have severe negative consequences for a large portion of the tea trade, which may result in reduced business activity and ultimately lead to a loss of revenue for the national exchequer via misusing several exemptions.

Two-thirds of Pakista­nis purchase tea at Rs700-950 per kg, reflecting socio-economic and regional price variations.

He said that MRP cannot be applied at the import stage as the tea has to follow various value-addition procedures before it is made shelf-ready. “This MRP disrupts the supply chain and eradicates the role of wholesalers and distributors who play a vital role in the business, while MRP at the import stage also eradicates the basic right of commercial imports,” the PTA chief observed.

Tea is a part of our daily diet, a staple food item, not a drink.

Most people in rural and urban areas consume tea as per their earnings. Further fixing of MRP will incentivise unscrupulous elements to exploit the situation, and thus, import of low-priced teas will find its way through illegal channels, Altaf feared.

Published in Dawn, November 13th, 2024

The Kīlauea volcano in Hawaii has begun erupting, spewing volcanic gas and ash across the island

This year could bring up to 25 named tropical storms in the Atlantic Ocean due to a shift to La Niña conditions, says the US National Oceanic and Atmospheric Administration

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Extract

It is of utmost importance that medicines are available at all times for our patients. Historically, medication unavailability has typically, if not exclusively, affected low- and middle-income countries [1]. More recently however, drug shortages have also been reported in high-income European countries [2]. Drug shortages have negative health consequences for patients [3], and a profound economic impact, with the need to resort to more expensive alternatives and demands on healthcare professionals’ time to find, prescribe and dispense alternatives [4].

The orexigenic gut peptide ghrelin is an endogenous ligand for the growth hormone secretagogue receptor type 1a (GHSR1a). Systemic ghrelin administration has previously been shown to increase gastric motility and emptying. While these effects are known to be mediated by the vagus nerve, the cellular mechanism underlying these effects remains unclear. Therefore, the purpose of the present study was to investigate the signaling mechanism by which GHSR1a inhibits voltage-gated Ca²⁺ channels in isolated rat gastric vagal afferent neurons using whole-cell patch-clamp electrophysiology. The ghrelin pharmacological profile indicated that Ca²⁺ currents were inhibited with a log (Ic₅₀) = –2.10 ± 0.44 and a maximal inhibition of 42.8 ± 5.0%. Exposure to the GHSR1a receptor antagonist (D-Lys3)-GHRP-6 reduced ghrelin-mediated Ca²⁺ channel inhibition (29.4 ± 16.7% vs. 1.9 ± 2.5%, n = 6, P = 0.0064). Interestingly, we observed that activation of GHSR1a inhibited Ca²⁺ currents through both voltage-dependent and voltage-independent pathways. We also treated the gastric neurons with either pertussis toxin (PTX) or YM-254890 to examine whether the Ca²⁺ current inhibition was mediated by the Gα_i/o or Gα_q/11 family of subunits. Treatment with both PTX (Ca²⁺ current inhibition = 15.7 ± 10.6%, n = 8, P = 0.0327) and YM-254890 (15.2 ± 11.9%, n = 8, P = 0.0269) blocked ghrelin’s effects on Ca²⁺ currents, as compared with control neurons (34.3 ± 18.9%, n = 8). These results indicate GHSR1a can couple to both Gα_i/o and Gα_q/11 in gastric vagal afferent neurons. Overall, our findings suggest GHSR1a-mediated inhibition of Ca²⁺ currents occurs through two distinct pathways, offering necessary insights into the cellular mechanisms underlying ghrelin’s regulation of gastric vagal afferents.

ABSTRACTIntroduction:Since the health information system (HIS) in public health care services in Serbia was introduced in 2009, it has gradually expanded. However, it is unclear how well the HIS components have developed and the whole system’s stage of maturity.Method:In June–September 2021, a maturity assessment of the Serbian HIS was conducted for the first time using the HIS Stages of Continuous Improvement (SOCI) toolkit. The toolkit measures HIS status across 5 HIS domains: leadership and governance, management and workforce, information and communication technology (ICT), standards and interoperability, and data quality and use. The domains were further divided into 13 components and 39 subcomponents whose maturity stage was assessed on a 5-point Likert scale, indicating the level of development: (1) emerging/ad hoc; (2) repeatable; (3) defined; (4) managed; and (5) optimized. The toolkit was applied in a working group of 32 professionals and experts who were engaged in developing the new national eHealth strategy and action plan.Results:The overall maturity score of the Serbian HIS was 1.6, which indicates a low level. The highest baseline score (2) was given to the standards and interoperability domain, and the lowest (1.1) was given to ICT infrastructure. The remaining 3 domains (leadership and governance, Management and Workforce, and Data Quality and Use) were similarly rated (1.7, 1.7, and 1.6, respectively).Conclusion:A baseline assessment of the maturity level of Serbian HIS indicates that the majority of components are between the emerging/ad hoc stage and repeatable, which represent isolated, ad hoc efforts, with some basic processes in place and existing and accessible policies. This exercise provided an opportunity to address identified weaknesses in the upcoming national eHealth strategy.

Despite a significant decrease in the number of prescriptions for opioids, the opioid crisis continues, fueled in large part by the availability of the phenylpiperidine mu opioid receptor (MOR) agonist fentanyl. In contrast, the number of prescriptions for and the off-label use of gabapentinoids (gabapentin and pregabalin) has increased dramatically, with gabapentinoids commonly detected in opioid overdose victims. Although gabapentinoids can decrease the potency of the opioid receptor antagonist naloxone to reverse heroin-induced hypoventilation in male rats, the specificity and nature of interaction between gabapentinoids and MOR agonists and any potential sex difference in those interactions are not well characterized. Gabapentinoids were studied in female and male rats discriminating fentanyl (0.0032 mg/kg, i.p.) or cocaine (3.2 mg/kg, i.p.). Alone, neither gabapentin nor pregabalin significantly increased fentanyl- or cocaine-appropriate responding. In rats discriminating fentanyl, each gabapentinoid dose-dependently shifted the fentanyl and heroin discrimination dose-effect functions to the left, whereas naloxone dose-dependently shifted the fentanyl and heroin discrimination dose-effect functions to the right. Each gabapentinoid (100 mg/kg) significantly decreased the potency of naloxone to antagonize the discriminative stimulus effect of fentanyl or heroin. In contrast, each gabapentinoid dose-dependently shifted the cocaine and d-methamphetamine discrimination dose-effect functions to the right. There were no significant sex differences in this study. These results suggest that gabapentinoids impact the misuse of opioids, the co-use of opioids and stimulant drugs, and the increasing number of overdose deaths in individuals using opioids, stimulant drugs, and gabapentinoids in mixtures.

Clinical reports suggest that the most effective strategies for managing opioid use disorder comprise a comprehensive treatment program of both pharmacological and nonpharmacological approaches. However, the conditions under which these combinations are most effective are not well characterized. This study examined whether the presence of an alternative reinforcer could alter the efficacy of Food and Drug Administration–approved opioid antagonist or agonist medications, as well as the nonopioid flumazenil, in decreasing oxycodone choice self-administration in nonhuman primates. Adult squirrel monkeys (n = 7; four females) responded under concurrent second-order fixed-ratio (FR)-3(FR5:S);TO45s schedules of reinforcement for intravenous oxycodone (0.1 mg/kg) or saline on one lever and 30% sweetened condensed milk or water on the other. Doses of naltrexone (0.00032–1.0 mg/kg), nalbuphine (0.32–10 mg/kg), buprenorphine (0.0032–0.032 mg/kg), methadone (0.32–1.0 mg/kg), or flumazenil (1–3.2 mg/kg) were administered intramuscularly prior to oxycodone self-administration sessions that occurred with either milk or water as the alternative. Naltrexone, a μ-opioid receptor antagonist, was >30-fold more potent when milk was available compared with water and abolished oxycodone intake (injections/session) while concomitantly increasing milk deliveries at the highest dose tested. Pretreatment with the low-efficacy μ-agonist nalbuphine was most effective in the presence of milk compared with water, decreasing oxycodone preference to <50% of control values. The higher efficacy μ-agonists, methadone and buprenorphine, and the benzodiazepine antagonist flumazenil did not appreciably alter the reinforcing potency of oxycodone under either condition. These results suggest that antagonist medications used in combination with alternative reinforcers may be an effective strategy to curtail opioid abuse–related behaviors.

Neuropathic pain is a form of chronic pain that develops because of damage to the nervous system. Treatment of neuropathic pain is often incompletely effective, and most available therapeutics have only moderate efficacy and present side effects that limit their use. Opioids are commonly prescribed for the management of neuropathic pain despite equivocal results in clinical studies and significant abuse potential. Thus, neuropathic pain represents an area of critical unmet medical need, and novel classes of therapeutics with improved efficacy and safety profiles are urgently needed. The cannabidiol structural analog and novel antagonist of GPR55, KLS-13019, was screened in rat models of neuropathic pain. Tactile sensitivity associated with chemotherapy exposure was induced in rats with once-daily 1-mg/kg paclitaxel injections for 4 days or 5 mg/kg oxaliplatin every third day for 1 week. Rats were then administered KLS-13019 or comparator drugs on day 7 in an acute dosing paradigm or days 7–10 in a chronic dosing paradigm, and mechanical or cold allodynia was assessed. Allodynia was reversed in a dose-dependent manner in the rats treated with KLS-13019, with the highest dose reverting the response to prepaclitaxel injection baseline levels with both intraperitoneal and oral administration after acute dosing. In the chronic dosing paradigm, four consecutive doses of KLS-13019 completely reversed allodynia for the duration of the phenotype in control animals. Additionally, coadministration of KLS-13019 with paclitaxel prevented the allodynic phenotype from developing. Together, these data suggest that KLS-13019 represents a potential new drug for the treatment of neuropathic pain.

BACKGROUND AND PURPOSE:

Reocclusion after treatment is a concern in endovascular therapy for isolated intracranial atherothrombotic stroke-related large-vessel occlusion (AT-LVO). However, the optimal endovascular therapy technique for AT-LVO has not yet been investigated. This study evaluated the optimal endovascular therapy technique for AT-LVO in a real-world setting.

BackgroundDuring the COVID-19 pandemic, global trends of reduced healthcare-seeking behaviour were observed. This raises concerns about the consequences of healthcare avoidance for population health.AimTo determine the association between healthcare avoidance during the early stages of the COVID-19 pandemic and all-cause mortality.Design and settingThis was a 32-month follow-up within the population-based Rotterdam Study, after sending a COVID-19 questionnaire at the onset of the pandemic in April 2020 to all communty dwelling participants (n = 6241/8732, response rate 71.5%).MethodCox proportional hazards models assessed the risk of all-cause mortality among respondents who avoided health care because of the COVID-19 pandemic. Mortality status was collected through municipality registries and medical records.ResultsOf 5656 respondents, one-fifth avoided health care because of the COVID-19 pandemic (n = 1143). Compared with non-avoiders, those who avoided health care more often reported symptoms of depression (n = 357, 31.2% versus n = 554, 12.3%) and anxiety (n = 340, 29.7% versus n = 549, 12.2%), and more often rated their health as poor to fair (n = 336, 29.4% versus n = 457, 10.1%) . Those who avoided health care had an increased adjusted risk of all-cause mortality (hazard ratio [HR] 1.30, 95% confidence interval [CI] = 1.01 to 1.67), which remained nearly identical after adjustment for history of any non-communicable disease (HR 1.20, 95% CI = 0.93 to 1.54). However, this association attenuated after additional adjustment for mental and physical self-perceived health factors (HR 0.93, 95% CI = 0.71 to 1.20).ConclusionThis study found an increased risk of all-cause mortality among individuals who avoided health care during COVID-19. These individuals were characterised by poor mental and physical self-perceived health. Therefore, interventions should be targeted to these vulnerable individuals to safeguard their access to primary and specialist care to limit health disparities, inside and beyond healthcare crises.

Stage III nonsmall cell lung cancer (NSCLC) represents a wide range of tumour (T1 to T4) and nodal (N0 to N3) components, requiring variable management and a multidisciplinary approach. Recent advancements in minimally invasive techniques, molecular biology and novel drug discoveries have accelerated the refinement of stage III NSCLC management. The latest developments in staging include the forthcoming update of the nodal component in the 9th TNM (tumour–node–metastasis) edition, which emphasises the critical role for endobronchial ultrasonography in mediastinal staging. Recent treatment developments include the use of immunotherapy and targeted molecular therapy in both the neoadjuvant and adjuvant setting, either in combination with other modalities or used alone as consolidation. Surgical and radiotherapy advancements have further enhanced patient outcomes. These developments have significantly improved the prognosis for patients with stage III NSCLC. Fast-changing recommendations have also brought about a challenge, with clinicians facing a number of options to choose from. Therefore, a multimodal approach by a multidisciplinary team has become even more crucial in managing stage III NSCLC.

Sir Andy Murray will swap Centre Court for the stage next summer as he embarks on a tour discussing his illustrious tennis career.

Tam plays the waifu games for the "plot." Chris teaches his cats to play DDR. Kelley blames everyone else for her Vampire Survivors addiction.

The post RPG Cast – Episode 661: “I Got Addicted to the Pentagram” appeared first on RPGamer.

If rumours are true and this one should be, I started it, we have a special edition of the Weekend show where we talk about the evolution of the role of the CIO with two incredible CIOs as the CIO Association of Canada turns 20. Don’t miss it.  MUSIC UP Can HP make you love […]

In Canada, your IP address has the right to remain silent. Elon Musk is suing OpenAI for not being Open. Apple faces a class action not allowing competitive access to backup services and the World Server Throwing Competition in March 2024 is accused of being too violent towards servers.   All this and more on the […]

Apple Music gives a whole new meaning to the phrase the hits just keep on coming.  It’s not the opposing candidates, it’s public AI systems that are spreading election disinformation, and LockBit, the cybercriminal gang may be back from the dead and saying so long to the ChatGPT plugins, which went from innovation to legacy […]

Imagine a world without Facebook. For just half an hour. A group of AI leaders get together but don’t seem to invite Elon Musk. Amazon takes data centres nuclear. A new competitor for ChatGPT and Google. And public trust in AI is declining.  All this and more on the “just breath, Facebook will be back” […]

Israeli President Isaac Herzog says hostages are "going through hell in the dungeons of Gaza" during meeting with President Biden at White House.

Atlantic Canadians say the region has room to grow, but is facing a shrinking labour pool

The science about whether mental health conditions can spread socially is uncertain, but exposure to an affected peer can drive awareness